JP2010531352A - 新規トロンビン機能性化合物およびそれらに基づいた医薬組成物 - Google Patents

新規トロンビン機能性化合物およびそれらに基づいた医薬組成物 Download PDF

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JP2010531352A
JP2010531352A JP2010514671A JP2010514671A JP2010531352A JP 2010531352 A JP2010531352 A JP 2010531352A JP 2010514671 A JP2010514671 A JP 2010514671A JP 2010514671 A JP2010514671 A JP 2010514671A JP 2010531352 A JP2010531352 A JP 2010531352A
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thrombin
group
hydrogen
alkyl group
compounds
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JP2010531352A5 (enExample
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イヴァノフナ シナウリゼ、エレナ
イノヤートヴィッチ アタウラークハノフ、ファゾイル
アレクサンドロヴィッチ ブチリン、アンドレイ
ボリソヴィッチ スリモフ、ウラジミール
ニコライヴィッチ ロマノフ、アレクセイ
アレクセーヴィッチ ボゴリューボフ、アレクセイ
ウラジーミロヴィッチ クズネツォフ、ユーリー
ウラジーミロフナ グリブコヴァ、イリーナ
セーギーヴィッチ ゴーバテンコ、アレクサンダー
アナトリーフナ コンダコヴァ、オルガ
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オブシェストヴォ エス オグラニチェノイ オトヴェトストヴェノスチュ “ビオニカ”
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Publication of JP2010531352A publication Critical patent/JP2010531352A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010514671A 2007-06-28 2008-06-27 新規トロンビン機能性化合物およびそれらに基づいた医薬組成物 Pending JP2010531352A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2007124201/04A RU2354647C2 (ru) 2007-06-28 2007-06-28 Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
PCT/RU2008/000400 WO2009002228A2 (en) 2007-06-28 2008-06-27 New thrombin function compounds and pharmaceutical compositions based on them

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JP2010531352A true JP2010531352A (ja) 2010-09-24
JP2010531352A5 JP2010531352A5 (enExample) 2012-08-23

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US (1) US20100324058A1 (enExample)
EP (1) EP2178838A2 (enExample)
JP (1) JP2010531352A (enExample)
KR (1) KR20100039867A (enExample)
CN (1) CN101861304A (enExample)
AU (1) AU2008269712B2 (enExample)
CA (1) CA2693226A1 (enExample)
EA (1) EA201000063A1 (enExample)
RU (1) RU2354647C2 (enExample)
UA (1) UA98970C2 (enExample)
WO (1) WO2009002228A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010531353A (ja) * 2007-06-28 2010-09-24 オブシェストヴォ エス オグラニチェノイ オトヴェトストヴェノスチュ “ビオニカ” 新規抗凝血組成物、それらを基にした血栓症疾患治療のための医薬組成品、および血液希釈による凝固亢進障害改善のための血漿代用液

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
WO2013048787A1 (en) 2011-09-26 2013-04-04 Yes, Inc. Novel hemostatic compositions and dressings for bleeding
WO2013056116A1 (en) * 2011-10-12 2013-04-18 The Trustees Of Columbia University In The City Of New York Hemostatic dressing for arterial bleeding
FR3030516B1 (fr) * 2014-12-19 2019-12-27 Galderma Research & Development Derives sulfonamides bicycles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t)
RU2685261C1 (ru) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза

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JPH10504833A (ja) * 1994-08-30 1998-05-12 ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の４−アミノピリダジン、その製造のための方法、及びこれらの化合物を含む薬剤
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JP2000507588A (ja) * 1996-03-29 2000-06-20 ３―ディメンショナル ファーマシュウティカルズ，インコーポレイテッド プロテアーゼインヒビターとしてのアミジノヒドラゾン
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WO2005094828A1 (en) * 2004-03-02 2005-10-13 F. Hoffmann-La Roche Ag 4- (sulfanyl-pyrimidin-4-ylmethyl) -morpholine derivatives and related compounds as gaba receptor ligands for the treatment of anxiety, depression and epilepsy
JP2009538931A (ja) * 2006-05-31 2009-11-12 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしてのチアゾール化合物およびそれの使用
JP2010531353A (ja) * 2007-06-28 2010-09-24 オブシェストヴォ エス オグラニチェノイ オトヴェトストヴェノスチュ “ビオニカ” 新規抗凝血組成物、それらを基にした血栓症疾患治療のための医薬組成品、および血液希釈による凝固亢進障害改善のための血漿代用液

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US3407229A (en) * 1964-09-09 1968-10-22 Baxter Laboratories Inc Phenylcarbamoylethylthiopseudoureas
US5089634A (en) * 1984-08-20 1992-02-18 Georgia Tech Research Corporation Isocoumarins with cationic substituents
JPH0341065A (ja) * 1989-07-06 1991-02-21 Morishita Pharmaceut Co Ltd アリールオキシアルキルイソチオウレア臭化水素酸塩類
JPH05134337A (ja) * 1991-11-08 1993-05-28 Konica Corp ハロゲン化銀写真感光材料
JPH08507503A (ja) * 1993-03-03 1996-08-13 ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規４−アミノピリジン、それらの製造方法およびそれらを含有する薬剤
JPH08509723A (ja) * 1993-04-27 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミジノおよびグアニジノ置換ボロン酸トリプシン様酵素阻害剤
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US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
US20050159457A1 (en) * 2000-10-06 2005-07-21 Wenxi Pan Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors
JP2005126428A (ja) * 2003-09-30 2005-05-19 Takeda Chem Ind Ltd チアゾリン誘導体およびその用途
WO2005094828A1 (en) * 2004-03-02 2005-10-13 F. Hoffmann-La Roche Ag 4- (sulfanyl-pyrimidin-4-ylmethyl) -morpholine derivatives and related compounds as gaba receptor ligands for the treatment of anxiety, depression and epilepsy
JP2009538931A (ja) * 2006-05-31 2009-11-12 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしてのチアゾール化合物およびそれの使用
JP2010531353A (ja) * 2007-06-28 2010-09-24 オブシェストヴォ エス オグラニチェノイ オトヴェトストヴェノスチュ “ビオニカ” 新規抗凝血組成物、それらを基にした血栓症疾患治療のための医薬組成品、および血液希釈による凝固亢進障害改善のための血漿代用液

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010531353A (ja) * 2007-06-28 2010-09-24 オブシェストヴォ エス オグラニチェノイ オトヴェトストヴェノスチュ “ビオニカ” 新規抗凝血組成物、それらを基にした血栓症疾患治療のための医薬組成品、および血液希釈による凝固亢進障害改善のための血漿代用液

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WO2009002228A3 (en) 2009-03-12
RU2354647C2 (ru) 2009-05-10
RU2007124201A (ru) 2009-01-10
US20100324058A1 (en) 2010-12-23
CN101861304A (zh) 2010-10-13
WO2009002228A2 (en) 2008-12-31
EA201000063A1 (ru) 2010-06-30
AU2008269712B2 (en) 2013-01-17
UA98970C2 (ru) 2012-07-10
AU2008269712A8 (en) 2010-04-15
KR20100039867A (ko) 2010-04-16
EP2178838A2 (en) 2010-04-28
AU2008269712A1 (en) 2008-12-31
CA2693226A1 (en) 2008-12-31

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