JP2010525059A5 - - Google Patents

Info

Publication number

JP2010525059A5

JP2010525059A5 JP2010506241A JP2010506241A JP2010525059A5 JP 2010525059 A5 JP2010525059 A5 JP 2010525059A5 JP 2010506241 A JP2010506241 A JP 2010506241A JP 2010506241 A JP2010506241 A JP 2010506241A JP 2010525059 A5 JP2010525059 A5 JP 2010525059A5

Authority

JP

Japan

Prior art keywords

composition

cyclodextrin

weight

water

solvent

Prior art date

2008-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims description 74
• 229920000858 Cyclodextrin Polymers 0.000 claims description 25
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 23
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
• 239000002904 solvent Substances 0.000 claims description 16
• AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 claims description 13
• 229960003760 florfenicol Drugs 0.000 claims description 13
• 150000003839 salts Chemical class 0.000 claims description 8
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
• 238000000034 method Methods 0.000 claims description 5
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 239000001116 FEMA 4028 Substances 0.000 claims description 3
• 229960004853 betadex Drugs 0.000 claims description 3
• OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical compound CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 claims description 2
• -1 2-pyrrole Chemical compound 0.000 claims description 2
• 239000003963 antioxidant agent Substances 0.000 claims description 2
• 239000003086 colorant Substances 0.000 claims description 2
• 239000003651 drinking water Substances 0.000 claims description 2
• 235000020188 drinking water Nutrition 0.000 claims description 2
• 239000000796 flavoring agent Substances 0.000 claims description 2
• 235000013355 food flavoring agent Nutrition 0.000 claims description 2
• 235000003599 food sweetener Nutrition 0.000 claims description 2
• 229940068886 polyethylene glycol 300 Drugs 0.000 claims description 2
• 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 2
• 239000003755 preservative agent Substances 0.000 claims description 2
• 229960004063 propylene glycol Drugs 0.000 claims description 2
• 239000003381 stabilizer Substances 0.000 claims description 2
• 239000003765 sweetening agent Substances 0.000 claims description 2
• DYUQAZSOFZSPHD-UHFFFAOYSA-N Phenylpropanol Chemical compound CCC(O)C1=CC=CC=C1 DYUQAZSOFZSPHD-UHFFFAOYSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
• HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
• 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
• 230000009918 complex formation Effects 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
• 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1