JP2011505164A5 - - Google Patents

Info

Publication number

JP2011505164A5

JP2011505164A5 JP2010537075A JP2010537075A JP2011505164A5 JP 2011505164 A5 JP2011505164 A5 JP 2011505164A5 JP 2010537075 A JP2010537075 A JP 2010537075A JP 2010537075 A JP2010537075 A JP 2010537075A JP 2011505164 A5 JP2011505164 A5 JP 2011505164A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

protein

mature

elastase

composition according

Prior art date

2008-12-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108010067372 Pancreatic elastase Proteins 0.000 claims 34
• 102000016387 Pancreatic elastase Human genes 0.000 claims 34
• 239000008194 pharmaceutical composition Substances 0.000 claims 33
• 238000000034 method Methods 0.000 claims 14
• 102000004169 proteins and genes Human genes 0.000 claims 14
• 108090000623 proteins and genes Proteins 0.000 claims 14
• 102000004142 Trypsin Human genes 0.000 claims 12
• 108090000631 Trypsin Proteins 0.000 claims 12
• 239000012588 trypsin Substances 0.000 claims 12
• -1 citrate compound Chemical class 0.000 claims 9
• 230000000694 effects Effects 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 210000001367 artery Anatomy 0.000 claims 6
• 210000003462 vein Anatomy 0.000 claims 6
• 230000003213 activating effect Effects 0.000 claims 4
• 238000003556 assay Methods 0.000 claims 3
• QQVNCBCBFNWLJX-KCHLEUMXSA-N n-[(2s)-1-[[(2s)-1-[[(2s)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]benzamide Chemical compound C([C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)NC(=O)C=1C=CC=CC=1)C1=CC=CC=C1 QQVNCBCBFNWLJX-KCHLEUMXSA-N 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 238000003860 storage Methods 0.000 claims 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
• 101800003414 Pro-elastase Proteins 0.000 claims 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010077805 Bacterial Proteins Proteins 0.000 claims 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 239000002158 endotoxin Substances 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 230000007062 hydrolysis Effects 0.000 claims 1
• 238000006460 hydrolysis reaction Methods 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
• 229940068968 polysorbate 80 Drugs 0.000 claims 1
• 229920000053 polysorbate 80 Polymers 0.000 claims 1
• 229910001414 potassium ion Inorganic materials 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 239000001632 sodium acetate Substances 0.000 claims 1
• 235000017281 sodium acetate Nutrition 0.000 claims 1
• 239000001509 sodium citrate Substances 0.000 claims 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
• 229910001415 sodium ion Inorganic materials 0.000 claims 1
• 229940074404 sodium succinate Drugs 0.000 claims 1
• ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims 1
• 239000001384 succinic acid Substances 0.000 claims 1