JP2010532348A5 - - Google Patents
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- Publication number
- JP2010532348A5 JP2010532348A5 JP2010514699A JP2010514699A JP2010532348A5 JP 2010532348 A5 JP2010532348 A5 JP 2010532348A5 JP 2010514699 A JP2010514699 A JP 2010514699A JP 2010514699 A JP2010514699 A JP 2010514699A JP 2010532348 A5 JP2010532348 A5 JP 2010532348A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- subject
- pharmaceutically acceptable
- ketoglutaric acid
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 12
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims 6
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 claims 6
- 230000002496 gastric effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000004204 blood vessel Anatomy 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 238000013110 gastrectomy Methods 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims 1
- 241000352333 Amegilla alpha Species 0.000 claims 1
- 206010007513 Cardiac aneurysm Diseases 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 208000014139 Retinal vascular disease Diseases 0.000 claims 1
- 206010047295 Ventricular hypertrophy Diseases 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- -1 alkaline earth metal salt Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- LADYPAWUSNPKJF-UHFFFAOYSA-L calcium;2-oxopentanedioate Chemical compound [Ca+2].[O-]C(=O)CCC(=O)C([O-])=O LADYPAWUSNPKJF-UHFFFAOYSA-L 0.000 claims 1
- 230000001071 malnutrition Effects 0.000 claims 1
- 235000000824 malnutrition Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000006069 physical mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0701602-5 | 2007-07-02 | ||
| SE0701602 | 2007-07-02 | ||
| PCT/SE2008/050797 WO2009005464A1 (en) | 2007-07-02 | 2008-06-27 | New use of known pharmacologically active chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532348A JP2010532348A (ja) | 2010-10-07 |
| JP2010532348A5 true JP2010532348A5 (enExample) | 2011-04-28 |
| JP5735274B2 JP5735274B2 (ja) | 2015-06-17 |
Family
ID=40226336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514699A Expired - Fee Related JP5735274B2 (ja) | 2007-07-02 | 2008-06-27 | 既知の薬理活性化合物の新たな用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110039935A1 (enExample) |
| EP (1) | EP2173336B1 (enExample) |
| JP (1) | JP5735274B2 (enExample) |
| KR (1) | KR20100039874A (enExample) |
| CN (1) | CN101730532B (enExample) |
| AU (1) | AU2008271307B2 (enExample) |
| BR (1) | BRPI0814184A2 (enExample) |
| CA (1) | CA2691746C (enExample) |
| EA (1) | EA018554B1 (enExample) |
| MX (1) | MX2009013937A (enExample) |
| WO (1) | WO2009005464A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2992382T3 (es) | 2014-02-12 | 2024-12-11 | Univ California | Composiciones y métodos para tratar el envejecimiento y enfermedades y síntomas relacionados con la edad |
| EP3007503B1 (en) | 2014-03-20 | 2021-06-30 | Huawei Device Co., Ltd. | Signal transmission method, user equipment, and base station |
| IL270162B2 (en) * | 2017-04-25 | 2025-07-01 | Buck Inst Res Aging | ?-ketoglutarate (akg) and (i) a vitamin a compound, or (ii) a vitamin d compound, for use in delaying onset or delaying progression of frailty |
| IL281761B2 (en) | 2018-09-25 | 2025-09-01 | Ponce De Leon Health Designated Activity Company | Process for preparing calcium alpha-ketoglutarate |
| EP3980000A4 (en) * | 2019-06-10 | 2023-06-21 | Buck Institute for Research on Aging | METHODS AND COMPOSITIONS FOR ALTERING THE SENSCENCE OF ASSOCIATED SECRETORY PHENOTYPES |
| JP2023533452A (ja) * | 2020-06-23 | 2023-08-03 | ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 動脈瘤を処置するための求電子化合物および求電子プロドラッグ |
| CN117530940A (zh) * | 2023-10-11 | 2024-02-09 | 四川大学华西第二医院 | α-酮戊二酸在制备促髓鞘修复、改善神经炎症的药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9402027D0 (sv) * | 1994-06-10 | 1994-06-10 | Pharmacia Ab | Energy substrates |
| JP2000093096A (ja) * | 1998-09-21 | 2000-04-04 | Snow Brand Milk Prod Co Ltd | ゼリー状食品 |
| DE19929993C2 (de) * | 1999-06-30 | 2001-07-05 | Sueddeutsche Kalkstickstoff | Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| CN1203168C (zh) * | 2001-08-17 | 2005-05-25 | 杨志东 | 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋 |
| US20040220265A1 (en) * | 2002-07-25 | 2004-11-04 | Celluar Sciences, Inc. | Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide |
| US7194301B2 (en) * | 2003-10-06 | 2007-03-20 | Transneuronic, Inc. | Method for screening and treating patients at risk of medical disorders |
| PL368572A1 (en) * | 2004-06-17 | 2005-12-27 | Sgp & Sons Ab | Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections |
| PL370937A1 (pl) * | 2004-10-29 | 2006-05-02 | Sgp & Sons Ab | Preparat żywieniowy i/lub farmaceutyczny do stosowania w profilaktyce i leczeniu niedoborów wchłaniania mikroelementów z przewodu pokarmowego oraz zastosowanie preparatu farmaceutycznego jako czynnika stymulującego wchłanianie mikroelementów z przewodu pokarmowego do krwi |
| WO2007002365A2 (en) * | 2005-06-24 | 2007-01-04 | Albert Einstein College Of Medicine Of Yeshiva University | Modulation of amino acid metabolism in the hypothalamus |
-
2008
- 2008-06-27 EA EA201070084A patent/EA018554B1/ru not_active IP Right Cessation
- 2008-06-27 US US12/667,040 patent/US20110039935A1/en not_active Abandoned
- 2008-06-27 JP JP2010514699A patent/JP5735274B2/ja not_active Expired - Fee Related
- 2008-06-27 BR BRPI0814184-3A2A patent/BRPI0814184A2/pt not_active IP Right Cessation
- 2008-06-27 CN CN2008800234187A patent/CN101730532B/zh not_active Expired - Fee Related
- 2008-06-27 EP EP08767263.0A patent/EP2173336B1/en not_active Not-in-force
- 2008-06-27 MX MX2009013937A patent/MX2009013937A/es active IP Right Grant
- 2008-06-27 AU AU2008271307A patent/AU2008271307B2/en not_active Ceased
- 2008-06-27 WO PCT/SE2008/050797 patent/WO2009005464A1/en not_active Ceased
- 2008-06-27 CA CA2691746A patent/CA2691746C/en not_active Expired - Fee Related
- 2008-06-27 KR KR1020107002345A patent/KR20100039874A/ko not_active Ceased
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