CN102015691B - 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 - Google Patents

作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 Download PDF

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CN102015691B
CN102015691B CN200980115503.0A CN200980115503A CN102015691B CN 102015691 B CN102015691 B CN 102015691B CN 200980115503 A CN200980115503 A CN 200980115503A CN 102015691 B CN102015691 B CN 102015691B
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pyridine
pyridin
imidazo
base
compound
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Chinese (zh)
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CN102015691A (zh
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C·勒布朗
C·里奇
D·肖
N·J·施蒂夫尔
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
CN200980115503.0A 2008-04-29 2009-04-27 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 Expired - Fee Related CN102015691B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155405.7 2008-04-29
EP08155405 2008-04-29
PCT/EP2009/055066 WO2009133070A1 (en) 2008-04-29 2009-04-27 Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors

Publications (2)

Publication Number Publication Date
CN102015691A CN102015691A (zh) 2011-04-13
CN102015691B true CN102015691B (zh) 2014-01-08

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CN200980115503.0A Expired - Fee Related CN102015691B (zh) 2008-04-29 2009-04-27 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物

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Country Link
US (1) US9079897B2 (enExample)
EP (1) EP2307402B1 (enExample)
JP (1) JP5507543B2 (enExample)
KR (1) KR20100130226A (enExample)
CN (1) CN102015691B (enExample)
AU (1) AU2009242145B2 (enExample)
BR (1) BRPI0911490A2 (enExample)
CA (1) CA2722131A1 (enExample)
EA (1) EA201001687A1 (enExample)
ES (1) ES2399175T3 (enExample)
MX (1) MX2010011867A (enExample)
PL (1) PL2307402T3 (enExample)
PT (1) PT2307402E (enExample)
WO (1) WO2009133070A1 (enExample)

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CA2789021C (en) 2010-02-05 2018-02-06 Merck Patent Gmbh Hetaryl-[1,8]naphthyridine derivatives
EA022064B1 (ru) 2010-02-22 2015-10-30 Мерк Патент Гмбх Гетариламинонафтиридины в качестве ингибиторов атф-связывающих белков
WO2011146287A1 (en) 2010-05-20 2011-11-24 Takeda Pharmaceutical Company Limited Pyrazolo[4,3-b]pyridine-7-amine inhibitors of alk5
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
AU2011327062B8 (en) 2010-11-08 2017-03-02 Sk Chemicals Co., Ltd. Polylactic acid resin, preparation method thereof, and packing film comprising the same
US20140088174A1 (en) * 2011-04-05 2014-03-27 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Compounds and methods for altering activin receptor-like kinase signaling
CA2901427A1 (en) 2013-03-07 2014-09-12 Califia Bio, Inc. Mixed lineage kinase inhibitors and method of treatments
ES2766835T3 (es) 2015-04-16 2020-06-15 Merck Patent Gmbh Derivados de 3-(1H-bencimidazol-2-il)-1H-piridin-2-ona
CN108290835B (zh) * 2015-09-23 2022-03-08 达纳-法伯癌症研究所股份有限公司 Alk和srpk的抑制剂和使用方法
RU2642456C2 (ru) * 2016-06-29 2018-01-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения N-арилзамещенных 3H-имидазо[4,5-b]пиридинов
KR102365333B1 (ko) 2016-07-29 2022-02-23 상하이 잉리 파마슈티컬 컴퍼니 리미티드 질소 함유 방향족 헤테로 고리 화합물, 이의 제조 방법, 약물 조성물 및 응용
CN106831770A (zh) * 2017-03-13 2017-06-13 牡丹江医学院 一种药物组合物及其用于治疗肝硬化的用途
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
US20200247812A1 (en) * 2018-07-10 2020-08-06 Integral Biosciences Private Limited Heterocyclic compounds and methods of use
KR20210125471A (ko) 2018-10-05 2021-10-18 안나푸르나 바이오, 인코포레이티드 Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물
JP2023509760A (ja) 2020-01-08 2023-03-09 シンシス セラピューティクス，インコーポレイテッド Ａｌｋ５阻害剤複合体およびその使用
EP4182322B1 (en) 2020-07-15 2024-04-24 Chiesi Farmaceutici S.p.A. Pyrido oxazine derivatives as alk5 inhibitors
JP7686741B2 (ja) 2020-07-15 2025-06-02 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ａｌｋ５阻害剤としてのピリダジニルアミノ誘導体
EP4182323B1 (en) 2020-07-15 2024-04-24 Chiesi Farmaceutici S.p.A. Pyrido oxazine amino derivatives as alk5 inhibitors
EP4267584A1 (en) 2020-12-23 2023-11-01 Chiesi Farmaceutici S.p.A. Pyrido oxazine derivatives as alk5 inhibitors
CA3232178A1 (en) 2021-09-21 2023-03-30 Daniela PIZZIRANI Pyridazinyl amino derivatives as alk5 inhibitors
US20250270215A1 (en) 2022-04-27 2025-08-28 Chiesi Farmaceutici S.P.A. Imidazole derivatives as alk5 inhibitors
WO2024258967A1 (en) 2023-06-13 2024-12-19 Synthis Therapeutics, Inc. Anti-cd5 antibodies and their uses

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WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors
WO2004013138A2 (en) * 2002-07-31 2004-02-12 Smithkline Beecham Corporation Imidazo`1,2-a!pyridines
WO2008006583A1 (en) * 2006-07-14 2008-01-17 Novartis Ag Pyrimidine derivatives as alk-5 inhibitors

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EP0563001A1 (en) * 1992-03-26 1993-09-29 Neurosearch A/S Imidazole compounds, their preparation and use
WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors
WO2004013138A2 (en) * 2002-07-31 2004-02-12 Smithkline Beecham Corporation Imidazo`1,2-a!pyridines
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Synthesis and biological evaluation of novel 2,4,5-triaryl-1H-pyrazol-3(2H)-ones as inhibitors of ALK5;Xing Zhou Li, et al.;《Chinses Chemical letters 》;20081231;第19卷;第379-382页 *

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PL2307402T3 (pl) 2013-05-31
EA201001687A1 (ru) 2011-06-30
AU2009242145A1 (en) 2009-11-05
US20110060004A1 (en) 2011-03-10
US9079897B2 (en) 2015-07-14
WO2009133070A1 (en) 2009-11-05
BRPI0911490A2 (pt) 2016-01-05
JP5507543B2 (ja) 2014-05-28
CN102015691A (zh) 2011-04-13
MX2010011867A (es) 2010-11-26
AU2009242145B2 (en) 2012-07-05
PT2307402E (pt) 2013-02-15
EP2307402A1 (en) 2011-04-13
EP2307402B1 (en) 2012-11-07
JP2011518856A (ja) 2011-06-30
KR20100130226A (ko) 2010-12-10
CA2722131A1 (en) 2009-11-05
ES2399175T3 (es) 2013-03-26

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