JP2011528706A5 - - Google Patents
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- Publication number
- JP2011528706A5 JP2011528706A5 JP2011519228A JP2011519228A JP2011528706A5 JP 2011528706 A5 JP2011528706 A5 JP 2011528706A5 JP 2011519228 A JP2011519228 A JP 2011519228A JP 2011519228 A JP2011519228 A JP 2011519228A JP 2011528706 A5 JP2011528706 A5 JP 2011528706A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- cor
- alkyl group
- nhcor
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0813339.9 | 2008-07-21 | ||
| GB0813339A GB0813339D0 (en) | 2008-07-21 | 2008-07-21 | Novel reagents and method for conjugating biological molecules |
| GB0905762.1 | 2009-04-02 | ||
| GB0905762A GB0905762D0 (en) | 2009-04-02 | 2009-04-02 | Novel reagents and method for conjugating biological molecules |
| PCT/GB2009/001764 WO2010010324A1 (en) | 2008-07-21 | 2009-07-17 | Novel reagents and method for conjugating biological molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011180530A Division JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528706A JP2011528706A (ja) | 2011-11-24 |
| JP2011528706A5 true JP2011528706A5 (https=) | 2014-06-26 |
| JP5622117B2 JP5622117B2 (ja) | 2014-11-12 |
Family
ID=41226122
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519228A Expired - Fee Related JP5622117B2 (ja) | 2008-07-21 | 2009-07-17 | 生体分子を接合するための新規な試薬及び方法 |
| JP2011180530A Expired - Fee Related JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011180530A Expired - Fee Related JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8969626B2 (https=) |
| EP (2) | EP2374481B1 (https=) |
| JP (2) | JP5622117B2 (https=) |
| KR (1) | KR101763559B1 (https=) |
| CN (1) | CN102099058B (https=) |
| AU (1) | AU2009275358C1 (https=) |
| DK (2) | DK2374481T3 (https=) |
| ES (2) | ES2560807T3 (https=) |
| PL (1) | PL2326349T3 (https=) |
| WO (1) | WO2010010324A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| EP2374481B1 (en) * | 2008-07-21 | 2015-11-04 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
| US9005598B2 (en) | 2009-03-04 | 2015-04-14 | Polytherics Limited | Conjugated proteins and peptides |
| CN106110311A (zh) | 2009-07-27 | 2016-11-16 | 百深公司 | 凝血蛋白缀合物 |
| KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| CN102497884A (zh) | 2009-07-27 | 2012-06-13 | 巴克斯特国际公司 | 凝血蛋白缀合物 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| CA2811869A1 (en) * | 2010-09-21 | 2012-03-29 | Cristal Delivery B.V. | Tunable, biodegradable linker molecules for transient conjugation of components in drug delivery systems, and drug delivery systems prepared therewith |
| HUE049352T2 (hu) | 2010-12-22 | 2020-09-28 | Baxalta GmbH | Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására |
| EP3808378A1 (en) * | 2011-05-27 | 2021-04-21 | Baxalta GmbH | Therapeutic proteins with increased half-life and methods of preparing same |
| JP5841768B2 (ja) * | 2011-08-05 | 2016-01-13 | 花王株式会社 | 脂肪蓄積抑制剤 |
| MY190257A (en) | 2012-04-16 | 2022-04-11 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| GB201210770D0 (en) * | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| PL2968440T3 (pl) | 2013-03-15 | 2019-12-31 | Zymeworks Inc. | Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania |
| MX379256B (es) | 2013-03-15 | 2025-03-10 | Regeneron Pharma | Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos. |
| KR102252925B1 (ko) | 2013-08-26 | 2021-05-18 | 리제너론 파마슈티칼스 인코포레이티드 | 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 |
| RU2729194C2 (ru) | 2013-12-27 | 2020-08-05 | Займворкс Инк. | Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов |
| AU2015229591B2 (en) | 2014-03-11 | 2020-10-22 | Regeneron Pharmaceuticals, Inc. | Anti-EGFRvlll antibodies and uses thereof |
| AU2015318556C1 (en) | 2014-09-17 | 2021-01-07 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| ES2885854T3 (es) | 2014-10-14 | 2021-12-15 | Polytherics Ltd | Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG |
| EA034950B1 (ru) | 2015-03-27 | 2020-04-09 | Регенерон Фармасьютикалз, Инк. | Производные майтанзиноида, их конъюгаты и способы использования |
| MY189159A (en) | 2015-07-06 | 2022-01-29 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| JP2018536682A (ja) | 2015-12-11 | 2018-12-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｅｇｆｒ及び／またはｅｒｂｂ３遮断に耐性のある腫瘍の成長を低減または防止するための方法 |
| WO2017132173A1 (en) | 2016-01-25 | 2017-08-03 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
| EP3423480A1 (en) * | 2016-03-01 | 2019-01-09 | The Board of Trustees of the University of Illinois | L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability |
| WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| WO2018002902A1 (en) | 2016-07-01 | 2018-01-04 | Glaxosmithkline Intellectual Property (No.2) Limited | Antibody-drug conjugates and therapeutic methods using the same |
| MX2019003325A (es) | 2016-09-23 | 2019-08-05 | Regeneron Pharma | Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos. |
| MY194596A (en) | 2016-09-23 | 2022-12-06 | Regeneron Pharma | Bi Specific Anti-Muc16-CD3 Antibodies And Anti-Muc16 Drug Conjugates |
| KR20250114431A (ko) | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| KR20250008984A (ko) | 2017-05-18 | 2025-01-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| FI3635009T3 (fi) | 2017-06-07 | 2026-04-07 | Regeneron Pharma | Koostumuksia ja menetelmiä entsyymien internalisoimiseksi |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| CN112004557B (zh) | 2018-01-08 | 2024-07-30 | 里珍纳龙药品有限公司 | 类固醇类化合物及其抗体偶联物 |
| MX2020011487A (es) | 2018-04-30 | 2020-12-07 | Regeneron Pharma | Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos. |
| CN112533951A (zh) | 2018-05-09 | 2021-03-19 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
| EP3793591A1 (en) | 2018-05-17 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
| JP7591503B2 (ja) | 2018-12-21 | 2024-11-28 | リジェネロン ファーマシューティカルズ，インク． | リファマイシンアナログおよびその抗体薬物コンジュゲート |
| US20220040319A1 (en) | 2019-02-21 | 2022-02-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met |
| US11896682B2 (en) | 2019-09-16 | 2024-02-13 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof |
| US11814428B2 (en) | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
| IL295312A (en) | 2020-02-28 | 2022-10-01 | Regeneron Pharma | Bispecific antigen binding molecules that bind her2, and methods of use thereof |
| IL319200A (en) | 2020-04-16 | 2025-04-01 | Regeneron Pharma | Antibody-drug conjugates prepared using Diels-Alder compression methods |
| KR20240038138A (ko) | 2020-07-13 | 2024-03-22 | 리제너론 파마슈티칼스 인코포레이티드 | 단백질에서 글루타민 잔기에 접합된 캄토테신 유사체 및 그의 용도 |
| CA3191304A1 (en) | 2020-09-14 | 2022-03-17 | Amy Han | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| AU2021366691B2 (en) | 2020-10-22 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Anti-FGFR2 antibodies and methods of use thereof |
| CN113461929B (zh) * | 2021-07-13 | 2023-04-21 | 浙江倍合德制药有限公司 | 一种tpgs系列产品的精制提纯方法 |
| CA3241734A1 (en) | 2022-01-12 | 2023-07-20 | Amy Han | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
| AU2023231305A1 (en) | 2022-03-11 | 2024-09-12 | Regeneron Pharmaceuticals, Inc. | Anti-GLP1r antibody-tethered drug conjugates comprising GLP1 peptidomimetics and uses thereof |
