JP2010524914A5 - - Google Patents

Download PDF

Info

Publication number
JP2010524914A5
JP2010524914A5 JP2010503606A JP2010503606A JP2010524914A5 JP 2010524914 A5 JP2010524914 A5 JP 2010524914A5 JP 2010503606 A JP2010503606 A JP 2010503606A JP 2010503606 A JP2010503606 A JP 2010503606A JP 2010524914 A5 JP2010524914 A5 JP 2010524914A5
Authority
JP
Japan
Prior art keywords
alkyl
heterocycloalkyl
group
cycloalkyl
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010503606A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010524914A (ja
JP4782239B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2008/000845 external-priority patent/WO2008129380A1/en
Publication of JP2010524914A publication Critical patent/JP2010524914A/ja
Publication of JP2010524914A5 publication Critical patent/JP2010524914A5/ja
Application granted granted Critical
Publication of JP4782239B2 publication Critical patent/JP4782239B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010503606A 2007-04-18 2008-04-07 異常細胞増殖治療のためのスルホニルアミド誘導体 Active JP4782239B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91259707P 2007-04-18 2007-04-18
US60/912,597 2007-04-18
PCT/IB2008/000845 WO2008129380A1 (en) 2007-04-18 2008-04-07 Sulfonyl amide derivatives for the treatment of abnormal cell growth

Publications (3)

Publication Number Publication Date
JP2010524914A JP2010524914A (ja) 2010-07-22
JP2010524914A5 true JP2010524914A5 (cg-RX-API-DMAC7.html) 2011-05-19
JP4782239B2 JP4782239B2 (ja) 2011-09-28

Family

ID=39646361

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010503606A Active JP4782239B2 (ja) 2007-04-18 2008-04-07 異常細胞増殖治療のためのスルホニルアミド誘導体

Country Status (32)

