AU2009236289B2 - Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS - Google Patents

Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS Download PDF

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Publication number
AU2009236289B2
AU2009236289B2 AU2009236289A AU2009236289A AU2009236289B2 AU 2009236289 B2 AU2009236289 B2 AU 2009236289B2 AU 2009236289 A AU2009236289 A AU 2009236289A AU 2009236289 A AU2009236289 A AU 2009236289A AU 2009236289 B2 AU2009236289 B2 AU 2009236289B2
Authority
AU
Australia
Prior art keywords
posaconazole
composition
hpmc
polymer
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2009236289A
Other languages
English (en)
Other versions
AU2009236289A1 (en
Inventor
Larry Yun Fang
David Harris
Gopal Krishna
Allen E. Moton Jr.
Russell C. Prestipino
Marc Steinman
Jiansheng Wan
Hetty Anne Waskin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41199703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009236289(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2009236289A1 publication Critical patent/AU2009236289A1/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Alteration of Name(s) of Applicant(s) under S113 Assignors: SCHERING CORPORATION
Application granted granted Critical
Publication of AU2009236289B2 publication Critical patent/AU2009236289B2/en
Priority to AU2014265059A priority Critical patent/AU2014265059A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009236289A 2008-04-15 2009-04-15 Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS Expired - Fee Related AU2009236289B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014265059A AU2014265059A1 (en) 2008-04-15 2014-11-20 Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4517708P 2008-04-15 2008-04-15
US61/045,177 2008-04-15
US16648709P 2009-04-03 2009-04-03
US61/166,487 2009-04-03
PCT/US2009/040652 WO2009129300A2 (en) 2008-04-15 2009-04-15 High density compositions containing posaconazole and formulations comprising the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014265059A Division AU2014265059A1 (en) 2008-04-15 2014-11-20 Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas

Publications (2)

Publication Number Publication Date
AU2009236289A1 AU2009236289A1 (en) 2009-10-22
AU2009236289B2 true AU2009236289B2 (en) 2014-08-21

Family

ID=41199703

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009236289A Expired - Fee Related AU2009236289B2 (en) 2008-04-15 2009-04-15 Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS

Country Status (19)

Country Link
US (2) US20110123627A1 (enExample)
EP (1) EP2285351A2 (enExample)
JP (3) JP2011516612A (enExample)
KR (1) KR20110004852A (enExample)
CN (2) CN104983701A (enExample)
AR (1) AR072858A1 (enExample)
AU (1) AU2009236289B2 (enExample)
BR (1) BRPI0910627A2 (enExample)
CA (1) CA2720849A1 (enExample)
CL (1) CL2009000902A1 (enExample)
CO (1) CO6311066A2 (enExample)
MX (1) MX2010011295A (enExample)
NZ (1) NZ588460A (enExample)
PE (1) PE20091778A1 (enExample)
PH (1) PH12015500492A1 (enExample)
SG (1) SG10201403986UA (enExample)
TW (1) TWI388324B (enExample)
WO (1) WO2009129300A2 (enExample)
ZA (1) ZA201007370B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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JP2011516613A (ja) * 2008-04-15 2011-05-26 シェーリング コーポレイション 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物
JP5749247B2 (ja) 2010-02-22 2015-07-15 第一三共株式会社 経口用徐放性固形製剤
CN105283203B (zh) * 2013-06-03 2018-12-28 信越化学工业株式会社 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法
EP2837391B1 (en) * 2013-08-12 2017-05-10 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate
CN104510707A (zh) * 2013-09-26 2015-04-15 博瑞生物医药技术(苏州)有限公司 一种泊沙康唑固体分散体及其制备方法
CN104546667A (zh) * 2013-10-22 2015-04-29 博瑞生物医药技术(苏州)有限公司 含泊沙康唑的固体分散体及其制备方法
CN104721827A (zh) * 2013-12-18 2015-06-24 博瑞生物医药技术(苏州)有限公司 一种难溶性抗真菌药物固体分散体及其制备方法
RU2019123406A (ru) 2014-02-05 2019-10-03 Мерк Шарп И Доум Корп. Технология приготовления таблеток для cgrp-активных соединений
CN104971045A (zh) * 2014-04-11 2015-10-14 上海宣泰医药科技有限公司 泊沙康唑药物组合物及其制备方法和药物制剂
WO2017025292A1 (en) 2015-08-08 2017-02-16 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant formulation containing posaconazole
EP4424308A3 (en) 2016-02-26 2024-12-04 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
CN106265526A (zh) * 2016-09-22 2017-01-04 山东大学 一种抗真菌药物泊沙康唑的固体分散体及制备方法与应用
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
US20180282527A1 (en) * 2017-03-30 2018-10-04 Shin-Etsu Chemical Co., Ltd. Injection molding composition containing hypromellose acetate succinate and method for producing same
US10702520B1 (en) 2019-01-29 2020-07-07 Slayback Pharma Llc Pharmaceutical compositions of posaconazole
US20230149452A1 (en) * 2020-04-06 2023-05-18 Yogesh BENDALE Structurally defined, better tolerated, orally adminstered, processed arsenolite, a process for its preparation, a pharmaceutical composition and uses thereof
US20240293399A1 (en) 2020-08-13 2024-09-05 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
CN112697937A (zh) * 2020-12-18 2021-04-23 卓和药业集团有限公司 泊沙康唑肠溶片溶出度的分析方法
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole
WO2023012378A1 (en) 2021-11-25 2023-02-09 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
CN114184721A (zh) * 2021-12-14 2022-03-15 江苏恒盛药业有限公司 泊沙康唑残留溶剂的检测方法
CN115721601A (zh) * 2022-11-23 2023-03-03 无锡福祈制药有限公司 一种泊沙康唑纳米晶口服固体药物组合物及其制备方法

Citations (3)

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WO1997044014A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
US20060062848A1 (en) * 2004-09-17 2006-03-23 Nektar Therapeutics Uk Limited Formulation comprising itraconazole
WO2007056205A2 (en) * 2005-11-04 2007-05-18 Eastman Chemical Company Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents

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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044014A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
US20060062848A1 (en) * 2004-09-17 2006-03-23 Nektar Therapeutics Uk Limited Formulation comprising itraconazole
WO2007056205A2 (en) * 2005-11-04 2007-05-18 Eastman Chemical Company Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents

Also Published As

Publication number Publication date
MX2010011295A (es) 2010-11-12
AU2009236289A1 (en) 2009-10-22
US20110123627A1 (en) 2011-05-26
PH12015500492A1 (en) 2017-04-10
KR20110004852A (ko) 2011-01-14
EP2285351A2 (en) 2011-02-23
WO2009129300A3 (en) 2010-02-11
JP2016074698A (ja) 2016-05-12
PE20091778A1 (es) 2009-11-13
CN104983701A (zh) 2015-10-21
NZ588460A (en) 2012-07-27
CL2009000902A1 (es) 2010-07-23
TW200946121A (en) 2009-11-16
CN102065842A (zh) 2011-05-18
AR072858A1 (es) 2010-09-29
JP2014139230A (ja) 2014-07-31
TWI388324B (zh) 2013-03-11
JP2011516612A (ja) 2011-05-26
BRPI0910627A2 (pt) 2015-09-22
CA2720849A1 (en) 2009-10-22
ZA201007370B (en) 2011-06-29
SG10201403986UA (en) 2014-10-30
US20150150990A1 (en) 2015-06-04
WO2009129300A2 (en) 2009-10-22
CO6311066A2 (es) 2011-08-22

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Legal Events

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MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee