JP2011506578A5 - - Google Patents
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- Publication number
- JP2011506578A5 JP2011506578A5 JP2010538769A JP2010538769A JP2011506578A5 JP 2011506578 A5 JP2011506578 A5 JP 2011506578A5 JP 2010538769 A JP2010538769 A JP 2010538769A JP 2010538769 A JP2010538769 A JP 2010538769A JP 2011506578 A5 JP2011506578 A5 JP 2011506578A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- compound according
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 10
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07123882 | 2007-12-20 | ||
| EP07123882.8 | 2007-12-20 | ||
| PCT/EP2008/068065 WO2009080769A1 (en) | 2007-12-20 | 2008-12-19 | Antitumoral compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506578A JP2011506578A (ja) | 2011-03-03 |
| JP2011506578A5 true JP2011506578A5 (enExample) | 2012-02-09 |
| JP5727228B2 JP5727228B2 (ja) | 2015-06-03 |
Family
ID=40580474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538765A Expired - Fee Related JP5529038B2 (ja) | 2007-12-20 | 2008-12-19 | 抗腫瘍化合物 |
| JP2010538769A Expired - Fee Related JP5727228B2 (ja) | 2007-12-20 | 2008-12-19 | 抗腫瘍化合物 |
| JP2014080887A Expired - Fee Related JP5860088B2 (ja) | 2007-12-20 | 2014-04-10 | 抗腫瘍化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538765A Expired - Fee Related JP5529038B2 (ja) | 2007-12-20 | 2008-12-19 | 抗腫瘍化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014080887A Expired - Fee Related JP5860088B2 (ja) | 2007-12-20 | 2014-04-10 | 抗腫瘍化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US8710264B2 (enExample) |
| EP (3) | EP2231633B1 (enExample) |
| JP (3) | JP5529038B2 (enExample) |
| KR (3) | KR101639772B1 (enExample) |
| CN (4) | CN102190643B (enExample) |
| AT (1) | ATE549313T1 (enExample) |
| AU (2) | AU2008341671B2 (enExample) |
| BR (2) | BRPI0821116B8 (enExample) |
| CA (2) | CA2715203C (enExample) |
| CY (1) | CY1117245T1 (enExample) |
| DK (2) | DK2231590T3 (enExample) |
| ES (3) | ES2384420T3 (enExample) |
| HR (2) | HRP20140015T1 (enExample) |
| IL (3) | IL206396A (enExample) |
| MX (2) | MX2010006795A (enExample) |
| MY (3) | MY148651A (enExample) |
| NZ (3) | NZ597526A (enExample) |
| PL (2) | PL2231590T3 (enExample) |
| PT (2) | PT2231590E (enExample) |
| RS (2) | RS53140B (enExample) |
| RU (3) | RU2493147C2 (enExample) |
| SG (2) | SG170778A1 (enExample) |
| SI (2) | SI2231590T1 (enExample) |
| UA (3) | UA106967C2 (enExample) |
| WO (2) | WO2009080769A1 (enExample) |
| ZA (3) | ZA201004017B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140015T1 (hr) | 2007-12-20 | 2014-02-14 | Pharma Mar, S.A. | Antitumorski spojevi |
| WO2013103155A1 (en) * | 2012-01-05 | 2013-07-11 | Kao Corporation | Agent for reduction of sensory irritation |
| MA38588B1 (fr) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| CN108467378A (zh) * | 2017-02-23 | 2018-08-31 | 复旦大学 | 一种二氢吡喃酮类化合物及其制备方法和用途 |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
| TWI824043B (zh) | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US4855086A (en) | 1982-10-15 | 1989-08-08 | Burroughs Wellcome Co. | Novel pesticides, preparation and use |