Country Link
US (13) US7928109B2 (cg-RX-API-DMAC7.html)
EP (1) EP2146779B1 (cg-RX-API-DMAC7.html)
JP (1) JP4782239B2 (cg-RX-API-DMAC7.html)
KR (1) KR101132880B1 (cg-RX-API-DMAC7.html)
CN (2) CN103951658B (cg-RX-API-DMAC7.html)
AP (1) AP2009005010A0 (cg-RX-API-DMAC7.html)
AR (1) AR066125A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008240359B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0810411B8 (cg-RX-API-DMAC7.html)
CA (1) CA2684447C (cg-RX-API-DMAC7.html)
CL (1) CL2008001076A1 (cg-RX-API-DMAC7.html)
CO (1) CO6260093A2 (cg-RX-API-DMAC7.html)
CU (1) CU23813A3 (cg-RX-API-DMAC7.html)
DK (1) DK2146779T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2009000248A (cg-RX-API-DMAC7.html)
EA (1) EA016679B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP099694A (cg-RX-API-DMAC7.html)
ES (1) ES2593486T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20125581B (cg-RX-API-DMAC7.html)
GT (1) GT200900272A (cg-RX-API-DMAC7.html)
IL (3) IL201468A (cg-RX-API-DMAC7.html)
MA (1) MA31319B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009011090A (cg-RX-API-DMAC7.html)
NI (1) NI200900190A (cg-RX-API-DMAC7.html)
NZ (1) NZ580372A (cg-RX-API-DMAC7.html)
PA (1) PA8777101A1 (cg-RX-API-DMAC7.html)
PE (1) PE20090434A1 (cg-RX-API-DMAC7.html)
TN (1) TN2009000428A1 (cg-RX-API-DMAC7.html)
TW (1) TWI369205B (cg-RX-API-DMAC7.html)
UA (1) UA97834C2 (cg-RX-API-DMAC7.html)
UY (1) UY31026A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008129380A1 (cg-RX-API-DMAC7.html)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4782239B2 (ja) * 2007-04-18 2011-09-28 ファイザー・プロダクツ・インク 異常細胞増殖治療のためのスルホニルアミド誘導体
JP2011515372A (ja) * 2008-03-20 2011-05-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリミジン類の位置選択的製造法
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
WO2009122180A1 (en) * 2008-04-02 2009-10-08 Medical Research Council Pyrimidine derivatives capable of inhibiting one or more kinases
WO2010025831A1 (de) * 2008-09-03 2010-03-11 Bayer Cropscience Ag Heterozyklisch substituierte anilinopyrimidine als fungizide
UY32240A (es) * 2008-11-14 2010-06-30 Boeringer Ingelheim Kg Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones.
JP2010111702A (ja) 2009-02-16 2010-05-20 Tetsuya Nishio 複素環化合物、その製造法および用途
CN101812016B (zh) * 2009-02-23 2013-01-16 浙江海翔药业股份有限公司 一种制备依托昔布中间体-6-甲基烟酸及其酯的方法
EP2261211A1 (en) * 2009-05-20 2010-12-15 Université de Lille 2 Droit et Santé 1,4-dihydropyridine derivatives and their uses
TW201100441A (en) * 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
AU2010254806C1 (en) 2009-06-05 2016-07-07 Cephalon, Inc. Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
WO2011018517A1 (en) 2009-08-14 2011-02-17 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
WO2011107585A1 (en) 2010-03-04 2011-09-09 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
RU2528386C2 (ru) 2010-05-21 2014-09-20 Кемилиа Аб Новые производные пиримидина
CA2797947C (en) * 2010-06-04 2019-07-09 Charles Baker-Glenn Aminopyrimidine derivatives as lrrk2 modulators
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
JP6000273B2 (ja) 2010-11-29 2016-09-28 オーエスアイ・ファーマシューティカルズ，エルエルシー 大環状キナーゼ阻害剤
WO2012110773A1 (en) 2011-02-17 2012-08-23 Cancer Therapeutics Crc Pty Limited Fak inhibitors
JP5937112B2 (ja) 2011-02-17 2016-06-22 カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ 選択的ｆａｋ阻害剤
DK2688883T3 (en) 2011-03-24 2016-09-05 Noviga Res Ab pyrimidine
FI2699553T3 (fi) 2011-04-22 2024-01-24 Signal Pharm Llc Substituoituja diaminokarboksamidi- ja diaminokarbonitriilipyrimidiinejä, niiden koostumuksia ja niitä käyttäviä hoitomenetelmiä
JP2014521623A (ja) * 2011-07-28 2014-08-28 セルゾーム リミティッド Ｊａｋ阻害剤としてのヘテロシクリルピリミジンアナログ
RU2564419C1 (ru) * 2011-07-28 2015-09-27 Целльзом Лимитид Гетероциклические аналоги пиримидина в качестве ингибиторов jak
WO2013041652A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
WO2013050508A1 (en) 2011-10-07 2013-04-11 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mtor inhibitors
CN104169272A (zh) 2011-12-23 2014-11-26 赛尔佐姆有限公司 作为激酶抑制剂的嘧啶-2,4-二胺衍生物
