MXPA04006834A - Compuestos de acridina y acridona terapeuticos. - Google Patents

Compuestos de acridina y acridona terapeuticos.

Info

Publication number
MXPA04006834A
MXPA04006834A MXPA04006834A MXPA04006834A MXPA04006834A MX PA04006834 A MXPA04006834 A MX PA04006834A MX PA04006834 A MXPA04006834 A MX PA04006834A MX PA04006834 A MXPA04006834 A MX PA04006834A MX PA04006834 A MXPA04006834 A MX PA04006834A
Authority
MX
Mexico
Prior art keywords
substituent
20aryl
7alkyl
compounds
optionally substituted
Prior art date
Application number
MXPA04006834A
Other languages
English (en)
Inventor
Reszka Anthony
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Publication of MXPA04006834A publication Critical patent/MXPA04006834A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Esta invencion se refiere a ciertos compuestos de acridona y acridina de la formula (1), que inhiben la telomerasa, regulan la proliferacion celular, etc., y/o trata el cancer, condiciones proliferativas, etc., en donde: ya sea que (a) K es =O, L es -H, un enlace sencillo alfa, beta es un enlace doble, gamma es un enlace sencillo (acridonas); o (b) K es un substituyente en la posicion 9, L esta ausente, alfa es un doble enlace, beta es un enlace sencillo, gamma es un doble enlace (acridinas); y en donde: J1 es un substituyente 2 o 3, J2 es un substituyente 6 o 7; J1 y J2 son cada uno un grupo de la formula -N(RN) -W, en donde: RN es un substituyente de nitrogeno y es un hidrogeno, C1-7alquilo, C3-20 heterociclilo o C5-20 arilo, y esta opcionalmente substituido; y W es C1-7 alquilo, C3-20 heterociclilo o C5-20 arilo, y esta opcionalmente substituido, y en donde cuando K es un substituyente en 9, K es un grupo de la formula -N(RN) -Q, en donde: RN es un substituyente amino y es hidrogeno, C1-7 alquilo, C3-20 heterociclilo o C5-20 arilo, y Q es C1-7 alquilo, C3-20 heterociclilo o C5-20 arilo, y esta opcionalmente substituido; y sales, esteres, amidas, solvatos, hidratos y formas protegidas farmaceuticamente aceptables de los mismos. La presente invencion tambien se refiere a composiciones farmaceuticas que comprenden tales compuestos, y al uso de tales compuestos y composiciones, in vitro e in vivo, para inhibir la telomerasa, regular la proliferacion celular, etc., y/o en el tratamiento del cancer, condiciones proliferativas, etc.
MXPA04006834A 2002-01-15 2003-01-14 Compuestos de acridina y acridona terapeuticos. MXPA04006834A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34789902P 2002-01-15 2002-01-15
PCT/GB2003/000102 WO2003059885A1 (en) 2002-01-15 2003-01-14 Therapeutic acridone and acridine compounds

Publications (1)

Publication Number Publication Date
MXPA04006834A true MXPA04006834A (es) 2004-12-06

Family

ID=23365764

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04006834A MXPA04006834A (es) 2002-01-15 2003-01-14 Compuestos de acridina y acridona terapeuticos.

Country Status (14)

Country Link
US (1) US7205311B2 (es)
EP (1) EP1474397A1 (es)
JP (1) JP2005519065A (es)
KR (1) KR20040075934A (es)
CN (1) CN1701063A (es)
AU (1) AU2003201042A1 (es)
BR (1) BR0306915A (es)
CA (1) CA2473170A1 (es)
EA (1) EA200400896A1 (es)
MX (1) MXPA04006834A (es)
NO (1) NO20043354L (es)
PL (1) PL370449A1 (es)
WO (1) WO2003059885A1 (es)
ZA (1) ZA200405774B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001269291A1 (en) * 2000-07-07 2002-02-05 Cancer Research Technology Limited Therapeutic acridone and acridine compounds
CN100386624C (zh) * 2005-01-27 2008-05-07 中国科学院大连化学物理研究所 一种荧光试剂的制备方法
DE102005009909A1 (de) 2005-03-01 2006-09-07 Heinrich-Heine-Universität Düsseldorf Verbindungen geeignet zur Beseitigung fehlgefalteter Proteine
GB0505045D0 (en) * 2005-03-11 2005-04-20 Antisoma Plc Cancer treatment
US20080119492A1 (en) * 2005-07-29 2008-05-22 Jean-Marie Lehn Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation
US8024762B2 (en) 2006-06-13 2011-09-20 Time Warner Cable Inc. Methods and apparatus for providing virtual content over a network
GB0623492D0 (en) * 2006-11-24 2007-01-03 Univ London Pharmacy Therapeutic G-quadruplex ligands
US8129519B2 (en) 2007-05-10 2012-03-06 Cholody Wieslaw M Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
JP2012526834A (ja) * 2009-05-12 2012-11-01 シェーリング コーポレイション ウイルス疾患治療に有用な縮合型三環式アリール化合物
BRPI1105924A2 (pt) * 2011-12-19 2013-11-12 Ct Brasileiro De Pesquisas Fisicas Cbpf Composto molecular para destruição seletiva de células de tumores sólidos
CN103923007B (zh) * 2014-01-03 2016-07-06 大连理工大学 一类吖啶类化合物及其应用
CN104326979B (zh) * 2014-09-30 2015-12-30 广西中医药大学 2-甲基-9-吖啶（对甲氧基苯甲酰胺基）硫脲及其制备方法和用途
CN107068881B (zh) * 2016-04-25 2019-12-03 中节能万润股份有限公司 一种含有吖啶酮类化合物的有机电致发光器件及其应用
CN115557890A (zh) * 2022-09-01 2023-01-03 宁波大学 一种多取代吖啶酮烷基衍生物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE488890C (de) * 1924-09-12 1930-01-23 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aminoalkylaminosubstitutionsprodukten der Acridinreihe
AU2001269291A1 (en) * 2000-07-07 2002-02-05 Cancer Research Technology Limited Therapeutic acridone and acridine compounds

Also Published As

Publication number Publication date
CA2473170A1 (en) 2003-07-24
KR20040075934A (ko) 2004-08-30
EP1474397A1 (en) 2004-11-10
EA200400896A1 (ru) 2004-12-30
NO20043354L (no) 2004-10-01
US7205311B2 (en) 2007-04-17
WO2003059885A1 (en) 2003-07-24
ZA200405774B (en) 2005-11-04
BR0306915A (pt) 2004-11-09
PL370449A1 (en) 2005-05-30
US20050070568A1 (en) 2005-03-31
CN1701063A (zh) 2005-11-23
JP2005519065A (ja) 2005-06-30
AU2003201042A1 (en) 2003-07-30

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