JP2010535031A5 - - Google Patents

Download PDF

Info

Publication number
JP2010535031A5
JP2010535031A5 JP2010519925A JP2010519925A JP2010535031A5 JP 2010535031 A5 JP2010535031 A5 JP 2010535031A5 JP 2010519925 A JP2010519925 A JP 2010519925A JP 2010519925 A JP2010519925 A JP 2010519925A JP 2010535031 A5 JP2010535031 A5 JP 2010535031A5
Authority
JP
Japan
Prior art keywords
sequence
target
reaction mixture
target sequence
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010519925A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010535031A (ja
JP5531367B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/009248 external-priority patent/WO2009017784A2/en
Publication of JP2010535031A publication Critical patent/JP2010535031A/ja
Publication of JP2010535031A5 publication Critical patent/JP2010535031A5/ja
Application granted granted Critical
Publication of JP5531367B2 publication Critical patent/JP5531367B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010519925A 2007-08-01 2008-07-31 標的配列の濃縮 Expired - Fee Related JP5531367B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96283807P 2007-08-01 2007-08-01
US60/962,838 2007-08-01
PCT/US2008/009248 WO2009017784A2 (en) 2007-08-01 2008-07-31 Enrichment of a target sequence

Publications (3)

Publication Number Publication Date
JP2010535031A JP2010535031A (ja) 2010-11-18
JP2010535031A5 true JP2010535031A5 (https=) 2013-08-08
JP5531367B2 JP5531367B2 (ja) 2014-06-25

Family

ID=40305136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010519925A Expired - Fee Related JP5531367B2 (ja) 2007-08-01 2008-07-31 標的配列の濃縮

Country Status (11)

