JP2010530245A5 - - Google Patents
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- JP2010530245A5 JP2010530245A5 JP2010513254A JP2010513254A JP2010530245A5 JP 2010530245 A5 JP2010530245 A5 JP 2010530245A5 JP 2010513254 A JP2010513254 A JP 2010513254A JP 2010513254 A JP2010513254 A JP 2010513254A JP 2010530245 A5 JP2010530245 A5 JP 2010530245A5
- Authority
- JP
- Japan
- Prior art keywords
- alphavirus
- rna molecule
- rna
- protein
- recognition sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000710929 Alphavirus Species 0.000 claims description 90
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 80
- 101710172711 Structural protein Proteins 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 26
- 230000010076 replication Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
- 239000002773 nucleotide Substances 0.000 claims description 14
- 125000003729 nucleotide group Chemical group 0.000 claims description 14
- 108090000565 Capsid Proteins Proteins 0.000 claims description 6
- 102100023321 Ceruloplasmin Human genes 0.000 claims description 6
- 101710125507 Integrase/recombinase Proteins 0.000 claims description 6
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims description 6
- 108091081024 Start codon Proteins 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 230000003362 replicative effect Effects 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 3
- 101800000120 Host translation inhibitor nsp1 Proteins 0.000 claims description 2
- 108020005350 Initiator Codon Proteins 0.000 claims description 2
- 101710128560 Initiator protein NS1 Proteins 0.000 claims description 2
- 101710144127 Non-structural protein 1 Proteins 0.000 claims description 2
- 101800000512 Non-structural protein 1 Proteins 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 210000002845 virion Anatomy 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93663707P | 2007-06-21 | 2007-06-21 | |
| US60/936,637 | 2007-06-21 | ||
| PCT/US2008/007701 WO2008156829A2 (en) | 2007-06-21 | 2008-06-20 | Promoterless cassettes for expression of alphavirus structural proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167257A Division JP5995926B2 (ja) | 2007-06-21 | 2014-08-20 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530245A JP2010530245A (ja) | 2010-09-09 |
| JP2010530245A5 true JP2010530245A5 (OSRAM) | 2012-06-21 |
| JP5602624B2 JP5602624B2 (ja) | 2014-10-08 |
Family
ID=40156867
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513254A Active JP5602624B2 (ja) | 2007-06-21 | 2008-06-20 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
| JP2014167257A Active JP5995926B2 (ja) | 2007-06-21 | 2014-08-20 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
| JP2016162382A Withdrawn JP2016198114A (ja) | 2007-06-21 | 2016-08-23 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167257A Active JP5995926B2 (ja) | 2007-06-21 | 2014-08-20 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
| JP2016162382A Withdrawn JP2016198114A (ja) | 2007-06-21 | 2016-08-23 | αウイルス構造タンパク質の発現のためのプロモーターレスカセット |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8460913B2 (OSRAM) |
| EP (2) | EP2947149B1 (OSRAM) |
| JP (3) | JP5602624B2 (OSRAM) |
| CN (1) | CN101802199B (OSRAM) |
| AU (1) | AU2008266807B2 (OSRAM) |
| CA (1) | CA2689588C (OSRAM) |
| DK (2) | DK2183368T3 (OSRAM) |
| ES (2) | ES2670813T3 (OSRAM) |
| IL (1) | IL202720A (OSRAM) |
| NZ (1) | NZ582495A (OSRAM) |
| PL (2) | PL2183368T3 (OSRAM) |
| WO (1) | WO2008156829A2 (OSRAM) |
| ZA (1) | ZA200909080B (OSRAM) |
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| WO2004055166A2 (en) * | 2002-12-13 | 2004-07-01 | Alphavax, Inc. | Multi-antigenic alphavirus replicon particles and methods |
| EP3246399B1 (en) | 2002-12-13 | 2021-07-07 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
| EP1608762B1 (en) | 2003-03-20 | 2014-01-08 | Alphavax, Inc. | Improved alphavirus replicons and helper constructs |
| US20060099587A1 (en) * | 2003-06-20 | 2006-05-11 | Johnston Robert E | Alphavirus vectors having attentuated virion structural proteins |
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| EP1687033A4 (en) * | 2003-11-12 | 2008-06-11 | Us Navy | IMPROVEMENT OF VACCINE-INDUCED IMMUNE REACTIONS AND PROTECTION THROUGH HETEROLOGY REINFORCEMENT WITH ALPHAVIRUS REPLICON VACCINE |
| US7078087B2 (en) * | 2003-12-31 | 2006-07-18 | Kimberly-Clark Worldwide, Inc. | Wipes with an edge treatment along a leading edge portion |
| ATE420965T1 (de) | 2004-05-18 | 2009-01-15 | Alphavax Inc | Von tc-83 abgeleitete alphavirus-vektoren, partikel und verfahren |
| US7862829B2 (en) | 2004-07-09 | 2011-01-04 | University Of North Carolina At Chapel Hill | Viral adjuvants |
| CA2597921A1 (en) * | 2005-02-15 | 2007-04-26 | University Of North Carolina At Chapel Hill | New live virus vaccines |
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| NZ587502A (en) * | 2008-01-24 | 2012-12-21 | Univ Texas | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
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