JP2010519543A - 糖尿病状態の代謝マーカーおよびその使用法 - Google Patents

糖尿病状態の代謝マーカーおよびその使用法 Download PDF

Info

Publication number
JP2010519543A
JP2010519543A JP2009550924A JP2009550924A JP2010519543A JP 2010519543 A JP2010519543 A JP 2010519543A JP 2009550924 A JP2009550924 A JP 2009550924A JP 2009550924 A JP2009550924 A JP 2009550924A JP 2010519543 A JP2010519543 A JP 2010519543A
Authority
JP
Japan
Prior art keywords
fatty acid
acid content
total fatty
relative
total
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009550924A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010519543A5 (enExample
Inventor
スティーブン エム. ワトキンス,
ミシェル エム. ウィースト,
Original Assignee
リポミクス テクノロジーズ, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by リポミクス テクノロジーズ, インコーポレイテッド filed Critical リポミクス テクノロジーズ, インコーポレイテッド
Publication of JP2010519543A publication Critical patent/JP2010519543A/ja
Publication of JP2010519543A5 publication Critical patent/JP2010519543A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009550924A 2007-02-22 2008-02-22 糖尿病状態の代謝マーカーおよびその使用法 Pending JP2010519543A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90297607P 2007-02-22 2007-02-22
US93176607P 2007-05-24 2007-05-24
US2185308P 2008-01-17 2008-01-17
PCT/US2008/002357 WO2008106054A2 (en) 2007-02-22 2008-02-22 Metabolic markers of diabetic conditions and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2010519543A true JP2010519543A (ja) 2010-06-03
JP2010519543A5 JP2010519543A5 (enExample) 2011-04-07

Family

ID=39721790

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009550924A Pending JP2010519543A (ja) 2007-02-22 2008-02-22 糖尿病状態の代謝マーカーおよびその使用法

Country Status (8)

Country Link
US (1) US20100197028A1 (enExample)
EP (1) EP2126589A4 (enExample)
JP (1) JP2010519543A (enExample)
CN (1) CN101802620A (enExample)
AU (1) AU2008219700B2 (enExample)
BR (1) BRPI0807612A2 (enExample)
CA (1) CA2678670A1 (enExample)
WO (1) WO2008106054A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509588A (ja) * 2009-10-29 2013-03-14 テシス バイオサイエンス, インコーポレイテッド 2型糖尿病の予防に対して一貫した改善をもたらすタンパク質バイオマーカーおよび脂質代謝物バイオマーカー
JP2014518140A (ja) * 2011-07-05 2014-07-28 エルジーシーエイチ インコーポレイテッド 痙攣の検出方法および検出装置
JP2017502304A (ja) * 2014-01-08 2017-01-19 ネステク ソシエテ アノニム 心外膜脂肪組織用のバイオマーカー
WO2021162033A1 (ja) * 2020-02-13 2021-08-19 東洋インキScホールディングス株式会社 回帰モデル作成方法、回帰モデル作成装置、及び、回帰モデル作成プログラム
JP2022056512A (ja) * 2020-09-30 2022-04-11 東ソー株式会社 統計的手法によるクロマトグラムの分類方法

