KR101376359B1 - 표적 서열 강화 - Google Patents
표적 서열 강화 Download PDFInfo
- Publication number
- KR101376359B1 KR101376359B1 KR1020107004305A KR20107004305A KR101376359B1 KR 101376359 B1 KR101376359 B1 KR 101376359B1 KR 1020107004305 A KR1020107004305 A KR 1020107004305A KR 20107004305 A KR20107004305 A KR 20107004305A KR 101376359 B1 KR101376359 B1 KR 101376359B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- sequence
- target
- pcr
- reference sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96283807P | 2007-08-01 | 2007-08-01 | |
| US60/962,838 | 2007-08-01 | ||
| PCT/US2008/009248 WO2009017784A2 (en) | 2007-08-01 | 2008-07-31 | Enrichment of a target sequence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100044870A KR20100044870A (ko) | 2010-04-30 |
| KR101376359B1 true KR101376359B1 (ko) | 2014-03-27 |
Family
ID=40305136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107004305A Expired - Fee Related KR101376359B1 (ko) | 2007-08-01 | 2008-07-31 | 표적 서열 강화 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8455190B2 (https=) |
| EP (1) | EP2183379B1 (https=) |
| JP (1) | JP5531367B2 (https=) |
| KR (1) | KR101376359B1 (https=) |
| CN (1) | CN101815789B (https=) |
| AU (1) | AU2008282780B2 (https=) |
| CA (1) | CA2695264C (https=) |
| DK (1) | DK2183379T3 (https=) |
| ES (1) | ES2547053T3 (https=) |
| PT (1) | PT2183379E (https=) |
| WO (1) | WO2009017784A2 (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| EP2140033B1 (en) | 2007-03-28 | 2012-10-10 | Signal Diagnostics | System and method for high resolution analysis of nucleic acids to detect sequence variations |
| EP2183379B1 (en) | 2007-08-01 | 2015-04-15 | Dana Farber Cancer Institute | Enrichment of a target sequence |
| EP3067694A1 (en) | 2008-05-05 | 2016-09-14 | Los Alamos National Security, LLC | Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control |
| US10669574B2 (en) | 2008-11-18 | 2020-06-02 | XCR Diagnostics, Inc. | DNA amplification technology |
| CN102859003B (zh) | 2010-03-08 | 2014-07-30 | 达纳-法伯癌症研究院有限公司 | 使用参考封闭序列的全cold-pcr富集 |
| KR101312241B1 (ko) * | 2010-04-27 | 2013-09-27 | 사회복지법인 삼성생명공익재단 | 증폭억제시발체를 이용하는 유전자 돌연변이 검출 방법 |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| EP2572003A4 (en) | 2010-05-18 | 2016-01-13 | Natera Inc | METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012088456A2 (en) | 2010-12-22 | 2012-06-28 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| AU2012223438A1 (en) * | 2011-02-28 | 2013-09-26 | Transgenomic, Inc | Kit and method for sequencing a target DNA in a mixed population |
| ITTO20110271A1 (it) | 2011-03-28 | 2012-09-29 | Fabio Gentilini | Metodo per l'identificazione di polimorfismi genetici di base singola. |
| EP3333269B1 (en) * | 2011-03-31 | 2021-05-05 | Dana-Farber Cancer Institute, Inc. | Methods to enable multiplex cold-pcr |
| US10519492B2 (en) | 2011-04-20 | 2019-12-31 | Mesa Biotech, Inc. | Integrated device for nucleic acid detection and identification |
| US9796748B2 (en) | 2011-05-02 | 2017-10-24 | President And Fellows Of Harvard College | Spatial sequestration of dynamic nucleic acid circuits |
| EP2758458A4 (en) | 2011-07-10 | 2015-10-21 | Harvard College | COMPOSITIONS AND METHODS FOR SELF-ASSEMBLING POLYMERS WITH COMPLEMENTARY MACROSCOPIC AND MICROSCOPIC SCALE UNITS |
| WO2013010074A1 (en) | 2011-07-13 | 2013-01-17 | Primeradx, Inc. | Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample |
| US9074247B2 (en) * | 2011-10-06 | 2015-07-07 | Drexel University | P53 assay for a urine test for HCC screening |
| CN103998921B (zh) * | 2011-10-14 | 2016-04-20 | 贝克顿·迪金森公司 | 方波热循环 |
| US9133490B2 (en) | 2012-05-16 | 2015-09-15 | Transgenomic, Inc. | Step-up method for COLD-PCR enrichment |
| WO2013188840A1 (en) * | 2012-06-14 | 2013-12-19 | Fred Hutchinson Cancer Research Center | Compositions and methods for sensitive mutation detection in nucleic acid molecules |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US10913977B2 (en) * | 2013-07-24 | 2021-02-09 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to enable enrichment of minor DNA alleles by limiting denaturation time in PCR or simply enable enrichment of minor DNA alleles by limiting the denaturation time in PCR |
| RU2016117929A (ru) | 2013-10-09 | 2017-11-15 | Флюоресентрик, Инк. | Мультиплексные зонды |
| CA2922261A1 (en) * | 2013-10-20 | 2015-05-21 | Trovagene, Inc. | Synthesis and enrichment of nucleic acid sequences |
