DK2132317T3 - Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer - Google Patents
Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrerInfo
- Publication number
- DK2132317T3 DK2132317T3 DK08742773.8T DK08742773T DK2132317T3 DK 2132317 T3 DK2132317 T3 DK 2132317T3 DK 08742773 T DK08742773 T DK 08742773T DK 2132317 T3 DK2132317 T3 DK 2132317T3
- Authority
- DK
- Denmark
- Prior art keywords
- desaturases
- delta
- preparation
- fatty acids
- polyunsaturated fatty
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91083107P | 2007-04-10 | 2007-04-10 | |
PCT/US2008/004700 WO2008124194A1 (en) | 2007-04-10 | 2008-04-10 | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2132317T3 true DK2132317T3 (da) | 2013-06-03 |
Family
ID=39708314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08742773.8T DK2132317T3 (da) | 2007-04-10 | 2008-04-10 | Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer |
Country Status (9)
Country | Link |
---|---|
US (5) | US8188338B2 (da) |
EP (2) | EP2132317B1 (da) |
JP (1) | JP5501952B2 (da) |
CN (1) | CN101679990B (da) |
AU (2) | AU2008237065A1 (da) |
BR (1) | BRPI0808222A2 (da) |
CA (2) | CA2683497C (da) |
DK (1) | DK2132317T3 (da) |
WO (2) | WO2008124806A2 (da) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8188338B2 (en) * | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
US7794701B2 (en) * | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
WO2009046231A1 (en) * | 2007-10-03 | 2009-04-09 | E. I. Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
WO2010147907A1 (en) | 2009-06-16 | 2010-12-23 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
IN2012DN03815A (da) | 2009-11-03 | 2015-08-28 | Dsm Ip Assets Bv | |
WO2011054800A1 (en) | 2009-11-03 | 2011-05-12 | Dsm Ip Assets B.V. | Composition comprising cells and a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
CN103282474A (zh) | 2010-04-22 | 2013-09-04 | 纳幕尔杜邦公司 | 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法 |
KR20130138760A (ko) | 2010-08-26 | 2013-12-19 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 고농도의 에이코사펜타엔산 생성을 위한 재조합 미생물 숙주 세포 |
BR112013004356A2 (pt) | 2010-08-26 | 2017-06-27 | Du Pont | polinucleotídeo isolado, polipeptídeo mutante, constructo recombinante, célula transformada, método para produção de um ácido graxo poli-insaturado, óleo microbiano e célula hospedeira microbiana recombinante. |
WO2012027698A1 (en) | 2010-08-26 | 2012-03-01 | E.I. Du Pont De Nemours And Company | Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
JP2014503216A (ja) | 2010-12-30 | 2014-02-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | スクロース利用のための、ヤロウィア・リポリティカ(Yarrowialipolytica)におけるサッカロミセス・セレビシア(Saccharomycescerevisiae)SUC2遺伝子の使用 |
US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
JP2016502851A (ja) | 2012-12-21 | 2016-02-01 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company | 微生物細胞中における脂質生成を改変するためのsou2ソルビトール利用タンパク質をコードするポリヌクレオチドの下方制御 |
CN115960896A (zh) | 2013-03-14 | 2023-04-14 | 先锋国际良种公司 | 用以防治昆虫害虫的组合物和方法 |
RU2015143825A (ru) | 2013-03-15 | 2017-04-26 | Пайонир Хай-Бред Интернэшнл, Инк. | Полипептиды phi-4 и способы их применения |
EA030896B1 (ru) | 2013-08-16 | 2018-10-31 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидные белки и способы их применения |
BR112016005543B1 (pt) | 2013-09-13 | 2022-03-08 | Pioneer Hi-Bred International, Inc | Polipeptídeo pip-72 recombinante, construto de dna, método de obtenção de planta transgênica, célula hospedeira, composição, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto, método para controlar uma infestação de insetos em uma planta transgênica, método para identificar em uma amostra biológica uma sequência de nucleotídeos, método para identificar em uma amostra um polipeptídeo pip-72 |
BR112016018103B1 (pt) | 2014-02-07 | 2024-01-16 | E.I. Du Pont De Nemours And Company | Polipeptídeo e seu uso, polinucleotídeo, composição, proteína de fusão, método para controlar uma população, método para inibir o crescimento, método para controlar a infestação, método para obtenção de uma planta ou célula vegetal, construto |
BR112016018287A2 (pt) | 2014-02-07 | 2017-10-10 | Du Pont | proteínas inseticidas e métodos para uso das mesmas |
WO2016044092A1 (en) | 2014-09-17 | 2016-03-24 | Pioneer Hi Bred International Inc | Compositions and methods to control insect pests |
CA2963558C (en) | 2014-10-16 | 2023-04-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CN108064233B (zh) | 2015-05-19 | 2022-07-15 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
BR112017027382A2 (pt) | 2015-06-16 | 2018-08-28 | Pioneer Hi-Bred International, Inc. | elemento de silenciamento, construto de dna, construto de expressão, cassete de expressão, célula hospedeira, composição, célula vegetal, planta ou parte de planta, semente transgênica, método para controlar um inseto-praga de planta, kit para controlar insetos-praga |
EP3331352B1 (en) | 2015-08-06 | 2022-07-06 | Pioneer Hi-Bred International, Inc. | Plant derived insecticidal proteins and methods for their use |
CA2992488A1 (en) | 2015-08-28 | 2017-03-09 | Pioneer Hi-Bred International, Inc. | Ochrobactrum-mediated transformation of plants |
CN105137844B (zh) * | 2015-08-31 | 2017-09-01 | 广东电网有限责任公司电力科学研究院 | 锅炉调试过程中风险预控方法和系统 |