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2407562A1 (en) * 2006-05-08 2012-01-18 Tethys Bioscience, Inc. Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
JP2011528117A (ja) * 2008-07-15 2011-11-10 メタノミクス ヘルス ゲーエムベーハー 胃バイパス及びそれに関連する状態を診断する手段及び方法
WO2010114897A1 (en) * 2009-03-31 2010-10-07 Metabolon, Inc. Biomarkers related to insulin resistance and methods using the same
US11835503B2 (en) * 2009-05-28 2023-12-05 The Cleveland Clinic Foundation TMA-formation inhibitor treatment for elevated TMA-containing compound diseases
CA2790371C (en) * 2009-05-28 2020-09-01 The Cleveland Clinic Foundation Trimethylamine-containing compounds for diagnosis and prediction of disease
EP3273247A1 (en) 2010-06-10 2018-01-24 Metanomics Health GmbH Methods for the diagnosis of liver diseases
US10226209B2 (en) 2010-10-15 2019-03-12 Brain Sentinel, Inc. Method and apparatus for classification of seizure type and severity using electromyography
KR101303825B1 (ko) * 2011-06-02 2013-09-05 연세대학교 산학협력단 혈장 대사체를 이용한 제2형 당뇨병 진단 키트
JP6158186B2 (ja) * 2011-09-14 2017-07-05 メタボロン,インコーポレイテッド インスリン抵抗性に関連するバイオマーカーおよびそれを使用する方法
CN102495217B (zh) * 2011-12-06 2014-06-25 黄传峰 一种临床病例监测管理系统
CN105008931A (zh) * 2013-03-08 2015-10-28 佐拉生物科学公司 非高密度脂蛋白来源的cvd标志物
WO2015109116A1 (en) * 2014-01-15 2015-07-23 The Regents Of The University Of California Metabolic screening for gestational diabetes
CN107076753B (zh) * 2014-09-30 2019-01-18 深圳华大基因科技有限公司 肥胖人群特异性生物标志组合物及其用途
US11255866B2 (en) * 2015-02-26 2022-02-22 Wisconsin Alumni Research Foundation Methods for predicting glucoregulatory dysfunction via diacylglycerol fatty acid species concentrations
CN105424841B (zh) * 2015-12-25 2017-11-03 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
CN105486773A (zh) * 2015-12-25 2016-04-13 齐炼文 用于诊断冠心病的代谢标志物
CN105628809B (zh) * 2015-12-25 2018-04-03 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
CN106979982B (zh) * 2016-01-19 2021-01-05 上海市第六人民医院 一种用于糖尿病风险预测、治疗评价的方法及试剂盒
CN105486778B (zh) * 2016-01-25 2017-11-03 齐炼文 诊断区分稳定型心绞痛和急性冠脉综合征的代谢标志物
CN105445408B (zh) * 2016-01-25 2018-06-12 齐炼文 诊断区分冠状动脉粥样硬化和稳定型心绞痛的代谢标志物
CN107121540B (zh) * 2016-02-24 2020-06-12 中国科学院上海营养与健康研究所 酰基肉碱谱或其检测试剂在2型糖尿病发病风险预测中的应用
CN106483212B (zh) * 2016-09-22 2019-03-01 南京医科大学 与特发性男性不育相关的尿液雌激素代谢物标志物及其检测方法和应用
CN106680473B (zh) * 2017-01-23 2019-04-09 首都医科大学附属北京朝阳医院 生物标志物在筛选治疗或缓解代谢综合征的药物中的用途
CN108152502A (zh) * 2017-11-23 2018-06-12 上海阿趣生物科技有限公司 可用于检测糖尿病早期的组合标志物及其用途
KR102377089B1 (ko) 2018-11-27 2022-03-21 대한민국 전당뇨 진단 키트 및 진단 방법
CN109709228B (zh) * 2019-01-14 2022-06-14 上海市内分泌代谢病研究所 脂质联合标志物在制备诊断糖尿病的检测试剂或检测物的用途
CN112697889B (zh) * 2019-10-22 2022-03-08 中国科学院大连化学物理研究所 一种血清代谢标志物的用途及检测试剂盒
CN112268962B (zh) * 2020-09-08 2022-12-23 南京医科大学 长链酰基肉碱作为缺血性脑卒中生物标志物的应用
CN112180013B (zh) * 2020-09-29 2022-11-15 上海脉示生物技术有限公司 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用
CN112230003B (zh) * 2020-11-05 2022-06-21 江苏省中医院 三种血清脂质联合用于糖尿病肾病诊断的用途
CN112630330B (zh) * 2020-12-08 2021-12-21 河北医科大学第二医院 小分子物质在脑梗死诊断中的应用
WO2022133738A1 (zh) * 2020-12-22 2022-06-30 中山大学附属第一医院 一种术前鉴别甲状腺良恶性结节的生物标志物、试剂盒及其应用
CN112986425B (zh) * 2021-02-09 2023-07-04 首都医科大学 Pm2.5对脂质代谢影响的检测标志物及应用
CN113008972B (zh) * 2021-02-26 2023-03-24 南芯芯仪(广州)制造有限公司 用于妊娠期糖尿病诊断的血清代谢标志物及其应用
CN115112776B (zh) * 2021-03-18 2023-07-04 中国科学院大连化学物理研究所 联合标志物及在诊断心房颤动中应用及诊断试剂或试剂盒
CN113484511B (zh) * 2021-06-30 2023-07-04 华中科技大学 妊娠期糖尿病的孕早期血液脂质生物标志物的筛选及应用
CN114317671B (zh) * 2021-12-27 2024-04-16 复旦大学附属儿科医院 可作为1型糖尿病生物标志物的肠道细菌和粪便代谢物及其应用
CN117169365A (zh) * 2023-08-18 2023-12-05 上海市内分泌代谢病研究所 多不饱和脂肪酸联合标志物在制备诊断糖尿病的检测产品中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004515785A (ja) * 2000-12-14 2004-05-27 ザ ブライハム アンド ウイミンズ ホスピタル, インコーポレイテッド 真性糖尿病の検出および予防のための炎症性マーカー
US20060088860A1 (en) * 2004-09-13 2006-04-27 Lipomics Technologies, Inc. Metabolite markers for weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2459508A1 (en) * 2001-09-24 2003-04-03 Lipomics Technologies, Inc. Methods of using quantitative lipid metabolome data
US20070218519A1 (en) * 2005-10-11 2007-09-20 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004515785A (ja) * 2000-12-14 2004-05-27 ザ ブライハム アンド ウイミンズ ホスピタル, インコーポレイテッド 真性糖尿病の検出および予防のための炎症性マーカー
US20060088860A1 (en) * 2004-09-13 2006-04-27 Lipomics Technologies, Inc. Metabolite markers for weight management

