JP2011508592A5 - - Google Patents
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- JP2011508592A5 JP2011508592A5 JP2010538920A JP2010538920A JP2011508592A5 JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5 JP 2010538920 A JP2010538920 A JP 2010538920A JP 2010538920 A JP2010538920 A JP 2010538920A JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- binding member
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 claims 3
- 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 102000055229 human IL4 Human genes 0.000 claims 3
- 102000054663 human IL4R Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 1
- 101001002707 Macaca fascicularis Interleukin-4 Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1586907P | 2007-12-21 | 2007-12-21 | |
| US61/015,869 | 2007-12-21 | ||
| PCT/GB2008/051212 WO2009081201A2 (en) | 2007-12-21 | 2008-12-19 | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Rα) - 173 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Division JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508592A JP2011508592A (ja) | 2011-03-17 |
| JP2011508592A5 true JP2011508592A5 (cg-RX-API-DMAC7.html) | 2012-02-09 |
| JP5571567B2 JP5571567B2 (ja) | 2014-08-13 |
Family
ID=40532664
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538920A Expired - Fee Related JP5571567B2 (ja) | 2007-12-21 | 2008-12-19 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP3211010A1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP5571567B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101759457B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104788563A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2008339576B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0822099A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2708871C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2245064T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2518415T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1212364A1 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2010006735A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2245064T3 (cg-RX-API-DMAC7.html) |
| RU (2) | RU2490278C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009081201A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| CN102317315A (zh) | 2009-02-11 | 2012-01-11 | 诺维信生物制药丹麦公司 | 白蛋白变体和缀合物 |
| CN102741280B (zh) | 2009-10-30 | 2015-12-02 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
| EP2556087A1 (en) * | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| WO2012085015A1 (en) * | 2010-12-20 | 2012-06-28 | Medimmune Limited | Anti-il-18 antibodies and their uses |
| EP2535714A1 (en) * | 2011-06-16 | 2012-12-19 | Istituto Nazionale Di Genetica Molecolare-INGM | Biomarkers for autoimmune liver diseases and uses thereof |
| AU2012321301B2 (en) * | 2011-10-10 | 2017-03-09 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| HK1200842A1 (en) | 2011-11-18 | 2015-08-14 | Albumedix Ltd | Proteins with improved half-life and other properties |
| EP2596802A1 (en) | 2011-11-23 | 2013-05-29 | PLS-Design GmbH | Pharmaceutical composition for treatment of allergic reactions |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| EP2674168A1 (en) | 2012-06-14 | 2013-12-18 | PLS-Design GmbH | Modulation of effector T cell responses by local depletion of complement component C3 |
| CN104755495A (zh) | 2012-08-21 | 2015-07-01 | 赛诺菲 | 通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| MX2015005363A (es) | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
| PL3010539T3 (pl) * | 2013-06-21 | 2020-01-31 | Sanofi Biotechnology | Sposoby leczenia polipowatości nosa przez podawanie antagonisty il-4r |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| CN113549153A (zh) | 2014-05-29 | 2021-10-26 | 宏观基因有限公司 | 三特异性结合分子和其使用方法 |
| WO2016023916A1 (en) | 2014-08-12 | 2016-02-18 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| TWI711629B (zh) | 2014-09-03 | 2020-12-01 | 德商包林格因蓋爾漢國際股份有限公司 | 靶向IL-23A與TNF-α之化合物及其用途 |
| CN106604744A (zh) * | 2014-09-03 | 2017-04-26 | 免疫医疗有限公司 | 稳定的抗IL‑4R‑α抗体配制品 |
| WO2016071701A1 (en) | 2014-11-07 | 2016-05-12 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| KR20230158131A (ko) * | 2014-11-14 | 2023-11-17 | 사노피 바이오테크놀로지 | Ｉｌ-4ｒ 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법 |
| AU2016239858B2 (en) | 2015-04-02 | 2021-07-01 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| CN108135976B (zh) | 2015-07-23 | 2022-10-18 | 博灵格英格尔海姆国际股份公司 | 靶向il-23a和b细胞激活因子(baff)的化合物和其用途 |
| MX2018001825A (es) | 2015-08-20 | 2018-05-07 | Albumedix As | Variantes y conjugados de albumina. |
| CN109069625A (zh) | 2016-02-19 | 2018-12-21 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂来增强疫苗功效的方法 |
| EP3433615A1 (en) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for diagnosis and treatment of solar lentigo |
| CN105753987A (zh) * | 2016-05-11 | 2016-07-13 | 贵阳中医学院 | 抗il-4r单链抗体的制备方法及其在抗肿瘤上的应用 |
| GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
| EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| KR102694419B1 (ko) | 2017-10-30 | 2024-08-09 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| RU2758092C1 (ru) * | 2018-02-01 | 2021-10-26 | Бэйцзин Кавин Текнолоджи Шеа-Холдинг Ко., Лтд. | АНТИТЕЛО К IL-4Rα И ЕГО ПРИМЕНЕНИЕ |
| PL3808774T3 (pl) * | 2018-08-24 | 2025-06-23 | Jiangsu Hengrui Medicine Co., Ltd. | Przeciwciało wiążące ludzki il-4r, jego fragment wiążący antygen i ich zastosowanie medyczne |
| CN109459372B (zh) * | 2018-10-29 | 2021-03-26 | 迪瑞医疗科技股份有限公司 | 有核红细胞模拟粒子及其制备方法与应用 |
| WO2020096381A1 (ko) * | 2018-11-09 | 2020-05-14 | 아주대학교 산학협력단 | 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도 |
| CN111514292B (zh) | 2018-12-25 | 2023-06-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
| JP7759255B2 (ja) * | 2018-12-27 | 2025-10-23 | 中山康方生物医▲藥▼有限公司 | ヒトｉｌ４ｒａに対する抗体及びその使用 |
| CN111592597B (zh) * | 2019-05-29 | 2022-04-26 | 山东博安生物技术股份有限公司 | 白介素4受体(il-4r)结合蛋白及其用途 |
| US12398212B2 (en) | 2019-07-16 | 2025-08-26 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| CN113527485B (zh) * | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN113549151A (zh) * | 2020-04-24 | 2021-10-26 | 苏州康乃德生物医药有限公司 | 与人IL-4Rα中特定表位结合的抗体及其应用 |
| EP4211169A4 (en) * | 2020-09-10 | 2024-12-04 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | ANTIBODIES THAT SPECIFICALLY RECOGNIZE THE INTERLEUKIN-4 RECEPTOR ALPHA AND USES THEREOF |
| CN114605539B (zh) * | 2020-12-09 | 2024-01-02 | 南京融捷康生物科技有限公司 | 人源化的抗IL-4Rα单域抗体及其应用 |
| TWI876192B (zh) * | 2021-08-05 | 2025-03-11 | 美商美國禮來大藥廠 | 人類介白素-4受體α抗體 |
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-
2008
- 2008-12-19 DK DK08865613.7T patent/DK2245064T3/da active
- 2008-12-19 AU AU2008339576A patent/AU2008339576B2/en not_active Ceased
- 2008-12-19 KR KR1020167011877A patent/KR101759457B1/ko not_active Expired - Fee Related
- 2008-12-19 EP EP16204833.4A patent/EP3211010A1/en not_active Withdrawn
- 2008-12-19 MX MX2010006735A patent/MX2010006735A/es active IP Right Grant
- 2008-12-19 CA CA2708871A patent/CA2708871C/en not_active Expired - Fee Related
- 2008-12-19 PL PL08865613T patent/PL2245064T3/pl unknown
- 2008-12-19 WO PCT/GB2008/051212 patent/WO2009081201A2/en not_active Ceased
- 2008-12-19 CN CN201410733833.9A patent/CN104788563A/zh active Pending
- 2008-12-19 ES ES08865613.7T patent/ES2518415T3/es active Active
- 2008-12-19 MX MX2013005138A patent/MX343594B/es unknown
- 2008-12-19 KR KR1020107016269A patent/KR101620539B1/ko not_active Expired - Fee Related
- 2008-12-19 RU RU2010129558/10A patent/RU2490278C2/ru not_active IP Right Cessation
- 2008-12-19 EP EP13152097.5A patent/EP2604628A3/en not_active Withdrawn
- 2008-12-19 EP EP08865613.7A patent/EP2245064B1/en not_active Not-in-force
- 2008-12-19 JP JP2010538920A patent/JP5571567B2/ja not_active Expired - Fee Related
- 2008-12-19 BR BRPI0822099A patent/BRPI0822099A2/pt active Search and Examination
- 2008-12-19 CN CN200880123045.0A patent/CN102046658B/zh not_active Expired - Fee Related
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2013
- 2013-05-24 RU RU2013123927/10A patent/RU2013123927A/ru not_active Application Discontinuation
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2014
- 2014-06-16 AU AU2014203248A patent/AU2014203248B2/en not_active Ceased
- 2014-06-26 JP JP2014130983A patent/JP6093734B2/ja not_active Expired - Fee Related
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2016
- 2016-01-12 HK HK16100316.9A patent/HK1212364A1/xx unknown
- 2016-12-16 JP JP2016244210A patent/JP2017095467A/ja active Pending
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2018
- 2018-06-05 JP JP2018107457A patent/JP2018148922A/ja active Pending
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