BRPI0815171A2 - Derivados do indol-2-ona di-substitu[idos em 3, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents

Derivados do indol-2-ona di-substitu[idos em 3, o respectivo preparo e a respectiva aplicação em terapêutica

Info

Publication number
BRPI0815171A2
BRPI0815171A2 BRPI0815171A BRPI0815171A2 BR PI0815171 A2 BRPI0815171 A2 BR PI0815171A2 BR PI0815171 A BRPI0815171 A BR PI0815171A BR PI0815171 A2 BRPI0815171 A2 BR PI0815171A2
Authority
BR
Brazil
Prior art keywords
indol
acids
preparation
substituted derivatives
therapeutic application
Prior art date
Application number
Other languages
English (en)
Inventor
Marco Baroni
Letizia Puleo
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0815171A2 publication Critical patent/BRPI0815171A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
BRPI0815171 2007-08-16 2008-08-14 Derivados do indol-2-ona di-substitu[idos em 3, o respectivo preparo e a respectiva aplicação em terapêutica BRPI0815171A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705858A FR2920023B1 (fr) 2007-08-16 2007-08-16 Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique
PCT/FR2008/001190 WO2009056707A2 (fr) 2007-08-16 2008-08-14 Dérivés de l'ind0l-2-0ne disubstitues en 3, leur preparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
BRPI0815171A2 true BRPI0815171A2 (pt) 2015-03-31

Family

ID=39197313

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815171 BRPI0815171A2 (pt) 2007-08-16 2008-08-14 Derivados do indol-2-ona di-substitu[idos em 3, o respectivo preparo e a respectiva aplicação em terapêutica

Country Status (42)

Country Link
US (2) US20100210662A1 (pt)
EP (1) EP2188253B8 (pt)
JP (1) JP5685440B2 (pt)
KR (1) KR20100051812A (pt)
CN (1) CN103443076B (pt)
AR (1) AR067937A1 (pt)
AT (1) ATE548349T1 (pt)
AU (1) AU2008320718B2 (pt)
BR (1) BRPI0815171A2 (pt)
CA (1) CA2696237C (pt)
CO (1) CO6251363A2 (pt)
CR (1) CR11273A (pt)
CY (1) CY1112809T1 (pt)
DK (1) DK2188253T3 (pt)
DO (1) DOP2010000050A (pt)
EA (1) EA019486B1 (pt)
EC (1) ECSP109961A (pt)
ES (1) ES2384080T3 (pt)
FR (1) FR2920023B1 (pt)
GT (1) GT201000032A (pt)
HN (1) HN2010000330A (pt)
HR (1) HRP20120466T1 (pt)
IL (1) IL203956A (pt)
JO (1) JO2749B1 (pt)
MA (1) MA31742B1 (pt)
ME (1) ME00979B (pt)
MX (1) MX2010001851A (pt)
MY (1) MY149649A (pt)
NI (1) NI201000023A (pt)
NZ (1) NZ583317A (pt)
PA (1) PA8793101A1 (pt)
PE (1) PE20090988A1 (pt)
PL (1) PL2188253T3 (pt)
PT (1) PT2188253E (pt)
RS (1) RS52321B (pt)
SI (1) SI2188253T1 (pt)
TN (1) TN2010000025A1 (pt)
TW (1) TWI432423B (pt)
UA (1) UA101162C2 (pt)
UY (1) UY31297A1 (pt)
WO (1) WO2009056707A2 (pt)
ZA (1) ZA201001085B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002427A1 (es) 2007-08-16 2009-09-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
JP5685550B2 (ja) 2009-02-13 2015-03-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
UY33937A (es) 2011-03-07 2012-09-28 Boehringer Ingelheim Int Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
CN108658836B (zh) * 2018-05-15 2021-04-20 宁波大学 一种3-取代-3-叠氮基吲哚-2-酮类化合物的制备方法
EP3912625A1 (en) * 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
US6576656B1 (en) * 1998-08-20 2003-06-10 Sumitomo Pharmaceuticals Co., Ltd. Oxindole derivative
FR2827604B1 (fr) * 2001-07-17 2003-09-19 Sanofi Synthelabo Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
WO2005035498A1 (ja) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. 含窒素二環性化合物の摂食調節剤としての用途

