JP2011116755A5 - - Google Patents
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- JP2011116755A5 JP2011116755A5 JP2010253326A JP2010253326A JP2011116755A5 JP 2011116755 A5 JP2011116755 A5 JP 2011116755A5 JP 2010253326 A JP2010253326 A JP 2010253326A JP 2010253326 A JP2010253326 A JP 2010253326A JP 2011116755 A5 JP2011116755 A5 JP 2011116755A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer
- inhibitor
- specifically binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 18
- 229940022399 cancer vaccine Drugs 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45103903P | 2003-02-28 | 2003-02-28 | |
| US60/451,039 | 2003-02-28 | ||
| US48214303P | 2003-06-24 | 2003-06-24 | |
| US60/482,143 | 2003-06-24 | ||
| US53170403P | 2003-12-22 | 2003-12-22 | |
| US60/531,704 | 2003-12-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508934A Division JP2006523226A (ja) | 2003-02-28 | 2004-03-01 | Ｔ細胞調節方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013217056A Division JP2014058523A (ja) | 2003-02-28 | 2013-10-18 | Ｔ細胞調節方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011116755A JP2011116755A (ja) | 2011-06-16 |
| JP2011116755A5 true JP2011116755A5 (enExample) | 2012-02-09 |
Family
ID=32966451
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508934A Withdrawn JP2006523226A (ja) | 2003-02-28 | 2004-03-01 | Ｔ細胞調節方法 |
| JP2010253326A Withdrawn JP2011116755A (ja) | 2003-02-28 | 2010-11-12 | Ｔ細胞調節方法 |
| JP2013217056A Withdrawn JP2014058523A (ja) | 2003-02-28 | 2013-10-18 | Ｔ細胞調節方法 |
| JP2016080113A Withdrawn JP2016169216A (ja) | 2003-02-28 | 2016-04-13 | Ｔ細胞調節方法 |
| JP2017142742A Expired - Lifetime JP6758259B2 (ja) | 2003-02-28 | 2017-07-24 | Ｔ細胞調節方法 |
| JP2019072698A Withdrawn JP2019135247A (ja) | 2003-02-28 | 2019-04-05 | Ｔ細胞調節方法 |
| JP2021214040A Pending JP2022034067A (ja) | 2003-02-28 | 2021-12-28 | Ｔ細胞調節方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508934A Withdrawn JP2006523226A (ja) | 2003-02-28 | 2004-03-01 | Ｔ細胞調節方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013217056A Withdrawn JP2014058523A (ja) | 2003-02-28 | 2013-10-18 | Ｔ細胞調節方法 |
| JP2016080113A Withdrawn JP2016169216A (ja) | 2003-02-28 | 2016-04-13 | Ｔ細胞調節方法 |
| JP2017142742A Expired - Lifetime JP6758259B2 (ja) | 2003-02-28 | 2017-07-24 | Ｔ細胞調節方法 |
| JP2019072698A Withdrawn JP2019135247A (ja) | 2003-02-28 | 2019-04-05 | Ｔ細胞調節方法 |
| JP2021214040A Pending JP2022034067A (ja) | 2003-02-28 | 2021-12-28 | Ｔ細胞調節方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US20060240024A1 (enExample) |
| EP (4) | EP1897548B2 (enExample) |
| JP (7) | JP2006523226A (enExample) |
| AU (1) | AU2004217526B2 (enExample) |
| CA (1) | CA2517287C (enExample) |
| CY (1) | CY1114755T1 (enExample) |
| DK (1) | DK1897548T4 (enExample) |
| ES (1) | ES2439580T5 (enExample) |
| FI (1) | FI1897548T4 (enExample) |
| PL (1) | PL1897548T5 (enExample) |
| PT (1) | PT1897548E (enExample) |
| SI (1) | SI1897548T2 (enExample) |
| WO (1) | WO2004078928A2 (enExample) |
Families Citing this family (82)
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| US20080085261A1 (en) * | 2004-10-19 | 2008-04-10 | Haynes Barton F | Vaccine Adjuvant |
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| US20090317407A1 (en) * | 2006-05-02 | 2009-12-24 | Lacelle Michael G | Augmentation of immune response to cancer vaccine |
| JPWO2008126940A1 (ja) * | 2007-04-10 | 2010-09-24 | 国立大学法人 東京大学 | 新規ｔ細胞 |
| US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| EP1987839A1 (en) * | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| JP5616782B2 (ja) * | 2008-03-14 | 2014-10-29 | 株式会社メディネット | 免疫増強機能を有する抗体 |
| WO2009119793A1 (ja) * | 2008-03-27 | 2009-10-01 | タカラバイオ株式会社 | 遺伝子導入細胞の製造方法 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| WO2010062966A2 (en) * | 2008-11-26 | 2010-06-03 | The General Hospital Corporation | Methods for inducing mixed chimerism |
| EP2726101B1 (en) | 2011-06-30 | 2018-08-08 | Genzyme Corporation | Inhibitors of t-cell activation |
| WO2013063504A1 (en) * | 2011-10-26 | 2013-05-02 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP2948469A4 (en) | 2013-01-23 | 2016-11-02 | Univ Leland Stanford Junior | STABILIZED HEPATITIS B CORE POLYPEPTIDE |
| SI2970464T1 (sl) | 2013-03-15 | 2020-08-31 | Glaxosmithkline Intellectual Propety Development Limited | Anti-LAG-3 vezavni proteini |
| US9944992B2 (en) | 2013-03-15 | 2018-04-17 | The University Of Chicago | Methods and compositions related to T-cell activity |
| US10081681B2 (en) | 2013-09-20 | 2018-09-25 | Bristol-Myers Squibb Company | Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors |
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| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
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| MX391478B (es) | 2014-10-10 | 2025-03-21 | Idera Pharmaceuticals Inc | Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer. |
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| TWI702290B (zh) * | 2015-04-07 | 2020-08-21 | 富禾生醫股份有限公司 | 經修飾之自然殺手ｔ細胞、醫藥組合物及其用途 |
| EA039293B1 (ru) * | 2015-06-05 | 2021-12-30 | Мерк Шарп И Доум Корп. | Антитела против lag3 и антигенсвязывающие фрагменты |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| US11059880B2 (en) | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
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| CA2447564A1 (en) | 2001-05-15 | 2002-11-21 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 101p3a11 or phor-1 useful in treatment and detection of cancer |
| CA2448320A1 (en) * | 2001-05-29 | 2002-12-05 | Sirna Therapeutics, Inc. | Ribozyme based treatment of female reproductive diseases |
| PT1483390E (pt) * | 2001-06-12 | 2008-07-07 | Bayer Cropscience Ag | Plantas transgénicas que sintetizam amido rico em amilose |
| CA2454183C (en) * | 2001-07-23 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| JP2006523226A (ja) | 2003-02-28 | 2006-10-12 | ザ ジョンズ ホプキンス ユニバーシティ | Ｔ細胞調節方法 |
| KR101531400B1 (ko) | 2003-06-27 | 2015-06-26 | 암젠 프레몬트 인코포레이티드 | 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그용도 |
| TWI580694B (zh) * | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-ｖｅｇｆ抗體 |
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2004
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- 2004-03-01 EP EP07021595.9A patent/EP1897548B2/en not_active Expired - Lifetime
- 2004-03-01 WO PCT/US2004/006133 patent/WO2004078928A2/en not_active Ceased
- 2004-03-01 EP EP20130179162 patent/EP2659893A3/en not_active Withdrawn
- 2004-03-01 SI SI200432110T patent/SI1897548T2/sl unknown
- 2004-03-01 CA CA2517287A patent/CA2517287C/en not_active Expired - Lifetime
- 2004-03-01 EP EP18177034.8A patent/EP3427741A3/en active Pending
- 2004-03-01 PL PL07021595.9T patent/PL1897548T5/pl unknown
- 2004-03-01 EP EP04716126A patent/EP1596871A4/en not_active Withdrawn
- 2004-03-01 DK DK07021595.9T patent/DK1897548T4/da active
- 2004-03-01 PT PT70215959T patent/PT1897548E/pt unknown
- 2004-03-01 AU AU2004217526A patent/AU2004217526B2/en not_active Expired
- 2004-03-01 ES ES07021595T patent/ES2439580T5/es not_active Expired - Lifetime
- 2004-03-01 US US10/547,371 patent/US20060240024A1/en not_active Abandoned
- 2004-03-01 FI FIEP07021595.9T patent/FI1897548T4/fi active
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2009
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2010
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2012
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2013
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2016
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2018
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2021
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