CN101730532B - 已知药理学活性化合物的用途 - Google Patents

已知药理学活性化合物的用途 Download PDF

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Publication number
CN101730532B
CN101730532B CN2008800234187A CN200880023418A CN101730532B CN 101730532 B CN101730532 B CN 101730532B CN 2008800234187 A CN2008800234187 A CN 2008800234187A CN 200880023418 A CN200880023418 A CN 200880023418A CN 101730532 B CN101730532 B CN 101730532B
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CN
China
Prior art keywords
akg
purposes
elasticity
ketoglutarate
hypertension
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Expired - Fee Related
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CN2008800234187A
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Chinese (zh)
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CN101730532A (zh
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斯特凡·G·彼任诺夫斯基
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ENTRESS AB
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ENTRESS AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN2008800234187A 2007-07-02 2008-06-27 已知药理学活性化合物的用途 Expired - Fee Related CN101730532B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0701602-5 2007-07-02
SE0701602 2007-07-02
PCT/SE2008/050797 WO2009005464A1 (en) 2007-07-02 2008-06-27 New use of known pharmacologically active chemical compounds

Publications (2)

Publication Number Publication Date
CN101730532A CN101730532A (zh) 2010-06-09
CN101730532B true CN101730532B (zh) 2012-05-30

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CN2008800234187A Expired - Fee Related CN101730532B (zh) 2007-07-02 2008-06-27 已知药理学活性化合物的用途

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US (1) US20110039935A1 (enExample)
EP (1) EP2173336B1 (enExample)
JP (1) JP5735274B2 (enExample)
KR (1) KR20100039874A (enExample)
CN (1) CN101730532B (enExample)
AU (1) AU2008271307B2 (enExample)
BR (1) BRPI0814184A2 (enExample)
CA (1) CA2691746C (enExample)
EA (1) EA018554B1 (enExample)
MX (1) MX2009013937A (enExample)
WO (1) WO2009005464A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2992382T3 (es) 2014-02-12 2024-12-11 Univ California Composiciones y métodos para tratar el envejecimiento y enfermedades y síntomas relacionados con la edad
EP3007503B1 (en) 2014-03-20 2021-06-30 Huawei Device Co., Ltd. Signal transmission method, user equipment, and base station
IL270162B2 (en) * 2017-04-25 2025-07-01 Buck Inst Res Aging ?-ketoglutarate (akg) and (i) a vitamin a compound, or (ii) a vitamin d compound, for use in delaying onset or delaying progression of frailty
IL281761B2 (en) 2018-09-25 2025-09-01 Ponce De Leon Health Designated Activity Company Process for preparing calcium alpha-ketoglutarate
EP3980000A4 (en) * 2019-06-10 2023-06-21 Buck Institute for Research on Aging METHODS AND COMPOSITIONS FOR ALTERING THE SENSCENCE OF ASSOCIATED SECRETORY PHENOTYPES
JP2023533452A (ja) * 2020-06-23 2023-08-03 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 動脈瘤を処置するための求電子化合物および求電子プロドラッグ
CN117530940A (zh) * 2023-10-11 2024-02-09 四川大学华西第二医院 α-酮戊二酸在制备促髓鞘修复、改善神经炎症的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401758A (zh) * 2001-08-17 2003-03-12 杨志东 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402027D0 (sv) * 1994-06-10 1994-06-10 Pharmacia Ab Energy substrates
JP2000093096A (ja) * 1998-09-21 2000-04-04 Snow Brand Milk Prod Co Ltd ゼリー状食品
DE19929993C2 (de) * 1999-06-30 2001-07-05 Sueddeutsche Kalkstickstoff Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung
US20040220265A1 (en) * 2002-07-25 2004-11-04 Celluar Sciences, Inc. Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide
US7194301B2 (en) * 2003-10-06 2007-03-20 Transneuronic, Inc. Method for screening and treating patients at risk of medical disorders
PL368572A1 (en) * 2004-06-17 2005-12-27 Sgp & Sons Ab Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections
PL370937A1 (pl) * 2004-10-29 2006-05-02 Sgp & Sons Ab Preparat żywieniowy i/lub farmaceutyczny do stosowania w profilaktyce i leczeniu niedoborów wchłaniania mikroelementów z przewodu pokarmowego oraz zastosowanie preparatu farmaceutycznego jako czynnika stymulującego wchłanianie mikroelementów z przewodu pokarmowego do krwi
WO2007002365A2 (en) * 2005-06-24 2007-01-04 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401758A (zh) * 2001-08-17 2003-03-12 杨志东 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨文.2420例体检者的脉压空腹血糖甘油三酯的分析.《心肺血管病杂志》.2005,第24卷(第4期),223-224. *

Also Published As

Publication number Publication date
AU2008271307B2 (en) 2013-10-24
CN101730532A (zh) 2010-06-09
CA2691746A1 (en) 2009-01-08
EA201070084A1 (ru) 2010-10-29
JP5735274B2 (ja) 2015-06-17
BRPI0814184A2 (pt) 2015-03-03
WO2009005464A1 (en) 2009-01-08
CA2691746C (en) 2016-02-02
US20110039935A1 (en) 2011-02-17
EP2173336A4 (en) 2010-11-10
KR20100039874A (ko) 2010-04-16
EP2173336B1 (en) 2016-03-30
JP2010532348A (ja) 2010-10-07
HK1140423A1 (en) 2010-10-15
EP2173336A1 (en) 2010-04-14
MX2009013937A (es) 2010-04-30
EA018554B1 (ru) 2013-08-30
AU2008271307A1 (en) 2009-01-08

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