CA2682162C - Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof - Google Patents
Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof Download PDFInfo
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- CA2682162C CA2682162C CA2682162A CA2682162A CA2682162C CA 2682162 C CA2682162 C CA 2682162C CA 2682162 A CA2682162 A CA 2682162A CA 2682162 A CA2682162 A CA 2682162A CA 2682162 C CA2682162 C CA 2682162C
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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Landscapes
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- Public Health (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92160407P | 2007-04-02 | 2007-04-02 | |
| US92160307P | 2007-04-02 | 2007-04-02 | |
| US60/921,603 | 2007-04-02 | ||
| US60/921,604 | 2007-04-02 | ||
| PCT/US2008/004202 WO2008123963A1 (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2682162A1 CA2682162A1 (en) | 2008-10-16 |
| CA2682162C true CA2682162C (en) | 2016-05-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2682162A Expired - Fee Related CA2682162C (en) | 2007-04-02 | 2008-03-31 | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8653091B2 (enExample) |
| EP (1) | EP2136639B1 (enExample) |
| JP (1) | JP5396379B2 (enExample) |
| CA (1) | CA2682162C (enExample) |
| ES (1) | ES2566387T3 (enExample) |
| WO (1) | WO2008123963A1 (enExample) |
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| US8076345B2 (en) * | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
| KR101685718B1 (ko) * | 2008-12-19 | 2016-12-12 | 제넨테크, 인크. | 헤테로시클릭 화합물 및 사용 방법 |
| UA112517C2 (uk) * | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| US20130196986A1 (en) * | 2010-09-21 | 2013-08-01 | Marc Labroli | Triazolopyrazinones as p2x7 receptor antagonists |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| JP6458429B2 (ja) * | 2014-09-30 | 2019-01-30 | 大日本印刷株式会社 | 導電材充填貫通電極基板及びその製造方法 |
| CU24411B1 (es) | 2014-12-09 | 2019-05-03 | Bayer Ag | Compuesto derivado de benzamida sustituida con 1,3-tiazol-2-ilo útil para el tratamiento de trastornos neurogénicos |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| JP6689297B2 (ja) * | 2015-07-23 | 2020-04-28 | 武田薬品工業株式会社 | 複素環化合物 |
| US20230096028A1 (en) * | 2019-03-01 | 2023-03-30 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| MA56022A (fr) | 2019-05-31 | 2022-04-06 | Chiesi Farm Spa | Dérivés d'amino quinazoline servant d'inhibiteurs de p2x3 |
| KR102923602B1 (ko) * | 2019-05-31 | 2026-02-06 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 피리도피리미딘 유도체 |
| CN116194446B (zh) * | 2020-08-06 | 2026-07-24 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| WO2022112490A1 (en) * | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN116745284A (zh) * | 2020-11-27 | 2023-09-12 | 奇斯药制品公司 | 作为p2x3抑制剂的酞嗪衍生物 |
| JP2023550830A (ja) * | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体 |
| IL305046A (en) * | 2021-02-08 | 2023-10-01 | Wuhan Humanwell Innovative Drug Res And Development Center Limited Company | Pyridopyrimidinone derivative, the method of preparation thereof and its use |
Family Cites Families (18)
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| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| NZ505845A (en) | 1997-12-22 | 2003-10-31 | Bayer Ag | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| IL136768A0 (en) | 1997-12-22 | 2001-06-14 | Bayer Ag | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
| EP1177188B1 (en) | 1999-05-12 | 2005-10-12 | Ortho-McNeil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| ATE336492T1 (de) | 2000-01-14 | 2006-09-15 | Us Gov Health & Human Serv | Methonocarbacycloalkylanaloga von nucleosiden |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| IL153884A0 (en) | 2000-07-20 | 2003-07-31 | Neurogen Corp | Capsaicin receptor ligands |
| CA2432578C (en) | 2001-01-02 | 2008-04-01 | F. Hoffmann-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| EP1480973B1 (en) | 2002-02-25 | 2008-02-13 | Boehringer Ingelheim Pharmaceuticals Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| US20060100245A1 (en) | 2002-12-19 | 2006-05-11 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues |
| US7838524B2 (en) | 2004-04-30 | 2010-11-23 | Bayer Healthcare Llc | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| JP5198256B2 (ja) * | 2005-05-04 | 2013-05-15 | エボテク エージー | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
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- 2008-03-31 JP JP2010502114A patent/JP5396379B2/ja not_active Expired - Fee Related
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- 2008-03-31 ES ES08727238.1T patent/ES2566387T3/es active Active
- 2008-03-31 EP EP08727238.1A patent/EP2136639B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2136639B1 (en) | 2016-03-09 |
| US8653091B2 (en) | 2014-02-18 |
| JP5396379B2 (ja) | 2014-01-22 |
| JP2010523562A (ja) | 2010-07-15 |
| ES2566387T3 (es) | 2016-04-12 |
| CA2682162A1 (en) | 2008-10-16 |
| EP2136639A4 (en) | 2011-11-02 |
| HK1140106A1 (zh) | 2010-10-08 |
| US20110009432A1 (en) | 2011-01-13 |
| WO2008123963A1 (en) | 2008-10-16 |
| EP2136639A1 (en) | 2009-12-30 |
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| EEER | Examination request |
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| MKLA | Lapsed |
Effective date: 20190401 |