JP2011513476A5 - - Google Patents
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- JP2011513476A5 JP2011513476A5 JP2010550262A JP2010550262A JP2011513476A5 JP 2011513476 A5 JP2011513476 A5 JP 2011513476A5 JP 2010550262 A JP2010550262 A JP 2010550262A JP 2010550262 A JP2010550262 A JP 2010550262A JP 2011513476 A5 JP2011513476 A5 JP 2011513476A5
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- Japan
- Prior art keywords
- disease
- independently
- nhr
- ring atoms
- dementia
- Prior art date
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- 125000006413 ring segment Chemical group 0.000 claims 20
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
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- VODWXIYHKVUFBI-UHFFFAOYSA-N [5-[2-[4-(1-hydroxyethyl)anilino]pyrimidin-4-yl]thiophen-3-yl]-piperidin-1-ylmethanone Chemical compound C1=CC(C(O)C)=CC=C1NC1=NC=CC(C=2SC=C(C=2)C(=O)N2CCCCC2)=N1 VODWXIYHKVUFBI-UHFFFAOYSA-N 0.000 claims 2
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| BRPI0511982A (pt) | 2004-06-09 | 2008-01-22 | Hoffmann La Roche | compostos antiviróticos heterocìclicos |
| TW200716576A (en) | 2005-06-07 | 2007-05-01 | Shionogi & Co | Heterocyclic derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP2009519218A (ja) * | 2005-11-03 | 2009-05-14 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | ピリミジニル−チオフェンキナーゼモジュレータ |
| KR101081293B1 (ko) | 2006-01-18 | 2011-11-08 | 에프. 호프만-라 로슈 아게 | 11 베타-에이치에스디1 억제제로서 티아졸 |
| ATE509921T1 (de) | 2006-06-08 | 2011-06-15 | Lilly Co Eli | Substituierte carbonsäureamide als antagonisten des gruppe-i-metabotropen rezeptors |
| AU2007275301A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
| GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
| US20100022590A1 (en) | 2008-01-17 | 2010-01-28 | Biovitrum Ab (Publ.) | Novel compounds |
| GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| US8609690B2 (en) | 2008-08-25 | 2013-12-17 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| WO2010146338A1 (en) | 2009-06-15 | 2010-12-23 | The University Of Edinburgh | Amido-isothiazole compounds and their use as inhibitors of 11beta-hsd1 for the treatment of metabolic syndrome and related disorders |
| AU2010297068B2 (en) | 2009-09-16 | 2015-10-01 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-1H-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use |
| KR101714820B1 (ko) | 2010-04-29 | 2017-03-09 | 더 유니버시티 오브 에든버러 | 11(베타)-ｈｓｄ1의 억제제로서 3,3-이치환된-(8-아자-비시클로[3.2.1]옥트-8-일)-[5-(1h-피라졸-4-일)-티오펜-3-일]-메탄온 |
-
2008
- 2008-03-13 GB GBGB0804685.6A patent/GB0804685D0/en not_active Ceased
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2009
- 2009-03-13 KR KR1020107022050A patent/KR101626627B1/ko active Active
- 2009-03-13 AU AU2009224017A patent/AU2009224017B2/en active Active
- 2009-03-13 ES ES09718896.5T patent/ES2545489T3/es active Active
- 2009-03-13 DK DK09718896.5T patent/DK2283004T3/en active
- 2009-03-13 CA CA2716679A patent/CA2716679C/en active Active
- 2009-03-13 US US12/920,774 patent/US8299063B2/en active Active
- 2009-03-13 EP EP09718896.5A patent/EP2283004B1/en active Active
- 2009-03-13 JP JP2010550262A patent/JP5570435B2/ja active Active
- 2009-03-13 WO PCT/GB2009/000686 patent/WO2009112845A1/en not_active Ceased
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- 2012-09-13 US US13/615,497 patent/US8614209B2/en active Active
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