JP2010540643A5 - - Google Patents
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- JP2010540643A5 JP2010540643A5 JP2010528032A JP2010528032A JP2010540643A5 JP 2010540643 A5 JP2010540643 A5 JP 2010540643A5 JP 2010528032 A JP2010528032 A JP 2010528032A JP 2010528032 A JP2010528032 A JP 2010528032A JP 2010540643 A5 JP2010540643 A5 JP 2010540643A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97650607P | 2007-10-01 | 2007-10-01 | |
| US60/976,506 | 2007-10-01 | ||
| US12/206,801 US8119658B2 (en) | 2007-10-01 | 2008-09-09 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| US12/206,801 | 2008-09-09 | ||
| PCT/US2008/076984 WO2009045753A1 (en) | 2007-10-01 | 2008-09-19 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540643A JP2010540643A (ja) | 2010-12-24 |
| JP2010540643A5 true JP2010540643A5 (https=) | 2011-07-28 |
| JP5611044B2 JP5611044B2 (ja) | 2014-10-22 |
Family
ID=40523804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528032A Expired - Fee Related JP5611044B2 (ja) | 2007-10-01 | 2008-09-19 | トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8119658B2 (https=) |
| EP (1) | EP2205598A1 (https=) |
| JP (1) | JP5611044B2 (https=) |
| KR (1) | KR20100085081A (https=) |
| CN (1) | CN101883772B (https=) |
| AR (1) | AR068601A1 (https=) |
| AU (1) | AU2008309101B2 (https=) |
| BR (1) | BRPI0817656A2 (https=) |
| CA (1) | CA2701355A1 (https=) |
| CL (1) | CL2008002916A1 (https=) |
| CO (1) | CO6280485A2 (https=) |
| EA (2) | EA019706B1 (https=) |
| IL (1) | IL204799A (https=) |
| MX (1) | MX2010003565A (https=) |
| NZ (1) | NZ584386A (https=) |
| PE (2) | PE20091219A1 (https=) |
| SG (1) | SG190638A1 (https=) |
| TW (1) | TW200916470A (https=) |
| WO (1) | WO2009045753A1 (https=) |
| ZA (1) | ZA201002043B (https=) |
Families Citing this family (64)
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| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
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| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| BR112012033402A2 (pt) | 2010-07-02 | 2017-01-24 | Gilead Sciences Inc | moduladores de canais de íons conforme os compostos heterocíclicos fundidos |
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| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
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| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (https=) | 2011-07-01 | 2018-04-28 | ||
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| EA026655B1 (ru) | 2011-09-15 | 2017-05-31 | Новартис Аг | 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ |
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| WO2013062966A2 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Novel trpv3 modulators |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| US9580422B2 (en) | 2013-10-22 | 2017-02-28 | Bristol-Myers Squibb Company | Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| GB201321742D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
| KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
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| AR105392A1 (es) * | 2015-07-20 | 2017-09-27 | Genzyme Corp | Inhibidores del receptor del factor estimulador de colonias 1 (csf-1r) |
| US10836742B2 (en) | 2015-08-11 | 2020-11-17 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
| WO2017024408A1 (en) | 2015-08-11 | 2017-02-16 | Neomed Institute | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
| LT3334709T (lt) | 2015-08-12 | 2025-03-10 | Incyte Holdings Corporation | Lsd1 inhibitoriaus druskos |
| CN108137539B (zh) | 2015-08-12 | 2022-01-11 | 尼奥迈德研究所 | 取代的苯并咪唑、它们的制备和它们作为药物的用途 |
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| JP6999574B2 (ja) | 2016-04-22 | 2022-01-18 | インサイト・コーポレイション | Ｌｓｄ１阻害剤の製剤 |
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| JP2024500919A (ja) | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤 |
| CN114426516B (zh) * | 2022-02-16 | 2022-11-04 | 安徽有吉医药科技有限公司 | 一种2-氨基-3-溴吡啶的制备方法 |
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-
2008
- 2008-09-09 US US12/206,801 patent/US8119658B2/en active Active
- 2008-09-19 CN CN2008801187338A patent/CN101883772B/zh not_active Expired - Fee Related
- 2008-09-19 SG SG2013035027A patent/SG190638A1/en unknown
- 2008-09-19 BR BRPI0817656 patent/BRPI0817656A2/pt not_active IP Right Cessation
- 2008-09-19 NZ NZ584386A patent/NZ584386A/en unknown
- 2008-09-19 WO PCT/US2008/076984 patent/WO2009045753A1/en not_active Ceased
- 2008-09-19 EA EA201000563A patent/EA019706B1/ru not_active IP Right Cessation
- 2008-09-19 EP EP08835346A patent/EP2205598A1/en not_active Withdrawn
- 2008-09-19 MX MX2010003565A patent/MX2010003565A/es not_active Application Discontinuation
- 2008-09-19 AU AU2008309101A patent/AU2008309101B2/en not_active Ceased
- 2008-09-19 KR KR1020107009665A patent/KR20100085081A/ko not_active Ceased
- 2008-09-19 JP JP2010528032A patent/JP5611044B2/ja not_active Expired - Fee Related
- 2008-09-19 EA EA201391705A patent/EA201391705A1/ru unknown
- 2008-09-19 CA CA2701355A patent/CA2701355A1/en not_active Abandoned
- 2008-09-30 AR ARP080104279A patent/AR068601A1/es not_active Application Discontinuation
- 2008-09-30 PE PE2008001701A patent/PE20091219A1/es not_active Application Discontinuation
- 2008-09-30 PE PE2012001254A patent/PE20121704A1/es not_active Application Discontinuation
- 2008-09-30 CL CL2008002916A patent/CL2008002916A1/es unknown
- 2008-10-01 TW TW097137800A patent/TW200916470A/zh unknown
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2010
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