JP2010527356A - 好酸球レベルを低下させる方法 - Google Patents

好酸球レベルを低下させる方法 Download PDF

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JP2010527356A
JP2010527356A JP2010508412A JP2010508412A JP2010527356A JP 2010527356 A JP2010527356 A JP 2010527356A JP 2010508412 A JP2010508412 A JP 2010508412A JP 2010508412 A JP2010508412 A JP 2010508412A JP 2010527356 A JP2010527356 A JP 2010527356A
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eosinophils
administration
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antibody
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JP2010527356A5 (enExample
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正道 小池
スピッタルニー，ジョージ，エル．
ウィーラー，アリステア
ホワイト，バーバラ
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メディミューン，エルエルシー
バイオワ，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2010508412A 2007-05-14 2008-05-14 好酸球レベルを低下させる方法 Pending JP2010527356A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92442207P 2007-05-14 2007-05-14
US92483207P 2007-06-01 2007-06-01
US93500507P 2007-07-20 2007-07-20
US6461208P 2008-03-14 2008-03-14
PCT/US2008/006156 WO2008143878A1 (en) 2007-05-14 2008-05-14 Methods of reducing eosinophil levels

Related Child Applications (1)

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JP2015151502A Division JP2016034940A (ja) 2007-05-14 2015-07-31 好酸球レベルを低下させる方法

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JP2010527356A5 JP2010527356A5 (enExample) 2011-04-28

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JP2010508412A Pending JP2010527356A (ja) 2007-05-14 2008-05-14 好酸球レベルを低下させる方法
JP2015151502A Pending JP2016034940A (ja) 2007-05-14 2015-07-31 好酸球レベルを低下させる方法
JP2017135920A Pending JP2018021017A (ja) 2007-05-14 2017-07-12 好酸球レベルを低下させる方法
JP2019129029A Pending JP2019194242A (ja) 2007-05-14 2019-07-11 好酸球レベルを低下させる方法
JP2021172302A Pending JP2022023157A (ja) 2007-05-14 2021-10-21 好酸球レベルを低下させる方法
JP2023136193A Pending JP2023159349A (ja) 2007-05-14 2023-08-24 好酸球レベルを低下させる方法
JP2025036248A Pending JP2025087854A (ja) 2007-05-14 2025-03-07 好酸球レベルを低下させる方法

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JP2015151502A Pending JP2016034940A (ja) 2007-05-14 2015-07-31 好酸球レベルを低下させる方法
JP2017135920A Pending JP2018021017A (ja) 2007-05-14 2017-07-12 好酸球レベルを低下させる方法
JP2019129029A Pending JP2019194242A (ja) 2007-05-14 2019-07-11 好酸球レベルを低下させる方法
JP2021172302A Pending JP2022023157A (ja) 2007-05-14 2021-10-21 好酸球レベルを低下させる方法
JP2023136193A Pending JP2023159349A (ja) 2007-05-14 2023-08-24 好酸球レベルを低下させる方法
JP2025036248A Pending JP2025087854A (ja) 2007-05-14 2025-03-07 好酸球レベルを低下させる方法

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US (3) US20100291073A1 (enExample)
EP (2) EP3072525B1 (enExample)
JP (7) JP2010527356A (enExample)
KR (3) KR101827179B1 (enExample)
CN (2) CN101848732B (enExample)
AU (3) AU2008255027B2 (enExample)
BR (1) BRPI0811526A2 (enExample)
CA (2) CA2685222C (enExample)
CY (2) CY1117594T1 (enExample)
DK (2) DK2068927T3 (enExample)
ES (2) ES2666165T3 (enExample)
HR (2) HRP20160058T1 (enExample)
HU (2) HUE036885T2 (enExample)
IL (2) IL202102A (enExample)
LT (1) LT3072525T (enExample)
MX (3) MX376656B (enExample)
NO (1) NO3072525T3 (enExample)
NZ (2) NZ599278A (enExample)
PL (2) PL3072525T3 (enExample)
PT (2) PT3072525T (enExample)
RU (2) RU2519227C2 (enExample)
SG (2) SG10201503254TA (enExample)
SI (2) SI3072525T1 (enExample)
WO (1) WO2008143878A1 (enExample)

