JP2011508774A5 - - Google Patents

Info

Publication number

JP2011508774A5

JP2011508774A5 JP2010541438A JP2010541438A JP2011508774A5 JP 2011508774 A5 JP2011508774 A5 JP 2011508774A5 JP 2010541438 A JP2010541438 A JP 2010541438A JP 2010541438 A JP2010541438 A JP 2010541438A JP 2011508774 A5 JP2011508774 A5 JP 2011508774A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

alcohol

volatile

silicon

Prior art date

2008-12-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 24
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
• 239000000203 mixture Substances 0.000 claims description 13
• 229910052710 silicon Inorganic materials 0.000 claims description 13
• 239000010703 silicon Substances 0.000 claims description 13
• 210000000282 nail Anatomy 0.000 claims description 8
• 210000004904 fingernail bed Anatomy 0.000 claims description 3
• 229920001296 polysiloxane Polymers 0.000 claims description 3
• 150000001875 compounds Chemical class 0.000 claims description 2
• NFEZZTICAUWDHU-RDTXWAMCSA-N efinaconazole Chemical group N1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)CCC(=C)CC1 NFEZZTICAUWDHU-RDTXWAMCSA-N 0.000 claims description 2
• 150000002148 esters Chemical class 0.000 claims 7
• 150000003852 triazoles Chemical class 0.000 claims 7
• 229940121375 antifungal agent Drugs 0.000 claims 6
• HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 4
• 239000003429 antifungal agent Substances 0.000 claims 4
• 229940026215 c12-15 alkyl lactate Drugs 0.000 claims 4
• 229940031578 diisopropyl adipate Drugs 0.000 claims 4
• 239000003963 antioxidant agent Substances 0.000 claims 3
• 230000003078 antioxidant effect Effects 0.000 claims 3
• HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 230000000843 anti-fungal effect Effects 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 229940086555 cyclomethicone Drugs 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• QQJIRQMOCFESJB-UHFFFAOYSA-N 1-(1,2,4-triazol-1-yl)butan-2-ol Chemical compound CCC(O)CN1C=NC=N1 QQJIRQMOCFESJB-UHFFFAOYSA-N 0.000 claims 1
• CDNNKGWZSNSADW-UHFFFAOYSA-N 2,2,4,4,6,6,8,8,10,10,12,12,14,14,16,16,18,18,20,20-icosamethyl-1,3,5,7,9,11,13,15,17,19-decaoxa-2,4,6,8,10,12,14,16,18,20-decasilacycloicosane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 CDNNKGWZSNSADW-UHFFFAOYSA-N 0.000 claims 1
• ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 claims 1
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 230000008020 evaporation Effects 0.000 claims 1
• 238000001704 evaporation Methods 0.000 claims 1
• 230000002538 fungal effect Effects 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• 235000006576 Althaea officinalis Nutrition 0.000 description 4
• 230000035515 penetration Effects 0.000 description 4
• 208000010195 Onychomycosis Diseases 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 201000005882 tinea unguium Diseases 0.000 description 3
• 239000013543 active substance Substances 0.000 description 2
• 230000007903 penetration ability Effects 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 229960003204 amorolfine Drugs 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 210000004877 mucosa Anatomy 0.000 description 1
• 208000026721 nail disease Diseases 0.000 description 1
• 239000000346 nonvolatile oil Substances 0.000 description 1
• -1 propylene glycol Chemical class 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1