JP2010523562A5 - - Google Patents
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- JP2010523562A5 JP2010523562A5 JP2010502114A JP2010502114A JP2010523562A5 JP 2010523562 A5 JP2010523562 A5 JP 2010523562A5 JP 2010502114 A JP2010502114 A JP 2010502114A JP 2010502114 A JP2010502114 A JP 2010502114A JP 2010523562 A5 JP2010523562 A5 JP 2010523562A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- pyrido
- tetrahydro
- methyl
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- RKPAFGOLZJQTPL-LJQANCHMSA-N (2s)-2-[[6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-yl]amino]-2-phenylethanol Chemical compound N1=CC(C)=CC=C1N1CC2=C(N[C@H](CO)C=3C=CC=CC=3)N=CN=C2CC1 RKPAFGOLZJQTPL-LJQANCHMSA-N 0.000 claims description 2
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- CMEYRTUYGFNHBD-FQEVSTJZSA-N 6-(5-chloropyridin-2-yl)-n-[(s)-cyclopropyl-[6-(trifluoromethyl)pyridin-3-yl]methyl]-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=NC(C(F)(F)F)=CC=C1[C@H](C1CC1)NC1=NC=NC2=C1CN(C=1N=CC(Cl)=CC=1)CC2 CMEYRTUYGFNHBD-FQEVSTJZSA-N 0.000 claims description 2
- DGCROPBFIBILRA-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(1-naphthalen-1-ylethyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 DGCROPBFIBILRA-UHFFFAOYSA-N 0.000 claims description 2
- XVVMIRNQEFEULE-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(1-phenylpropyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC=CC=1C(CC)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 XVVMIRNQEFEULE-UHFFFAOYSA-N 0.000 claims description 2
- UUWHBMBIWZIRLD-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(1-pyridin-2-ylethyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC=NC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 UUWHBMBIWZIRLD-UHFFFAOYSA-N 0.000 claims description 2
- KHKPRVFTDKPHCV-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(1-pyridin-3-ylethyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CN=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 KHKPRVFTDKPHCV-UHFFFAOYSA-N 0.000 claims description 2
- QVWXUUHKIMGPFG-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(1-pyridin-4-ylethyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=NC=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 QVWXUUHKIMGPFG-UHFFFAOYSA-N 0.000 claims description 2
- MEMSDESZGNUHMN-UHFFFAOYSA-N 6-(5-methylpyridin-2-yl)-n-(2,2,2-trifluoro-1-phenylethyl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N1=CC(C)=CC=C1N1CC2=C(NC(C=3C=CC=CC=3)C(F)(F)F)N=CN=C2CC1 MEMSDESZGNUHMN-UHFFFAOYSA-N 0.000 claims description 2
- XNAFMMCWOUXFDU-CQSZACIVSA-N 6-(5-methylpyridin-2-yl)-n-[(1r)-1-(2-methylpyrimidin-5-yl)ethyl]-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@H](C)C=1C=NC(C)=NC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 XNAFMMCWOUXFDU-CQSZACIVSA-N 0.000 claims description 2
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- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 2
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- BSHIAFMHMKJSPC-MRXNPFEDSA-N n-[(1r)-1-(3-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound COC1=CC=CC([C@@H](C)NC=2C=3CN(CCC=3N=CN=2)C=2N=CC(C)=CC=2)=C1 BSHIAFMHMKJSPC-MRXNPFEDSA-N 0.000 claims description 2
- CJYBSPSAYUVDMV-CYBMUJFWSA-N n-[(1r)-1-(4-chlorophenyl)ethyl]-6-(5-chloropyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@H](C)C=1C=CC(Cl)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(Cl)C=N1 CJYBSPSAYUVDMV-CYBMUJFWSA-N 0.000 claims description 2
- NAJWMPSVESSMGN-OAHLLOKOSA-N n-[(1r)-1-(4-chlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@H](C)C=1C=CC(Cl)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 NAJWMPSVESSMGN-OAHLLOKOSA-N 0.000 claims description 2
- DUPYPBQTFOKCSC-OAHLLOKOSA-N n-[(1r)-1-(4-fluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@H](C)C=1C=CC(F)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 DUPYPBQTFOKCSC-OAHLLOKOSA-N 0.000 claims description 2
- YGIOSPPWRLVBJP-MRXNPFEDSA-N n-[(1r)-1-(4-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=CC(OC)=CC=C1[C@@H](C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 YGIOSPPWRLVBJP-MRXNPFEDSA-N 0.000 claims description 2
- JSQPMXXGCBUZST-QGZVFWFLSA-N n-[(1r)-1-(4-methylphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@H](C)C=1C=CC(C)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 JSQPMXXGCBUZST-QGZVFWFLSA-N 0.000 claims description 2
- BSHIAFMHMKJSPC-INIZCTEOSA-N n-[(1s)-1-(3-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound COC1=CC=CC([C@H](C)NC=2C=3CN(CCC=3N=CN=2)C=2N=CC(C)=CC=2)=C1 BSHIAFMHMKJSPC-INIZCTEOSA-N 0.000 claims description 2
- NAJWMPSVESSMGN-HNNXBMFYSA-N n-[(1s)-1-(4-chlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@@H](C)C=1C=CC(Cl)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 NAJWMPSVESSMGN-HNNXBMFYSA-N 0.000 claims description 2
- DUPYPBQTFOKCSC-HNNXBMFYSA-N n-[(1s)-1-(4-fluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@@H](C)C=1C=CC(F)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 DUPYPBQTFOKCSC-HNNXBMFYSA-N 0.000 claims description 2
- YGIOSPPWRLVBJP-INIZCTEOSA-N n-[(1s)-1-(4-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=CC(OC)=CC=C1[C@H](C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 YGIOSPPWRLVBJP-INIZCTEOSA-N 0.000 claims description 2
- JSQPMXXGCBUZST-KRWDZBQOSA-N n-[(1s)-1-(4-methylphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound N([C@@H](C)C=1C=CC(C)=CC=1)C(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 JSQPMXXGCBUZST-KRWDZBQOSA-N 0.000 claims description 2
- CLBSVPYCZLWSCF-UHFFFAOYSA-N n-[1-(2,4-dichlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 CLBSVPYCZLWSCF-UHFFFAOYSA-N 0.000 claims description 2
- HUNKNRMFRKNUAR-UHFFFAOYSA-N n-[1-(2,4-difluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=C(F)C=C(F)C=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 HUNKNRMFRKNUAR-UHFFFAOYSA-N 0.000 claims description 2
- YCUDKFILFQRHLI-UHFFFAOYSA-N n-[1-(2-chlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC=C(Cl)C=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 YCUDKFILFQRHLI-UHFFFAOYSA-N 0.000 claims description 2
- GGDAJJXTRCEWJF-UHFFFAOYSA-N n-[1-(2-fluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC=C(F)C=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 GGDAJJXTRCEWJF-UHFFFAOYSA-N 0.000 claims description 2
- VUJYFXHHIVJFMA-UHFFFAOYSA-N n-[1-(2-methoxy-5-methylphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound COC1=CC=C(C)C=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 VUJYFXHHIVJFMA-UHFFFAOYSA-N 0.000 claims description 2
- KCOZDLJGLHTDIQ-UHFFFAOYSA-N n-[1-(2-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound COC1=CC=CC=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 KCOZDLJGLHTDIQ-UHFFFAOYSA-N 0.000 claims description 2
- STMMULZVHSKPDR-UHFFFAOYSA-N n-[1-(3,5-difluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C(F)=CC(F)=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 STMMULZVHSKPDR-UHFFFAOYSA-N 0.000 claims description 2
- IUPSCNROFMBCEW-UHFFFAOYSA-N n-[1-(3-chlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC(Cl)=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 IUPSCNROFMBCEW-UHFFFAOYSA-N 0.000 claims description 2
- DQEIWRKPVLQBJW-UHFFFAOYSA-N n-[1-(3-fluoro-4-methoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=C(F)C(OC)=CC=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 DQEIWRKPVLQBJW-UHFFFAOYSA-N 0.000 claims description 2
- GJAUWURFLVNMPO-UHFFFAOYSA-N n-[1-(3-fluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=CC(F)=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 GJAUWURFLVNMPO-UHFFFAOYSA-N 0.000 claims description 2
- YVOGFFAHHJCXSZ-UHFFFAOYSA-N n-[1-(4-bromophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=C(Br)C=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 YVOGFFAHHJCXSZ-UHFFFAOYSA-N 0.000 claims description 2
- CNUGQOFQIIDDCR-UHFFFAOYSA-N n-[1-(4-chloro-3-fluorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=C(Cl)C(F)=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 CNUGQOFQIIDDCR-UHFFFAOYSA-N 0.000 claims description 2
- NAJWMPSVESSMGN-UHFFFAOYSA-N n-[1-(4-chlorophenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C=C(Cl)C=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 NAJWMPSVESSMGN-UHFFFAOYSA-N 0.000 claims description 2
- RHMCVUQKMIMGDA-UHFFFAOYSA-N n-[1-(4-ethoxyphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=CC(OCC)=CC=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 RHMCVUQKMIMGDA-UHFFFAOYSA-N 0.000 claims description 2
- WTEFMFHLHIXCDB-UHFFFAOYSA-N n-[1-(4-ethylphenyl)ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=CC(CC)=CC=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 WTEFMFHLHIXCDB-UHFFFAOYSA-N 0.000 claims description 2
- UFOPSRNDIOHMMG-UHFFFAOYSA-N n-[1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C=1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1C(C)NC(C=1C2)=NC=NC=1CCN2C1=CC=C(C)C=N1 UFOPSRNDIOHMMG-UHFFFAOYSA-N 0.000 claims description 2
- UWKZKGGSAWUHAF-UHFFFAOYSA-N n-[1-[4-(2-methylpropyl)phenyl]ethyl]-6-(5-methylpyridin-2-yl)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-4-amine Chemical compound C1=CC(CC(C)C)=CC=C1C(C)NC1=NC=NC2=C1CN(C=1N=CC(C)=CC=1)CC2 UWKZKGGSAWUHAF-UHFFFAOYSA-N 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 210000001738 temporomandibular joint Anatomy 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims description 2
- 230000001594 aberrant effect Effects 0.000 claims 1
- 230000001364 causal effect Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
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- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
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| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
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| PT2139334E (pt) * | 2007-04-17 | 2013-10-02 | Evotec Ag | Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos |
| WO2010080503A1 (en) * | 2008-12-19 | 2010-07-15 | Genentech, Inc. | Heterocyclic compounds and methods of use |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2619204A4 (en) * | 2010-09-21 | 2014-08-27 | Merck Sharp & Dohme | TRIAZOLOPYRAZINONE AS P2X7 RECEPTOR ANTAGONISTS |
| EP2790705B1 (en) | 2011-12-15 | 2017-12-06 | Novartis AG | Use of inhibitors of the activity or function of pi3k |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| EP3230281B1 (en) | 2014-12-09 | 2021-05-26 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| EP3325490B1 (en) * | 2015-07-23 | 2019-12-18 | Takeda Pharmaceutical Company Limited | 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists |
| MX2021010323A (es) * | 2019-03-01 | 2021-12-10 | Revolution Medicines Inc | Compuestos bicíclicos de heterociclilo y usos de este. |
| JP7797204B2 (ja) | 2019-05-31 | 2026-01-13 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体 |
| CA3139018A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN116194446A (zh) * | 2020-08-06 | 2023-05-30 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| WO2022112490A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| JP2023550830A (ja) * | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体 |
| CA3196335A1 (en) * | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| CA3207590A1 (en) * | 2021-02-08 | 2022-08-11 | Xuejun Zhang | Pyridopyrimidinone derivative, preparation method therefor, and use thereof |
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| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| PT1056725E (pt) | 1997-12-22 | 2006-09-29 | Bayer Pharmaceuticals Corp | Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo |
| IL136768A0 (en) | 1997-12-22 | 2001-06-14 | Bayer Ag | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
| AU778393B2 (en) | 1999-05-12 | 2004-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| US7087589B2 (en) | 2000-01-14 | 2006-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methanocarba cycloakyl nucleoside analogues |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| EP1301484A2 (en) | 2000-07-20 | 2003-04-16 | Neurogen Corporation | Capsaicin receptor ligands |
| WO2002053558A1 (en) | 2001-01-02 | 2002-07-11 | F.Hoffman-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| EP1480973B1 (en) | 2002-02-25 | 2008-02-13 | Boehringer Ingelheim Pharmaceuticals Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| JPWO2003104230A1 (ja) | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| WO2004056774A2 (en) | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| EP2295426A1 (en) | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| MX2007013595A (es) * | 2005-05-04 | 2008-01-24 | Renovis Inc | Compuestos heterociclicos fusionados y composiciones y usos de estos. |
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2008
- 2008-03-31 EP EP08727238.1A patent/EP2136639B1/en not_active Not-in-force
- 2008-03-31 WO PCT/US2008/004202 patent/WO2008123963A1/en not_active Ceased
- 2008-03-31 JP JP2010502114A patent/JP5396379B2/ja not_active Expired - Fee Related
- 2008-03-31 CA CA2682162A patent/CA2682162C/en not_active Expired - Fee Related
- 2008-03-31 US US12/594,364 patent/US8653091B2/en not_active Expired - Fee Related
- 2008-03-31 ES ES08727238.1T patent/ES2566387T3/es active Active
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