CN110996933A - 用于帕金森病的预防性和/或支持性治疗处理的药剂 - Google Patents
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Abstract
本发明涉及用于帕金森病的预防性和/或支持治疗处理的药剂,所述药剂包含生理有效量的丙酸和/或丁酸和/或其生理上相容的盐或酯。
Description
本发明涉及用于帕金森病的预防性和/或支持性治疗处理的药剂。
许多疾病与肠道定殖不足有关,也就是说,无论是由于定殖不足或由于维持身体机能的必需成分的丧失,肠道的微生物组失衡。对于诸如肥胖症、溃疡性结肠炎、多发性硬化(MS)、帕金森病、可能还有精神病、以及风湿性疾病形式和牛皮癣等所有这些疾病,都可以检测到肠道微生物组的显著变化。这表明由于共同原因或由于交互作用的影响因素,微生物组和各自的疾病是相互关联的。
进一步发现,肠道微生物组可受到所消耗的营养类型的影响,并且能够适应给定食品种类要满足的要求。这意味着,可以通过采取旨在改善患者免疫状况的适当饮食措施来改变不利于患者免疫状况的不利肠微生物群。
本发明基于以下发现:与健康对照个体相比,在帕金森病中微生物组发生了特征性变化。特别是,微生物组中几乎不存在或根本不存在产生短链脂肪酸的细菌。因此,在健康对照者的肠道中作为降解产物存在的短链脂肪酸缺乏。Braak推测帕金森病始于肠道。这与微生物组从患有帕金森病的小鼠向健康小鼠的转移产生可比较的帕金森病图像这一观察结果一致。
帕金森病患者缺乏产生短链脂肪酸的微生物,导致缺乏特别是乙酸、丙酸和丁酸。虽然食物会大量供应乙酸,但通常不会弥补丙酸和丁酸的不足。
α-突触核蛋白是存在于大脑中并在帕金森病中发挥作用的转运蛋白,其可以在疾病非常早期在肠道内检测到,并可以作为疾病的指示剂。这也表明疾病与肠道中发生的事情之间存在联系。
已经进行了通过采取医学或饮食措施来补偿肠道定殖不足的实验,但这仅在有限的程度上取得了成功。
已经令人惊讶地发现,丙酸和丁酸对帕金森病的发展和进程具有积极作用。这也适用于其生理上可耐受的盐和酯。还观察到这些物质的靶向给药改善了帕金森病的药物治疗,即具有增强效果。特别是,可以显著降低通常用于治疗帕金森病的多巴胺能药物的剂量。
因此,本发明涉及用于帕金森病的预防性和/或支持性治疗处理的药剂,所述药剂包含生理有效量的丙酸和/或丁酸和/或其生理上可接受的盐或酯。
本发明提出的药剂可以出于预防性和治疗性目的而向易患帕金森病的人或向帕金森病患者给药。但是,该药剂特别适合于另外接受常规药物治疗的帕金森病患者的支持性治疗处理。
本发明的药剂可以单独含有丙酸或丁酸,或含有其组合。但是,以生理上可接受的盐的形式给药是优选的,其中生理上重要的金属盐是最重要的。除了碱金属盐和碱土金属盐以外,这些盐还可以包括锌盐和铁盐。
特别优选的是丙酸和丁酸的钠盐、钾盐、镁盐和钙盐。
另外,丙酸和丁酸也可以以酯的形式给药。C1至C6醇的酯,特别是甲酯和乙酯特别合适。酯在体内水解成游离酸。
本发明的药剂可以以常规形式给药,例如片剂、糖衣丸(dragées)、丸剂、胶囊、锭剂、粉剂和颗粒剂。以果汁、滴剂和茶形式的液体形式给药也是可行的。在任何情况下,该药剂旨在口服给药。
优选的药剂递送形式是片剂、胶囊和粉剂。含有单位剂量的本发明药剂的片剂和胶囊优选每天给药两次。例如可以将粉剂搅拌成饮料/饮品,或添加到食物中。
前述药剂递送形式的单位剂量为0.2-5g,特别是0.3-3g。片剂、胶囊和粉剂的特别优选量是0.5-2.0g,旨在各自用于早晨和晚上给药,并且若合适,另外在中午给药,特别是与膳食一起。
特别优选的是丙酸和丁酸或其盐和酯以单剂联合给药,但也可以以分开的形式联合给药。例如,对于上述总剂量,在这种情况下的重量比可以为3:1至1:3,特别是3:2至2:3。
如已经提到的,本发明提出的药剂可以用于帕金森病患者的支持性治疗处理。在这种情况下,除常规药物治疗外,还与例如左旋多巴和其他常用的多巴胺能药物一起给药。本发明药剂的剂量如上所述。
在患者研究中,对丁酸/丁酸盐的作用进行了研究,其中超过1,000名测试患者各自至少参与了一年。与早上、中午和晚上的膳食一起,每日三个剂量,施用总计6g丁酸或丁酸盐(作为盐)和医师指导的药物(左旋多巴等)。确定了全身状况的显著改善,尤其是在运动机能方面。
令人惊讶地发现,用丁酸/丁酸盐治疗的帕金森病患者使用的多巴胺量减少了至少50%,在某些情况下减少高达90%。这一点尤其重要,因为帕金森病患者的常用药物不仅仅与左旋多巴一起使用可导致相当大的副作用,例如头晕、恶心、心律加快、精神病、运动障碍和循环问题。
最后,本发明涉及单独含有丙酸和/或丁酸、其生理上可接受的盐或酯的饮食补充剂,或含有其混合物的饮食补充剂。为此,优选的是丁酸或丁酸盐,当认为合适时与丙酸或丙酸盐一起,特别是采用胶囊或片剂的形式。
胶囊或片剂形式的饮食补充剂优选含有各自盐形式的丙酸和丁酸。在这种情况下的重量比特别是3:1至1:3,总量为0.5-2.0g。
Claims (13)
1.用于帕金森病的预防性和/或支持性治疗处理的药剂,所述药剂包含生理有效量的丙酸和/或丁酸和/或其生理上可接受的盐或酯。
2.根据权利要求1所述的药剂,其特征在于所述丙酸和/或丁酸的盐是碱金属盐或碱土金属盐。
3.根据权利要求2所述的药剂,其特征在于所述盐是钠盐、钾盐、镁盐或钙盐。
