JP2010526813A5 - - Google Patents
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- Publication number
- JP2010526813A5 JP2010526813A5 JP2010507482A JP2010507482A JP2010526813A5 JP 2010526813 A5 JP2010526813 A5 JP 2010526813A5 JP 2010507482 A JP2010507482 A JP 2010507482A JP 2010507482 A JP2010507482 A JP 2010507482A JP 2010526813 A5 JP2010526813 A5 JP 2010526813A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- here
- compound
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- -1 polycyclic aromatic Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004350 aryl cycloalkyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003630 glycyl group Chemical class [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 125000006277 halobenzyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92859207P | 2007-05-10 | 2007-05-10 | |
| US60/928,592 | 2007-05-10 | ||
| US99915307P | 2007-10-15 | 2007-10-15 | |
| US60/999,153 | 2007-10-15 | ||
| PCT/US2008/006015 WO2008140792A1 (en) | 2007-05-10 | 2008-05-09 | Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014066444A Division JP6352017B2 (ja) | 2007-05-10 | 2014-03-27 | フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526813A JP2010526813A (ja) | 2010-08-05 |
| JP2010526813A5 true JP2010526813A5 (https=) | 2011-06-23 |
| JP5782586B2 JP5782586B2 (ja) | 2015-09-24 |
Family
ID=40002552
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507482A Active JP5782586B2 (ja) | 2007-05-10 | 2008-05-09 | フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用 |
| JP2014066444A Active JP6352017B2 (ja) | 2007-05-10 | 2014-03-27 | フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014066444A Active JP6352017B2 (ja) | 2007-05-10 | 2014-03-27 | フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8129519B2 (https=) |
| EP (1) | EP2152258B1 (https=) |
| JP (2) | JP5782586B2 (https=) |
| KR (1) | KR101486026B1 (https=) |
| CN (2) | CN108314663B (https=) |
| AU (1) | AU2008251800B2 (https=) |
| CA (2) | CA2686402C (https=) |
| DK (1) | DK2152258T3 (https=) |
| ES (1) | ES2584188T3 (https=) |
| HU (1) | HUE029155T2 (https=) |
| IL (2) | IL202039A (https=) |
| MX (2) | MX354256B (https=) |
| NZ (2) | NZ597731A (https=) |
| PL (1) | PL2152258T3 (https=) |
| PT (1) | PT2152258T (https=) |
| WO (1) | WO2008140792A1 (https=) |
| ZA (1) | ZA200907859B (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2152258T (pt) * | 2007-05-10 | 2016-08-18 | Avalon Pharmaceuticals | Derivados de fluoreno, antraceno, xanteno, dibenzosuberona e acridina e suas utilizações |
| CA2696288A1 (en) * | 2007-08-15 | 2009-02-19 | Schering Corporation | 6-substituted sulfonyl azabicyclo[3.2.1]octanes useful to inhibit 11.beta.-hydroxysteroid dehydrogenase type-1 |
| EP2987487B1 (en) | 2009-08-10 | 2020-10-07 | Samumed, LLC | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| KR101161290B1 (ko) | 2009-10-16 | 2012-07-02 | 에스에프씨 주식회사 | 축합방향족화합물 및 이를 이용한 유기전계발광소자 |
| EP2515655B1 (en) | 2009-12-21 | 2015-08-05 | Samumed, LLC | 1h-pyrazolo[3,4-beta]pyridines and therapeutic uses thereof |
| EP3473099A1 (en) | 2011-09-14 | 2019-04-24 | Samumed, LLC | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| EP2773607B1 (en) * | 2011-11-06 | 2017-03-29 | Beta Cat Pharmaceuticals LLC | Treatment of diseases and disorders related to transducin beta-like protein 1 (tbl 1) activity, including myeloproliferative neoplasia and chronic myeloid leukemia |
