CN101990433B - 提高Atoh1表达的化合物 - Google Patents
提高Atoh1表达的化合物 Download PDFInfo
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- CN101990433B CN101990433B CN200980112358.0A CN200980112358A CN101990433B CN 101990433 B CN101990433 B CN 101990433B CN 200980112358 A CN200980112358 A CN 200980112358A CN 101990433 B CN101990433 B CN 101990433B
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- 0 CCC(C(C)C1C2)=C(C)*C1=CC2c1ccc(*)cc1 Chemical compound CCC(C(C)C1C2)=C(C)*C1=CC2c1ccc(*)cc1 0.000 description 2
- XNYPCDIWVSCQDN-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1C(SC1C(C)=O)=CC1N Chemical compound CC(C)(C)c(cc1)ccc1C(SC1C(C)=O)=CC1N XNYPCDIWVSCQDN-UHFFFAOYSA-N 0.000 description 1
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2703208P | 2008-02-07 | 2008-02-07 | |
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Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2094836B1 (en) | 2006-11-15 | 2016-06-08 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| TWI580356B (zh) | 2007-08-13 | 2017-05-01 | 孟山都科技有限責任公司 | 控制植物寄生性線蟲的化合物及方法以及被覆有該化合物之種子 |
| EP2732819B1 (en) | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| WO2010093650A2 (en) | 2009-02-10 | 2010-08-19 | Divergence, Inc. | Compositions and methods for controlling nematodes |
| US20100222381A1 (en) * | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| KR101552760B1 (ko) | 2009-12-18 | 2015-09-11 | 미쓰비시 타나베 파마 코퍼레이션 | 신규 항혈소판약 |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| CA2799207C (en) * | 2010-05-26 | 2019-03-26 | Curna, Inc. | Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1 |
| EP2678050B1 (en) * | 2011-02-24 | 2020-10-14 | Emory University | Noggin blocking compositions for ossification and methods related thereto |
| WO2013120107A1 (en) * | 2012-02-09 | 2013-08-15 | University Of Rochester | Methods and compositions for treating a subject to inhibit hearing loss |
| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| CA2883896C (en) | 2012-09-07 | 2023-03-07 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| CR20190436A (es) | 2012-10-02 | 2019-10-29 | Bayer Cropscience Ag | COMPUESTOS HETEROCICLICOS COMO PLAGUICIDAS (Divisional 2015-0182) |
| DK2931897T3 (en) | 2012-12-12 | 2018-02-05 | Broad Inst Inc | CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS |
| EP2951170B1 (en) | 2013-02-04 | 2018-10-24 | Janssen Pharmaceutica NV | Flap modulators |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
| CN110179795A (zh) | 2013-03-15 | 2019-08-30 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途 |
| HK1214252A1 (zh) | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| US9572815B2 (en) | 2013-03-15 | 2017-02-21 | St. Jude Children's Research Hospital | Methods and compositions of p27KIP1 transcriptional modulators |
| US9694005B2 (en) | 2013-04-04 | 2017-07-04 | University Of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| KR20160019553A (ko) | 2013-06-17 | 2016-02-19 | 더 브로드 인스티튜트, 인코퍼레이티드 | 유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화 |
| EP3470089A1 (en) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| AU2014361781B2 (en) | 2013-12-12 | 2021-04-01 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing |
| US20150272999A1 (en) * | 2014-03-31 | 2015-10-01 | Banner Health | Retrograde coronary vein delivery of stem cells |
| CN104072425B (zh) * | 2014-07-09 | 2016-12-07 | 大连理工大学 | 苯并咪唑类化合物及其应用 |
| WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| WO2016106244A1 (en) | 2014-12-24 | 2016-06-30 | The Broad Institute Inc. | Crispr having or associated with destabilization domains |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| EP3786164B1 (en) | 2015-06-18 | 2024-08-14 | Ting Therapeutics LLC | Methods and compositions for the prevention and treatment of hearing loss |
| CA3012607A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzymes and systems |
| TWI625332B (zh) | 2015-07-07 | 2018-06-01 | 美國禮來大藥廠 | 刻痕(notch)路徑傳訊抑制化合物 |
| JP2017073472A (ja) * | 2015-10-07 | 2017-04-13 | 株式会社ディスコ | 半導体装置の製造方法 |
| WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー,インク. | トリグリセリド耳用製剤とその使用 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| FI3562487T3 (fi) | 2016-12-29 | 2023-12-14 | Ji Xing Pharmaceuticals Hong Kong Ltd | Metalloentsyymi-inhibiittoriyhdisteitä |
| WO2018172997A1 (en) * | 2017-03-24 | 2018-09-27 | Novartis Ag | Isoxazole carboxamide compounds and uses thereof |
| MX2021011775A (es) | 2017-04-26 | 2023-01-10 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| CN119410636A (zh) * | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11911416B2 (en) | 2018-08-01 | 2024-02-27 | University Of Iowa Research Foundation | Compositions and methods to restore hearing loss and balance through embryonic ear transplant |