| JPS61109717A (ja) | 1984-11-02 | 1986-05-28 | Teruhiko Beppu | 抗腫瘍剤 |
| JPH06504547A (ja) * | 1990-12-28 | 1994-05-26 | ジョージア・テック・リサーチ・コーポレーション | ペプチドケトアミド、ケト酸およびケトエステル |
| JPH0539283A (ja) | 1991-01-31 | 1993-02-19 | Suntory Ltd | 新規物質Ｓ−５９９１７ａ及びその製造方法 |
| ZA938019B (en) | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
| US5523456A (en) | 1994-09-29 | 1996-06-04 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
| US5834506A (en) | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| US5840974A (en) * | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
| US6380400B1 (en) | 1998-09-11 | 2002-04-30 | Victor Fedij | Methods of making dihydropyrone HIV protease inhibitors |
| US6528510B1 (en) | 1998-09-11 | 2003-03-04 | Warner-Lambert Company | HIV protease inhibitors |
| AU2000241948A1 (en) * | 2000-04-04 | 2001-10-15 | Novartis Ag | Method for treating cells resistant to antineoplastic agents |
| MXPA04008577A (es) * | 2002-03-04 | 2005-07-13 | Aton Pharma Inc | Metodos para inducir diferenciacion terminal. |
| AU2004263287B2 (en) * | 2003-07-25 | 2009-02-12 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
| RU2006142690A (ru) * | 2004-06-03 | 2008-06-10 | Козан Байосайенсиз Инкорпорейтед (Us) | Соединения лептомицина |
| US7446196B2 (en) | 2004-06-03 | 2008-11-04 | Kosan Biosciences, Incorporated | Leptomycin compounds |
| WO2007014423A1 (en) * | 2005-08-02 | 2007-02-08 | Medvet Science Pty, Ltd. | Exercise apparatus |
| EP2404912A3 (en) | 2006-06-16 | 2012-07-25 | Pharma Mar S.A. | Process and intermediates for the preparation of antitumoral dihydropyran-2-one compounds |
| HRP20140015T1 (hr) | 2007-12-20 | 2014-02-14 | Pharma Mar, S.A. | Antitumorski spojevi |
-
2008
- 2008-12-19 HR HRP20140015AT patent/HRP20140015T1/hr unknown
- 2008-12-19 CA CA2715203A patent/CA2715203C/en active Active
- 2008-12-19 CA CA2710087A patent/CA2710087C/en active Active
- 2008-12-19 UA UAA201009034A patent/UA106967C2/uk unknown
- 2008-12-19 DK DK08865009.8T patent/DK2231590T3/da active
- 2008-12-19 US US12/746,966 patent/US8710264B2/en not_active Expired - Fee Related
- 2008-12-19 PT PT08865009T patent/PT2231590E/pt unknown
- 2008-12-19 BR BRPI0821116A patent/BRPI0821116B8/pt not_active IP Right Cessation
- 2008-12-19 DK DK08864895.1T patent/DK2231633T3/da active
- 2008-12-19 SG SG201102163-1A patent/SG170778A1/en unknown
- 2008-12-19 SG SG201102164-9A patent/SG170779A1/en unknown
- 2008-12-19 RU RU2010130180/04A patent/RU2493147C2/ru active
- 2008-12-19 EP EP08864895.1A patent/EP2231633B1/en active Active
- 2008-12-19 CN CN201110073931.0A patent/CN102190643B/zh not_active Expired - Fee Related
- 2008-12-19 MY MYPI2010002590A patent/MY148651A/en unknown
- 2008-12-19 MY MYPI2010002591A patent/MY155342A/en unknown
- 2008-12-19 CN CN2008801218410A patent/CN101903337B/zh not_active Expired - Fee Related
- 2008-12-19 WO PCT/EP2008/068065 patent/WO2009080769A1/en not_active Ceased
- 2008-12-19 KR KR1020157016575A patent/KR101639772B1/ko not_active Expired - Fee Related
- 2008-12-19 JP JP2010538765A patent/JP5529038B2/ja not_active Expired - Fee Related
