JP2007523087A - Ｌｘｒモジュレーターとしての化合物および組成物 - Google Patents

Ｌｘｒモジュレーターとしての化合物および組成物 Download PDF

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JP2007523087A
JP2007523087A JP2006553323A JP2006553323A JP2007523087A JP 2007523087 A JP2007523087 A JP 2007523087A JP 2006553323 A JP2006553323 A JP 2006553323A JP 2006553323 A JP2006553323 A JP 2006553323A JP 2007523087 A JP2007523087 A JP 2007523087A
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alkyl
substituted
halo
methyl
carbonyl
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JP2007523087A5 (https=
Inventor
ヴァレンティーナ・モルテーニ
リ・シャオリン
リアン・ファン
ジュリエット・ナバッカ
エンリケ・サエス
ジョン・ウィトヤック
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IRM LLC
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/00—Sulfones; Sulfoxides
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    • C07—ORGANIC CHEMISTRY
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006553323A 2004-02-11 2005-02-11 Ｌｘｒモジュレーターとしての化合物および組成物 Pending JP2007523087A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54414904P 2004-02-11 2004-02-11
PCT/US2005/004652 WO2005077122A2 (en) 2004-02-11 2005-02-11 Compounds and compositions as lxr modulators

Publications (2)

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JP2007523087A true JP2007523087A (ja) 2007-08-16
JP2007523087A5 JP2007523087A5 (https=) 2008-03-21

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US (1) US7846949B2 (https=)
EP (1) EP1713465A4 (https=)
JP (1) JP2007523087A (https=)
CN (1) CN1917870A (https=)
AU (1) AU2005211807C1 (https=)
BR (1) BRPI0507626A (https=)
CA (1) CA2553442A1 (https=)
WO (1) WO2005077122A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008504312A (ja) * 2004-06-28 2008-02-14 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング フェニルカルボン酸誘導体および糖尿病の処置のためのその使用
WO2012102239A1 (ja) * 2011-01-25 2012-08-02 三井化学アグロ株式会社 芳香族アミドカルボン酸誘導体の製造方法
JP2021528451A (ja) * 2018-06-28 2021-10-21 フェネックス−エフイクスエル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式コア部分を有する新規ｌｘｒモジュレーター
JP2022001620A (ja) * 2020-06-22 2022-01-06 東ソー株式会社 重合性化合物、重合体、光学薄膜

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US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
JP2008507518A (ja) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
CN101456863B (zh) * 2007-12-14 2012-04-25 华北制药集团新药研究开发有限责任公司 Lxr激动剂及其制备方法和用途
US7786171B2 (en) * 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
US20130274212A1 (en) 2010-09-07 2013-10-17 Snu R&Db Foundation Sesterterpene Compounds and Use Thereof
US10669296B2 (en) 2014-01-10 2020-06-02 Rgenix, Inc. LXR agonists and uses thereof
CA3010883A1 (en) 2016-01-11 2017-07-20 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
SI3796975T1 (sl) 2018-05-22 2024-02-29 Orsobio, Inc. Derivati sulfonilaminobenzamida
HUE067466T2 (hu) 2019-12-13 2024-10-28 Inspirna Inc Fémsók és alkalmazásuk

