CA2714370C - Compounds that enhance atoh-1 expression - Google Patents

Compounds that enhance atoh-1 expression Download PDF

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Publication number
CA2714370C
CA2714370C CA2714370A CA2714370A CA2714370C CA 2714370 C CA2714370 C CA 2714370C CA 2714370 A CA2714370 A CA 2714370A CA 2714370 A CA2714370 A CA 2714370A CA 2714370 C CA2714370 C CA 2714370C
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Prior art keywords
alkyl
optionally substituted
cells
atoms
compounds
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CA2714370A
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English (en)
French (fr)
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CA2714370A1 (en
Inventor
Albert Edge
Kathleen Seyb
Marcie Glicksman
Lixin Qiao
Gregory D. Cuny
Sang-Jun Jeon
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Brigham and Womens Hospital Inc
Massachusetts Eye and Ear
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Brigham and Womens Hospital Inc
Massachusetts Eye and Ear Infirmary
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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CA2714370A1 (en) 2009-08-13
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WO2009100438A2 (en) 2009-08-13
US20150157607A1 (en) 2015-06-11
JP2015163636A (ja) 2015-09-10
US10406163B2 (en) 2019-09-10
EP2254572B1 (en) 2013-10-16
US20120328580A1 (en) 2012-12-27
EP2732819B1 (en) 2019-10-16
HK1155652A1 (en) 2012-05-25
CN101990433B (zh) 2014-11-05
JP2011511806A (ja) 2011-04-14
AU2009212135A1 (en) 2009-08-13
US20170095481A1 (en) 2017-04-06
CN101990433A (zh) 2011-03-23
US8859597B2 (en) 2014-10-14
US11160808B2 (en) 2021-11-02
JP5749829B2 (ja) 2015-07-15
US9433610B2 (en) 2016-09-06
US8188131B2 (en) 2012-05-29
JP2014156470A (ja) 2014-08-28
AU2009212135B2 (en) 2014-08-21
US20200179394A1 (en) 2020-06-11
US20090232780A1 (en) 2009-09-17
EP2254572A2 (en) 2010-12-01
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EP2732819A2 (en) 2014-05-21

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