JP5611044B2 - トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤 - Google Patents

トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤 Download PDF

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JP5611044B2
JP5611044B2 JP2010528032A JP2010528032A JP5611044B2 JP 5611044 B2 JP5611044 B2 JP 5611044B2 JP 2010528032 A JP2010528032 A JP 2010528032A JP 2010528032 A JP2010528032 A JP 2010528032A JP 5611044 B2 JP5611044 B2 JP 5611044B2
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aryl
heteroaryl
alkoxy
cycloalkyl
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JP2010540643A5 (https=
JP2010540643A (ja
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ジュン・リ
ジェフリー・エイ・ロブル
ジェイムズ・ジェイ・リ
ローレンス・ジェイ・ケネディー
ワン・ハイシア
ジエ・ジャック・リ
シンフア・キアン
ラジェンドラ・ピー・デシュパンデ
ラクスマ・アール・コラ
レジナルド・オー・キャン
チェンコウ・ウェイ
マイケル・ガレラ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010528032A 2007-10-01 2008-09-19 トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤 Expired - Fee Related JP5611044B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97650607P 2007-10-01 2007-10-01
US60/976,506 2007-10-01
US12/206,801 2008-09-09
US12/206,801 US8119658B2 (en) 2007-10-01 2008-09-09 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
PCT/US2008/076984 WO2009045753A1 (en) 2007-10-01 2008-09-19 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors

Publications (3)

Publication Number Publication Date
JP2010540643A JP2010540643A (ja) 2010-12-24
JP2010540643A5 JP2010540643A5 (https=) 2011-07-28
JP5611044B2 true JP5611044B2 (ja) 2014-10-22

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JP2010528032A Expired - Fee Related JP5611044B2 (ja) 2007-10-01 2008-09-19 トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤

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US (2) US8119658B2 (https=)
EP (1) EP2205598A1 (https=)
JP (1) JP5611044B2 (https=)
KR (1) KR20100085081A (https=)
CN (1) CN101883772B (https=)
AR (1) AR068601A1 (https=)
AU (1) AU2008309101B2 (https=)
BR (1) BRPI0817656A2 (https=)
CA (1) CA2701355A1 (https=)
CL (1) CL2008002916A1 (https=)
CO (1) CO6280485A2 (https=)
EA (2) EA019706B1 (https=)
IL (1) IL204799A (https=)
MX (1) MX2010003565A (https=)
NZ (1) NZ584386A (https=)
PE (2) PE20121704A1 (https=)
SG (1) SG190638A1 (https=)
TW (1) TW200916470A (https=)
WO (1) WO2009045753A1 (https=)
ZA (1) ZA201002043B (https=)

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