Also Published As

Publication number Publication date
AU2008320718B2 (en) 2013-09-19
CN103443076B (zh) 2016-06-22
JO2749B1 (en) 2014-03-15
FR2920023B1 (fr) 2013-02-08
HRP20120466T1 (hr) 2012-07-31
WO2009056707A2 (fr) 2009-05-07
AR067937A1 (es) 2009-10-28
JP2010536736A (ja) 2010-12-02
MY149649A (en) 2013-09-30
EP2188253B8 (fr) 2012-04-11
MX2010001851A (es) 2010-03-11
WO2009056707A3 (fr) 2009-10-01
TWI432423B (zh) 2014-04-01
RS52321B (en) 2012-12-31
TW200914438A (en) 2009-04-01
US8202871B2 (en) 2012-06-19
CR11273A (es) 2010-07-16
UY31297A1 (es) 2009-03-31
US20100210662A1 (en) 2010-08-19
DOP2010000050A (es) 2010-04-15
ECSP109961A (es) 2010-03-31
ATE548349T1 (de) 2012-03-15
SI2188253T1 (sl) 2012-09-28
US20110118280A1 (en) 2011-05-19
ZA201001085B (en) 2011-04-28
WO2009056707A8 (fr) 2010-03-18
MA31742B1 (fr) 2010-10-01
JP5685440B2 (ja) 2015-03-18
PE20090988A1 (es) 2009-08-14
PT2188253E (pt) 2012-05-11
EP2188253A2 (fr) 2010-05-26
DK2188253T3 (da) 2012-07-02
TN2010000025A1 (fr) 2011-09-26
AU2008320718A1 (en) 2009-05-07
FR2920023A1 (fr) 2009-02-20
CY1112809T1 (el) 2016-02-10
PA8793101A1 (es) 2009-01-23
EA201070281A1 (ru) 2010-08-30
ME00979B (me) 2012-06-20
EA019486B1 (ru) 2014-04-30
KR20100051812A (ko) 2010-05-18
NI201000023A (es) 2010-03-11
CA2696237C (fr) 2016-07-05
PL2188253T3 (pl) 2012-08-31
CA2696237A1 (fr) 2009-05-07
CN103443076A (zh) 2013-12-11
ES2384080T3 (es) 2012-06-29
CO6251363A2 (es) 2011-02-21
EP2188253B1 (fr) 2012-03-07
NZ583317A (en) 2011-11-25
UA101162C2 (ru) 2013-03-11
GT201000032A (es) 2012-03-12
IL203956A (en) 2014-06-30
HN2010000330A (es) 2012-03-19

Similar Documents

Publication Publication Date Title
BRPI0815171A2 (pt) Derivados do indol-2-ona di-substitu[idos em 3, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0810440A2 (pt) Derivados de triazolopiridina-carboxamidas e triazolopirimidina-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0907439A2 (pt) Derivado de carboxamidas azabiciclicos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0906567A2 (pt) Derivados de ureia de tetra-hidroquinoxalina, o respectivo preparo e a respectiva aplicação em terapêutica j
BRPI0907381A2 (pt) Derivados de carboxamidas azabicíclicos, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI0910309A2 (pt) derivados poli-substituídos de 2-aril --fenil-imidazo [1,2-a] piridinas, o respectivo preparo e a respectiva aplicação em terapêtica
BRPI0810412A2 (pt) Derivados de triazolo piridina-carboxamidas e triazolo pirimidina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1012857A2 (pt) derivados de ciclopenta[c]pirrol-2-carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0908999A2 (pt) Derivados poli-substituídos de 2-aril-6-imidazo[1,2-a]piridinas, o respectivo preparo e respectiva aplicação em terapêutica
IL213168A0 (en) 1,2,4-oxadiazole derivatives and their therapeutic use
BRPI0907578A2 (pt) derivados de 3-aminoalquil-1,3-di-hidro-2h-indol-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica
BR112012000104A2 (pt) derivados de pirazóis, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0923182A2 (pt) derivados de 6-cicloamino-2,3-di-piridinil-imidazo[1,2-b]piridazina, o respectivo preparo e a respectivo preparo e a respectiva aplicação terapêutica
BRPI0821992A2 (pt) Derivados de n-heterocíclico-imidazo[1,2-a]piridina-2-carboxamida s, respectivo preparo e respectiva aplicação em terapêutica
BRPI0822054A2 (pt) Derivados de azetidinas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0924060A2 (pt) Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, o respectivo preparo e a respectiva aplicacao em terapeuutica com atividaores de hif
BRPI0806969A2 (pt) Derivados de azabicicloalcano, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0821458A2 (pt) Derivado 6-heterocíclico-imidazo[1,2-a]pirroína-2-carboxamida s, o respectivo preparo e a respectiva aplicação em, terapêutica
BRPI0821674A2 (pt) Derivados de n-fenil-imidazo[1,2-a] piridina-2- carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0812588A2 (pt) Derivados de 1-benzilpirazol, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1008501A2 (pt) derivados de 3-benzo furanil - indol-2-ona substituídos em posição 3, o respectivo preparo e a respectiva aplicação em terapêutica
BR112012002980A2 (pt) oligossacarídeo n-sulfatos ativadores dos receptores dos fgfs, o respectivo preparo e a repectiva utilização em terapêutica
BRPI1008562A2 (pt) derivados de 3-benzofuranil-indol-2-ona-3-acetamino piperazinas substituídos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0915884A2 (pt) derivados de 1-benzil-cinolin-4-(1h)-ona substituídos, o respectivo preparo e a respectiva aplicação em terapêutica
AP2008004568A0 (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL