CA2682162C - Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof - Google Patents
Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof Download PDFInfo
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- CA2682162C CA2682162C CA2682162A CA2682162A CA2682162C CA 2682162 C CA2682162 C CA 2682162C CA 2682162 A CA2682162 A CA 2682162A CA 2682162 A CA2682162 A CA 2682162A CA 2682162 C CA2682162 C CA 2682162C
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- 125000005580 triphenylene group Chemical group 0.000 description 1
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- ADZJWYULTMTLQZ-UHFFFAOYSA-N tritylphosphane;hydrobromide Chemical compound [Br-].C=1C=CC=CC=1C(C=1C=CC=CC=1)([PH3+])C1=CC=CC=C1 ADZJWYULTMTLQZ-UHFFFAOYSA-N 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92160307P | 2007-04-02 | 2007-04-02 | |
| US92160407P | 2007-04-02 | 2007-04-02 | |
| US60/921,603 | 2007-04-02 | ||
| US60/921,604 | 2007-04-02 | ||
| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2682162A1 CA2682162A1 (en) | 2008-10-16 |
| CA2682162C true CA2682162C (en) | 2016-05-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2682162A Expired - Fee Related CA2682162C (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8653091B2 (enExample) |
| EP (1) | EP2136639B1 (enExample) |
| JP (1) | JP5396379B2 (enExample) |
| CA (1) | CA2682162C (enExample) |
| ES (1) | ES2566387T3 (enExample) |
| WO (1) | WO2008123963A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8076345B2 (en) * | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
| CA2747170C (en) * | 2008-12-19 | 2017-07-18 | Abbott Laboratories | Tetrahydroisoquinoline derivatives and their uses to treat cancers and autoimmune disorders |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2619204A4 (en) * | 2010-09-21 | 2014-08-27 | Merck Sharp & Dohme | TRIAZOLOPYRAZINONE AS P2X7 RECEPTOR ANTAGONISTS |
| CA2857302C (en) | 2011-12-15 | 2020-08-25 | Novartis Ag | Use of inhibitors of the activity or function of pi3k |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| AU2015359626B2 (en) | 2014-12-09 | 2020-07-23 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| EP3325490B1 (en) * | 2015-07-23 | 2019-12-18 | Takeda Pharmaceutical Company Limited | 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists |
| CN113727758A (zh) * | 2019-03-01 | 2021-11-30 | 锐新医药公司 | 双环杂环基化合物及其用途 |
| KR102921974B1 (ko) | 2019-05-31 | 2026-02-05 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 아미노 퀴나졸린 유도체 |
| KR102923602B1 (ko) * | 2019-05-31 | 2026-02-06 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 피리도피리미딘 유도체 |
| TWI793704B (zh) * | 2020-08-06 | 2023-02-21 | 大陸商北京泰德製藥股份有限公司 | Sos1抑制劑、包含其的藥物組合物及其用途 |
| EP4251273B1 (en) * | 2020-11-27 | 2025-03-12 | Chiesi Farmaceutici S.p.A. | Phthalazine derivatives as p2x3 inhibitors |
| WO2022112491A1 (en) * | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| CA3196333A1 (en) * | 2020-11-27 | 2022-06-02 | Claudio FIORELLI | Amino quinazoline derivatives as p2x3 inhibitors |
| WO2022166974A1 (zh) * | 2021-02-08 | 2022-08-11 | 武汉人福创新药物研发中心有限公司 | 吡啶并嘧啶酮类衍生物及其制备方法和用途 |
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| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE69834842T2 (de) | 1997-12-22 | 2007-05-10 | Bayer Pharmaceuticals Corp., West Haven | Hemmung von raf-kinase unter verwendung von aryl- und heteroarylsubstituierten heterocyclischen harnstoffen |
| DE69836563T2 (de) | 1997-12-22 | 2007-05-16 | Bayer Pharmaceuticals Corp., West Haven | INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYL-SUBSTITUIERTEN HARNSTOFFEN |
| AU778393B2 (en) | 1999-05-12 | 2004-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| EP1252160B1 (en) * | 2000-01-14 | 2006-08-16 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Methanocarba cycloalkyl nucleoside analogues |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| KR100554813B1 (ko) | 2001-01-02 | 2006-02-22 | 에프. 호프만-라 로슈 아게 | 알파 1에이/비 아드레날린성 수용체 길항제로서의퀴나졸론 유도체 |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| JP4629978B2 (ja) | 2002-02-25 | 2011-02-09 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン媒介疾患の治療に有用な１，４−二置換ベンゾ縮合シクロアルキル尿素化合物 |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| WO2004056774A2 (en) | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| ATE517885T1 (de) | 2004-04-30 | 2011-08-15 | Bayer Healthcare Llc | Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs |
| CA2606760C (en) | 2005-05-04 | 2014-12-23 | Renovis, Inc. | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and disfunctions |
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2008
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- 2008-03-31 WO PCT/US2008/004202 patent/WO2008123963A1/en not_active Ceased
- 2008-03-31 JP JP2010502114A patent/JP5396379B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2008123963A1 (en) | 2008-10-16 |
| ES2566387T3 (es) | 2016-04-12 |
| EP2136639A4 (en) | 2011-11-02 |
| JP5396379B2 (ja) | 2014-01-22 |
| CA2682162A1 (en) | 2008-10-16 |
| EP2136639B1 (en) | 2016-03-09 |
| US20110009432A1 (en) | 2011-01-13 |
| HK1140106A1 (zh) | 2010-10-08 |
| EP2136639A1 (en) | 2009-12-30 |
| JP2010523562A (ja) | 2010-07-15 |
| US8653091B2 (en) | 2014-02-18 |
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| EEER | Examination request |
Effective date: 20130228 |
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| MKLA | Lapsed |
Effective date: 20190401 |