JP2011511806A5 - - Google Patents
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- Publication number
- JP2011511806A5 JP2011511806A5 JP2010546093A JP2010546093A JP2011511806A5 JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5 JP 2010546093 A JP2010546093 A JP 2010546093A JP 2010546093 A JP2010546093 A JP 2010546093A JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- moiety
- atoms
- haloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* Chemical compound *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2703208P | 2008-02-07 | 2008-02-07 | |
| PCT/US2009/033569 WO2009100438A2 (en) | 2008-02-07 | 2009-02-09 | Compounds that enhance atoh-1 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Division JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511806A JP2011511806A (ja) | 2011-04-14 |
| JP2011511806A5 true JP2011511806A5 (https=) | 2012-03-29 |
Family
ID=40408118
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546093A Ceased JP2011511806A (ja) | 2008-02-07 | 2009-02-09 | Ａｔｏｈ１発現を増強する化合物 |
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Ａｔｏｈ１発現を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Ａｔｏｈ１発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Ａｔｏｈ１発現を増強する化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US8188131B2 (https=) |
| EP (2) | EP2254572B1 (https=) |
| JP (3) | JP2011511806A (https=) |
| CN (1) | CN101990433B (https=) |
| AU (1) | AU2009212135B2 (https=) |
| CA (1) | CA2714370C (https=) |
| WO (1) | WO2009100438A2 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008076556A2 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| AU2008286879B2 (en) | 2007-08-13 | 2013-08-22 | Monsanto Technology Llc | Compositions and methods for controlling nematodes |
| US8188131B2 (en) | 2008-02-07 | 2012-05-29 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh1 expression |
| CN105418598B (zh) | 2009-02-10 | 2019-05-17 | 孟山都技术有限公司 | 用于控制线虫的组合物和方法 |
| WO2010098866A1 (en) * | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
| WO2011074658A1 (ja) | 2009-12-18 | 2011-06-23 | 田辺三菱製薬株式会社 | 新規抗血小板薬 |
| CN102918034B (zh) | 2010-03-30 | 2015-06-03 | 维颂公司 | 多取代芳族化合物作为凝血酶的抑制剂 |
| US8895528B2 (en) * | 2010-05-26 | 2014-11-25 | Curna, Inc. | Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1 |
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| WO2013120107A1 (en) * | 2012-02-09 | 2013-08-15 | University Of Rochester | Methods and compositions for treating a subject to inhibit hearing loss |
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| DK2903440T3 (en) | 2012-10-02 | 2017-12-11 | Bayer Cropscience Ag | THETEROCYCLIC COMPOUNDS AS PESTICIDES |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| US9079866B2 (en) | 2013-02-04 | 2015-07-14 | Janssen Pharmaceutica Nv | Flap modulators |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| ES2791749T3 (es) | 2013-03-15 | 2020-11-05 | Verseon Corp | Halogenopirazoles como inhibidores de la trombina |
| US9572815B2 (en) | 2013-03-15 | 2017-02-21 | St. Jude Children's Research Hospital | Methods and compositions of p27KIP1 transcriptional modulators |
| LT2968297T (lt) | 2013-03-15 | 2019-01-10 | Verseon Corporation | Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai |
| EP2991644B1 (en) | 2013-04-04 | 2020-03-25 | University of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
| MX374532B (es) | 2013-06-17 | 2025-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos. |
| CN105683379A (zh) | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| JP7103750B2 (ja) | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのＣＲＩＳＰＲ－Ｃａｓ系及び組成物の送達、使用及び治療適用 |
| EP3470089A1 (en) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
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| CN104072425B (zh) * | 2014-07-09 | 2016-12-07 | 大连理工大学 | 苯并咪唑类化合物及其应用 |
| WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| CN106687445A (zh) | 2014-09-17 | 2017-05-17 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物 |
| US11370823B2 (en) | 2014-10-29 | 2022-06-28 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
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| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| CA2970370A1 (en) | 2014-12-24 | 2016-06-30 | Massachusetts Institute Of Technology | Crispr having or associated with destabilization domains |
