JP2010523147A5 - - Google Patents
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- Publication number
- JP2010523147A5 JP2010523147A5 JP2010503068A JP2010503068A JP2010523147A5 JP 2010523147 A5 JP2010523147 A5 JP 2010523147A5 JP 2010503068 A JP2010503068 A JP 2010503068A JP 2010503068 A JP2010503068 A JP 2010503068A JP 2010523147 A5 JP2010523147 A5 JP 2010523147A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- acid
- desaturase
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims description 20
- 125000003729 nucleotide group Chemical group 0.000 claims description 20
- 229920001184 polypeptide Polymers 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 230000000813 microbial effect Effects 0.000 claims description 18
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 6
- 229940098330 gamma linoleic acid Drugs 0.000 claims description 6
- 108020004705 Codon Proteins 0.000 claims description 5
- 241000235013 Yarrowia Species 0.000 claims description 5
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims description 4
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims description 4
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims description 4
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108091033319 polynucleotide Proteins 0.000 claims description 3
- 102000040430 polynucleotide Human genes 0.000 claims description 3
- 239000002157 polynucleotide Substances 0.000 claims description 3
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 2
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000223252 Rhodotorula Species 0.000 description 2
- 241001466451 Stramenopiles Species 0.000 description 2
- 241000235015 Yarrowia lipolytica Species 0.000 description 2
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000195620 Euglena Species 0.000 description 1
- 241001149698 Lipomyces Species 0.000 description 1
- 241000235575 Mortierella Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000233671 Schizochytrium Species 0.000 description 1
- 241000233675 Thraustochytrium Species 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 1
- 238000010230 functional analysis Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91083107P | 2007-04-10 | 2007-04-10 | |
| US60/910,831 | 2007-04-10 | ||
| PCT/US2008/004700 WO2008124194A1 (en) | 2007-04-10 | 2008-04-10 | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523147A JP2010523147A (ja) | 2010-07-15 |
| JP2010523147A5 true JP2010523147A5 (OSRAM) | 2011-05-06 |
| JP5501952B2 JP5501952B2 (ja) | 2014-05-28 |
Family
ID=39708314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503068A Expired - Fee Related JP5501952B2 (ja) | 2007-04-10 | 2008-04-10 | Δ８デサチュラーゼ、および多価不飽和脂肪酸の作成におけるそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7790156B2 (OSRAM) |
| EP (2) | EP2132317B1 (OSRAM) |
| JP (1) | JP5501952B2 (OSRAM) |
| CN (1) | CN101679990B (OSRAM) |
| AU (2) | AU2008236595B2 (OSRAM) |
| BR (1) | BRPI0808222A2 (OSRAM) |
| CA (2) | CA2681145C (OSRAM) |
| DK (1) | DK2132317T3 (OSRAM) |
| WO (2) | WO2008124194A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) * | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| EP2195415A1 (en) * | 2007-10-03 | 2010-06-16 | E. I. du Pont de Nemours and Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| AU2010260234B2 (en) | 2009-06-16 | 2015-02-26 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| WO2011054801A1 (en) | 2009-11-03 | 2011-05-12 | Dsm Ip Assets B.V. | Vegatable oil comprising a polyunsaturaded fatty acid having at least 20 carbon atoms |
| US20130129902A1 (en) | 2009-11-03 | 2013-05-23 | Dsm Ip Assets B.V. | Composition comprising cells and a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
| US20110263709A1 (en) | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| AU2011293167B2 (en) | 2010-08-26 | 2016-12-08 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| AU2011293189B2 (en) | 2010-08-26 | 2017-02-16 | E. I. Du Pont De Nemours And Company | Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| KR20130138760A (ko) | 2010-08-26 | 2013-12-19 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 고농도의 에이코사펜타엔산 생성을 위한 재조합 미생물 숙주 세포 |
| WO2012091812A1 (en) | 2010-12-30 | 2012-07-05 | E. I. Du Pont De Nemours And Company | Use of saccharomyces cerevisiae suc2 gene in yarrowia lipolytica for sucrose utilization |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| CA2892516A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| UA121847C2 (uk) | 2013-03-14 | 2020-08-10 | Піонір Хай-Бред Інтернешнл Інк. | Полінуклеотид, що кодує елемент сайленсингу з інсектицидною активністю проти шкідника рослин із ряду coleoptera, та спосіб його застосування |
| US10023877B2 (en) | 2013-03-15 | 2018-07-17 | Pioneer Hi-Bred International, Inc. | PHI-4 polypeptides and methods for their use |
| CN106232820A (zh) | 2013-08-16 | 2016-12-14 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| US10667524B2 (en) | 2013-09-13 | 2020-06-02 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| PH12016501534B1 (en) | 2014-02-07 | 2024-06-05 | Du Pont | Insecticidal proteins and methods for their use |