- 2008-12-19 MX MX2010006795A patent/MX2010006795A/es active IP Right Grant
- 2008-12-19 PL PL08865009T patent/PL2231590T3/pl unknown
- 2008-12-19 NZ NZ597526A patent/NZ597526A/en not_active IP Right Cessation
- 2008-12-19 JP JP2010538769A patent/JP5727228B2/ja not_active Expired - Fee Related
- 2008-12-19 WO PCT/EP2008/068049 patent/WO2009080761A1/en not_active Ceased
- 2008-12-19 KR KR1020107015965A patent/KR101541436B1/ko not_active Expired - Fee Related
- 2008-12-19 KR KR1020107015968A patent/KR101579553B1/ko not_active Expired - Fee Related
- 2008-12-19 ES ES08865009T patent/ES2384420T3/es active Active
- 2008-12-19 UA UAA201009035A patent/UA104281C2/ru unknown
- 2008-12-19 UA UAA201406894A patent/UA119963C2/uk unknown
- 2008-12-19 MX MX2010006796A patent/MX2010006796A/es active IP Right Grant
- 2008-12-19 AU AU2008341671A patent/AU2008341671B2/en not_active Ceased
- 2008-12-19 RU RU2013112003/04A patent/RU2528393C9/ru active
- 2008-12-19 AU AU2008341670A patent/AU2008341670B2/en not_active Ceased
- 2008-12-19 CN CN200880121840.6A patent/CN101903367B/zh not_active Expired - Fee Related
- 2008-12-19 EP EP13154647.5A patent/EP2597091B1/en active Active
- 2008-12-19 ES ES08864895.1T patent/ES2442140T3/es active Active
- 2008-12-19 RU RU2010130253/04A patent/RU2489429C2/ru active
- 2008-12-19 SI SI200830644T patent/SI2231590T1/sl unknown
- 2008-12-19 NZ NZ586013A patent/NZ586013A/en not_active IP Right Cessation
- 2008-12-19 RS RS20140007A patent/RS53140B/sr unknown
- 2008-12-19 NZ NZ586012A patent/NZ586012A/en not_active IP Right Cessation
- 2008-12-19 MY MYPI2014002392A patent/MY164533A/en unknown
- 2008-12-19 PT PT88648951T patent/PT2231633E/pt unknown
- 2008-12-19 PL PL08864895T patent/PL2231633T3/pl unknown
- 2008-12-19 AT AT08865009T patent/ATE549313T1/de active
- 2008-12-19 CN CN2011100568656A patent/CN102174058A/zh active Pending
- 2008-12-19 EP EP08865009A patent/EP2231590B9/en active Active
- 2008-12-19 US US12/746,974 patent/US9187445B2/en active Active
- 2008-12-19 RS RS20120242A patent/RS52343B/sr unknown
- 2008-12-19 HR HRP20120464AT patent/HRP20120464T1/hr unknown
- 2008-12-19 ES ES13154647.5T patent/ES2578606T3/es active Active
- 2008-12-19 BR BRPI0821114A patent/BRPI0821114B8/pt not_active IP Right Cessation
- 2008-12-19 SI SI200831122T patent/SI2231633T1/sl unknown
-
2010
- 2010-06-04 ZA ZA2010/04017A patent/ZA201004017B/en unknown
- 2010-06-04 ZA ZA2010/04018A patent/ZA201004018B/en unknown
- 2010-06-15 IL IL206396A patent/IL206396A/en active IP Right Grant
- 2010-06-15 IL IL206397A patent/IL206397A/en active IP Right Grant
-
2011
- 2011-08-31 ZA ZA2011/06371A patent/ZA201106371B/en unknown
-
2013
- 2013-11-24 IL IL229594A patent/IL229594A/en active IP Right Grant
-
2014
- 2014-01-27 CY CY20141100069T patent/CY1117245T1/el unknown
- 2014-04-10 JP JP2014080887A patent/JP5860088B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-12 US US14/824,699 patent/US9827257B2/en not_active Expired - Fee Related
- 2015-08-12 US US14/824,690 patent/US9750759B2/en not_active Expired - Fee Related
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