JP2011511806A5 - - Google Patents
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- Publication number
- JP2011511806A5 JP2011511806A5 JP2010546093A JP2010546093A JP2011511806A5 JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5 JP 2010546093 A JP2010546093 A JP 2010546093A JP 2010546093 A JP2010546093 A JP 2010546093A JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- moiety
- atoms
- haloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* Chemical compound *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2703208P | 2008-02-07 | 2008-02-07 | |
| PCT/US2009/033569 WO2009100438A2 (en) | 2008-02-07 | 2009-02-09 | Compounds that enhance atoh-1 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Division JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511806A JP2011511806A (ja) | 2011-04-14 |
| JP2011511806A5 true JP2011511806A5 (https=) | 2012-03-29 |
Family
ID=40408118
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546093A Ceased JP2011511806A (ja) | 2008-02-07 | 2009-02-09 | Ａｔｏｈ１発現を増強する化合物 |
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Ａｔｏｈ１発現を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Ａｔｏｈ１発現を増強する化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US8188131B2 (https=) |
| EP (2) | EP2732819B1 (https=) |
| JP (3) | JP2011511806A (https=) |
| CN (1) | CN101990433B (https=) |
| AU (1) | AU2009212135B2 (https=) |
| CA (1) | CA2714370C (https=) |
| WO (1) | WO2009100438A2 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2094836B1 (en) | 2006-11-15 | 2016-06-08 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| TWI580356B (zh) | 2007-08-13 | 2017-05-01 | 孟山都科技有限責任公司 | 控制植物寄生性線蟲的化合物及方法以及被覆有該化合物之種子 |
| EP2732819B1 (en) | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
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| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| CA2799207C (en) * | 2010-05-26 | 2019-03-26 | Curna, Inc. | Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1 |
| EP2678050B1 (en) * | 2011-02-24 | 2020-10-14 | Emory University | Noggin blocking compositions for ossification and methods related thereto |
| WO2013120107A1 (en) * | 2012-02-09 | 2013-08-15 | University Of Rochester | Methods and compositions for treating a subject to inhibit hearing loss |
| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| CA2883896C (en) | 2012-09-07 | 2023-03-07 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| CR20190436A (es) | 2012-10-02 | 2019-10-29 | Bayer Cropscience Ag | COMPUESTOS HETEROCICLICOS COMO PLAGUICIDAS (Divisional 2015-0182) |
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| EP2951170B1 (en) | 2013-02-04 | 2018-10-24 | Janssen Pharmaceutica NV | Flap modulators |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| CN110179795A (zh) | 2013-03-15 | 2019-08-30 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途 |
| HK1214252A1 (zh) | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| US9572815B2 (en) | 2013-03-15 | 2017-02-21 | St. Jude Children's Research Hospital | Methods and compositions of p27KIP1 transcriptional modulators |
| US9694005B2 (en) | 2013-04-04 | 2017-07-04 | University Of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| KR20160019553A (ko) | 2013-06-17 | 2016-02-19 | 더 브로드 인스티튜트, 인코퍼레이티드 | 유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화 |
| EP3470089A1 (en) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| AU2014361781B2 (en) | 2013-12-12 | 2021-04-01 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing |
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| CN104072425B (zh) * | 2014-07-09 | 2016-12-07 | 大连理工大学 | 苯并咪唑类化合物及其应用 |
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| EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| WO2016106244A1 (en) | 2014-12-24 | 2016-06-30 | The Broad Institute Inc. | Crispr having or associated with destabilization domains |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| EP3786164B1 (en) | 2015-06-18 | 2024-08-14 | Ting Therapeutics LLC | Methods and compositions for the prevention and treatment of hearing loss |
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| JP2017073472A (ja) * | 2015-10-07 | 2017-04-13 | 株式会社ディスコ | 半導体装置の製造方法 |
| WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| FI3562487T3 (fi) | 2016-12-29 | 2023-12-14 | Ji Xing Pharmaceuticals Hong Kong Ltd | Metalloentsyymi-inhibiittoriyhdisteitä |
| WO2018172997A1 (en) * | 2017-03-24 | 2018-09-27 | Novartis Ag | Isoxazole carboxamide compounds and uses thereof |
| MX2021011775A (es) | 2017-04-26 | 2023-01-10 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| CN119410636A (zh) * | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11911416B2 (en) | 2018-08-01 | 2024-02-27 | University Of Iowa Research Foundation | Compositions and methods to restore hearing loss and balance through embryonic ear transplant |
| WO2020035880A1 (en) * | 2018-08-13 | 2020-02-20 | National Centre For Biological Sciences-Tifr | Inhibitors to target hiv-1 nef-cd80/cd86 interactions for therapeutic intervention |
| WO2020041380A1 (en) | 2018-08-20 | 2020-02-27 | The Broad Institute, Inc. | Methods and compositions for optochemical control of crispr-cas9 |
| TW202034900A (zh) | 2018-10-02 | 2020-10-01 | 美商頻率醫療公司 | 有關耳用治療劑之醫藥組成物及方法 |
| CA3124110A1 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Crispr-associated transposase systems and methods of use thereof |
| CA3126224A1 (en) | 2019-01-08 | 2020-07-16 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| AU2020218547A1 (en) * | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| KR20220007050A (ko) | 2019-04-08 | 2022-01-18 | 프리퀀시 테라퓨틱스, 인크. | 난청을 치료하기 위한 chir99021과 발프로산의 조합 |
| CN111849968A (zh) | 2019-04-30 | 2020-10-30 | 中美瑞康核酸技术(南通)研究院有限公司 | 寡核苷酸分子及其在急性间歇性卟啉症治疗中的应用 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| US20220313721A1 (en) * | 2019-07-04 | 2022-10-06 | Ractigen Therapeutics | Oligomeric nucleic acid molecule activating atoh1 gene and use thereof |
| WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| AU2020358863A1 (en) | 2019-10-03 | 2022-05-12 | Celyntra Therapeutics Sa | CRISPR systems with engineered dual guide nucleic acids |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2021146641A1 (en) | 2020-01-17 | 2021-07-22 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| EP4419672A2 (en) | 2021-06-01 | 2024-08-28 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| EP4426832A1 (en) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Precise genome editing using retrons |
| WO2023149548A1 (ja) * | 2022-02-03 | 2023-08-10 | 国立大学法人富山大学 | 新規医薬組成物 |
| EP4486881A1 (en) | 2022-03-01 | 2025-01-08 | Celyntra Therapeutics SA | Composition and methods for transgene insertion |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
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| US3429890A (en) | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3686110A (en) | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
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| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
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-
2009
- 2009-02-09 EP EP13182379.1A patent/EP2732819B1/en active Active
- 2009-02-09 US US12/368,173 patent/US8188131B2/en not_active Expired - Fee Related
- 2009-02-09 AU AU2009212135A patent/AU2009212135B2/en not_active Ceased
- 2009-02-09 CA CA2714370A patent/CA2714370C/en active Active
- 2009-02-09 JP JP2010546093A patent/JP2011511806A/ja not_active Ceased
- 2009-02-09 CN CN200980112358.0A patent/CN101990433B/zh not_active Expired - Fee Related
- 2009-02-09 WO PCT/US2009/033569 patent/WO2009100438A2/en not_active Ceased
- 2009-02-09 EP EP09708566.6A patent/EP2254572B1/en not_active Not-in-force
-
2012
- 2012-04-24 US US13/454,702 patent/US8859597B2/en active Active
-
2014
- 2014-04-21 JP JP2014087579A patent/JP5749829B2/ja not_active Expired - Fee Related
- 2014-10-10 US US14/511,911 patent/US9433610B2/en not_active Expired - Fee Related
-
2015
- 2015-05-14 JP JP2015099316A patent/JP6199340B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-18 US US15/240,303 patent/US10406163B2/en active Active
-
2019
- 2019-07-22 US US16/518,788 patent/US11160808B2/en not_active Expired - Fee Related
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