EA033124B1 (ru) * 2012-03-06 2019-08-30 Сефалон, Инк. Применение конденсированного бициклического 2,4-диаминопиримидинового производного для лечения alk- или fak-опосредованного заболевания или нарушения у субъекта
KR20150013554A (ko) 2012-05-24 2015-02-05 셀좀 리미티드 Tyk2 억제제로서의 헤테로시클릴 피리미딘 유사체
CN115708827A (zh) * 2014-01-09 2023-02-24 维瑞斯特姆股份有限公司 用于治疗异常细胞生长的组合物和方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9962385B2 (en) * 2014-02-07 2018-05-08 Verastem, Inc. Methods and compositions for treating abnormal cell growth
JP6663857B2 (ja) 2014-05-14 2020-03-13 ファイザー・インク ピラゾロピリジンおよびピラゾロピリミジン
KR102606253B1 (ko) 2014-12-16 2023-11-27 시그날 파마소티칼 엘엘씨 2-(tert-부틸아미노)-4-((1r,3r,4r)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복사마이드의 제형
US9513297B2 (en) 2014-12-16 2016-12-06 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
WO2016100452A2 (en) * 2014-12-17 2016-06-23 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2016123291A1 (en) 2015-01-29 2016-08-04 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
ES2987376T3 (es) 2015-06-29 2024-11-14 Verastem Inc Composiciones terapéuticas, combinaciones y métodos de uso
CA3208587A1 (en) 2015-07-24 2017-02-02 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
CN105111204B (zh) * 2015-08-14 2016-09-14 天津小新医药科技有限公司 吡啶盐类酪氨酸激酶抑制剂、制备方法及其用途
CN105153150B (zh) * 2015-08-14 2016-09-14 天津小新医药科技有限公司 一类吡啶盐类jak抑制剂、制备方法及其用途
CN105503860B (zh) * 2015-10-13 2017-03-01 天津小新医药科技有限公司 一类腈基取代的吡啶盐类jak抑制剂、制备方法及其用途
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
CN106279011A (zh) * 2016-08-16 2017-01-04 成都百事兴科技实业有限公司 一种2,4‑二羟基‑6‑甲基烟酸乙酯的制备方法
WO2019117813A1 (en) * 2017-12-15 2019-06-20 National University Of Singapore Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
RU2020133451A (ru) 2018-03-12 2022-04-12 Инститьют Насьонал Де Ла Санте Et De La Решерш Медикаль (Инсерм) Применение терапевтически эффективной комбинации химиотерапиии и ингибитора контрольной точки иммунного ответа с миметиком ограничения калорийности для лечения рака
KR102632257B1 (ko) * 2018-05-07 2024-01-31 하이노바 파마슈티컬스 인코포레이티드 중수소화 데팍티닙 화합물 및 이의 용도
WO2020006724A1 (zh) * 2018-07-05 2020-01-09 清华大学 一种靶向降解fak蛋白的化合物及其应用
US20220040317A1 (en) * 2018-09-27 2022-02-10 Dana-Farber Cancer Institute, Inc. Degradation of fak or fak and alk by conjugation of fak and alk inhibitors with e3 ligase ligands and methods of use
BR112021012682A2 (pt) * 2018-12-27 2021-09-08 Hinova Pharmaceuticals Inc. Inibidor de fak e combinação de fármaco do mesmo
WO2021047783A1 (en) 2019-09-13 2021-03-18 The Institute Of Cancer Research: Royal Cancer Hospital Vs-6063 in combination with ch5126766 for the treatment of cancer
CN115151252B (zh) * 2020-03-02 2024-08-27 维泰瑞隆有限公司 铁死亡抑制剂-二芳基胺对乙酰胺类
CA3202990A1 (en) * 2020-11-27 2022-06-02 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Aminoheteroaryl kinase inhibitors
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用
CN112624966B (zh) * 2020-12-25 2022-12-23 杭州澳赛诺生物科技有限公司 一种2-氨甲基-4-甲基-5-吡啶羧酸的合成方法
US20240059678A1 (en) * 2021-01-18 2024-02-22 Hinova Pharmaceuticals Inc. Synthesis Method for Aminopyrimidine FAK Inhibitor Compound
JP2024519388A (ja) * 2021-05-25 2024-05-10 ヒノバ ファーマシューティカルズ インコーポレイテッド 癌を治療するための医薬組成物及びその使用
CN113372334B (zh) * 2021-05-25 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基-5-三氟甲基嘧啶衍生物及其应用
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
CN114716385B (zh) * 2022-04-08 2024-03-12 北京师范大学 靶向粘着斑激酶的化合物及制备方法和应用
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor
WO2024071371A1 (ja) * 2022-09-30 2024-04-04 ユビエンス株式会社 複素環式化合物
WO2024249831A2 (en) * 2023-06-02 2024-12-05 Unogen Biotech Ltd. Triple kinase inhibitors
CN117105916B (zh) * 2023-10-23 2024-01-16 希格生科（深圳）有限公司 苯并呋喃类化合物及其医药用途
WO2025166124A1 (en) * 2024-02-02 2025-08-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof
WO2025166180A1 (en) * 2024-02-02 2025-08-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof
KR20250169302A (ko) 2024-03-22 2025-12-02 브리스톨-마이어스 스큅 컴퍼니 신규 fak 분해제 화합물 및 그의 용도

