FR2967362B1 - Cartouche microfluidique pour diagnostic moleculaire - Google Patents

Cartouche microfluidique pour diagnostic moleculaire

Info

Publication number
FR2967362B1
FR2967362B1 FR1059425A FR1059425A FR2967362B1 FR 2967362 B1 FR2967362 B1 FR 2967362B1 FR 1059425 A FR1059425 A FR 1059425A FR 1059425 A FR1059425 A FR 1059425A FR 2967362 B1 FR2967362 B1 FR 2967362B1
Authority
FR
France
Prior art keywords
face
cartridge
sample
actuation
microfluidic cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1059425A
Other languages
English (en)
Other versions
FR2967362A1 (fr
Inventor
Lucio Martinelli
Yann Marcy
Marc Artigue
Christof Schafauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genewave
Original Assignee
Genewave
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genewave filed Critical Genewave
Priority to FR1059425A priority Critical patent/FR2967362B1/fr
Priority to US13/885,507 priority patent/US20130230906A1/en
Priority to PCT/FR2011/052667 priority patent/WO2012066239A1/fr
Priority to EP11794823.2A priority patent/EP2640517A1/fr
Publication of FR2967362A1 publication Critical patent/FR2967362A1/fr
Application granted granted Critical
Publication of FR2967362B1 publication Critical patent/FR2967362B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne une cartouche permettant la réalisation d'un procédé d'analyse d'acides nucléiques compris dans un échantillon, comprenant un corps principal (1) réalisé en un substrat, dans lequel sont formés au moins une chambre réactionnelle (6) et une chambre de détection (10) d'au moins un acide nucléique, susceptible d'être contenu dans l'échantillon, un circuit microfluidique comportant un moyen d'injection de l'échantillon (7), des moyen d'injection et d'évacuation de fluides (4 et 13) respectivement dans et hors de la cartouche, des cavités, des canaux fluidiques (2) et des vannes aptes à les obturer. Selon l'invention, ladite cartouche comprend (a) une première face dite face d'actuation (16), à partir de laquelle est réalisée l'actuation des vannes de la cartouche, et (b) une deuxième face, opposée à ladite face d'actuation comportant la chambre de détection (10) d'au moins un acide nucléique susceptible d'être contenu dans l'échantillon, dite face de détection (15).
FR1059425A 2010-11-16 2010-11-16 Cartouche microfluidique pour diagnostic moleculaire Active FR2967362B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR1059425A FR2967362B1 (fr) 2010-11-16 2010-11-16 Cartouche microfluidique pour diagnostic moleculaire
US13/885,507 US20130230906A1 (en) 2010-11-16 2011-11-16 Microfluid cartridge for molecular diagnostics
PCT/FR2011/052667 WO2012066239A1 (fr) 2010-11-16 2011-11-16 Cartouche microfluidique pour diagnostic moleculaire
EP11794823.2A EP2640517A1 (fr) 2010-11-16 2011-11-16 Cartouche microfluidique pour diagnostic moleculaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059425A FR2967362B1 (fr) 2010-11-16 2010-11-16 Cartouche microfluidique pour diagnostic moleculaire

Publications (2)

Publication Number Publication Date
FR2967362A1 FR2967362A1 (fr) 2012-05-18
FR2967362B1 true FR2967362B1 (fr) 2012-12-21

Family

ID=44172385

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1059425A Active FR2967362B1 (fr) 2010-11-16 2010-11-16 Cartouche microfluidique pour diagnostic moleculaire

Country Status (4)

Country Link
US (1) US20130230906A1 (fr)
EP (1) EP2640517A1 (fr)
FR (1) FR2967362B1 (fr)
WO (1) WO2012066239A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
GB2516666B (en) * 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
WO2015179098A1 (fr) 2014-05-21 2015-11-26 Integenx Inc. Cartouche fluidique comprenant un mécanisme de soupape
WO2016065073A1 (fr) 2014-10-22 2016-04-28 Integenx Inc. Systèmes et méthodes de préparation, de traitement et d'analyse d'échantillon
GB201501705D0 (en) 2015-02-02 2015-03-18 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
GB2531615B (en) * 2015-02-02 2017-11-22 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
GB201700340D0 (en) * 2017-01-09 2017-02-22 Gsg Tech Ltd fluid manipulation cartridge and controller mechanism
EP3611508B1 (fr) * 2017-05-16 2022-08-03 SK Telecom Co., Ltd. Appareil d'analyse d'acides nucléiques utilisant une cartouche
KR102105558B1 (ko) * 2018-03-23 2020-04-28 (주)바이오니아 고속 중합효소 연쇄반응 분석 플레이트
US20220105510A1 (en) * 2020-10-07 2022-04-07 Massachusetts Institute Of Technology Microfluidic cell culture devices
FI130673B1 (en) 2020-11-24 2024-01-11 Mobidiag Oy Method and system for performing a cumulative nucleic acid amplification reaction

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776672A (en) * 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
FR2813207B1 (fr) * 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
KR20030038739A (ko) 2000-09-22 2003-05-16 자이단호진 가와무라 리카가쿠 겐큐쇼 미소 케미컬 디바이스 및 그 유량 조절 방법
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
JP4996248B2 (ja) * 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
WO2006085948A2 (fr) * 2004-07-01 2006-08-17 Cornell Research Foundation, Inc. Detection de micro-organismes en temps reel par reaction en chaine de la polymerase a l'aide d'une plate-forme microfluidique integree
TWI300141B (en) 2005-06-30 2008-08-21 Mitsui Chemicals Inc Optical waveguide film and optoelectrical hybrid film
FR2892196B1 (fr) 2005-10-18 2008-06-20 Genewave Soc Par Actions Simpl Procede de fabrication d'un biocapteur a detection integree
CN101541962A (zh) * 2007-03-23 2009-09-23 株式会社东芝 核酸检测盒以及核酸检测装置
CA2722242C (fr) * 2007-07-23 2018-07-17 Clondiag Gmbh Procedes et dispositifs permettant de determiner des valeurs indiquant la presence ou la quantite d'acides nucleiques
JP5523327B2 (ja) 2007-10-12 2014-06-18 レオニックス，インコーポレイテッド 統合型マイクロ流体デバイスおよび方法
FR2932885B1 (fr) 2008-06-24 2010-08-27 Genewave Procede et dispositif de detection de la fluorescence d'une biopuce
DE102008030664A1 (de) 2008-07-01 2010-01-21 Carl Zeiss Smt Ag Optische Abbildungseinrichtung mit Bestimmung von Abbildungsfehlern

Also Published As

Publication number Publication date
US20130230906A1 (en) 2013-09-05
EP2640517A1 (fr) 2013-09-25
WO2012066239A1 (fr) 2012-05-24
FR2967362A1 (fr) 2012-05-18

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