| CA3261366A1 (en) | 2022-07-21 | 2024-01-25 | Firefly Bio, Inc. | GLUCOCORTICOID RECEPTOR AGONISTS AND THEIR CONJUGATES |
| IL321285A (en) | 2022-12-21 | 2025-08-01 | Regeneron Pharma | Topoisomerase I inhibitor prodrugs for ADC conjugates and a regimen for their use |
| EP4705343A1 (en) | 2023-05-02 | 2026-03-11 | Regeneron Pharmaceuticals, Inc. | Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells |
| WO2025014533A1 (en) | 2023-07-10 | 2025-01-16 | Regeneron Pharmaceuticals, Inc. | Anti-human cacng1 antibody-drug conjugates and uses thereof |
| US20250171516A1 (en) | 2023-11-03 | 2025-05-29 | Regeneron Pharmaceuticals, Inc. | Peptide acids as a glp1r agonist and antibody-drug conjugates thereof |
| WO2026020031A2 (en) | 2024-07-18 | 2026-01-22 | Novarock Biotherapeutics, Ltd. | Cdh17 antibodies and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US147443A (en) * | 1874-02-10 | Improvement in lamp-extinguishers | ||
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5414135A (en) | 1991-12-30 | 1995-05-09 | Sterling Winthrop Inc. | Vinyl sulfone coupling of polyoxyalkylenes to proteins |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| GB9713979D0 (en) | 1997-07-03 | 1997-09-10 | Univ Nottingham | Method for attaching peg to macromolecules |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6828412B1 (en) | 1999-09-03 | 2004-12-07 | School Of Pharmacy, University Of London | Degradable polymers |
| EP1222217B1 (en) | 1999-09-08 | 2005-06-15 | Polytherics Limited | Uniform molecular weight polymers |
| WO2004060965A2 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| JP4009721B2 (ja) * | 2003-05-23 | 2007-11-21 | 独立行政法人産業技術総合研究所 | イオン結合性ポリマー含有基板、該基板を含有する検出用センサー及び病原菌又は病原菌が生産する毒素の検出方法 |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| AU2005318097A1 (en) | 2004-12-22 | 2006-06-29 | Kuros Biosurgery Ag | Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors |
| KR20100090684A (ko) | 2007-10-09 | 2010-08-16 | 폴리테릭스 리미티드 | 신규한 접합 단백질 및 펩티드 |
| EP2374481B1 (en) | 2008-07-21 | 2015-11-04 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
| GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| US9005598B2 (en) | 2009-03-04 | 2015-04-14 | Polytherics Limited | Conjugated proteins and peptides |
-
2009
- 2009-07-17 EP EP11171786.4A patent/EP2374481B1/en not_active Not-in-force
- 2009-07-17 ES ES11171786.4T patent/ES2560807T3/es active Active
- 2009-07-17 PL PL09784718T patent/PL2326349T3/pl unknown
- 2009-07-17 US US13/055,455 patent/US8969626B2/en not_active Expired - Fee Related
- 2009-07-17 ES ES09784718.0T patent/ES2536882T3/es active Active
- 2009-07-17 AU AU2009275358A patent/AU2009275358C1/en not_active Ceased
- 2009-07-17 KR KR1020117003833A patent/KR101763559B1/ko not_active Expired - Fee Related
- 2009-07-17 JP JP2011519228A patent/JP5622117B2/ja not_active Expired - Fee Related
- 2009-07-17 EP EP09784718.0A patent/EP2326349B1/en not_active Not-in-force
- 2009-07-17 WO PCT/GB2009/001764 patent/WO2010010324A1/en not_active Ceased
- 2009-07-17 DK DK11171786.4T patent/DK2374481T3/en active
- 2009-07-17 CN CN200980128495.3A patent/CN102099058B/zh not_active Expired - Fee Related
- 2009-07-17 DK DK09784718.0T patent/DK2326349T3/en active
-
2011
- 2011-07-01 US US13/175,820 patent/US8618333B2/en not_active Expired - Fee Related
- 2011-08-22 JP JP2011180530A patent/JP5626655B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-21 US US14/086,702 patent/US9896412B2/en not_active Expired - Fee Related
-
2015
- 2015-02-04 US US14/614,152 patent/US20150148544A1/en not_active Abandoned
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