JP2010520273A5 - - Google Patents
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- Publication number
- JP2010520273A5 JP2010520273A5 JP2009552583A JP2009552583A JP2010520273A5 JP 2010520273 A5 JP2010520273 A5 JP 2010520273A5 JP 2009552583 A JP2009552583 A JP 2009552583A JP 2009552583 A JP2009552583 A JP 2009552583A JP 2010520273 A5 JP2010520273 A5 JP 2010520273A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- alcohol
- hydrate
- wide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 4
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 2
- 230000036571 hydration Effects 0.000 claims 2
- 238000006703 hydration reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 101100352919 Caenorhabditis elegans ppm-2 gene Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20070020999 | 2007-03-02 | ||
| PCT/KR2008/001218 WO2008108572A1 (en) | 2007-03-02 | 2008-03-03 | Novel crystal forms of pyrrolylheptanoic acid derivatives |
| KR1020080019764A KR101012917B1 (ko) | 2007-03-02 | 2008-03-03 | 피롤 헵탄산 화합물의 신규한 결정형 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520273A JP2010520273A (ja) | 2010-06-10 |
| JP2010520273A5 true JP2010520273A5 (https=) | 2012-06-14 |
Family
ID=40020978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552583A Pending JP2010520273A (ja) | 2007-03-02 | 2008-03-03 | ピロリルヘプタン酸誘導体の新規な結晶形態 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7915302B2 (https=) |
| EP (1) | EP2132171A4 (https=) |
| JP (1) | JP2010520273A (https=) |
| KR (1) | KR101012917B1 (https=) |
| CN (1) | CN101657419A (https=) |
| CA (1) | CA2679317A1 (https=) |
| RU (1) | RU2421445C1 (https=) |
| WO (1) | WO2008108572A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011219437A (ja) * | 2010-04-14 | 2011-11-04 | Towa Yakuhin Kk | 結晶性形態ｔｗ−１のアトルバスタチンヘミカルシウム水和物とその製造方法 |
| KR20120011249A (ko) * | 2010-07-28 | 2012-02-07 | 주식회사 경보제약 | 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법 |
| RU2555360C2 (ru) * | 2012-11-06 | 2015-07-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ определения воды в координационных соединениях |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| KR100389518B1 (ko) * | 1995-07-17 | 2003-11-15 | 워너-램버트 캄파니 엘엘씨 | 결정질[r-(r*,r*)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1h-피롤-1-헵탄산헤미칼슘염(아토르바스타틴) |
| DE19951107A1 (de) * | 1999-10-23 | 2001-05-23 | Zahnradfabrik Friedrichshafen | Steuerung eines Automatgetriebes eines Kraftfahrzeuges |
| EP2206497A1 (en) * | 1999-11-17 | 2010-07-14 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
| IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| US7501450B2 (en) * | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| SK16002003A3 (sk) * | 2001-06-29 | 2004-12-01 | Warner-Lambert Company Llc | Kryštalické formy vápenatej soli (2:1) [R-(R*,R*)]-2-(4-fluóro- fenyl)-beta,delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptánovej kyseliny (atorvastatín) |
| CN100406436C (zh) * | 2002-02-15 | 2008-07-30 | 特瓦制药工业有限公司 | 阿托韦兹他汀半钙结晶以及制备阿托韦兹他汀半钙形式ix的方法 |
| AU2002330735A1 (en) * | 2002-09-03 | 2004-03-29 | Morepen Laboratories Limited | Atorvastatin calcium form vi or hydrates thereof |
| CA2508871C (en) * | 2002-11-28 | 2008-09-09 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
| EP1761489A1 (en) * | 2004-03-17 | 2007-03-14 | Ranbaxy Laboratories Limited | Crystalline form of atorvastatin hemi calcium |
| WO2006048894A1 (en) * | 2004-11-05 | 2006-05-11 | Morepen Laboratories Limited | Novel crystalline forms of atorvastatin calcium and processes for preparing them. |
-
2008
- 2008-03-03 US US12/449,867 patent/US7915302B2/en not_active Expired - Fee Related
- 2008-03-03 CN CN200880006877A patent/CN101657419A/zh active Pending
- 2008-03-03 RU RU2009136427/04A patent/RU2421445C1/ru not_active IP Right Cessation
- 2008-03-03 EP EP08723256A patent/EP2132171A4/en not_active Withdrawn
- 2008-03-03 WO PCT/KR2008/001218 patent/WO2008108572A1/en not_active Ceased
- 2008-03-03 KR KR1020080019764A patent/KR101012917B1/ko active Active
- 2008-03-03 JP JP2009552583A patent/JP2010520273A/ja active Pending
- 2008-03-03 CA CA002679317A patent/CA2679317A1/en not_active Abandoned
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