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507146A (en) 1982-12-28 1985-03-26 Ciba-Geigy Corporation 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
WO1992020642A1 (en) 1991-05-10 1992-11-26 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9314884D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Tricyclic derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
GB9424233D0 (en) 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
JP3053222B2 (ja) 1995-04-20 2000-06-19 ファイザー・インコーポレーテッド Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
PT780386E (pt) 1995-12-20 2003-02-28 Hoffmann La Roche Inibidores de metaloprotease de matriz
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
TW440563B (en) 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
EP0818442A3 (en) 1996-07-12 1998-12-30 Pfizer Inc. Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
PT912559E (pt) 1996-07-13 2003-03-31 Glaxo Group Ltd Compostos heterociclicos fundidos como inibidores de proteina tirosina quinase
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
CN1230185A (zh) 1996-07-13 1999-09-29 葛兰素集团有限公司 双环芳杂环化合物用作蛋白质酪氨酸激酶的抑制剂
AU712973B2 (en) 1996-07-18 1999-11-18 Pfizer Inc. Phosphinate based inhibitors of matrix metalloproteases
AU711585B2 (en) 1996-08-23 1999-10-14 Pfizer Inc. Arylsulfonylamino hydroxamic acid derivatives
AU5131998A (en) 1997-01-06 1998-08-03 Pfizer Inc. Cyclic sulfone derivatives
PL335027A1 (en) 1997-02-03 2000-03-27 Pfizer Prod Inc Derivatives of arylsulphonylamino hydroxamic acid
BR9807824A (pt) 1997-02-07 2000-03-08 Pfizer Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
JP3710489B2 (ja) 1997-02-11 2005-10-26 ファイザー・インク アリールスルホニルヒドロキサム酸誘導体
DK1003720T3 (da) 1997-08-08 2004-05-10 Pfizer Prod Inc Aryloxyarylsulfonylaminohydroxamsyrederivater
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
EA200000840A1 (ru) 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
IT1302431B1 (it) * 1998-08-12 2000-09-05 Alasi Di Arcieri Franco & C S Dispositivo di controllo di accessi in rete tramite il riconoscimentoveloce di trame applicative che soddisfano un insieme di regole
DK1004578T3 (da) 1998-11-05 2004-06-28 Pfizer Prod Inc 5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
ES2252996T3 (es) 1999-01-13 2006-05-16 Warner-Lambert Company Llc Derivados de bencenosulfonamida y su uso como inhibidores de mek.
EP1081137A1 (en) 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
US6525051B2 (en) 2000-03-27 2003-02-25 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
CA2406562C (en) 2000-05-08 2009-09-15 Janssen Pharmaceutica N.V. Hiv replication inhibiting pyrimidines and triazines
EP1282607B1 (en) 2000-05-08 2015-11-11 Janssen Pharmaceutica NV Prodrugs of hiv replication inhibiting pyrimidines
US6630469B2 (en) 2000-05-09 2003-10-07 Bristol-Myers Squibb Company 5-HT7 receptor antagonists
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
US6853233B1 (en) * 2000-09-13 2005-02-08 Infineon Technologies Ag Level-shifting circuitry having “high” output impedance during disable mode
IT1319686B1 (it) 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
PT1355905E (pt) 2000-12-21 2007-05-31 Vertex Pharma Compostos de pirazole úteis como inibidores de proteínaquinase
WO2002096888A1 (de) 2001-05-29 2002-12-05 Schering Aktiengesellschaft Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
WO2002102783A1 (en) 2001-06-19 2002-12-27 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2005500294A (ja) 2001-06-19 2005-01-06 ブリストル−マイヤーズ　スクイブ　カンパニー ホスホジエステラーゼ７に対するピリミジン阻害剤
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
WO2003030909A1 (en) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
WO2003040141A1 (en) 2001-09-28 2003-05-15 Bayer Pharmaceuticals Corporation Oxazolyl-phenyl-2,4-diamino-pyrimidine compounds and methods for treating hyperproliferative disorders
CA2463989C (en) 2001-10-17 2012-01-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US7008378B2 (en) * 2002-03-07 2006-03-07 Dean Melanie A Patient conditional diagnosis assessment and symptom tracking system
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AU2003231231A1 (en) * 2002-05-06 2003-11-11 Bayer Pharmaceuticals Corporation Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
US7449456B2 (en) 2002-06-28 2008-11-11 Astellas Pharma, Inc. Diaminopyrimidinecarboxamide derivative
BR0313059B8 (pt) 2002-07-29 2021-07-27 Rigel Pharmaceuticals composto, e, composição farmacêutica
CA2503715A1 (en) 2002-10-30 2004-05-21 Merck & Co., Inc. Kinase inhibitors
RS20050363A (sr) 2002-11-28 2007-11-15 Schering Aktiengesellschaft, Chk-,Pdk- I Akt-INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH SREDSTAVA
SE0203820D0 (sv) * 2002-12-20 2002-12-20 Astrazeneca Ab chemical compounds
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
US7109337B2 (en) 2002-12-20 2006-09-19 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GEP20084357B (en) * 2002-12-20 2008-04-29 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
AP2065A (en) 2003-02-07 2009-11-26 Janssen Pharmaceutica Nv Pyrimidine derivatives for the prevention of HIV infection
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
US7504396B2 (en) 2003-06-24 2009-03-17 Amgen Inc. Substituted heterocyclic compounds and methods of use
WO2005003103A2 (en) 2003-06-30 2005-01-13 Astrazeneca Ab 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
CN1826328A (zh) 2003-07-22 2006-08-30 神经能质公司 经取代的吡啶－2－基胺类似物
SI2287156T1 (sl) 2003-08-15 2013-09-30 Novartis Ag 2,4-di(fenilamino)-pirimidini, uporabni pri zdravljenju neoplastičnih bolezni, vnetnih motenj in motenj imunskega sistema
WO2005023780A1 (en) 2003-09-05 2005-03-17 Pfizer Products Inc. Selective synthesis of cf3-substituted pyrimidines
US7363505B2 (en) * 2003-12-03 2008-04-22 Pen-One Inc Security authentication method and system
AP2241A (en) * 2004-05-14 2011-06-01 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth.
MXPA06011658A (es) 2004-05-14 2006-12-14 Pfizer Prod Inc Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
CA2564199A1 (en) * 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
EP1751142A1 (en) * 2004-05-14 2007-02-14 Pfizer Products Incorporated Pyrimidines derivatives for the treatment of abnormal cell growth
EP1598343A1 (de) 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
DK1756084T3 (da) 2004-06-04 2009-03-23 Arena Pharm Inc Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed
EP1765325A4 (en) 2004-07-01 2009-08-12 Synta Pharmaceuticals Corp HETEROARYL COMPOUNDS SUBSTITUTED IN 2
US7521457B2 (en) * 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
MX2007004488A (es) 2004-10-13 2007-09-11 Wyeth Corp Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos.
US7923557B2 (en) 2004-11-10 2011-04-12 Synta Pharmaceuticals Corporation Process for preparing trisubstituted pyrimidine compounds
TW200628463A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp Heteroaryl compounds
EP1912636B1 (en) 2005-07-21 2014-06-25 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek
US8722884B2 (en) * 2005-12-01 2014-05-13 Verastem, Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
JP4332590B2 (ja) 2005-12-21 2009-09-16 ファイザー・プロダクツ・インク 異常細胞増殖を治療するためのピリミジン誘導体
JP4782239B2 (ja) * 2007-04-18 2011-09-28 ファイザー・プロダクツ・インク 異常細胞増殖治療のためのスルホニルアミド誘導体