| CN114763376A (zh) | 2014-02-07 | 2022-07-19 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| US20170247719A1 (en) | 2014-09-17 | 2017-08-31 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| UA126192C2 (uk) | 2014-10-16 | 2022-08-31 | Піонір Хай-Бред Інтернешнл, Інк. | Інсектицидний білок та спосіб його застосування |
| CN114075267B (zh) | 2015-01-15 | 2025-03-18 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| CN116333064A (zh) | 2015-05-19 | 2023-06-27 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| CN107771181A (zh) | 2015-06-16 | 2018-03-06 | 先锋国际良种公司 | 用以防治昆虫有害生物的组合物和方法 |
| US11198709B2 (en) | 2015-08-06 | 2021-12-14 | E. I. Du Pont De Nemours And Company | Plant derived insecticidal proteins and methods for their use |
| JP2018527931A (ja) | 2015-08-28 | 2018-09-27 | パイオニア ハイ−ブレッド インターナショナル， インコーポレイテッド | 植物のオクロバクテリウム（ｏｃｈｒｏｂａｃｔｒｕｍ）媒介形質転換 |
| CN105137844B (zh) * | 2015-08-31 | 2017-09-01 | 广东电网有限责任公司电力科学研究院 | 锅炉调试过程中风险预控方法和系统 |
| EP3390431A1 (en) | 2015-12-18 | 2018-10-24 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| EP3451837B1 (en) | 2016-05-04 | 2021-08-25 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| EP3472323A1 (en) | 2016-06-16 | 2019-04-24 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| MX387506B (es) | 2016-07-01 | 2025-03-18 | Pioneer Hi Bred Int | Proteinas insecticidas de plantas y metodos para sus usos. |
| US20210292778A1 (en) | 2016-07-12 | 2021-09-23 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| MX387927B (es) | 2016-11-01 | 2025-03-19 | Pioneer Hi Bred Int | Proteinas insecticidas y metodos para su uso. |
| EA201991467A1 (ru) | 2016-12-15 | 2019-11-29 | Состав смеси, содержащий силикат и микробные и/или растительные клетки и полиненасыщенную жирную кислоту, имеющую по меньшей мере 20 атомов углерода (lc-pufa) | |
| EP3764798B1 (en) | 2018-03-14 | 2025-12-17 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| US11820791B2 (en) | 2018-03-14 | 2023-11-21 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| BR112022027035A2 (pt) | 2020-07-14 | 2023-04-11 | Pioneer Hi Bred Int | Proteínas inseticidas e métodos para uso das mesmas |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670285A (en) | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| PL336077A1 (en) | 1997-04-11 | 2000-06-05 | Calgene Llc | Methods of and compositions for synthesising long-chain polyunsaturated fatty acids in plants |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| JP4383671B2 (ja) | 1998-12-07 | 2009-12-16 | ワシントン ステート ユニバーシティ リサーチ ファウンデーション | 不飽和化酵素、およびそれらを多価不飽和脂肪酸の合成のために用いる方法 |
| US6825017B1 (en) * | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| JP2004513623A (ja) | 2000-07-21 | 2004-05-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 植物の脂肪酸におけるδ１２−エポキシ基の合成に関連するシトクロムｐ４５０酵素 |
| GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| TWI350854B (en) | 2001-04-16 | 2011-10-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| AU2003296638B2 (en) | 2002-12-19 | 2009-06-11 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| AU2004290051A1 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| US7202356B2 (en) | 2003-11-14 | 2007-04-10 | E. I. Du Pont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
| CA3023314C (en) | 2004-04-22 | 2019-12-10 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2006012325A1 (en) * | 2004-06-25 | 2006-02-02 | E.I. Dupont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) * | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7588931B2 (en) | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7943823B2 (en) * | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| AU2007322223B2 (en) * | 2006-10-23 | 2012-12-13 | Corteva Agriscience Llc | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| WO2008073275A2 (en) | 2006-12-07 | 2008-06-19 | E. I. Du Pont De Nemours And Company | Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8013215B2 (en) * | 2007-02-12 | 2011-09-06 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
-
2008
- 2008-04-09 US US12/099,811 patent/US7790156B2/en active Active
- 2008-04-09 US US12/099,799 patent/US8188338B2/en active Active
- 2008-04-10 AU AU2008236595A patent/AU2008236595B2/en not_active Ceased
- 2008-04-10 JP JP2010503068A patent/JP5501952B2/ja not_active Expired - Fee Related
- 2008-04-10 EP EP08742773A patent/EP2132317B1/en not_active Not-in-force
- 2008-04-10 WO PCT/US2008/004700 patent/WO2008124194A1/en not_active Ceased
- 2008-04-10 EP EP08745451.8A patent/EP2121737B1/en not_active Not-in-force
- 2008-04-10 WO PCT/US2008/059844 patent/WO2008124806A2/en not_active Ceased
- 2008-04-10 CA CA2681145A patent/CA2681145C/en active Active
- 2008-04-10 CN CN2008800187631A patent/CN101679990B/zh not_active Expired - Fee Related
- 2008-04-10 US US12/530,839 patent/US20100099900A1/en not_active Abandoned
- 2008-04-10 AU AU2008237065A patent/AU2008237065A1/en not_active Abandoned
- 2008-04-10 CA CA2683497A patent/CA2683497C/en not_active Expired - Fee Related
- 2008-04-10 BR BRPI0808222-7A patent/BRPI0808222A2/pt not_active Application Discontinuation
- 2008-04-10 DK DK08742773.8T patent/DK2132317T3/da active
-
2010
- 2010-06-29 US US12/825,537 patent/US8318463B2/en not_active Expired - Fee Related
-
2012
- 2012-04-18 US US13/449,395 patent/US8338152B2/en not_active Expired - Fee Related
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