Country Link
US (1) US8455190B2 (https=)
EP (1) EP2183379B1 (https=)
JP (1) JP5531367B2 (https=)
KR (1) KR101376359B1 (https=)
CN (1) CN101815789B (https=)
AU (1) AU2008282780B2 (https=)
CA (1) CA2695264C (https=)
DK (1) DK2183379T3 (https=)
ES (1) ES2547053T3 (https=)
PT (1) PT2183379E (https=)
WO (1) WO2009017784A2 (https=)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
US20090047673A1 (en) 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
ES2582602T3 (es) 2007-03-28 2016-09-14 Signal Diagnostics Sistema y método de análisis de alta resolución de ácidos nucleicos para detectar variaciones de secuencia
JP5531367B2 (ja) 2007-08-01 2014-06-25 ダナ−ファーバー キャンサー インスチテュート 標的配列の濃縮
EP2279403B1 (en) 2008-05-05 2016-03-16 Los Alamos National Security, LLC Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
US10669574B2 (en) 2008-11-18 2020-06-02 XCR Diagnostics, Inc. DNA amplification technology
AU2011224534B2 (en) * 2010-03-08 2014-10-09 Dana-Farber Cancer Institute, Inc. Full COLD-PCR enrichment with reference blocking sequence
KR101312241B1 (ko) * 2010-04-27 2013-09-27 사회복지법인 삼성생명공익재단 증폭억제시발체를 이용하는 유전자 돌연변이 검출 방법
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12545960B2 (en) 2010-05-18 2026-02-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
JP2014507950A (ja) * 2011-02-28 2014-04-03 トランスゲノミック,インク. 混合個体群における標的dnaを配列決定するためのキットおよび方法
ITTO20110271A1 (it) 2011-03-28 2012-09-29 Fabio Gentilini Metodo per l'identificazione di polimorfismi genetici di base singola.
EP2691541B1 (en) * 2011-03-31 2017-10-18 Dana-Farber Cancer Institute, Inc. Method for enriching in single-stranded mutant sequences from mixture of wild-type and mutant sequences
CN103608467B (zh) 2011-04-20 2017-07-21 美飒生物技术公司 用于核酸的振荡扩增反应
US9796748B2 (en) 2011-05-02 2017-10-24 President And Fellows Of Harvard College Spatial sequestration of dynamic nucleic acid circuits
US9617392B2 (en) 2011-07-10 2017-04-11 President And Fellows Of Harvard College Compositions and methods for self-assembly of polymers with complementary macroscopic and microscopic scale units
WO2013010074A1 (en) 2011-07-13 2013-01-17 Primeradx, Inc. Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample
US9074247B2 (en) * 2011-10-06 2015-07-07 Drexel University P53 assay for a urine test for HCC screening
CN103998921B (zh) 2011-10-14 2016-04-20 贝克顿·迪金森公司 方波热循环
US9133490B2 (en) 2012-05-16 2015-09-15 Transgenomic, Inc. Step-up method for COLD-PCR enrichment
US20150126376A1 (en) * 2012-06-14 2015-05-07 Fred Hutchinson Cancer Research Center Compositions and methods for sensitive mutation detection in nucleic acid molecules
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US10913977B2 (en) * 2013-07-24 2021-02-09 Dana-Farber Cancer Institute, Inc. Methods and compositions to enable enrichment of minor DNA alleles by limiting denaturation time in PCR or simply enable enrichment of minor DNA alleles by limiting the denaturation time in PCR
KR102323375B1 (ko) 2013-10-09 2021-11-08 플루어레센트릭 인코포레이티드 다중 프로브
CA2922261A1 (en) * 2013-10-20 2015-05-21 Trovagene, Inc. Synthesis and enrichment of nucleic acid sequences
CN105283555A (zh) * 2013-10-20 2016-01-27 特罗瓦基因公司 核酸序列的合成和富集
CN103602748A (zh) * 2013-11-28 2014-02-26 瑞希基因科技(北京)股份有限公司 一种结合荧光定量pcr技术的焦磷酸测序方法
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CN106687589B (zh) * 2014-07-10 2021-05-07 弗洛雷森特里克公司 Dna扩增技术
TWI813141B (zh) 2014-07-18 2023-08-21 香港中文大學 Dna混合物中之組織甲基化模式分析
EP3286546B1 (en) 2015-04-24 2023-07-19 Mesa Biotech, Inc. Fluidic test cassette
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
PL3298162T3 (pl) 2015-05-18 2020-07-27 Saga Diagnostics Ab Wykrywanie docelowego kwasu nukleinowego i wariantów
US10689710B2 (en) * 2015-05-27 2020-06-23 Quest Diagnostics Investments Incorporated Methods for screening solid tumors for mutations
WO2017070339A1 (en) * 2015-10-20 2017-04-27 Richardson Katherine Microfluidic device for enrichment of nucleic acid sequence alterations
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
KR20260032575A (ko) 2016-11-30 2026-03-09 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2018111835A1 (en) 2016-12-12 2018-06-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for molecular barcoding of dna molecules prior to mutation enrichment and/or mutation detection
US11174511B2 (en) 2017-07-24 2021-11-16 Dana-Farber Cancer Institute, Inc. Methods and compositions for selecting and amplifying DNA targets in a single reaction mixture
WO2019099420A1 (en) * 2017-11-15 2019-05-23 Yan Wang A method for detecting multiple dna mutations and copy number variations
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
DE202019005627U1 (de) 2018-04-02 2021-05-31 Grail, Inc. Methylierungsmarker und gezielte Methylierungssondenpanels
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
JP6544783B1 (ja) 2018-07-31 2019-07-17 学校法人 岩手医科大学 がんの診断のためのプローブ/プライマーライブラリー
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
WO2021034999A1 (en) 2019-08-21 2021-02-25 Dana-Farber Cancer Institute, Inc. Multi-site enrichment of deletions in dna microsatellites
US11866793B2 (en) 2020-03-27 2024-01-09 Regents Of The University Of Minnesota Assay for detecting palmer amaranth DNA in individual and mixed samples
EP4624573A1 (en) 2022-11-22 2025-10-01 Quantdetect, Inc. Probe/primer library for cancer diagnosis

