JP5396379B2 - ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 - Google Patents
ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 Download PDFInfo
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- JP5396379B2 JP5396379B2 JP2010502114A JP2010502114A JP5396379B2 JP 5396379 B2 JP5396379 B2 JP 5396379B2 JP 2010502114 A JP2010502114 A JP 2010502114A JP 2010502114 A JP2010502114 A JP 2010502114A JP 5396379 B2 JP5396379 B2 JP 5396379B2
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- Prior art keywords
- pyridin
- substituted
- pyrimidin
- pyrido
- tetrahydro
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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| US60/921,603 | 2007-04-02 | ||
| US60/921,604 | 2007-04-02 | ||
| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Publications (3)
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| JP2010523562A JP2010523562A (ja) | 2010-07-15 |
| JP2010523562A5 JP2010523562A5 (enExample) | 2011-04-07 |
| JP5396379B2 true JP5396379B2 (ja) | 2014-01-22 |
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| EP (1) | EP2136639B1 (enExample) |
| JP (1) | JP5396379B2 (enExample) |
| CA (1) | CA2682162C (enExample) |
| ES (1) | ES2566387T3 (enExample) |
| WO (1) | WO2008123963A1 (enExample) |
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| PT2139334E (pt) * | 2007-04-17 | 2013-10-02 | Evotec Ag | Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos |
| CN102316733B (zh) * | 2008-12-19 | 2014-01-01 | 健泰科生物技术公司 | 杂环化合物和使用方法 |
| UA112517C2 (uk) * | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| WO2012040048A2 (en) * | 2010-09-21 | 2012-03-29 | Schering Corporation | Triazolopyrazinones as p2x7 receptor antagonists |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| PT3587417T (pt) | 2014-12-09 | 2022-03-16 | Bayer Ag | Benzamidas substituídas por 1,3-tiazol-2-ilo |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| CA2993312A1 (en) * | 2015-07-23 | 2017-01-26 | Takeda Pharmaceutical Company Limited | 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists |
| EP3930845A1 (en) * | 2019-03-01 | 2022-01-05 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| WO2020239953A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| AU2020285336A1 (en) | 2019-05-31 | 2022-01-06 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as P2X3 inhibitors |
| CN116194446A (zh) * | 2020-08-06 | 2023-05-30 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| EP4251273B1 (en) * | 2020-11-27 | 2025-03-12 | Chiesi Farmaceutici S.p.A. | Phthalazine derivatives as p2x3 inhibitors |
| CA3196333A1 (en) * | 2020-11-27 | 2022-06-02 | Claudio FIORELLI | Amino quinazoline derivatives as p2x3 inhibitors |
| MX2023005805A (es) * | 2020-11-27 | 2023-06-01 | Chiesi Farm Spa | Derivados de 4-aminas de (aza)quinolina como inhibidores del purinorreceptor 3 p2x (p2x3). |
| WO2022166974A1 (zh) * | 2021-02-08 | 2022-08-11 | 武汉人福创新药物研发中心有限公司 | 吡啶并嘧啶酮类衍生物及其制备方法和用途 |
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| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| SK285371B6 (sk) | 1997-12-22 | 2006-12-07 | Bayer Corporation | Aryl- a heteroaryl-substituované heterocyklické močoviny, ich použitie a farmaceutické kompozície sich obsahom |
| WO1999032110A1 (en) | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
| AU778393B2 (en) | 1999-05-12 | 2004-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| EP1252160B1 (en) | 2000-01-14 | 2006-08-16 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Methanocarba cycloalkyl nucleoside analogues |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| BR0112631A (pt) | 2000-07-20 | 2003-09-23 | Neurogen Corp | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, pacote, métodos de reduzir a condutáncia de cálcio de um receptor de capsaicina e de tratar um mamìfero e uso de um composto |
| KR100554813B1 (ko) | 2001-01-02 | 2006-02-22 | 에프. 호프만-라 로슈 아게 | 알파 1에이/비 아드레날린성 수용체 길항제로서의퀴나졸론 유도체 |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| DE60319066T2 (de) | 2002-02-25 | 2009-02-26 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | 1,4-disubstituierte benzokondensierte cycloalkyl-harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| WO2003104230A1 (ja) | 2002-06-07 | 2003-12-18 | 協和醱酵工業株式会社 | 二環性ピリミジン誘導体 |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| WO2004056774A2 (en) | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| MXPA06012394A (es) | 2004-04-30 | 2007-01-31 | Bayer Pharmaceuticals Corp | Derivados de pirazolilurea sustituidos utiles en el tratamiento de cancer. |
| EP1885369B1 (en) * | 2005-05-04 | 2015-09-23 | Evotec AG | Fused heterocyclic compounds, and compositions and uses thereof |
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2008
- 2008-03-31 CA CA2682162A patent/CA2682162C/en not_active Expired - Fee Related
- 2008-03-31 EP EP08727238.1A patent/EP2136639B1/en not_active Not-in-force
- 2008-03-31 US US12/594,364 patent/US8653091B2/en not_active Expired - Fee Related
- 2008-03-31 WO PCT/US2008/004202 patent/WO2008123963A1/en not_active Ceased
- 2008-03-31 JP JP2010502114A patent/JP5396379B2/ja not_active Expired - Fee Related
- 2008-03-31 ES ES08727238.1T patent/ES2566387T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110009432A1 (en) | 2011-01-13 |
| HK1140106A1 (zh) | 2010-10-08 |
| WO2008123963A1 (en) | 2008-10-16 |
| ES2566387T3 (es) | 2016-04-12 |
| EP2136639A4 (en) | 2011-11-02 |
| JP2010523562A (ja) | 2010-07-15 |
| US8653091B2 (en) | 2014-02-18 |
| EP2136639A1 (en) | 2009-12-30 |
| CA2682162C (en) | 2016-05-10 |
| EP2136639B1 (en) | 2016-03-09 |
| CA2682162A1 (en) | 2008-10-16 |
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