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54106424A (en) * 1977-12-30 1979-08-21 Biku Guruden Romuberuku Chem F N substituted omegaaaminoalkanoyllomegaa aminoalkanoic acid* its use and manufacture and drug containing it
JPS63227555A (ja) * 1987-02-27 1988-09-21 シエル・インターナシヨネイル・リサーチ・マーチヤツピイ・ベー・ウイ グリシン化合物
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
WO2002038554A1 (en) * 2000-11-10 2002-05-16 Yamanouchi Pharmaceutical Co., Ltd. Amide derivatives
JP2002539155A (ja) * 1999-03-15 2002-11-19 テュラリク インコーポレイテッド Ｌｘｒ調節剤
JP2005521721A (ja) * 2002-03-27 2005-07-21 スミスクライン・ビーチャム・コーポレイション 酸およびエステル化合物ならびにその使用方法
JP2005527621A (ja) * 2002-05-24 2005-09-15 ファーマシア コーポレイション アニリノ肝ｘ受容体調節因子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185194B (de) * 1959-06-11 1965-01-14 Nippon Shinyaku Co Ltd Verfahren zur Herstellung von Abkoemmlingen des Salicylsaeureamides
CH480299A (fr) * 1967-04-11 1969-10-31 Sogespar S A Procédé de préparation de dérivés des acides a-aminés N-disubstitués
CH516523A (fr) * 1969-11-25 1971-12-15 Sogespar S A Procédé de préparation des dérivés des acides a-aminés N-disubstitués par benzoylation
JPS5683458A (en) * 1979-12-10 1981-07-08 Hodogaya Chem Co Ltd Benzamide derivative and herbicide containing the same
JPH07258224A (ja) 1994-03-24 1995-10-09 Dai Ichi Seiyaku Co Ltd 二環性化合物
JPH111456A (ja) * 1997-06-13 1999-01-06 Otsuka Pharmaceut Co Ltd アミド誘導体

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54106424A (en) * 1977-12-30 1979-08-21 Biku Guruden Romuberuku Chem F N substituted omegaaaminoalkanoyllomegaa aminoalkanoic acid* its use and manufacture and drug containing it
JPS63227555A (ja) * 1987-02-27 1988-09-21 シエル・インターナシヨネイル・リサーチ・マーチヤツピイ・ベー・ウイ グリシン化合物
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JP2002539155A (ja) * 1999-03-15 2002-11-19 テュラリク インコーポレイテッド Ｌｘｒ調節剤
WO2002038554A1 (en) * 2000-11-10 2002-05-16 Yamanouchi Pharmaceutical Co., Ltd. Amide derivatives
JP2005521721A (ja) * 2002-03-27 2005-07-21 スミスクライン・ビーチャム・コーポレイション 酸およびエステル化合物ならびにその使用方法
JP2005527621A (ja) * 2002-05-24 2005-09-15 ファーマシア コーポレイション アニリノ肝ｘ受容体調節因子

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008504312A (ja) * 2004-06-28 2008-02-14 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング フェニルカルボン酸誘導体および糖尿病の処置のためのその使用
WO2012102239A1 (ja) * 2011-01-25 2012-08-02 三井化学アグロ株式会社 芳香族アミドカルボン酸誘導体の製造方法
JP5674823B2 (ja) * 2011-01-25 2015-02-25 三井化学アグロ株式会社 芳香族アミドカルボン酸誘導体の製造方法
US9079827B2 (en) 2011-01-25 2015-07-14 Mitsui Chemicals Agro, Inc. Process for production of aromatic amide carboxylic acid derivative
US9458091B2 (en) 2011-01-25 2016-10-04 Mitsui Chemicals Agro, Inc. Aromatic amidecarboxylic acid and process for producing the same
JP2021528451A (ja) * 2018-06-28 2021-10-21 フェネックス−エフイクスエル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式コア部分を有する新規ｌｘｒモジュレーター
JP7214086B2 (ja) 2018-06-28 2023-01-30 オルソバイオ，インコーポレイティド 二環式コア部分を有する新規ｌｘｒモジュレーター
US11618747B2 (en) 2018-06-28 2023-04-04 Orsobio, Inc. LXR modulators with bicyclic core moiety
US11970484B2 (en) 2018-06-28 2024-04-30 Orsobio, Inc. LXR modulators with bicyclic core moiety
US12291523B2 (en) 2018-06-28 2025-05-06 Orsobio, Inc. LXR modulators with bicyclic core moiety
JP2022001620A (ja) * 2020-06-22 2022-01-06 東ソー株式会社 重合性化合物、重合体、光学薄膜
JP7555204B2 (ja) 2020-06-22 2024-09-24 東ソー株式会社 重合性化合物、重合体、光学薄膜

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US7846949B2 (en) 2010-12-07
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AU2005211807B2 (en) 2008-08-28
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AU2005211807A1 (en) 2005-08-25

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