4.根据前述权利要求中任一项所述的药剂,其特征在于所述酯是甲酯或乙酯。
5.根据前述权利要求中任一项所述的药剂,其为片剂、胶囊或粉剂形式。
6.根据前述权利要求中任一项所述的药剂,其特征在于所述药剂以0.2-5g的单个剂量组成。
7.根据权利要求6所述的药剂,其特征在于单个剂量含有0.5-2.0g的活性物质,并且在适当时,还含有常规制剂和辅助物质。
8.根据前述权利要求中任一项所述的药剂,其含有丙酸和丁酸或其盐或酯的组合。
9.根据权利要求8所述的药剂,其含有重量比为25/75至75/25的丙酸和丁酸或其盐或酯。
10.丙酸和丁酸或其盐和酯在制备用于帕金森病的预防和/或支持性处理的药剂中的用途。
11.饮食补充剂,含有丙酸和丁酸和/或其生理上可接受的盐或酯。
12.根据权利要求11所述的饮食补充剂,其特征在于所述补充剂含有生理相容性盐形式的丙酸和丁酸,特别是其钠盐和/或钙盐。
13.根据权利要求11或12所述的饮食补充剂,其为胶囊形式。
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DE102017115819.7A DE102017115819A1 (de) | 2017-07-13 | 2017-07-13 | Mittel zur prophylaktischen und/oder unterstützenden therapeutischen Behandlung von Morbus Parkinson |
DE102017115819.7 | 2017-07-13 | ||
PCT/EP2018/069089 WO2019012108A1 (de) | 2017-07-13 | 2018-07-13 | Propion- und/oder buttersäure zur verwendung zur prophylaktischen und/oder unterstützenden therapeutischen behandlung von morbus parkinson |
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EP (1) | EP3651754A1 (zh) |
JP (1) | JP7206223B2 (zh) |
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CN (1) | CN110996933A (zh) |
AU (2) | AU2018298862A1 (zh) |
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CN113332266A (zh) * | 2021-06-10 | 2021-09-03 | 徐州医科大学 | 含丁酸的治疗与预防神经退行性疾病的药物及丁酸的应用 |
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JP7234710B2 (ja) | 2019-03-14 | 2023-03-08 | ブラザー工業株式会社 | プリンタ |
WO2021048440A1 (en) | 2019-09-13 | 2021-03-18 | Basf Se | Composition for the treatment of neurodegenerative diseases |
CN111450238A (zh) * | 2020-03-31 | 2020-07-28 | 上海交通大学医学院附属瑞金医院 | 骨钙素或丙酸在制备抗帕金森病药物中的应用 |
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- 2018-07-13 KR KR1020207003431A patent/KR20200027976A/ko not_active Application Discontinuation
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AU2021273627A1 (en) | 2021-12-16 |
AU2018298862A1 (en) | 2020-01-23 |
AU2021273627B2 (en) | 2024-01-25 |
WO2019012108A1 (de) | 2019-01-17 |
JP7206223B2 (ja) | 2023-01-17 |
DE102017115819A1 (de) | 2019-01-17 |
EP3651754A1 (de) | 2020-05-20 |
CA3067728A1 (en) | 2019-01-17 |
US20200163914A1 (en) | 2020-05-28 |
KR20200027976A (ko) | 2020-03-13 |
US20220313634A1 (en) | 2022-10-06 |
JP2020526485A (ja) | 2020-08-31 |
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