JP2010536378A5 - - Google Patents
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- JP2010536378A5 JP2010536378A5 JP2010521980A JP2010521980A JP2010536378A5 JP 2010536378 A5 JP2010536378 A5 JP 2010536378A5 JP 2010521980 A JP2010521980 A JP 2010521980A JP 2010521980 A JP2010521980 A JP 2010521980A JP 2010536378 A5 JP2010536378 A5 JP 2010536378A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- group
- binding protein
- antigen binding
- cdrh2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000025417 antigen binding proteins Human genes 0.000 claims description 142
- 108091000829 antigen binding proteins Proteins 0.000 claims description 142
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 92
- 150000001413 amino acids Chemical class 0.000 claims description 67
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 claims description 44
- 238000006467 substitution reaction Methods 0.000 claims description 36
- 108090001123 antibodies Proteins 0.000 claims description 22
- 102000004965 antibodies Human genes 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 8
- 210000004027 cells Anatomy 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 6
- 210000001616 Monocytes Anatomy 0.000 claims description 5
- 102100005176 CSF1 Human genes 0.000 claims description 4
- 230000035693 Fab Effects 0.000 claims description 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 4
- 210000002540 Macrophages Anatomy 0.000 claims description 4
- 102220419176 UQCRB E29R Human genes 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000005012 migration Effects 0.000 claims description 4
- 108010045030 monoclonal antibodies Proteins 0.000 claims description 4
- 102000005614 monoclonal antibodies Human genes 0.000 claims description 4
- 230000028550 monocyte chemotaxis Effects 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 208000003432 Bone Disease Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 102100000329 CDHR2 Human genes 0.000 claims description 2
- 101700036375 CDHR2 Proteins 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010024324 Leukaemias Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 241000948165 Milk vetch dwarf virus Species 0.000 claims description 2
- 206010025310 Other lymphomas Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 231100000765 Toxin Toxicity 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 230000035578 autophosphorylation Effects 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 108091006028 chimera Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 201000003908 endometrial adenocarcinoma Diseases 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 200000000018 inflammatory disease Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000546 pharmaceutic aid Substances 0.000 claims description 2
- 108091008117 polyclonal antibodies Proteins 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 230000001105 regulatory Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 102000015434 Humanized Monoclonal Antibodies Human genes 0.000 claims 1
- 108010064750 Humanized Monoclonal Antibodies Proteins 0.000 claims 1
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 claims 1
- 102000024070 binding proteins Human genes 0.000 claims 1
- 108091007650 binding proteins Proteins 0.000 claims 1
- 230000003399 chemotactic Effects 0.000 claims 1
- 229960000060 monoclonal antibodies Drugs 0.000 claims 1
- 230000003248 secreting Effects 0.000 claims 1
- 230000003466 anti-cipated Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95714807P | 2007-08-21 | 2007-08-21 | |
| US60/957,148 | 2007-08-21 | ||
| US8458808P | 2008-07-29 | 2008-07-29 | |
| US61/084,588 | 2008-07-29 | ||
| PCT/US2008/073611 WO2009026303A1 (en) | 2007-08-21 | 2008-08-19 | Human c-fms antigen binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014254993A Division JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536378A JP2010536378A (ja) | 2010-12-02 |
| JP2010536378A5 true JP2010536378A5 (sr) | 2012-08-02 |
| JP5718640B2 JP5718640B2 (ja) | 2015-05-13 |
Family
ID=40019258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521980A Active JP5718640B2 (ja) | 2007-08-21 | 2008-08-19 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2014254993A Active JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2017148838A Withdrawn JP2018007683A (ja) | 2007-08-21 | 2017-08-01 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014254993A Active JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2017148838A Withdrawn JP2018007683A (ja) | 2007-08-21 | 2017-08-01 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8182813B2 (sr) |
| EP (4) | EP2188313B1 (sr) |
| JP (3) | JP5718640B2 (sr) |
| KR (1) | KR101770429B1 (sr) |
| CN (1) | CN101802008B (sr) |
| AR (1) | AR068347A1 (sr) |
| AU (1) | AU2008288974B2 (sr) |
| BR (1) | BRPI0815368A2 (sr) |
| CA (1) | CA2696761C (sr) |
| CL (1) | CL2008002444A1 (sr) |
| CR (1) | CR11282A (sr) |
| CY (1) | CY1119755T1 (sr) |
| DK (1) | DK2188313T3 (sr) |
| EA (2) | EA023555B1 (sr) |
| ES (1) | ES2650224T3 (sr) |
| HR (1) | HRP20171741T1 (sr) |
| HU (1) | HUE037265T2 (sr) |
| LT (1) | LT2188313T (sr) |
| MX (1) | MX2010001918A (sr) |
| NO (1) | NO2188313T3 (sr) |
| NZ (1) | NZ583282A (sr) |
| PE (1) | PE20091004A1 (sr) |
| PL (1) | PL2188313T3 (sr) |
| PT (1) | PT2188313T (sr) |
| RS (1) | RS56743B1 (sr) |
| SG (1) | SG10201500328QA (sr) |
| SI (1) | SI2188313T1 (sr) |
| TW (1) | TWI595005B (sr) |
| WO (1) | WO2009026303A1 (sr) |
| ZA (1) | ZA201001541B (sr) |
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| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| WO2010062399A2 (en) | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Csf1r extracellular domain fusion molecules and treatments using same |
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| IT1394281B1 (it) * | 2009-01-19 | 2012-06-06 | Zardi | Processo per la produzione di proteine di fusione polivalenti e polispecifiche utilizzando come struttura portante l'uteroglobina e prodotti cosi' ottenuti. |
| WO2011002494A1 (en) * | 2009-07-01 | 2011-01-06 | University Of Tenessee Research Foundation | Use of immunoglobulin heavy and light chains or fragments therof to bind to aggregated amyloidogenic proteins |
| RU2565541C2 (ru) | 2009-12-10 | 2015-10-20 | Ф.Хоффманн-Ля Рош Аг | Антитела, связывающиеся преимущественно с внеклеточным доменом 4 человеческого csf-1r, и их применение |
| US9169323B2 (en) | 2010-03-05 | 2015-10-27 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
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