| WO2020035880A1 (en) * | 2018-08-13 | 2020-02-20 | National Centre For Biological Sciences-Tifr | Inhibitors to target hiv-1 nef-cd80/cd86 interactions for therapeutic intervention |
| WO2020041380A1 (en) | 2018-08-20 | 2020-02-27 | The Broad Institute, Inc. | Methods and compositions for optochemical control of crispr-cas9 |
| TW202034900A (zh) | 2018-10-02 | 2020-10-01 | 美商頻率醫療公司 | 有關耳用治療劑之醫藥組成物及方法 |
| CA3124110A1 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Crispr-associated transposase systems and methods of use thereof |
| CA3126224A1 (en) | 2019-01-08 | 2020-07-16 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| AU2020218547A1 (en) * | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| KR20220007050A (ko) | 2019-04-08 | 2022-01-18 | 프리퀀시 테라퓨틱스, 인크. | 난청을 치료하기 위한 chir99021과 발프로산의 조합 |
| CN111849968A (zh) | 2019-04-30 | 2020-10-30 | 中美瑞康核酸技术(南通)研究院有限公司 | 寡核苷酸分子及其在急性间歇性卟啉症治疗中的应用 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| US20220313721A1 (en) * | 2019-07-04 | 2022-10-06 | Ractigen Therapeutics | Oligomeric nucleic acid molecule activating atoh1 gene and use thereof |
| WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| AU2020358863A1 (en) | 2019-10-03 | 2022-05-12 | Celyntra Therapeutics Sa | CRISPR systems with engineered dual guide nucleic acids |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2021146641A1 (en) | 2020-01-17 | 2021-07-22 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| EP4419672A2 (en) | 2021-06-01 | 2024-08-28 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| EP4426832A1 (en) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Precise genome editing using retrons |
| WO2023149548A1 (ja) * | 2022-02-03 | 2023-08-10 | 国立大学法人富山大学 | 新規医薬組成物 |
| EP4486881A1 (en) | 2022-03-01 | 2025-01-08 | Celyntra Therapeutics SA | Composition and methods for transgene insertion |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006076009A2 (en) * | 2004-04-23 | 2006-07-20 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429890A (en) | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3686110A (en) | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
| US3646049A (en) | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
| US5157046A (en) | 1988-11-29 | 1992-10-20 | Janssen Pharmaceutica N.V. | Method of treating epithelial disorders |
| US5342957A (en) | 1988-11-29 | 1994-08-30 | Janssen Pharmaceutica N.V. | Benzimidazoles useful in treating epithelial disorders |
| US5140034A (en) * | 1989-03-14 | 1992-08-18 | Merck Sharp & Dohme Ltd. | Five-membered ring systems with bonded imidazolyl ring substituents |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| EP0675955A1 (en) | 1992-12-23 | 1995-10-11 | Iowa State University Research Foundation, Inc. | Molecular flashlight |
| EP0800391A1 (en) | 1994-12-28 | 1997-10-15 | Janssen Pharmaceutica N.V. | Benzimidazoles as inhibitors of calcitriol metabolism |
| AU2207897A (en) | 1996-03-11 | 1997-10-01 | Eli Lilly And Company | Methods of treating or preventing interstitial cystitis |
| GB2326760B (en) | 1997-06-28 | 2002-02-13 | Mitel Semiconductor Ab | Optical source with monitor |
| US6339782B1 (en) | 1997-11-21 | 2002-01-15 | International Business Machines Corporation | Persistence mechanism and method for objects |
| PT1471926E (pt) * | 1999-06-01 | 2011-03-11 | Baylor College Medicine | Composições e métodos para a utilização terapêutica de uma sequência associada a atonal |
| US20020192665A1 (en) * | 1999-06-01 | 2002-12-19 | Zoghbi Huda Y. | Compositions and methods for the therapeutic use of an atonal-associated sequence for a gastrointestinal condition |
| NZ517221A (en) * | 1999-08-19 | 2004-01-30 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US20070004713A1 (en) | 2000-12-07 | 2007-01-04 | Bernard Barlaam | Therapeutic benimidazole compounds |
| US7405235B2 (en) | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2004001058A2 (en) * | 2001-05-04 | 2003-12-31 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| KR20040004705A (ko) | 2001-06-08 | 2004-01-13 | 시토비아 인크. | 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도 |
| US6855714B2 (en) | 2001-07-06 | 2005-02-15 | Schering Aktiengesellschaft | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| US20030082362A1 (en) | 2001-07-31 | 2003-05-01 | Khandpur Ashish K. | High cohesive strength pressure sensitive adhesive foam |