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
GB2228086A (en) 1988-11-25 1990-08-15 Ici Plc Characterisation of genomic DNA
KR920700360A (ko) 1989-03-22 1992-02-19 하리크 프리드리히 미끄럼 베어링
US5075217A (en) 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
AU5645690A (en) 1989-05-05 1990-11-29 Lifecodes Corporation Method for genetic analysis of a nucleic acid sample
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5045450A (en) * 1989-07-13 1991-09-03 Massachusetts Institute Of Technology Determination of a mutational spectrum
DE3938907C2 (de) 1989-11-24 1999-11-04 Dade Behring Marburg Gmbh Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten
CA2035010C (en) 1990-01-26 1996-12-10 Keith C. Backman Method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
EP0516753A4 (en) 1990-02-26 1994-05-18 Us Health A method for the fluorescent detection of a dna sequence in real time
WO1991014003A2 (en) 1990-03-09 1991-09-19 Ig Laboratories, Inc. Characterization and analysis of polymorphic vntr loci
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5631147A (en) 1995-09-21 1997-05-20 Becton, Dickinson And Company Detection of nucleic acids in cells by thermophilic strand displacement amplification
DK0862656T3 (da) 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
US5849497A (en) 1997-04-03 1998-12-15 The Research Foundation Of State University Of New York Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker
JP3785517B2 (ja) 1997-06-05 2006-06-14 東ソー株式会社 核酸融解温度測定法
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ/エス オリゴヌクレオチド類似体
US6174680B1 (en) 1998-12-30 2001-01-16 Dana-Farber Cancer Institute, Inc. Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US6850846B2 (en) * 2000-01-11 2005-02-01 Affymetrix, Inc. Computer software for genotyping analysis using pattern recognition
US6762049B2 (en) * 2001-07-05 2004-07-13 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
AUPS076902A0 (en) 2002-02-26 2002-03-21 Commonwealth Scientific And Industrial Research Organisation Novel selective polymerase chain reaction
AU2003289651A1 (en) * 2002-12-18 2004-07-09 Dingbang Xu Pcr method and application by transnormal low thermo-denaturation temperature
CN100334223C (zh) * 2002-12-18 2007-08-29 徐定邦 一种超低变性温度的聚合酶链式反应方法及其应用
US7456281B2 (en) * 2005-04-20 2008-11-25 Idaho Technology, Inc. Nucleic acid melting analysis with saturation dyes
US20070000020A1 (en) * 2005-06-30 2007-01-04 Kimberly-Clark Worldwide, Inc. Surgical glove with modified frictional interface and method for producing same
US20070154892A1 (en) * 2005-12-30 2007-07-05 Simon Wain-Hobson Differential amplification of mutant nucleic acids by PCR in a mixure of nucleic acids
EP2171097A2 (en) * 2007-06-29 2010-04-07 Population Genetics Technologies LTD. Methods and compositions for isolating nucleic acid sequence variants
JP5531367B2 (ja) 2007-08-01 2014-06-25 ダナ−ファーバー キャンサー インスチテュート 標的配列の濃縮
US8071338B2 (en) 2007-08-08 2011-12-06 Roche Molecular Systems, Inc. Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity

Similar Documents

Publication Publication Date Title
JP2010535031A5 (https=)
DK2545189T3 (en) COMPLETE COLD-PCR ENRICHMENT WITH REFERENCE BLOCKING SEQUENCE
CN104250663B (zh) 甲基化CpG岛的高通量测序检测方法
JP2018518967A5 (https=)
JP2013521776A5 (https=)
JP2016535987A5 (https=)
US20130309724A1 (en) Step-up method for cold-pcr enrichment
CN103320514B (zh) 一种检测邻近snp的多重pcr方法
JP2011512153A5 (https=)
US20200063125A1 (en) Adaptor for sequencing dna at ultratrace level and use thereof
CN110392739A (zh) 检测dna突变的测序方法
CN106164287A (zh) 高分辨率hla分型
CN103320518B (zh) 突触核蛋白内含子1甲基化水平检测方法
US20210301333A1 (en) Methods and kits for highly multiplex single primer extension
Hu et al. Genetic analysis of 15 mtDNA SNP loci in Chinese Yi ethnic group using SNaPshot minisequencing
CN107338240B (zh) 对样品中目标核酸序列进行偏向扩增的方法和试剂盒
Bérubé et al. Polymorphic microsatellite loci isolated from humpback whale, Megaptera novaeangliae and fin whale, Balaenoptera physalus
Garcia et al. Polymerase chain reaction: A landmark in the history of gene technology
Li et al. Development of eighteen tetranucleotide microsatellite markers in Tibetan Macaque (Macaca thibetana) and genetic diversity analysis of captive population
SenGupta et al. SeqSharp: A general approach for improving cycle-sequencing that facilitates a robust one-step combined amplification and sequencing method
Zhu et al. Genotyping microhaplotype markers through massively parallel sequencing
Chen et al. Development of an extended multilocus sequence typing for genotyping of Brucella isolates
CN105483117A (zh) 一种提高聚合酶链式反应特异性的方法
CN104762406B (zh) 一种两核苷酸不同步合成测序分析pcr产物单体型方法
Millat et al. Development of a high resolution melting method for the detection of genetic variations in Long QT Syndrome