EA018554B1 - Применение альфа-кетоглутаровой кислоты и ее солей для улучшения эластичности кровеносных сосудов - Google Patents

Применение альфа-кетоглутаровой кислоты и ее солей для улучшения эластичности кровеносных сосудов Download PDF

Info

Publication number
EA018554B1
EA018554B1 EA201070084A EA201070084A EA018554B1 EA 018554 B1 EA018554 B1 EA 018554B1 EA 201070084 A EA201070084 A EA 201070084A EA 201070084 A EA201070084 A EA 201070084A EA 018554 B1 EA018554 B1 EA 018554B1
Authority
EA
Eurasian Patent Office
Prior art keywords
alpha
stomach
elasticity
subject
ketoglutaric acid
Prior art date
Application number
EA201070084A
Other languages
English (en)
Russian (ru)
Other versions
EA201070084A1 (ru
Inventor
Стефан Г. Пежиновский
Original Assignee
Энтресс Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Энтресс Аб filed Critical Энтресс Аб
Publication of EA201070084A1 publication Critical patent/EA201070084A1/ru
Publication of EA018554B1 publication Critical patent/EA018554B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
EA201070084A 2007-07-02 2008-06-27 Применение альфа-кетоглутаровой кислоты и ее солей для улучшения эластичности кровеносных сосудов EA018554B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0701602 2007-07-02
PCT/SE2008/050797 WO2009005464A1 (en) 2007-07-02 2008-06-27 New use of known pharmacologically active chemical compounds

Publications (2)

Publication Number Publication Date
EA201070084A1 EA201070084A1 (ru) 2010-10-29
EA018554B1 true EA018554B1 (ru) 2013-08-30

Family

ID=40226336

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070084A EA018554B1 (ru) 2007-07-02 2008-06-27 Применение альфа-кетоглутаровой кислоты и ее солей для улучшения эластичности кровеносных сосудов

Country Status (11)

Country Link
US (1) US20110039935A1 (enExample)
EP (1) EP2173336B1 (enExample)
JP (1) JP5735274B2 (enExample)
KR (1) KR20100039874A (enExample)
CN (1) CN101730532B (enExample)
AU (1) AU2008271307B2 (enExample)
BR (1) BRPI0814184A2 (enExample)
CA (1) CA2691746C (enExample)
EA (1) EA018554B1 (enExample)
MX (1) MX2009013937A (enExample)
WO (1) WO2009005464A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2992382T3 (es) 2014-02-12 2024-12-11 Univ California Composiciones y métodos para tratar el envejecimiento y enfermedades y síntomas relacionados con la edad
EP3007503B1 (en) 2014-03-20 2021-06-30 Huawei Device Co., Ltd. Signal transmission method, user equipment, and base station
IL270162B2 (en) * 2017-04-25 2025-07-01 Buck Inst Res Aging ?-ketoglutarate (akg) and (i) a vitamin a compound, or (ii) a vitamin d compound, for use in delaying onset or delaying progression of frailty
IL281761B2 (en) 2018-09-25 2025-09-01 Ponce De Leon Health Designated Activity Company Process for preparing calcium alpha-ketoglutarate
EP3980000A4 (en) * 2019-06-10 2023-06-21 Buck Institute for Research on Aging METHODS AND COMPOSITIONS FOR ALTERING THE SENSCENCE OF ASSOCIATED SECRETORY PHENOTYPES
JP2023533452A (ja) * 2020-06-23 2023-08-03 ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 動脈瘤を処置するための求電子化合物および求電子プロドラッグ
CN117530940A (zh) * 2023-10-11 2024-02-09 四川大学华西第二医院 α-酮戊二酸在制备促髓鞘修复、改善神经炎症的药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123056A1 (en) * 2004-06-17 2005-12-29 Sgp & Sons Ab Use of alpha-ketoglutarate and related compounds for lowering plasma lipids
WO2006046880A1 (en) * 2004-10-29 2006-05-04 Sgp & Sons Ab Nutritional and/or pharmaceutical preparation for use in prophylaxis and treatment of disturbances in microelements absorption from the alimentary canal