Cited By (5)

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JP2016527325A (ja) * 2013-08-12 2016-09-08 メディミューン，エルエルシー ベンラリツマブを使用して喘息患者の努力肺活量を増大させる方法
JP2016527324A (ja) * 2013-08-12 2016-09-08 メディミューン，エルエルシー ベンラリツマブを使用して喘息の増悪率を低減する方法
JP2016527326A (ja) * 2013-08-12 2016-09-08 メディミューン，エルエルシー ベンラリツマブによる喘息症状の改善方法
JP2016534996A (ja) * 2013-10-15 2016-11-10 メディミューン，エルエルシー ベンラリズマブを使用して慢性閉塞性肺疾患を治療するための方法
JP2021501568A (ja) * 2017-10-03 2021-01-21 ジョイント・ストック・カンパニー “バイオキャド” 抗ＩＬ−５Ｒαモノクローナル抗体

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MX376656B (es) * 2007-05-14 2025-03-07 Kyowa Kirin Co Ltd Metodos para reducir niveles de basófilos.
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US20140328839A1 (en) * 2011-11-01 2014-11-06 Medlmmune, Llc Methods For Reducing The Frequency And Severity Of Acute Exacerbations Of Asthma
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CA2926089C (en) 2013-10-24 2022-08-30 Medimmune, Llc Stable, aqueous antibody formulations
RU2552929C1 (ru) 2013-11-14 2015-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний
CN113975386A (zh) * 2014-05-23 2022-01-28 塞尔德克斯医疗公司 嗜酸性粒细胞或肥大细胞相关病症的治疗
AU2016272399B2 (en) * 2015-06-01 2021-09-09 Kyowa Kirin Co., Ltd. Therapeutic agent and therapeutic method for pulmonary hypertension
EP3371225A2 (en) 2015-11-04 2018-09-12 AstraZeneca AB Dipeptidyl peptidase-4 and periostin as predictors of clinical response to eosinophil-targeted therapeutic agents in eosinophilic diseases
CN109942706A (zh) * 2017-12-21 2019-06-28 三生国健药业（上海）股份有限公司 结合人il-5的单克隆抗体、其制备方法和用途
KR20240132386A (ko) * 2017-12-29 2024-09-03 코넬 유니버시티 호산구성 장애에 대한 유전자 요법
EP3841201A1 (en) 2018-08-24 2021-06-30 Yeda Research and Development Co. Ltd Methods of modulating m2 macrophage polarization and use of same in therapy
TW202110479A (zh) 2019-05-16 2021-03-16 瑞典商阿斯特捷利康公司 使用貝那利珠單抗治療增強型患者群體慢性阻塞性肺病之方法
TW202126688A (zh) 2019-09-27 2021-07-16 瑞典商阿斯特捷利康公司 使用貝那利珠單抗治療遲發性氣喘之方法
TW202214692A (zh) 2020-06-05 2022-04-16 瑞典商阿斯特捷利康公司 治療患有鼻瘜肉的患者的重度氣喘之方法
CN113769081A (zh) * 2020-06-10 2021-12-10 三生国健药业（上海）股份有限公司 一种稳定的高浓度抗人il-5单克隆抗体液体制剂
KR102697770B1 (ko) * 2020-09-14 2024-08-23 아주대학교산학협력단 인간 IL-5Rα에 결합하는 항체 및 이의 용도
US20220193238A1 (en) * 2020-12-17 2022-06-23 Astrazeneca Ab Anti-il5r antibody formulations
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CN115671140B (zh) * 2022-10-31 2024-03-22 华中科技大学同济医学院附属同济医院 丙酸痤疮杆菌在制备治疗鼻息肉的药品中的应用
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

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