AR067937A1 - Derivados de indol -2- ona disustituidos en 3, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de indol -2- ona disustituidos en 3, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR067937A1 AR067937A1 ARP080103547A ARP080103547A AR067937A1 AR 067937 A1 AR067937 A1 AR 067937A1 AR P080103547 A ARP080103547 A AR P080103547A AR P080103547 A ARP080103547 A AR P080103547A AR 067937 A1 AR067937 A1 AR 067937A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- group
- perhalogenoalkyl
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
El procedimiento de preparacion, intermediarios y la aplicacion terapéutica de dichos compuestos en obesidad, diabetes, trastornos del apetito y sobrecarga ponderal. Reivindicacion 1: Compuesto que responde a la formula (1): en la que ---- representa un enlace sencillo o doble, X representa -NN- o >CH-, entendiéndose que al menos uno de X, Y representa N; Ar representa un grupo arilo o heteroarilo sustituido opcionalmente con uno o varios sustituyentes, idénticos o diferentes, elegidos entre los átomos de halogeno, los grupos alquilo C1-6, halogenoalquilo C1-6, perhalogenoalquilo C1-3, alcoxi C1-6, perhalogenoalcoxi C1-3, arilo; R1 representa un átomo de hidrogeno o un grupo alquilo C1-6, -C(=O)alquilo C1-6, -C(=O)arilo; R2, R3, R4, idénticos o diferentes, situados en una cualquiera de las posiciones disponibles del nucleo fenilo, representan independientemente un átomo de hidrogeno, un átomo de halogeno, CN , OH, un grupo alquilo C1-6 sustituido opcionalmente con un átomo de halogeno o un OH; perhalogenoalquilo C1-3, alcoxi C1-6, perhalogenoalcoxi C1-3, aminocarbonilo, alquil C1-6-aminocarbonilo, dialquil C1-6-aminocarbonilo, arilo, ariloxi; heteroarilo; pudiendo estar el grupo arilo, ariloxi o heteroarilo sustituido opcionalmente con un átomo de halogeno, CN, OH o un grupo alquilo C1-6, perhalogenoalquilo C1-3 o alcoxi C1-6; entendiéndose que al menos uno de R2, R3, R4 es diferente de H y que el grupo arilo, ariloxi o heteroarilo puede estar sustituido opcionalmente con un átomo de halogeno, CN, OH o un grupo alquilo C1-6, perhalogenoalquilo C1-3, alcoxi C1-6; R5 representa un grupo alquilo C1-6 o un alquenilo C2-6; y n representa 1 o2, en forma de base o de sal de adicion a un ácido; con la excepcion de 5-cloro-3-(2-clorofenil)-1,3-dihidro-3-[2-(4-metilpiperacin-1-il)acetamido]indol-2-ona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705858A FR2920023B1 (fr) | 2007-08-16 | 2007-08-16 | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067937A1 true AR067937A1 (es) | 2009-10-28 |
Family
ID=39197313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103547A AR067937A1 (es) | 2007-08-16 | 2008-08-14 | Derivados de indol -2- ona disustituidos en 3, su preparacion y su aplicacion en terapeutica |
Country Status (42)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
| FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
| CA2751834C (en) | 2009-02-13 | 2018-07-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof |
| AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| CN108658836B (zh) * | 2018-05-15 | 2021-04-20 | 宁波大学 | 一种3-取代-3-叠氮基吲哚-2-酮类化合物的制备方法 |
| EP3912625A1 (en) * | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
| AU5301199A (en) * | 1998-08-20 | 2000-03-14 | Sumitomo Pharmaceuticals Company, Limited | Oxindole derivatives as growth hormone releasers |