| CN105283555A (zh) | 2013-10-20 | 2016-01-27 | 特罗瓦基因公司 | 核酸序列的合成和富集 |
| CN103602748A (zh) * | 2013-11-28 | 2014-02-26 | 瑞希基因科技(北京)股份有限公司 | 一种结合荧光定量pcr技术的焦磷酸测序方法 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| CA2954420A1 (en) * | 2014-07-10 | 2016-01-14 | Fluoresentric, Inc. | Dna amplification technology |
| ES2741400T3 (es) | 2014-07-18 | 2020-02-10 | Univ Hong Kong Chinese | Análisis de patrones de metilación de tejidos en mezcla de ADN |
| US20160310948A1 (en) | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic Test Cassette |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| LT3298162T (lt) | 2015-05-18 | 2020-03-10 | Saga Diagnostics Ab | Tikslinės nukleorūgšties ir variantų aptikimas |
| EP4435112A3 (en) * | 2015-05-27 | 2025-02-26 | Quest Diagnostics Investments Incorporated | Compositions and methods for screening solid tumors |
| WO2017070339A1 (en) * | 2015-10-20 | 2017-04-27 | Richardson Katherine | Microfluidic device for enrichment of nucleic acid sequence alterations |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| WO2018099418A1 (en) | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| US11371090B2 (en) | 2016-12-12 | 2022-06-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for molecular barcoding of DNA molecules prior to mutation enrichment and/or mutation detection |
| WO2019023243A1 (en) | 2017-07-24 | 2019-01-31 | Dana-Farber Cancer Institute, Inc. | METHODS AND COMPOSITIONS FOR SELECTING AND AMPLIFYING DNA TARGETS IN A SINGLE REACTION MIXTURE |
| WO2019099420A1 (en) * | 2017-11-15 | 2019-05-23 | Yan Wang | A method for detecting multiple dna mutations and copy number variations |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドTai Diagnostics,Inc. | 移植のための移植片適合性の評価 |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| GB201812192D0 (en) | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| JP6544783B1 (ja) | 2018-07-31 | 2019-07-17 | 学校法人 岩手医科大学 | がんの診断のためのプローブ/プライマーライブラリー |
| IL281741B2 (en) | 2018-09-27 | 2026-04-01 | Grail Inc | Methylation markers and a targeted methylation detection panel |
| EP3980559A1 (en) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| EP4017998B1 (en) | 2019-08-21 | 2024-11-06 | Dana-Farber Cancer Institute, Inc. | Multi-site enrichment of deletions in dna microsatellites |
| US11866793B2 (en) | 2020-03-27 | 2024-01-09 | Regents Of The University Of Minnesota | Assay for detecting palmer amaranth DNA in individual and mixed samples |
| AU2022486981A1 (en) | 2022-11-22 | 2025-06-12 | Quantdetect, Inc. | Probe/primer library for diagnosis of cancer |
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| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
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-
2008
- 2008-07-31 EP EP08794916.0A patent/EP2183379B1/en active Active
- 2008-07-31 ES ES08794916.0T patent/ES2547053T3/es active Active
- 2008-07-31 WO PCT/US2008/009248 patent/WO2009017784A2/en not_active Ceased
- 2008-07-31 AU AU2008282780A patent/AU2008282780B2/en not_active Ceased
- 2008-07-31 DK DK08794916.0T patent/DK2183379T3/en active
- 2008-07-31 US US12/671,295 patent/US8455190B2/en not_active Expired - Fee Related
- 2008-07-31 KR KR1020107004305A patent/KR101376359B1/ko not_active Expired - Fee Related
- 2008-07-31 CA CA2695264A patent/CA2695264C/en not_active Expired - Fee Related
- 2008-07-31 CN CN2008801098230A patent/CN101815789B/zh active Active
- 2008-07-31 PT PT87949160T patent/PT2183379E/pt unknown
- 2008-07-31 JP JP2010519925A patent/JP5531367B2/ja not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Nat. Genet., Vol. 39, pp. 347-351 (2007) * |
| Nat. Med., Vol. 12, pp. 852-855 (2006) * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2183379A4 (en) | 2011-08-10 |
| DK2183379T3 (en) | 2015-07-27 |
| JP2010535031A (ja) | 2010-11-18 |
| CN101815789B (zh) | 2013-06-12 |
| CN101815789A (zh) | 2010-08-25 |
| US20100203532A1 (en) | 2010-08-12 |
| JP5531367B2 (ja) | 2014-06-25 |
| KR20100044870A (ko) | 2010-04-30 |
| WO2009017784A3 (en) | 2009-03-26 |
| AU2008282780B2 (en) | 2014-04-17 |
| ES2547053T3 (es) | 2015-10-01 |
| CA2695264A1 (en) | 2009-02-05 |
| EP2183379A2 (en) | 2010-05-12 |
| AU2008282780A1 (en) | 2009-02-05 |
| PT2183379E (pt) | 2015-09-25 |
| US8455190B2 (en) | 2013-06-04 |
| EP2183379B1 (en) | 2015-04-15 |
| WO2009017784A2 (en) | 2009-02-05 |
| CA2695264C (en) | 2015-01-27 |
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