| RU2017131562A (ru) | 2015-02-27 | 2019-03-27 | Версеон Корпорейшн | Замещенные пиразольные соединения как ингибиторы сериновых протеаз |
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| US20180161340A1 (en) | 2015-06-18 | 2018-06-14 | St. Jude Children's Research Hospital | Methods and compositions for the prevention and treatment of hearing loss |
| JO3491B1 (ar) | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| JP2017073472A (ja) * | 2015-10-07 | 2017-04-13 | 株式会社ディスコ | 半導体装置の製造方法 |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| EP3407901B1 (en) * | 2016-01-29 | 2021-07-21 | Massachusetts Eye & Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
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| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| JP7227157B2 (ja) | 2016-12-29 | 2023-02-21 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| EP3601276A1 (en) * | 2017-03-24 | 2020-02-05 | Novartis AG | Isoxazole carboxamide compounds and uses thereof |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| CN112703016B (zh) * | 2018-04-27 | 2024-11-22 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11911416B2 (en) | 2018-08-01 | 2024-02-27 | University Of Iowa Research Foundation | Compositions and methods to restore hearing loss and balance through embryonic ear transplant |
| EP3836933A4 (en) * | 2018-08-13 | 2022-08-10 | National Centre for Biological Sciences-TIFR | INHIBITORS AGAINST HIV-1-NEF-CD80/CD86 INTERACTIONS FOR THERAPEUTIC INTERVENTIONS |
| US12421507B2 (en) | 2018-08-20 | 2025-09-23 | The Broad Institute, Inc. | Methods and compositions for optochemical control of CRISPR-CAS9 |
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| CN113544266A (zh) | 2018-12-17 | 2021-10-22 | 博德研究所 | Crispr相关转座酶系统和其使用方法 |
| JP2022516969A (ja) | 2019-01-08 | 2022-03-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| CA3129422A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| US20220175776A1 (en) | 2019-04-08 | 2022-06-09 | Frequency Therapeutics, Inc. | Combination of chir99021 and valproic acid for treating hearing loss |
| CN111849968A (zh) | 2019-04-30 | 2020-10-30 | 中美瑞康核酸技术(南通)研究院有限公司 | 寡核苷酸分子及其在急性间歇性卟啉症治疗中的应用 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| CA3145567A1 (en) * | 2019-07-04 | 2021-01-07 | Ractigen Therapeutics | Oligomeric nucleic acid molecule activating atoh1 gene and use thereof |
| WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| JP7689949B2 (ja) | 2019-10-03 | 2025-06-09 | アーティサン ディベロップメント ラブズ インコーポレイテッド | 操作されたデュアルガイド核酸を有するｃｒｉｓｐｒシステム |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
| WO2021146641A1 (en) | 2020-01-17 | 2021-07-22 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| EP4419672A2 (en) | 2021-06-01 | 2024-08-28 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| JPWO2023149548A1 (https=) * | 2022-02-03 | 2023-08-10 | ||
| EP4486881A1 (en) | 2022-03-01 | 2025-01-08 | Celyntra Therapeutics SA | Composition and methods for transgene insertion |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| AU2024357861A1 (en) | 2023-10-12 | 2026-04-23 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
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-
2009
- 2009-02-09 US US12/368,173 patent/US8188131B2/en not_active Expired - Fee Related
- 2009-02-09 CA CA2714370A patent/CA2714370C/en active Active
- 2009-02-09 WO PCT/US2009/033569 patent/WO2009100438A2/en not_active Ceased
- 2009-02-09 JP JP2010546093A patent/JP2011511806A/ja not_active Ceased
- 2009-02-09 CN CN200980112358.0A patent/CN101990433B/zh not_active Expired - Fee Related
- 2009-02-09 EP EP09708566.6A patent/EP2254572B1/en not_active Not-in-force
- 2009-02-09 AU AU2009212135A patent/AU2009212135B2/en not_active Ceased
- 2009-02-09 EP EP13182379.1A patent/EP2732819B1/en active Active
-
2012
- 2012-04-24 US US13/454,702 patent/US8859597B2/en active Active
-
2014
- 2014-04-21 JP JP2014087579A patent/JP5749829B2/ja not_active Expired - Fee Related
- 2014-10-10 US US14/511,911 patent/US9433610B2/en not_active Expired - Fee Related
-
2015
- 2015-05-14 JP JP2015099316A patent/JP6199340B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-18 US US15/240,303 patent/US10406163B2/en active Active
-
2019
- 2019-07-22 US US16/518,788 patent/US11160808B2/en not_active Expired - Fee Related
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