| US20130123281A1 (en) * | 2011-11-11 | 2013-05-16 | Beta Cat Pharmaceuticals, Llc | Compositions and Methods for Inhibition of TBL-1 Binding to Disease-Associated Molecules |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| EP2770994B1 (en) | 2012-05-04 | 2019-08-21 | Samumed, LLC | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| WO2014110086A2 (en) | 2013-01-08 | 2014-07-17 | Samumed, Llc | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| JP7065610B6 (ja) * | 2014-10-24 | 2022-06-06 | コーニンクレッカ フィリップス エヌ ヴェ | 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測 |
| TW201718495A (zh) * | 2015-07-28 | 2017-06-01 | 貝塔貓製藥股份有限公司 | 蒽-9, 10-二酮二肟化合物前驅藥及其用途 |
| US10166218B2 (en) | 2015-08-03 | 2019-01-01 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| WO2017023972A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023975A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10226448B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017024010A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10226453B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10188634B2 (en) | 2015-08-03 | 2019-01-29 | Samumed, Llc | 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023996A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| US10285982B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| WO2017058716A1 (en) * | 2015-09-28 | 2017-04-06 | Vivace Therapeutics, Inc. | Tricyclic compounds |
| BR112018009252A2 (pt) | 2015-11-06 | 2018-11-06 | Samumed Llc | tratamento da osteoartrite |
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| LT3464285T (lt) | 2016-06-01 | 2022-12-27 | Biosplice Therapeutics, Inc. | N-(5-(3-(7-(3-fluorfenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)- 3-metilbutanamido gamybos būdas |
| CN106106481B (zh) * | 2016-06-16 | 2019-06-28 | 湖北工业大学 | 一种棉铃虫甾醇载体蛋白2抑制剂及其虚拟筛选方法 |
| CN110709082A (zh) | 2016-10-21 | 2020-01-17 | 萨穆梅德有限公司 | 吲唑-3-甲酰胺的使用方法及其作为Wnt/β-连环蛋白信号传导途径抑制剂的用途 |
| US10758523B2 (en) | 2016-11-07 | 2020-09-01 | Samumed, Llc | Single-dose, ready-to-use injectable formulations |
| WO2018118711A1 (en) * | 2016-12-19 | 2018-06-28 | The Trustees Of Columbia University In The City Of New York | Small molecule ferroptosis inducers |
| EP4656191A1 (en) | 2017-06-02 | 2025-12-03 | Iterion Therapeutics, Inc. | Methods for treatment of fibrotic diseases |
| JP7551507B2 (ja) * | 2018-06-01 | 2024-09-17 | イテリオン・セラピューティクス・インコーポレイテッド | テガビビントおよび関連化合物の製剤 |
| CN112638375A (zh) | 2018-06-15 | 2021-04-09 | 旗舰创业创新五公司 | 通过后细胞信号传导因子的调节来增加免疫活性 |
| JP2023509359A (ja) | 2019-12-17 | 2023-03-08 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 鉄依存性細胞分解の誘導物質との併用抗癌療法 |
| US11136307B1 (en) * | 2020-09-29 | 2021-10-05 | Iterion Therapeutics, Inc. | Crystalline form of tegavivint, method of preparation, and use thereof |
| US11571388B2 (en) | 2020-11-24 | 2023-02-07 | Iterion Therapeutics, Inc. | Lyophilized formulations of tegavivint |
| CN117567385B (zh) * | 2023-11-23 | 2024-04-30 | 中国人民解放军军事科学院军事医学研究院 | 一种靶向clec5a的小分子抑制剂及其应用 |
| CN119409635B (zh) * | 2024-11-04 | 2026-01-09 | 河南师范大学 | 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3627791A (en) * | 1968-11-21 | 1971-12-14 | Richardson Merrell Inc | Bis(aminoalkylsulfamoyl) anthraquinones |
| US3983248A (en) | 1968-11-21 | 1976-09-28 | Richardson-Merrell Inc. | Bis(aminoalkylsulfamoyl)anthraquinone antiviral agents |
| US3829578A (en) * | 1970-12-10 | 1974-08-13 | Richardson Merrell Inc | Antiviral compositions containing bis-basic ethers and thioethers of xanthene and xanthen-9-ones and methods of treating viruses therewith |
