JP5396379B2 - ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 - Google Patents
ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 Download PDFInfo
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- JP5396379B2 JP5396379B2 JP2010502114A JP2010502114A JP5396379B2 JP 5396379 B2 JP5396379 B2 JP 5396379B2 JP 2010502114 A JP2010502114 A JP 2010502114A JP 2010502114 A JP2010502114 A JP 2010502114A JP 5396379 B2 JP5396379 B2 JP 5396379B2
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- Prior art keywords
- pyridin
- substituted
- pyrimidin
- pyrido
- tetrahydro
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- A61P37/08—Antiallergic agents
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| US92160407P | 2007-04-02 | 2007-04-02 | |
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| US60/921,603 | 2007-04-02 | ||
| US60/921,604 | 2007-04-02 | ||
| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Publications (3)
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| JP2010523562A JP2010523562A (ja) | 2010-07-15 |
| JP2010523562A5 JP2010523562A5 (enExample) | 2011-04-07 |
| JP5396379B2 true JP5396379B2 (ja) | 2014-01-22 |
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| JP (1) | JP5396379B2 (enExample) |
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| ES (1) | ES2566387T3 (enExample) |
| WO (1) | WO2008123963A1 (enExample) |
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| US8076345B2 (en) * | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
| CA2747170C (en) * | 2008-12-19 | 2017-07-18 | Abbott Laboratories | Tetrahydroisoquinoline derivatives and their uses to treat cancers and autoimmune disorders |
| UA112517C2 (uk) * | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2619204A4 (en) * | 2010-09-21 | 2014-08-27 | Merck Sharp & Dohme | TRIAZOLOPYRAZINONE AS P2X7 RECEPTOR ANTAGONISTS |
| EA029473B1 (ru) | 2011-12-15 | 2018-03-30 | Новартис Аг | Применение ингибиторов pi3k для лечения острой и церебральной малярии |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| HRP20211002T1 (hr) | 2014-12-09 | 2021-09-17 | Bayer Aktiengesellschaft | 1,3-tiazol-2-il supstituirani benzamidi |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| JP6689297B2 (ja) * | 2015-07-23 | 2020-04-28 | 武田薬品工業株式会社 | 複素環化合物 |
| US20230096028A1 (en) * | 2019-03-01 | 2023-03-30 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| AU2020285336A1 (en) | 2019-05-31 | 2022-01-06 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as P2X3 inhibitors |
| EP3976609A1 (en) | 2019-05-31 | 2022-04-06 | Chiesi Farmaceutici S.p.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| WO2022028506A1 (zh) * | 2020-08-06 | 2022-02-10 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| KR20230113536A (ko) * | 2020-11-27 | 2023-07-31 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 (아자)퀴놀린 4-아민 유도체 |
| ES3026309T3 (en) | 2020-11-27 | 2025-06-11 | Chiesi Farm Spa | Amino quinazoline derivatives as p2x3 inhibitors |
| CA3196335A1 (en) * | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| IL305046A (en) * | 2021-02-08 | 2023-10-01 | Wuhan Humanwell Innovative Drug Res And Development Center Limited Company | Pyridopyrimidinone derivative, the method of preparation thereof and its use |
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| US3424760A (en) * | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) * | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| PL341356A1 (en) | 1997-12-22 | 2001-04-09 | Bayer Ag | Raf kinase inhibition employing aryl- and heteroaryl-substituted heterocyclic ureas |
| ATE346600T1 (de) | 1997-12-22 | 2006-12-15 | Bayer Pharmaceuticals Corp | Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen |
| DE60023128T2 (de) | 1999-05-12 | 2006-07-06 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazolcarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
| ATE336492T1 (de) | 2000-01-14 | 2006-09-15 | Us Gov Health & Human Serv | Methonocarbacycloalkylanaloga von nucleosiden |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| WO2002053558A1 (en) | 2001-01-02 | 2002-07-11 | F.Hoffman-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| CA2473634C (en) | 2002-02-25 | 2011-11-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| EP1552842A1 (en) * | 2002-06-07 | 2005-07-13 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| US20060100245A1 (en) | 2002-12-19 | 2006-05-11 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues |
| WO2005110994A2 (en) | 2004-04-30 | 2005-11-24 | Bayer Pharmaceuticals Corporation | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| WO2006119504A2 (en) * | 2005-05-04 | 2006-11-09 | Renovis, Inc. | Fused heterocyclic compounds, and compositions and uses thereof |
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2008
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- 2008-03-31 CA CA2682162A patent/CA2682162C/en not_active Expired - Fee Related
- 2008-03-31 WO PCT/US2008/004202 patent/WO2008123963A1/en not_active Ceased
- 2008-03-31 EP EP08727238.1A patent/EP2136639B1/en not_active Not-in-force
- 2008-03-31 ES ES08727238.1T patent/ES2566387T3/es active Active
- 2008-03-31 US US12/594,364 patent/US8653091B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008123963A1 (en) | 2008-10-16 |
| HK1140106A1 (zh) | 2010-10-08 |
| US8653091B2 (en) | 2014-02-18 |
| EP2136639A1 (en) | 2009-12-30 |
| CA2682162C (en) | 2016-05-10 |
| JP2010523562A (ja) | 2010-07-15 |
| EP2136639A4 (en) | 2011-11-02 |
| ES2566387T3 (es) | 2016-04-12 |
| US20110009432A1 (en) | 2011-01-13 |
| EP2136639B1 (en) | 2016-03-09 |
| CA2682162A1 (en) | 2008-10-16 |
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