UA101162C2 - Производные индол-2-она, двузамещенные в положении 3, их получение и применение в терапии - Google Patents

Производные индол-2-она, двузамещенные в положении 3, их получение и применение в терапии

Info

Publication number
UA101162C2
UA101162C2 UAA201002977A UAA201002977A UA101162C2 UA 101162 C2 UA101162 C2 UA 101162C2 UA A201002977 A UAA201002977 A UA A201002977A UA A201002977 A UAA201002977 A UA A201002977A UA 101162 C2 UA101162 C2 UA 101162C2
Authority
UA
Ukraine
Prior art keywords
indol
therapeutic use
preparation
derivatives disubstituted
disubstituted
Prior art date
Application number
UAA201002977A
Other languages
English (en)
Ukrainian (uk)
Inventor
Марко Барони
Летиция Пулео
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of UA101162C2 publication Critical patent/UA101162C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Объектом данного изобретения являются производные индол-2-она, двузамещенные в положении 3, общей формулы (I)(I),в которой R1, R2, R3, R4, R5, Ar и n такие, как определено в п. 1 формулы изобретения, способ получения и применения указанных соединений в терапии.
UAA201002977A 2007-08-16 2008-08-14 Производные индол-2-она, двузамещенные в положении 3, их получение и применение в терапии UA101162C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705858A FR2920023B1 (fr) 2007-08-16 2007-08-16 Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique
PCT/FR2008/001190 WO2009056707A2 (fr) 2007-08-16 2008-08-14 Dérivés de l'ind0l-2-0ne disubstitues en 3, leur preparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
UA101162C2 true UA101162C2 (ru) 2013-03-11

Family

ID=39197313

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201002977A UA101162C2 (ru) 2007-08-16 2008-08-14 Производные индол-2-она, двузамещенные в положении 3, их получение и применение в терапии

Country Status (42)

Country Link
US (2) US20100210662A1 (ru)
EP (1) EP2188253B8 (ru)
JP (1) JP5685440B2 (ru)
KR (1) KR20100051812A (ru)
CN (1) CN103443076B (ru)
AR (1) AR067937A1 (ru)
AT (1) ATE548349T1 (ru)
AU (1) AU2008320718B2 (ru)
BR (1) BRPI0815171A2 (ru)
CA (1) CA2696237C (ru)
CO (1) CO6251363A2 (ru)
CR (1) CR11273A (ru)
CY (1) CY1112809T1 (ru)
DK (1) DK2188253T3 (ru)
DO (1) DOP2010000050A (ru)
EA (1) EA019486B1 (ru)
EC (1) ECSP109961A (ru)
ES (1) ES2384080T3 (ru)
FR (1) FR2920023B1 (ru)
GT (1) GT201000032A (ru)
HN (1) HN2010000330A (ru)
HR (1) HRP20120466T1 (ru)
IL (1) IL203956A (ru)
JO (1) JO2749B1 (ru)
MA (1) MA31742B1 (ru)
ME (1) ME00979B (ru)
MX (1) MX2010001851A (ru)
MY (1) MY149649A (ru)
NI (1) NI201000023A (ru)
NZ (1) NZ583317A (ru)
PA (1) PA8793101A1 (ru)
PE (1) PE20090988A1 (ru)
PL (1) PL2188253T3 (ru)
PT (1) PT2188253E (ru)
RS (1) RS52321B (ru)
SI (1) SI2188253T1 (ru)
TN (1) TN2010000025A1 (ru)
TW (1) TWI432423B (ru)
UA (1) UA101162C2 (ru)
UY (1) UY31297A1 (ru)
WO (1) WO2009056707A2 (ru)
ZA (1) ZA201001085B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090938A1 (es) 2007-08-16 2009-08-08 Boehringer Ingelheim Int Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
CA2751834C (en) 2009-02-13 2018-07-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof
AR085689A1 (es) 2011-03-07 2013-10-23 Boehringer Ingelheim Int Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
CN108658836B (zh) * 2018-05-15 2021-04-20 宁波大学 一种3-取代-3-叠氮基吲哚-2-酮类化合物的制备方法
EP3912625A1 (en) * 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
AU5301199A (en) * 1998-08-20 2000-03-14 Sumitomo Pharmaceuticals Company, Limited Oxindole derivatives as growth hormone releasers
FR2827604B1 (fr) * 2001-07-17 2003-09-19 Sanofi Synthelabo Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
WO2005035498A1 (ja) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. 含窒素二環性化合物の摂食調節剤としての用途

Also Published As

Publication number Publication date
TW200914438A (en) 2009-04-01
ES2384080T3 (es) 2012-06-29
ECSP109961A (es) 2010-03-31
KR20100051812A (ko) 2010-05-18
PL2188253T3 (pl) 2012-08-31
MY149649A (en) 2013-09-30
RS52321B (en) 2012-12-31
PA8793101A1 (es) 2009-01-23
CN103443076B (zh) 2016-06-22
MX2010001851A (es) 2010-03-11
CA2696237C (fr) 2016-07-05
US20110118280A1 (en) 2011-05-19
EA019486B1 (ru) 2014-04-30
MA31742B1 (fr) 2010-10-01
NZ583317A (en) 2011-11-25
AR067937A1 (es) 2009-10-28
ATE548349T1 (de) 2012-03-15
BRPI0815171A2 (pt) 2015-03-31
WO2009056707A2 (fr) 2009-05-07
JP5685440B2 (ja) 2015-03-18
JP2010536736A (ja) 2010-12-02
EP2188253B8 (fr) 2012-04-11
PE20090988A1 (es) 2009-08-14
CA2696237A1 (fr) 2009-05-07
HRP20120466T1 (hr) 2012-07-31
AU2008320718A1 (en) 2009-05-07
AU2008320718B2 (en) 2013-09-19
DK2188253T3 (da) 2012-07-02
CO6251363A2 (es) 2011-02-21
EA201070281A1 (ru) 2010-08-30
IL203956A (en) 2014-06-30
PT2188253E (pt) 2012-05-11
NI201000023A (es) 2010-03-11
ZA201001085B (en) 2011-04-28
US20100210662A1 (en) 2010-08-19
JO2749B1 (en) 2014-03-15
US8202871B2 (en) 2012-06-19
EP2188253B1 (fr) 2012-03-07
GT201000032A (es) 2012-03-12
WO2009056707A8 (fr) 2010-03-18
EP2188253A2 (fr) 2010-05-26
CN103443076A (zh) 2013-12-11
FR2920023A1 (fr) 2009-02-20
CY1112809T1 (el) 2016-02-10
TN2010000025A1 (fr) 2011-09-26
HN2010000330A (es) 2012-03-19
TWI432423B (zh) 2014-04-01
CR11273A (es) 2010-07-16
DOP2010000050A (es) 2010-04-15
FR2920023B1 (fr) 2013-02-08
UY31297A1 (es) 2009-03-31
ME00979B (me) 2012-06-20
SI2188253T1 (sl) 2012-09-28
WO2009056707A3 (fr) 2009-10-01

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