JP2011516612A5 - - Google Patents
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- Publication number
- JP2011516612A5 JP2011516612A5 JP2011505163A JP2011505163A JP2011516612A5 JP 2011516612 A5 JP2011516612 A5 JP 2011516612A5 JP 2011505163 A JP2011505163 A JP 2011505163A JP 2011505163 A JP2011505163 A JP 2011505163A JP 2011516612 A5 JP2011516612 A5 JP 2011516612A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- posaconazole
- hpmc
- dissolved
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 claims description 46
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims description 24
- 229960001589 posaconazole Drugs 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 17
- 239000002552 dosage form Substances 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 10
- 238000004090 dissolution Methods 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims description 6
- 239000000155 melt Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 239000008247 solid mixture Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims description 4
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical group OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 4
- 235000020937 fasting conditions Nutrition 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 230000009477 glass transition Effects 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 208000004235 neutropenia Diseases 0.000 claims description 2
- 239000011236 particulate material Substances 0.000 claims description 2
- 230000036470 plasma concentration Effects 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4517708P | 2008-04-15 | 2008-04-15 | |
| US61/045,177 | 2008-04-15 | ||
| US16648709P | 2009-04-03 | 2009-04-03 | |
| US61/166,487 | 2009-04-03 | ||
| PCT/US2009/040652 WO2009129300A2 (en) | 2008-04-15 | 2009-04-15 | High density compositions containing posaconazole and formulations comprising the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075980A Division JP2014139230A (ja) | 2008-04-15 | 2014-04-02 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516612A JP2011516612A (ja) | 2011-05-26 |
| JP2011516612A5 true JP2011516612A5 (enExample) | 2012-08-16 |
Family
ID=41199703
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011505163A Ceased JP2011516612A (ja) | 2008-04-15 | 2009-04-15 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
| JP2014075980A Pending JP2014139230A (ja) | 2008-04-15 | 2014-04-02 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
| JP2015228422A Withdrawn JP2016074698A (ja) | 2008-04-15 | 2015-11-24 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075980A Pending JP2014139230A (ja) | 2008-04-15 | 2014-04-02 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
| JP2015228422A Withdrawn JP2016074698A (ja) | 2008-04-15 | 2015-11-24 | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20110123627A1 (enExample) |
| EP (1) | EP2285351A2 (enExample) |
| JP (3) | JP2011516612A (enExample) |
| KR (1) | KR20110004852A (enExample) |
| CN (2) | CN102065842A (enExample) |
| AR (1) | AR072858A1 (enExample) |
| AU (1) | AU2009236289B2 (enExample) |
| BR (1) | BRPI0910627A2 (enExample) |
| CA (1) | CA2720849A1 (enExample) |
| CL (1) | CL2009000902A1 (enExample) |
| CO (1) | CO6311066A2 (enExample) |
| MX (1) | MX2010011295A (enExample) |
| NZ (1) | NZ588460A (enExample) |
| PE (1) | PE20091778A1 (enExample) |
| PH (1) | PH12015500492A1 (enExample) |
| SG (1) | SG10201403986UA (enExample) |
| TW (1) | TWI388324B (enExample) |
| WO (1) | WO2009129300A2 (enExample) |
| ZA (1) | ZA201007370B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009236290A1 (en) * | 2008-04-15 | 2009-10-22 | Merck Sharp & Dohme Corp. | Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS |
| WO2011102504A1 (ja) | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| PT3006049T (pt) * | 2013-06-03 | 2018-03-20 | Shinetsu Chemical Co | Composição para extrusão por fusão a quente e método para produzir um produto extrudido por fusão a quente |
| EP2837391B1 (en) | 2013-08-12 | 2017-05-10 | Shin-Etsu Chemical Co., Ltd. | Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate |
| CN104510707A (zh) * | 2013-09-26 | 2015-04-15 | 博瑞生物医药技术(苏州)有限公司 | 一种泊沙康唑固体分散体及其制备方法 |
| CN104546667A (zh) * | 2013-10-22 | 2015-04-29 | 博瑞生物医药技术(苏州)有限公司 | 含泊沙康唑的固体分散体及其制备方法 |
| CN104721827A (zh) * | 2013-12-18 | 2015-06-24 | 博瑞生物医药技术(苏州)有限公司 | 一种难溶性抗真菌药物固体分散体及其制备方法 |
| HK1232218A1 (zh) | 2014-02-05 | 2018-01-05 | Merck Sharp & Dohme Llc | Cgrp-活性化合物的片剂制剂 |
| CN110179801B (zh) * | 2014-04-11 | 2021-08-06 | 上海宣泰医药科技股份有限公司 | 泊沙康唑药物组合物及其制备方法和药物制剂 |
| EP3590505B1 (en) | 2015-08-08 | 2024-11-06 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole |
| EP3210599B1 (en) | 2016-02-26 | 2024-08-28 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| CN106265526A (zh) * | 2016-09-22 | 2017-01-04 | 山东大学 | 一种抗真菌药物泊沙康唑的固体分散体及制备方法与应用 |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| US20180282527A1 (en) * | 2017-03-30 | 2018-10-04 | Shin-Etsu Chemical Co., Ltd. | Injection molding composition containing hypromellose acetate succinate and method for producing same |
