JP2011511837A5 - - Google Patents

Info

Publication number

JP2011511837A5

JP2011511837A5 JP2010546820A JP2010546820A JP2011511837A5 JP 2011511837 A5 JP2011511837 A5 JP 2011511837A5 JP 2010546820 A JP2010546820 A JP 2010546820A JP 2010546820 A JP2010546820 A JP 2010546820A JP 2011511837 A5 JP2011511837 A5 JP 2011511837A5

Authority

JP

Japan

Prior art keywords

methyl

imidazol

pyrrolidinyl

carbonyl

carbamate

Prior art date

2009-02-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 30
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 30
• -1 carboxy, formyl Chemical group 0.000 claims 29
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 28
• 125000000217 alkyl group Chemical group 0.000 claims 26
• 150000001875 compounds Chemical class 0.000 claims 19
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 12
• 229910052739 hydrogen Inorganic materials 0.000 claims 9
• 239000001257 hydrogen Substances 0.000 claims 9
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
• 125000001188 haloalkyl group Chemical group 0.000 claims 8
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 8
• 108010047761 Interferon-alpha Proteins 0.000 claims 6
• 102000006992 Interferon-alpha Human genes 0.000 claims 6
• 108010050904 Interferons Proteins 0.000 claims 6
• 102000014150 Interferons Human genes 0.000 claims 6
• 125000003545 alkoxy group Chemical group 0.000 claims 6
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
• 125000003710 aryl alkyl group Chemical group 0.000 claims 6
• 125000003118 aryl group Chemical group 0.000 claims 6
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
• 229940079322 interferon Drugs 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 125000000753 cycloalkyl group Chemical group 0.000 claims 5
• 125000005843 halogen group Chemical group 0.000 claims 5
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
• 229910052717 sulfur Chemical group 0.000 claims 5
• 125000004391 aryl sulfonyl group Chemical group 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000004432 carbon atom Chemical group C* 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 125000004043 oxo group Chemical group O=* 0.000 claims 4
• 239000001301 oxygen Chemical group 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 3
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
• 125000004438 haloalkoxy group Chemical group 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 2
• 102100040018 Interferon alpha-2 Human genes 0.000 claims 2
• 108010079944 Interferon-alpha2b Proteins 0.000 claims 2
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 2
• 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 2
• 125000004429 atom Chemical group 0.000 claims 2
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 229960000329 ribavirin Drugs 0.000 claims 2
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
• 125000003003 spiro group Chemical group 0.000 claims 2
• 239000011593 sulfur Chemical group 0.000 claims 2
• NBDAPJYUBQSVPV-KVXOYYPDSA-N (2s)-2-(diethylamino)-1-[(2s)-2-[5-[3-[2-[(2s)-1-[(2s)-2-(diethylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1h-imidazol-5-yl]-5,7-dihydrobenzo[d][2]benzoxepin-9-yl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-2-phenylethanone Chemical compound C1([C@H](N(CC)CC)C(=O)N2CCC[C@H]2C=2NC=C(N=2)C=2C=C3COCC=4C(C3=CC=2)=CC=C(C=4)C=2N=C(NC=2)[C@@H]2CCCN2C(=O)[C@@H](N(CC)CC)C=2C=CC=CC=2)=CC=CC=C1 NBDAPJYUBQSVPV-KVXOYYPDSA-N 0.000 claims 1
• XKZRJRVAGGAIBM-HVRJTYTESA-N (2s)-2-(diethylamino)-1-[(2s)-2-[5-[3-[2-[(2s)-1-[(2s)-2-(diethylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1h-imidazol-5-yl]-6-methyl-5,7-dihydrobenzo[d][2]benzazepin-9-yl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-2-phenylethanone Chemical compound C1([C@H](N(CC)CC)C(=O)N2CCC[C@H]2C=2NC=C(N=2)C=2C=C3CN(C)CC=4C(C3=CC=2)=CC=C(C=4)C=2N=C(NC=2)[C@@H]2CCCN2C(=O)[C@@H](N(CC)CC)C=2C=CC=CC=2)=CC=CC=C1 XKZRJRVAGGAIBM-HVRJTYTESA-N 0.000 claims 1
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
• 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 1
• 125000005018 aryl alkenyl group Chemical group 0.000 claims 1
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
• 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000004858 cycloalkoxyalkyl group Chemical group 0.000 claims 1
• 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims 1
• 125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 0 CC(CCNC)N(C)C(C*)OC Chemical compound CC(CCNC)N(C)C(C*)OC 0.000 description 4