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6012040727; T. Decsi, R. Hermann, A. Kozari, et al.: 'Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children' Prostaglandins, Leukotrienes and Essential Fatty Acids Vol. 67, No. 4, 203-210, 2002 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509588A (ja) * 2009-10-29 2013-03-14 テシス バイオサイエンス, インコーポレイテッド 2型糖尿病の予防に対して一貫した改善をもたらすタンパク質バイオマーカーおよび脂質代謝物バイオマーカー
JP2014518140A (ja) * 2011-07-05 2014-07-28 エルジーシーエイチ インコーポレイテッド 痙攣の検出方法および検出装置
JP2017502304A (ja) * 2014-01-08 2017-01-19 ネステク ソシエテ アノニム 心外膜脂肪組織用のバイオマーカー
US10648991B2 (en) 2014-01-08 2020-05-12 Societe Des Produits Nestle S.A. Biomarkers for epicardial adipose tissue
WO2021162033A1 (ja) * 2020-02-13 2021-08-19 東洋インキScホールディングス株式会社 回帰モデル作成方法、回帰モデル作成装置、及び、回帰モデル作成プログラム
JP2021128042A (ja) * 2020-02-13 2021-09-02 東洋インキScホールディングス株式会社 回帰モデル作成方法、回帰モデル作成装置、及び、回帰モデル作成プログラム
JP2022056512A (ja) * 2020-09-30 2022-04-11 東ソー株式会社 統計的手法によるクロマトグラムの分類方法
JP7517036B2 (ja) 2020-09-30 2024-07-17 東ソー株式会社 統計的手法によるクロマトグラムの分類方法

Also Published As

Publication number Publication date
CN101802620A (zh) 2010-08-11
AU2008219700B2 (en) 2014-05-29
CA2678670A1 (en) 2009-09-04
US20100197028A1 (en) 2010-08-05
EP2126589A4 (en) 2011-06-08
WO2008106054A3 (en) 2008-12-11
AU2008219700A1 (en) 2008-09-04
WO2008106054A2 (en) 2008-09-04
EP2126589A2 (en) 2009-12-02
BRPI0807612A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
JP2010519543A (ja) 糖尿病状態の代謝マーカーおよびその使用法
JP2010519543A5 (enExample)
EP2607902B1 (en) Markers of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and methods of use thereof
EP2164977B1 (en) Biomarkers for pre-diabetes and methods using the same
EP3321686B1 (en) Biomarkers related to insulin resistance progression and methods using the same
JP6158186B2 (ja) インスリン抵抗性に関連するバイオマーカーおよびそれを使用する方法
Zhang et al. Human serum poly-and perfluoroalkyl substance concentrations and their associations with gestational diabetes mellitus
WO2013139584A1 (en) Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing
Djekic et al. Metabolomics in atherosclerosis
WO2013139579A1 (en) 9-oxo-octadecadienoic acid (9-oxo-hode) as as biomarker for healthy ageing
KR101598597B1 (ko) 혈장 대사체를 이용한 고-ldl-콜레스테롤 질환 진단 장치 및 방법
US20220308071A1 (en) Methods and compositions for determination of liver fibrosis
Jain et al. Identification of novel plasma lipid markers of cardiovascular disease risk in White and Black women
Meuronen Gene x diet interactions and fatty acid metabolism: FADS genotype and dietary polyunsaturated fatty acids
AU2016206265B2 (en) Method for Determining Insulin Sensitivity with Biomarkers
JP5020239B6 (ja) インスリン抵抗性病態を示す疾患の検出方法
JP5020239B2 (ja) インスリン抵抗性病態を示す疾患の検出方法
HK1131209B (en) Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof
Djekic et al. IJC Metabolic & Endocrine
US20150247841A1 (en) Neurofurans-indices of oxidant stress
HK1142636B (en) Biomarkers for pre-diabetes and methods using the same
JPWO2007139224A6 (ja) インスリン抵抗性病態を示す疾患の検出方法

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110218

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120207

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120705

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121102

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121130

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121228

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130424