Similar Documents

Publication Publication Date Title
JP2010524914A5 (cg-RX-API-DMAC7.html)
CA2684447A1 (en) Sulfonyl amide derivatives for the treatment of abnormal cell growth
JP7169412B2 (ja) 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体
JP2010540458A5 (cg-RX-API-DMAC7.html)
JP2016519685A5 (cg-RX-API-DMAC7.html)
JP2009535335A5 (cg-RX-API-DMAC7.html)
JP2013056930A5 (cg-RX-API-DMAC7.html)
JP2015503529A5 (cg-RX-API-DMAC7.html)
RU2008145662A (ru) Ингибиторы фосфоинозитид-3-киназы и содержащие их фармацевтические композиции
SI2797918T1 (en) Bromodomain inhibitors
RU2015148359A (ru) Хиназолины и азахиназолины - двойные ингибиторы путей ras/raf/mek/erk и pi3k/akt/pten/mtor
JP2009513703A5 (cg-RX-API-DMAC7.html)
JP2010512337A5 (cg-RX-API-DMAC7.html)
NZ593594A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP2020515571A5 (cg-RX-API-DMAC7.html)
JP2014514317A5 (cg-RX-API-DMAC7.html)
JP2009511490A5 (cg-RX-API-DMAC7.html)
JP2014513704A5 (cg-RX-API-DMAC7.html)
CA2651363A1 (en) Triazolopyrazine derivatives useful as anti-cancer agents
JP2012512887A5 (cg-RX-API-DMAC7.html)
RU2009125916A (ru) Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения
JP2005518382A5 (cg-RX-API-DMAC7.html)
JP2016525078A5 (cg-RX-API-DMAC7.html)
SI2824100T1 (en) 1,2,5-oxadiazoles as inhibitors of indolamine 2,3-dioxygenase
RU2014101464A (ru) Циклопропил-конденсированные-1,3-тиазепины в качестве ингибиторов васе 1 и(или) васе 2