JP2011500005A5 - - Google Patents
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- JP2011500005A5 JP2011500005A5 JP2010528256A JP2010528256A JP2011500005A5 JP 2011500005 A5 JP2011500005 A5 JP 2011500005A5 JP 2010528256 A JP2010528256 A JP 2010528256A JP 2010528256 A JP2010528256 A JP 2010528256A JP 2011500005 A5 JP2011500005 A5 JP 2011500005A5
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- Prior art keywords
- polypeptide
- nod
- sirpα
- human
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002540 macrophage Anatomy 0.000 claims description 24
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000044459 human CD47 Human genes 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 10
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Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96072407P | 2007-10-11 | 2007-10-11 | |
| PCT/CA2008/001814 WO2009046541A1 (en) | 2007-10-11 | 2008-10-10 | MODULATION OF SIRPα - CD47 INTERACTION FOR INCREASING HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT AND COMPOUNDS THEREFOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500005A JP2011500005A (ja) | 2011-01-06 |
| JP2011500005A5 true JP2011500005A5 (https=) | 2011-11-24 |
Family
ID=40548916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528256A Pending JP2011500005A (ja) | 2007-10-11 | 2008-10-10 | ヒト造血幹細胞の生着を増加させるためのＳＩＲＰα−ＣＤ４７相互作用の調節およびそのための化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100239578A1 (https=) |
| EP (3) | EP2388270A3 (https=) |
| JP (1) | JP2011500005A (https=) |
| CN (2) | CN103242444A (https=) |
| AU (1) | AU2008310263B2 (https=) |
| CA (1) | CA2702217A1 (https=) |
| WO (1) | WO2009046541A1 (https=) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3342415B1 (en) | 2006-08-08 | 2022-01-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
| CA2965198C (en) | 2008-01-15 | 2021-02-16 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| AU2016203572A1 (en) * | 2008-01-15 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| AU2009205665B2 (en) | 2008-01-15 | 2013-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| AU2014201010B2 (en) * | 2008-01-15 | 2016-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| US20110237498A1 (en) * | 2008-12-19 | 2011-09-29 | Novartis Ag | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
| PL2995315T3 (pl) * | 2009-05-15 | 2024-04-22 | University Health Network | Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47 |
| AU2010334974A1 (en) | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| MX2013014789A (es) | 2011-06-16 | 2014-01-20 | Novartis Ag | Proteinas solubles para utilizarse como productos terapeuticos. |
| SI2804617T1 (sl) * | 2012-01-17 | 2020-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Visokoafinitetni SIRP-alfa reagenti |
| IN2015DN02032A (https=) * | 2012-09-07 | 2015-08-14 | Univ Yale | |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
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| US9873747B2 (en) | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| PT2970493T (pt) | 2013-03-15 | 2019-06-27 | Univ Leland Stanford Junior | Métodos para obter doses terapeuticamente eficazes de agentes anti-cd47 |
| CN103665165B (zh) * | 2013-08-28 | 2016-02-24 | 江苏匡亚生物医药科技有限公司 | 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途 |
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| US10358472B2 (en) | 2015-05-06 | 2019-07-23 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity CD47 analogs |
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2008
- 2008-10-10 US US12/682,307 patent/US20100239578A1/en not_active Abandoned
- 2008-10-10 EP EP11169933A patent/EP2388270A3/en not_active Withdrawn
- 2008-10-10 AU AU2008310263A patent/AU2008310263B2/en not_active Expired - Fee Related
- 2008-10-10 EP EP08838285A patent/EP2207797A4/en not_active Withdrawn
- 2008-10-10 EP EP12189613A patent/EP2573112A1/en not_active Withdrawn
- 2008-10-10 JP JP2010528256A patent/JP2011500005A/ja active Pending
- 2008-10-10 CN CN2013101029534A patent/CN103242444A/zh active Pending
- 2008-10-10 CN CN2008801197876A patent/CN101970478A/zh active Pending
- 2008-10-10 CA CA2702217A patent/CA2702217A1/en not_active Abandoned
- 2008-10-10 WO PCT/CA2008/001814 patent/WO2009046541A1/en not_active Ceased
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2012
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