| US10702520B1 (en) | 2019-01-29 | 2020-07-07 | Slayback Pharma Llc | Pharmaceutical compositions of posaconazole |
| US20230149452A1 (en) * | 2020-04-06 | 2023-05-18 | Yogesh BENDALE | Structurally defined, better tolerated, orally adminstered, processed arsenolite, a process for its preparation, a pharmaceutical composition and uses thereof |
| EP4196096A1 (en) | 2020-08-13 | 2023-06-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant high-strength formulation containing posaconazole |
| CN112697937A (zh) * | 2020-12-18 | 2021-04-23 | 卓和药业集团有限公司 | 泊沙康唑肠溶片溶出度的分析方法 |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| AU2022324717A1 (en) | 2021-11-25 | 2024-06-13 | Alfred E. Tiefenbacher (Gmbh Und Co. Kg) | Granules containing posaconazole |
| CN114184721A (zh) * | 2021-12-14 | 2022-03-15 | 江苏恒盛药业有限公司 | 泊沙康唑残留溶剂的检测方法 |
| CN115721601A (zh) * | 2022-11-23 | 2023-03-03 | 无锡福祈制药有限公司 | 一种泊沙康唑纳米晶口服固体药物组合物及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144346A (en) * | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4978672A (en) * | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| GB8908250D0 (en) * | 1989-04-12 | 1989-05-24 | Fisons Plc | Formulations |
| US5278175A (en) * | 1990-02-02 | 1994-01-11 | Pfizer Inc. | Triazole antifungal agents |
| US5703079A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5661151A (en) * | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| GB9602080D0 (en) * | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| CN1165291C (zh) * | 1996-05-20 | 2004-09-08 | 詹森药业有限公司 | 具有改进的生物利用度的抗真菌组合物 |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| US5972381A (en) * | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| US6713481B1 (en) * | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
| AU2331801A (en) * | 1999-12-23 | 2001-07-09 | F.H. Faulding & Co. Limited | Improved pharmaceutical compositions for poorly soluble drugs |
| AR028253A1 (es) * | 2000-03-16 | 2003-04-30 | Pfizer Prod Inc | Inhibidores de la glucogeno fosforilasa |
| MXPA03009021A (es) * | 2001-04-03 | 2004-02-12 | Schering Corp | Composicion antifungal con biodisponibilidad aumentada. |
| WO2003077827A1 (en) * | 2002-03-19 | 2003-09-25 | Nippon Shinyaku Co., Ltd. | Process for producing drug solid dispersion |
| US20050043251A1 (en) * | 2003-08-20 | 2005-02-24 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| US20060062848A1 (en) * | 2004-09-17 | 2006-03-23 | Nektar Therapeutics Uk Limited | Formulation comprising itraconazole |
| US20060275230A1 (en) * | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
| WO2007056205A2 (en) * | 2005-11-04 | 2007-05-18 | Eastman Chemical Company | Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents |
| MX2008015275A (es) * | 2006-05-30 | 2009-02-06 | Elan Pharma Int Ltd | Formulaciones de posaconazol en nanoparticulas. |
| CA2686756A1 (en) * | 2007-05-11 | 2008-11-20 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions for poorly soluble drugs |
| AU2009236290A1 (en) * | 2008-04-15 | 2009-10-22 | Merck Sharp & Dohme Corp. | Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS |
-
2009
- 2009-04-15 WO PCT/US2009/040652 patent/WO2009129300A2/en not_active Ceased
- 2009-04-15 CN CN2009801224878A patent/CN102065842A/zh active Pending
- 2009-04-15 PE PE2009000520A patent/PE20091778A1/es active IP Right Grant
- 2009-04-15 TW TW098112539A patent/TWI388324B/zh active
- 2009-04-15 MX MX2010011295A patent/MX2010011295A/es active IP Right Grant
- 2009-04-15 CL CL2009000902A patent/CL2009000902A1/es unknown
- 2009-04-15 BR BRPI0910627A patent/BRPI0910627A2/pt not_active IP Right Cessation
- 2009-04-15 NZ NZ588460A patent/NZ588460A/en unknown
- 2009-04-15 EP EP09732010A patent/EP2285351A2/en not_active Withdrawn
- 2009-04-15 CA CA2720849A patent/CA2720849A1/en not_active Abandoned
- 2009-04-15 AR ARP090101320A patent/AR072858A1/es unknown
- 2009-04-15 SG SG10201403986UA patent/SG10201403986UA/en unknown
- 2009-04-15 KR KR1020107023010A patent/KR20110004852A/ko not_active Ceased
- 2009-04-15 CN CN201510421108.2A patent/CN104983701A/zh active Pending
- 2009-04-15 AU AU2009236289A patent/AU2009236289B2/en not_active Expired - Fee Related
- 2009-04-15 JP JP2011505163A patent/JP2011516612A/ja not_active Ceased
- 2009-04-15 US US12/999,547 patent/US20110123627A1/en not_active Abandoned
-
2010
- 2010-10-14 ZA ZA2010/07370A patent/ZA201007370B/en unknown
- 2010-11-11 CO CO10141841A patent/CO6311066A2/es not_active Application Discontinuation
-
2014
- 2014-04-02 JP JP2014075980A patent/JP2014139230A/ja active Pending
- 2014-11-24 US US14/551,903 patent/US20150150990A1/en not_active Abandoned
-
2015
- 2015-03-06 PH PH12015500492A patent/PH12015500492A1/en unknown
- 2015-11-24 JP JP2015228422A patent/JP2016074698A/ja not_active Withdrawn
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