WO2017105987A1 (en) | 2015-12-18 | 2017-06-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US11008585B2 (en) | 2016-05-04 | 2021-05-18 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US20190185867A1 (en) | 2016-06-16 | 2019-06-20 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
WO2018005411A1 (en) | 2016-07-01 | 2018-01-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
WO2018013333A1 (en) | 2016-07-12 | 2018-01-18 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
US11021716B2 (en) | 2016-11-01 | 2021-06-01 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018109059A1 (en) | 2016-12-15 | 2018-06-21 | Dsm Ip Assets B.V. | Blend formulation comprising silicate and microbial and / or plant cells comprising a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
BR112022027035A2 (pt) | 2020-07-14 | 2023-04-11 | Pioneer Hi Bred Int | Proteínas inseticidas e métodos para uso das mesmas |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4670285A (en) | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
TR199902474T2 (xx) | 1997-04-11 | 2000-02-21 | Calgene Llc | Bitkilerde uzun zincirli �ok-doymam�� ya�l� asitlerin sentezi i�in y�ntemler ve bile�imler. |
US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
US6825017B1 (en) * | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
CA2354672C (en) | 1998-12-07 | 2012-10-02 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
WO2002008269A2 (en) | 2000-07-21 | 2002-01-31 | E. I. Du Pont De Nemours And Company | A cytochrome p450 enzyme associated with the synthesis of δ12-epoxy groups in fatty acids of plants |
GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
WO2004057001A2 (en) | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
AU2004290052B2 (en) | 2003-11-12 | 2008-12-04 | Corteva Agriscience Llc | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
WO2005049805A2 (en) | 2003-11-14 | 2005-06-02 | E.I. Dupont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
EP2363492A3 (en) | 2004-04-22 | 2012-03-14 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. |
US7256033B2 (en) | 2004-06-25 | 2007-08-14 | E. I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
US7588931B2 (en) | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
EP1957641A2 (en) | 2005-11-23 | 2008-08-20 | E.I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
PL2390339T3 (pl) | 2006-10-23 | 2013-12-31 | Du Pont | Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych |
US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
WO2008073275A2 (en) | 2006-12-07 | 2008-06-19 | E. I. Du Pont De Nemours And Company | Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids |
EP2121934A2 (en) | 2007-02-12 | 2009-11-25 | E. I. Du Pont de Nemours and Company | Production of arachidonic acid in oilseed plants |
US8188338B2 (en) | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
-
2008
- 2008-04-09 US US12/099,799 patent/US8188338B2/en active Active
- 2008-04-09 US US12/099,811 patent/US7790156B2/en active Active
- 2008-04-10 CN CN2008800187631A patent/CN101679990B/zh not_active Expired - Fee Related
- 2008-04-10 EP EP08742773A patent/EP2132317B1/en not_active Not-in-force
- 2008-04-10 AU AU2008237065A patent/AU2008237065A1/en not_active Abandoned
- 2008-04-10 WO PCT/US2008/059844 patent/WO2008124806A2/en active Application Filing
- 2008-04-10 JP JP2010503068A patent/JP5501952B2/ja not_active Expired - Fee Related
- 2008-04-10 BR BRPI0808222-7A patent/BRPI0808222A2/pt not_active Application Discontinuation
- 2008-04-10 DK DK08742773.8T patent/DK2132317T3/da active
- 2008-04-10 EP EP08745451.8A patent/EP2121737B1/en not_active Not-in-force
- 2008-04-10 US US12/530,839 patent/US20100099900A1/en not_active Abandoned
- 2008-04-10 CA CA2683497A patent/CA2683497C/en not_active Expired - Fee Related
- 2008-04-10 AU AU2008236595A patent/AU2008236595B2/en not_active Ceased
- 2008-04-10 WO PCT/US2008/004700 patent/WO2008124194A1/en active Application Filing
- 2008-04-10 CA CA2681145A patent/CA2681145C/en active Active
-
2010
- 2010-06-29 US US12/825,537 patent/US8318463B2/en active Active
-
2012
- 2012-04-18 US US13/449,395 patent/US8338152B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8188338B2 (en) | 2012-05-29 |
AU2008237065A1 (en) | 2008-10-16 |
CA2681145A1 (en) | 2008-10-16 |
BRPI0808222A2 (pt) | 2014-07-08 |
WO2008124806A3 (en) | 2010-07-22 |
CA2683497A1 (en) | 2008-10-16 |
US20120196347A1 (en) | 2012-08-02 |
US8338152B2 (en) | 2012-12-25 |
US20100099900A1 (en) | 2010-04-22 |
CN101679990A (zh) | 2010-03-24 |
US8318463B2 (en) | 2012-11-27 |
WO2008124194A1 (en) | 2008-10-16 |
US20080254521A1 (en) | 2008-10-16 |
CN101679990B (zh) | 2013-06-19 |
CA2683497C (en) | 2015-08-11 |
AU2008236595A1 (en) | 2008-10-16 |
EP2132317A1 (en) | 2009-12-16 |
US20080254192A1 (en) | 2008-10-16 |
EP2121737A2 (en) | 2009-11-25 |
US20100267099A1 (en) | 2010-10-21 |
JP2010523147A (ja) | 2010-07-15 |
CA2681145C (en) | 2016-02-16 |
WO2008124806A2 (en) | 2008-10-16 |
US7790156B2 (en) | 2010-09-07 |
EP2132317B1 (en) | 2013-02-27 |
AU2008236595B2 (en) | 2013-06-13 |
EP2121737B1 (en) | 2015-05-27 |
JP5501952B2 (ja) | 2014-05-28 |
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