JP2011501665A5 - - Google Patents
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- JP2011501665A5 JP2011501665A5 JP2010529130A JP2010529130A JP2011501665A5 JP 2011501665 A5 JP2011501665 A5 JP 2011501665A5 JP 2010529130 A JP2010529130 A JP 2010529130A JP 2010529130 A JP2010529130 A JP 2010529130A JP 2011501665 A5 JP2011501665 A5 JP 2011501665A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- microfluidic device
- sample
- region
- acid amplification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical class 0.000 claims 45
- 108020004707 nucleic acids Proteins 0.000 claims 44
- 102000039446 nucleic acids Human genes 0.000 claims 44
- 239000000523 sample Substances 0.000 claims 41
- 230000003321 amplification Effects 0.000 claims 25
- 238000003199 nucleic acid amplification method Methods 0.000 claims 25
- 238000000034 method Methods 0.000 claims 15
- 238000002360 preparation method Methods 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 238000000746 purification Methods 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 8
- 239000012530 fluid Substances 0.000 claims 7
- 238000004458 analytical method Methods 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000000605 extraction Methods 0.000 claims 3
- 238000003752 polymerase chain reaction Methods 0.000 claims 3
- 239000004793 Polystyrene Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 102100034343 Integrase Human genes 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
- 238000005273 aeration Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000011344 liquid material Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000011343 solid material Substances 0.000 claims 1
- 238000005382 thermal cycling Methods 0.000 claims 1
- 239000002699 waste material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97951507P | 2007-10-12 | 2007-10-12 | |
| US60/979,515 | 2007-10-12 | ||
| PCT/US2008/079659 WO2009049268A1 (en) | 2007-10-12 | 2008-10-10 | Integrated microfluidic device and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501665A JP2011501665A (ja) | 2011-01-13 |
| JP2011501665A5 true JP2011501665A5 (enExample) | 2011-11-24 |
| JP5523327B2 JP5523327B2 (ja) | 2014-06-18 |
Family
ID=40251703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529130A Active JP5523327B2 (ja) | 2007-10-12 | 2008-10-10 | 統合型マイクロ流体デバイスおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9132398B2 (enExample) |
| EP (1) | EP2265375A1 (enExample) |
| JP (1) | JP5523327B2 (enExample) |
| CN (1) | CN101903104B (enExample) |
| WO (1) | WO2009049268A1 (enExample) |
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2008
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