| US3714194A (en) * | 1971-06-09 | 1973-01-30 | Upjohn Co | Di(azidosulfonyl)xanthones |
| US3919211A (en) * | 1973-02-12 | 1975-11-11 | American Home Prod | 9-Oxoxanthene-N,N{40 -bis(substituted)-2,7-disulfonamides |
| US3981248A (en) * | 1975-02-28 | 1976-09-21 | Hall Ski-Lift Company, Inc. | Timing gate for ski-lifts |
| US4250097A (en) * | 1978-03-08 | 1981-02-10 | Syntex (U.S.A.) Inc. | Compositions for and a method of preventing diabetic complications |
| US4276224A (en) * | 1978-06-07 | 1981-06-30 | Ciba-Geigy Corporation | Anthraquinone sulphonamide compounds and preparation |
| DE3044072A1 (de) * | 1980-11-24 | 1982-07-15 | Hoechst Ag, 6000 Frankfurt | Bis-aminomehtyl-anthrachinon-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| IT1223302B (it) | 1987-09-16 | 1990-09-19 | Baldacci Lab Spa | Composti solfonamido derivati inibitori del sistema enzimatico aldoso-reduttasi e composizioni farmaceutiche che li contengono |
| HUT67314A (en) * | 1993-04-09 | 1995-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them |
| EP1363888A2 (en) * | 2000-07-07 | 2003-11-26 | Cancer Research Technology Limited | Therapeutic acridone and acridine compounds |
| EP1307117A1 (en) * | 2000-08-10 | 2003-05-07 | BENETTON GROUP S.p.A. | Sports shoe |
| CN1701063A (zh) * | 2002-01-15 | 2005-11-23 | 癌症研究科技有限公司 | 治疗性吖啶酮及吖啶化合物 |
| US6693136B1 (en) * | 2002-07-26 | 2004-02-17 | Abbott Laboratories | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| PT2152258T (pt) * | 2007-05-10 | 2016-08-18 | Avalon Pharmaceuticals | Derivados de fluoreno, antraceno, xanteno, dibenzosuberona e acridina e suas utilizações |
-
2008
- 2008-05-09 PT PT87543443T patent/PT2152258T/pt unknown
- 2008-05-09 US US12/451,313 patent/US8129519B2/en active Active
- 2008-05-09 WO PCT/US2008/006015 patent/WO2008140792A1/en not_active Ceased
- 2008-05-09 AU AU2008251800A patent/AU2008251800B2/en not_active Ceased
- 2008-05-09 JP JP2010507482A patent/JP5782586B2/ja active Active
- 2008-05-09 PL PL08754344T patent/PL2152258T3/pl unknown
- 2008-05-09 CA CA2686402A patent/CA2686402C/en active Active
- 2008-05-09 KR KR1020097025845A patent/KR101486026B1/ko active Active
- 2008-05-09 NZ NZ597731A patent/NZ597731A/xx not_active IP Right Cessation
- 2008-05-09 HU HUE08754344A patent/HUE029155T2/hu unknown
- 2008-05-09 CN CN201810249295.4A patent/CN108314663B/zh active Active
- 2008-05-09 ES ES08754344.3T patent/ES2584188T3/es active Active
- 2008-05-09 MX MX2012009228A patent/MX354256B/es unknown
- 2008-05-09 MX MX2009011970A patent/MX2009011970A/es active IP Right Grant
- 2008-05-09 NZ NZ581647A patent/NZ581647A/en not_active IP Right Cessation
- 2008-05-09 EP EP08754344.3A patent/EP2152258B1/en active Active
- 2008-05-09 CA CA2871493A patent/CA2871493C/en active Active
- 2008-05-09 CN CN200880023589A patent/CN101730531A/zh active Pending
- 2008-05-09 DK DK08754344.3T patent/DK2152258T3/en active
-
2009
- 2009-11-09 ZA ZA2009/07859A patent/ZA200907859B/en unknown
- 2009-11-10 IL IL202039A patent/IL202039A/en active IP Right Grant
-
2012
- 2012-01-30 US US13/361,761 patent/US9120754B2/en active Active
-
2014
- 2014-03-27 JP JP2014066444A patent/JP6352017B2/ja active Active
-
2015
- 2015-01-21 IL IL236827A patent/IL236827A/en active IP Right Grant
- 2015-07-09 US US14/795,709 patent/US9446021B2/en active Active
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