CY1111642T1 - Παραγωγα διυδροπυριδινων - Google Patents

Παραγωγα διυδροπυριδινων

Info

Publication number
CY1111642T1
CY1111642T1 CY20111100516T CY111100516T CY1111642T1 CY 1111642 T1 CY1111642 T1 CY 1111642T1 CY 20111100516 T CY20111100516 T CY 20111100516T CY 111100516 T CY111100516 T CY 111100516T CY 1111642 T1 CY1111642 T1 CY 1111642T1
Authority
CY
Cyprus
Prior art keywords
alkyl
heteroaryl
alkynyl
alkenyl
dihydropyridine derivatives
Prior art date
Application number
CY20111100516T
Other languages
English (en)
Inventor
Straten Nicole Corine Renee Van
Gerritdina Geziena Gerritsma
Der Veen Lars Anders Van
Original Assignee
N.V. Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35837336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111642(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by N.V. Organon filed Critical N.V. Organon
Publication of CY1111642T1 publication Critical patent/CY1111642T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε παράγωγα διιδροπυριδινών που έχουν το γενικό τύπο (I) ή ένα φαρκακευτικά αποδεκτό άλας τους, R1 είναι (1-6C)αλκυλ, (2-C)αλκενυλ, (2-6C)αλκυνυλ, φαινυλ, (Ι-5C)ετεροαρυλ R2,R3 είναι ανεξάρτητα (1-4C)αλκυλ, (2-4C)αλκενυλ, (2-4C)αλκυνυλ, (1-4C)αλκοξυ, (24C)αλκενυλοξυ, (2-4C)αλκυνυλοξυ, αλογόνο Χ είναι SO2, CH2, C(O) ή Χ είναι απών R4 είναι (1-6C)αλκυλ, (2-6C)αλκενυλ, (2-6C)αλκυνυλ, (3-6C)κυκλοαλκυλ, (3-6C) κυκλοαλκενυλ, (3-6C)κυκλοαλκυλ (1-4C)αλκυλ, (2-6C)ετεροκυκλοαλκυλ, (2-6C) ετεροκυκλοαλκυλ (14C)αλκυλ, (6-10C)αρυλ, (6-10C)αρυλ (1-4C)αλκυλ, (1-9C)ετεροαρυλ ή (1-9C)ετεροαρυλ (14C)αλκυλ. Οι ενώσεις είναι χρήσιμες για τη θεραπεία διαταραχών στειρότητας.
CY20111100516T 2005-05-04 2011-05-27 Παραγωγα διυδροπυριδινων CY1111642T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05738155A EP1879866B1 (en) 2005-05-04 2005-05-04 Dihydropyridine derivatives
PCT/EP2005/052042 WO2006117023A1 (en) 2005-05-04 2005-05-04 Dihydropyridine derivatives

Publications (1)

Publication Number Publication Date
CY1111642T1 true CY1111642T1 (el) 2015-10-07

Family

ID=35837336

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100516T CY1111642T1 (el) 2005-05-04 2011-05-27 Παραγωγα διυδροπυριδινων

Country Status (23)

Country Link
US (1) US7994189B2 (el)
EP (1) EP1879866B1 (el)
JP (1) JP4869336B2 (el)
CN (1) CN101171234B (el)
AT (1) ATE502014T1 (el)
AU (1) AU2005331482B2 (el)
BR (1) BRPI0520259A2 (el)
CA (1) CA2606521C (el)
CY (1) CY1111642T1 (el)
DE (1) DE602005027002D1 (el)
DK (1) DK1879866T3 (el)
ES (1) ES2361674T3 (el)
HK (1) HK1110855A1 (el)
HR (1) HRP20110344T1 (el)
IL (1) IL186660A0 (el)
MX (1) MX2007013745A (el)
NO (1) NO20075579L (el)
NZ (1) NZ562541A (el)
PL (1) PL1879866T3 (el)
PT (1) PT1879866E (el)
RS (1) RS51784B (el)
SI (1) SI1879866T1 (el)
WO (1) WO2006117023A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
US20150296779A1 (en) * 2012-11-28 2015-10-22 Stichting Dienst Landbouwkundig Onderzoek Substituted dihydropyridines for somatic embryogenesis in plants
CN110357993B (zh) * 2019-07-09 2020-05-05 清华大学 一种可作为抑菌添加剂的含1,4-二氢吡啶结构的新型高分子

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070162B (de) 1959-12-03 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
GB9515445D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa Dihydropyridine and pyridine derivatives and process for their preparation
AU7333496A (en) 1995-10-19 1997-05-07 Takeda Chemical Industries Ltd. Quinoline derivatives as gnrh antagonists
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
ATE329911T1 (de) 1998-08-07 2006-07-15 Applied Research Systems Fsh mimetika zur behandlung von infertilität
WO2002009706A1 (en) 2000-07-27 2002-02-07 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
RU2347570C2 (ru) 2001-07-02 2009-02-27 Н.В.Органон Тетрагидрохинолиновые производные
JP2003026630A (ja) 2001-07-13 2003-01-29 Taoka Chem Co Ltd カラーカプラー中間体用カルボン酸クロリド類の製造法
TWI322012B (en) 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия

Also Published As

Publication number Publication date
JP2008540349A (ja) 2008-11-20
US20090215773A1 (en) 2009-08-27
AU2005331482B2 (en) 2011-06-02
JP4869336B2 (ja) 2012-02-08
CA2606521A1 (en) 2006-11-09
CN101171234B (zh) 2011-11-16
ATE502014T1 (de) 2011-04-15
CN101171234A (zh) 2008-04-30
EP1879866A1 (en) 2008-01-23
NO20075579L (no) 2008-01-18
BRPI0520259A2 (pt) 2009-09-15
WO2006117023A1 (en) 2006-11-09
PL1879866T3 (pl) 2011-07-29
ES2361674T3 (es) 2011-06-21
CA2606521C (en) 2012-09-18
NZ562541A (en) 2009-02-28
SI1879866T1 (sl) 2011-06-30
IL186660A0 (en) 2008-01-20
AU2005331482A1 (en) 2006-11-09
MX2007013745A (es) 2008-01-24
US7994189B2 (en) 2011-08-09
DE602005027002D1 (en) 2011-04-28
DK1879866T3 (da) 2011-06-06
PT1879866E (pt) 2011-06-01
EP1879866B1 (en) 2011-03-16
RS51784B (en) 2011-12-31
HK1110855A1 (en) 2008-07-25
HRP20110344T1 (hr) 2011-06-30

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