| FR2827604B1 (fr) * | 2001-07-17 | 2003-09-19 | Sanofi Synthelabo | Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
| WO2005035498A1 (ja) * | 2003-10-08 | 2005-04-21 | Dainippon Sumitomo Pharma Co., Ltd. | 含窒素二環性化合物の摂食調節剤としての用途 |
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2007
- 2007-08-16 FR FR0705858A patent/FR2920023B1/fr not_active Expired - Fee Related
-
2008
- 2008-08-14 MY MYPI2010000685A patent/MY149649A/en unknown
- 2008-08-14 WO PCT/FR2008/001190 patent/WO2009056707A2/fr active Application Filing
- 2008-08-14 CN CN200880103992.3A patent/CN103443076B/zh not_active Expired - Fee Related
- 2008-08-14 KR KR1020107003267A patent/KR20100051812A/ko active IP Right Grant
- 2008-08-14 RS RS20120207A patent/RS52321B/en unknown
- 2008-08-14 BR BRPI0815171 patent/BRPI0815171A2/pt not_active Application Discontinuation
- 2008-08-14 AR ARP080103547A patent/AR067937A1/es unknown
- 2008-08-14 SI SI200830646T patent/SI2188253T1/sl unknown
- 2008-08-14 DK DK08845678.5T patent/DK2188253T3/da active
- 2008-08-14 JO JO2008376A patent/JO2749B1/en active
- 2008-08-14 ME MEP-2010-29A patent/ME00979B/me unknown
- 2008-08-14 EP EP08845678A patent/EP2188253B8/fr active Active
- 2008-08-14 AU AU2008320718A patent/AU2008320718B2/en not_active Ceased
- 2008-08-14 AT AT08845678T patent/ATE548349T1/de active
- 2008-08-14 UA UAA201002977A patent/UA101162C2/ru unknown
- 2008-08-14 NZ NZ583317A patent/NZ583317A/en not_active IP Right Cessation
- 2008-08-14 EA EA201070281A patent/EA019486B1/ru not_active IP Right Cessation
- 2008-08-14 MX MX2010001851A patent/MX2010001851A/es active IP Right Grant
- 2008-08-14 JP JP2010520610A patent/JP5685440B2/ja not_active Expired - Fee Related
- 2008-08-14 CA CA2696237A patent/CA2696237C/fr active Active
- 2008-08-14 ES ES08845678T patent/ES2384080T3/es active Active
- 2008-08-14 PE PE2008001384A patent/PE20090988A1/es not_active Application Discontinuation
- 2008-08-14 PT PT08845678T patent/PT2188253E/pt unknown
- 2008-08-14 PA PA20088793101A patent/PA8793101A1/es unknown
- 2008-08-14 PL PL08845678T patent/PL2188253T3/pl unknown
- 2008-08-15 UY UY31297A patent/UY31297A1/es not_active Application Discontinuation
- 2008-08-15 TW TW097131363A patent/TWI432423B/zh not_active IP Right Cessation
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2010
- 2010-01-13 TN TNP2010000025A patent/TN2010000025A1/fr unknown
- 2010-02-03 NI NI201000023A patent/NI201000023A/es unknown
- 2010-02-04 DO DO2010000050A patent/DOP2010000050A/es unknown
- 2010-02-05 CO CO10012804A patent/CO6251363A2/es not_active Application Discontinuation
- 2010-02-09 US US12/702,687 patent/US20100210662A1/en not_active Abandoned
- 2010-02-10 GT GT201000032A patent/GT201000032A/es unknown
- 2010-02-12 EC EC2010009961A patent/ECSP109961A/es unknown
- 2010-02-12 CR CR11273A patent/CR11273A/es unknown
- 2010-02-14 IL IL203956A patent/IL203956A/en not_active IP Right Cessation
- 2010-02-15 ZA ZA2010/01085A patent/ZA201001085B/en unknown
- 2010-02-16 HN HN2010000330A patent/HN2010000330A/es unknown
- 2010-03-08 MA MA32676A patent/MA31742B1/fr unknown
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2011
- 2011-01-24 US US13/012,321 patent/US8202871B2/en not_active Expired - Fee Related
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2012
- 2012-05-30 CY CY20121100490T patent/CY1112809T1/el unknown
- 2012-06-04 HR HRP20120466AT patent/HRP20120466T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |