JP5396379B2 - ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 - Google Patents
ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 Download PDFInfo
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- JP5396379B2 JP5396379B2 JP2010502114A JP2010502114A JP5396379B2 JP 5396379 B2 JP5396379 B2 JP 5396379B2 JP 2010502114 A JP2010502114 A JP 2010502114A JP 2010502114 A JP2010502114 A JP 2010502114A JP 5396379 B2 JP5396379 B2 JP 5396379B2
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- Prior art keywords
- pyridin
- substituted
- pyrimidin
- pyrido
- tetrahydro
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- A61P37/08—Antiallergic agents
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
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| US60/921,604 | 2007-04-02 | ||
| US60/921,603 | 2007-04-02 | ||
| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Publications (3)
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| JP2010523562A JP2010523562A (ja) | 2010-07-15 |
| JP2010523562A5 JP2010523562A5 (enExample) | 2011-04-07 |
| JP5396379B2 true JP5396379B2 (ja) | 2014-01-22 |
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| EP (1) | EP2136639B1 (enExample) |
| JP (1) | JP5396379B2 (enExample) |
| CA (1) | CA2682162C (enExample) |
| ES (1) | ES2566387T3 (enExample) |
| WO (1) | WO2008123963A1 (enExample) |
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| DK2139334T3 (da) * | 2007-04-17 | 2013-09-23 | Evotec Ag | Kondenserede heterocykliske 2-cyanophenylforbindelser og sammensætninger og anvendelser deraf |
| CA2747170C (en) * | 2008-12-19 | 2017-07-18 | Abbott Laboratories | Tetrahydroisoquinoline derivatives and their uses to treat cancers and autoimmune disorders |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| WO2012040048A2 (en) * | 2010-09-21 | 2012-03-29 | Schering Corporation | Triazolopyrazinones as p2x7 receptor antagonists |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| CN107207507B (zh) | 2014-12-09 | 2020-11-06 | 拜耳公司 | 1,3-噻唑-2-基取代的苯甲酰胺 |
| DK3325490T3 (da) * | 2015-07-23 | 2020-02-03 | Takeda Pharmaceuticals Co | 1-substituerede 1,2,3,4-tetrahydro-1,7-naphthyridin-8-aminderivater og deres anvendelse som ep4-receptorantagonister |
| AU2020232616A1 (en) * | 2019-03-01 | 2021-09-09 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| CA3139019A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN114222741B (zh) * | 2019-05-31 | 2025-12-30 | 奇斯药制品公司 | 作为p2x3抑制剂的吡啶并嘧啶类衍生物 |
| TWI793704B (zh) * | 2020-08-06 | 2023-02-21 | 大陸商北京泰德製藥股份有限公司 | Sos1抑制劑、包含其的藥物組合物及其用途 |
| US20230416233A1 (en) * | 2020-11-27 | 2023-12-28 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| AU2021386405A1 (en) * | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| MX2023005803A (es) * | 2020-11-27 | 2023-05-29 | Chiesi Farm Spa | Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3). |
| AU2022217353B2 (en) * | 2021-02-08 | 2025-01-09 | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company | Pyridopyrimidinone derivative, preparation method therefor, and use thereof |
Family Cites Families (18)
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| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) * | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DK1056725T3 (da) | 1997-12-22 | 2006-10-02 | Bayer Pharmaceuticals Corp | Inhibering af raf-kinase ved hjælp af aryl- og heteroaryl-substituerede heterocykliske urinstoffer |
| IL136768A0 (en) | 1997-12-22 | 2001-06-14 | Bayer Ag | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
| EP1177188B1 (en) | 1999-05-12 | 2005-10-12 | Ortho-McNeil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| WO2001051490A1 (en) * | 2000-01-14 | 2001-07-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methanocarba cycloalkyl nucleoside analogues |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| MXPA03000458A (es) | 2000-07-20 | 2004-06-02 | Neurogen Corp | Ligandos receptores de capsaicina. |
| DE60110844T2 (de) | 2001-01-02 | 2006-01-12 | F. Hoffmann-La Roche Ag | Chinazolone derivate als alfa 1a/b adrenozeptor antagonisten |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| ES2299689T3 (es) | 2002-02-25 | 2008-06-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas. |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| EP1552842A1 (en) * | 2002-06-07 | 2005-07-13 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| AU2003299797A1 (en) | 2002-12-19 | 2004-07-14 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| EP2295427A1 (en) | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| JP5198256B2 (ja) * | 2005-05-04 | 2013-05-15 | エボテク エージー | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
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- 2008-03-31 EP EP08727238.1A patent/EP2136639B1/en not_active Not-in-force
- 2008-03-31 JP JP2010502114A patent/JP5396379B2/ja not_active Expired - Fee Related
- 2008-03-31 WO PCT/US2008/004202 patent/WO2008123963A1/en not_active Ceased
- 2008-03-31 ES ES08727238.1T patent/ES2566387T3/es active Active
- 2008-03-31 CA CA2682162A patent/CA2682162C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2682162C (en) | 2016-05-10 |
| HK1140106A1 (zh) | 2010-10-08 |
| EP2136639A1 (en) | 2009-12-30 |
| JP2010523562A (ja) | 2010-07-15 |
| US8653091B2 (en) | 2014-02-18 |
| EP2136639B1 (en) | 2016-03-09 |
| ES2566387T3 (es) | 2016-04-12 |
| CA2682162A1 (en) | 2008-10-16 |
| US20110009432A1 (en) | 2011-01-13 |
| WO2008123963A1 (en) | 2008-10-16 |
| EP2136639A4 (en) | 2011-11-02 |
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