| JP4481011B2 (ja) | 2002-03-05 | 2010-06-16 | トランス テック ファーマ,インコーポレイテッド | リガンドのrageとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| US7206639B2 (en) | 2002-03-15 | 2007-04-17 | Sarcos Investments Lc | Cochlear drug delivery system and method |
| US20040106553A1 (en) | 2002-06-24 | 2004-06-03 | Alekshun Michael N. | Methods for preventing and treating microbial infections by modulating transcription factors |
| US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
| EP4101846B1 (en) * | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| PT1673349E (pt) | 2003-09-22 | 2010-09-28 | S Bio Pte Ltd | Derivados benzimidazole: preparação e aplicações farmacêuticas |
| US8673634B2 (en) | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| WO2005072793A1 (en) | 2004-01-29 | 2005-08-11 | The Charles Stark Draper Laboratory, Inc. | Implantable drug delivery apparatus |
| CN1993363A (zh) * | 2004-08-03 | 2007-07-04 | 默克公司 | 1,3-二取代的杂芳基nmda/nr2b拮抗剂 |
| JP2006117536A (ja) | 2004-10-19 | 2006-05-11 | Kyoto Univ | 内耳の有毛細胞を誘導するための医薬 |
| US20090005344A1 (en) | 2004-11-01 | 2009-01-01 | Nkuada, Llc | Compounds and Methods of Use Thereof |
| EP1910385B1 (en) * | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| US9265933B2 (en) | 2005-09-08 | 2016-02-23 | Massachusetts Eye And Ear Infirmary | Cochlear implants containing biological cells and uses thereof |
| MX2008008339A (es) | 2005-12-21 | 2008-09-03 | Schering Corp | Derivados de anilina sustituida ùtiles como antagonistas de la histamina h3. |
| JP2009521448A (ja) | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用なフェノキシピペリジンおよびそのアナログ |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| CA2681813A1 (en) | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US7947723B2 (en) | 2008-02-01 | 2011-05-24 | Spelman College | Synthesis and anti-proliferative effect of benzimidazole derivatives |
| EP2732819B1 (en) | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
-
2009
- 2009-02-09 EP EP13182379.1A patent/EP2732819B1/en active Active
- 2009-02-09 US US12/368,173 patent/US8188131B2/en not_active Expired - Fee Related
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- 2009-02-09 CA CA2714370A patent/CA2714370C/en active Active
- 2009-02-09 JP JP2010546093A patent/JP2011511806A/ja not_active Ceased
- 2009-02-09 CN CN200980112358.0A patent/CN101990433B/zh not_active Expired - Fee Related
- 2009-02-09 WO PCT/US2009/033569 patent/WO2009100438A2/en not_active Ceased
- 2009-02-09 EP EP09708566.6A patent/EP2254572B1/en not_active Not-in-force
-
2012
- 2012-04-24 US US13/454,702 patent/US8859597B2/en active Active
-
2014
- 2014-04-21 JP JP2014087579A patent/JP5749829B2/ja not_active Expired - Fee Related
- 2014-10-10 US US14/511,911 patent/US9433610B2/en not_active Expired - Fee Related
-
2015
- 2015-05-14 JP JP2015099316A patent/JP6199340B2/ja not_active Expired - Fee Related
-
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- 2016-08-18 US US15/240,303 patent/US10406163B2/en active Active
-
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- 2019-07-22 US US16/518,788 patent/US11160808B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006076009A2 (en) * | 2004-04-23 | 2006-07-20 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
Non-Patent Citations (3)
| Title |
|---|
| Chen W. et. al..The human fetal cochlea can be a source for auditory progenitors/stem cells isolation.《Hearing Research》.2007,(第223期),23-29. * |
| Kokare et al.Design,synthesis and utilization of a novel coupling reagent for the preparation of O-alkyl hydroxamic acids.《Tetrahedron Letters》.2007,第48卷(第25期),4437-4440. * |
| Kokareetal.Design synthesis and utilization of a novel coupling reagent for the preparation of O-alkyl hydroxamic acids.《Tetrahedron Letters》.2007 * |
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| JP6199340B2 (ja) | 2017-09-20 |
| CA2714370A1 (en) | 2009-08-13 |
| CA2714370C (en) | 2017-05-02 |
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| US20120328580A1 (en) | 2012-12-27 |
| EP2732819B1 (en) | 2019-10-16 |
| HK1155652A1 (en) | 2012-05-25 |
| JP2011511806A (ja) | 2011-04-14 |
| AU2009212135A1 (en) | 2009-08-13 |
| US20170095481A1 (en) | 2017-04-06 |
| CN101990433A (zh) | 2011-03-23 |
| US8859597B2 (en) | 2014-10-14 |
| US11160808B2 (en) | 2021-11-02 |
| JP5749829B2 (ja) | 2015-07-15 |
| US9433610B2 (en) | 2016-09-06 |
| US8188131B2 (en) | 2012-05-29 |
| JP2014156470A (ja) | 2014-08-28 |
| AU2009212135B2 (en) | 2014-08-21 |
| US20200179394A1 (en) | 2020-06-11 |
| US20090232780A1 (en) | 2009-09-17 |
| EP2254572A2 (en) | 2010-12-01 |
| EP2732819A3 (en) | 2014-09-03 |
| EP2732819A2 (en) | 2014-05-21 |
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