JP2007523087A5 - - Google Patents
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- Publication number
- JP2007523087A5 JP2007523087A5 JP2006553323A JP2006553323A JP2007523087A5 JP 2007523087 A5 JP2007523087 A5 JP 2007523087A5 JP 2006553323 A JP2006553323 A JP 2006553323A JP 2006553323 A JP2006553323 A JP 2006553323A JP 2007523087 A5 JP2007523087 A5 JP 2007523087A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- halo
- methyl
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 57
- -1 optionally Chemical group 0.000 claims 44
- 125000003545 alkoxy group Chemical group 0.000 claims 20
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 102000004311 liver X receptors Human genes 0.000 claims 4
- 108090000865 liver X receptors Proteins 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000006655 (C3-C8) heteroaryl group Chemical group 0.000 claims 2
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000005955 1H-indazolyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54414904P | 2004-02-11 | 2004-02-11 | |
| PCT/US2005/004652 WO2005077122A2 (en) | 2004-02-11 | 2005-02-11 | Compounds and compositions as lxr modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523087A JP2007523087A (ja) | 2007-08-16 |
| JP2007523087A5 true JP2007523087A5 (https=) | 2008-03-21 |
Family
ID=34860491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553323A Pending JP2007523087A (ja) | 2004-02-11 | 2005-02-11 | Ｌｘｒモジュレーターとしての化合物および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7846949B2 (https=) |
| EP (1) | EP1713465A4 (https=) |
| JP (1) | JP2007523087A (https=) |
| CN (1) | CN1917870A (https=) |
| AU (1) | AU2005211807C1 (https=) |
| BR (1) | BRPI0507626A (https=) |
| CA (1) | CA2553442A1 (https=) |
| WO (1) | WO2005077122A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2872159B1 (fr) * | 2004-06-28 | 2007-10-05 | Merck Sante Soc Par Actions Si | Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
| JP2008507518A (ja) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するためのチエノピリジン |
| CN101456863B (zh) * | 2007-12-14 | 2012-04-25 | 华北制药集团新药研究开发有限责任公司 | Lxr激动剂及其制备方法和用途 |
| US7786171B2 (en) * | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
| US20130274212A1 (en) | 2010-09-07 | 2013-10-17 | Snu R&Db Foundation | Sesterterpene Compounds and Use Thereof |
| RU2556004C2 (ru) | 2011-01-25 | 2015-07-10 | Мицуй Кемикалс Агро, Инк. | Способ получения производного ароматического амида карбоновой кислоты |
| US10669296B2 (en) | 2014-01-10 | 2020-06-02 | Rgenix, Inc. | LXR agonists and uses thereof |
| CA3010883A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| SI3796975T1 (sl) | 2018-05-22 | 2024-02-29 | Orsobio, Inc. | Derivati sulfonilaminobenzamida |
| TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Ｆｘｒ有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
| HUE067466T2 (hu) | 2019-12-13 | 2024-10-28 | Inspirna Inc | Fémsók és alkalmazásuk |
| JP7555204B2 (ja) * | 2020-06-22 | 2024-09-24 | 東ソー株式会社 | 重合性化合物、重合体、光学薄膜 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185194B (de) * | 1959-06-11 | 1965-01-14 | Nippon Shinyaku Co Ltd | Verfahren zur Herstellung von Abkoemmlingen des Salicylsaeureamides |
| CH480299A (fr) * | 1967-04-11 | 1969-10-31 | Sogespar S A | Procédé de préparation de dérivés des acides a-aminés N-disubstitués |
| CH516523A (fr) * | 1969-11-25 | 1971-12-15 | Sogespar S A | Procédé de préparation des dérivés des acides a-aminés N-disubstitués par benzoylation |
| LU78804A1 (de) * | 1977-12-30 | 1979-07-20 | Byk Gulden Lomberg Chem Fab | N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPS5683458A (en) * | 1979-12-10 | 1981-07-08 | Hodogaya Chem Co Ltd | Benzamide derivative and herbicide containing the same |
| GB8704671D0 (en) * | 1987-02-27 | 1987-04-01 | Shell Int Research | Glycine compounds |
| JPH07258224A (ja) | 1994-03-24 | 1995-10-09 | Dai Ichi Seiyaku Co Ltd | 二環性化合物 |
| US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
| JPH08143556A (ja) * | 1994-11-15 | 1996-06-04 | Terumo Corp | ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物 |
| JPH111456A (ja) * | 1997-06-13 | 1999-01-06 | Otsuka Pharmaceut Co Ltd | アミド誘導体 |
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| KR20030045180A (ko) * | 2000-11-10 | 2003-06-09 | 야마노우치세이야쿠 가부시키가이샤 | 아미드 유도체 |
| EP1487776A4 (en) * | 2002-03-27 | 2005-05-25 | Smithkline Beecham Corp | ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF |
| MXPA04011691A (es) * | 2002-05-24 | 2005-09-12 | Pharmacia Corp | Moduladores del receptor x anilino hepaticos. |
-
2005
- 2005-02-11 AU AU2005211807A patent/AU2005211807C1/en not_active Ceased
- 2005-02-11 WO PCT/US2005/004652 patent/WO2005077122A2/en not_active Ceased
- 2005-02-11 US US10/589,410 patent/US7846949B2/en not_active Expired - Fee Related
- 2005-02-11 CA CA002553442A patent/CA2553442A1/en not_active Abandoned
- 2005-02-11 BR BRPI0507626-9A patent/BRPI0507626A/pt not_active IP Right Cessation
- 2005-02-11 JP JP2006553323A patent/JP2007523087A/ja active Pending
- 2005-02-11 CN CNA2005800046748A patent/CN1917870A/zh active Pending
- 2005-02-11 EP EP05723051A patent/EP1713465A4/en not_active Withdrawn
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