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402027D0 (sv) * 1994-06-10 1994-06-10 Pharmacia Ab Energy substrates
JP2000093096A (ja) * 1998-09-21 2000-04-04 Snow Brand Milk Prod Co Ltd ゼリー状食品
DE19929993C2 (de) * 1999-06-30 2001-07-05 Sueddeutsche Kalkstickstoff Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung
CN1203168C (zh) * 2001-08-17 2005-05-25 杨志东 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋
US20040220265A1 (en) * 2002-07-25 2004-11-04 Celluar Sciences, Inc. Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide
US7194301B2 (en) * 2003-10-06 2007-03-20 Transneuronic, Inc. Method for screening and treating patients at risk of medical disorders
WO2007002365A2 (en) * 2005-06-24 2007-01-04 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123056A1 (en) * 2004-06-17 2005-12-29 Sgp & Sons Ab Use of alpha-ketoglutarate and related compounds for lowering plasma lipids
WO2006046880A1 (en) * 2004-10-29 2006-05-04 Sgp & Sons Ab Nutritional and/or pharmaceutical preparation for use in prophylaxis and treatment of disturbances in microelements absorption from the alimentary canal

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Kjellman U.W., Björk K. et al. Addition of alpha-ketoglutaric acid to blood cardioplegia improves cardioprotection. In: Ann Thorac. Surg., 1997, vol. 63, p. 1625-1634, abstract *
WO -A1-9534301 *

Also Published As

Publication number Publication date
AU2008271307B2 (en) 2013-10-24
CN101730532A (zh) 2010-06-09
CA2691746A1 (en) 2009-01-08
EA201070084A1 (ru) 2010-10-29
JP5735274B2 (ja) 2015-06-17
BRPI0814184A2 (pt) 2015-03-03
WO2009005464A1 (en) 2009-01-08
CA2691746C (en) 2016-02-02
US20110039935A1 (en) 2011-02-17
EP2173336A4 (en) 2010-11-10
KR20100039874A (ko) 2010-04-16
EP2173336B1 (en) 2016-03-30
JP2010532348A (ja) 2010-10-07
HK1140423A1 (en) 2010-10-15
EP2173336A1 (en) 2010-04-14
MX2009013937A (es) 2010-04-30
AU2008271307A1 (en) 2009-01-08
CN101730532B (zh) 2012-05-30

Similar Documents

Publication Publication Date Title
EA018554B1 (ru) Применение альфа-кетоглутаровой кислоты и ее солей для улучшения эластичности кровеносных сосудов
US20130338228A1 (en) Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate
JP5999209B2 (ja) 血行動態改善剤
ES2363368T3 (es) Utilización de vitamina k para revertir la calcificación de los vasos sanguíneos.
US11730713B2 (en) Composition for preventing or improving nociceptive pain
KR101342648B1 (ko) D-알로오스의 고혈압, 심장 비대발증 억제 효과에의 이용
FR3027491A1 (fr) Composition comprenant des proteines vegetales et utilisation pour la prevention des pathologies metaboliques et cardiovasculaires associees au risque cardiometabolique en particulier avec hyperglycemie
JP7558193B2 (ja) 食品用ブチレート
JP2010059084A (ja) 機能性食品及び医薬
WO2016132483A1 (ja) ヒトキマーゼ阻害剤及びヒトキマーゼの活性が関与する疾患の予防治療用薬剤
KR20150056190A (ko) 비쑥을 포함하는 혈압 상승 억제조성물
JP2002145767A (ja) 循環器疾患治療剤および健康食品
HK1140423B (en) Use of known pharmacologically active chemical compounds
JP2022533315A (ja) 食品用ブチレート
JP2005314435A (ja) 循環器疾患治療剤および健康食品
JP2024026781A (ja) 内臓脂肪蓄積減少剤
JP6764856B2 (ja) 胃容量の減少剤
Sakai et al. Fructooligosaccharide Consumption Improves the Decreased Cortical Bone Following Gastrectomy in Rats

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU