CN101802620A - 糖尿病状况的代谢标志物及其使用方法 - Google Patents

糖尿病状况的代谢标志物及其使用方法 Download PDF

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CN101802620A
CN101802620A CN200880012978A CN200880012978A CN101802620A CN 101802620 A CN101802620 A CN 101802620A CN 200880012978 A CN200880012978 A CN 200880012978A CN 200880012978 A CN200880012978 A CN 200880012978A CN 101802620 A CN101802620 A CN 101802620A
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S·M·沃特金斯
M·M·维斯特
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Tethys Bioscience Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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CN200880012978A 2007-02-22 2008-02-22 糖尿病状况的代谢标志物及其使用方法 Pending CN101802620A (zh)

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US90297607P 2007-02-22 2007-02-22
US60/902,976 2007-02-22
US93176607P 2007-05-24 2007-05-24
US60/931,766 2007-05-24
US2185308P 2008-01-17 2008-01-17
US61/021,853 2008-01-17
PCT/US2008/002357 WO2008106054A2 (en) 2007-02-22 2008-02-22 Metabolic markers of diabetic conditions and methods of use thereof

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US (1) US20100197028A1 (enExample)
EP (1) EP2126589A4 (enExample)
JP (1) JP2010519543A (enExample)
CN (1) CN101802620A (enExample)
AU (1) AU2008219700B2 (enExample)
BR (1) BRPI0807612A2 (enExample)
CA (1) CA2678670A1 (enExample)
WO (1) WO2008106054A2 (enExample)

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CN102495217A (zh) * 2011-12-06 2012-06-13 谢文茹 一种临床病例监测管理系统
CN105008931A (zh) * 2013-03-08 2015-10-28 佐拉生物科学公司 非高密度脂蛋白来源的cvd标志物
CN105424841A (zh) * 2015-12-25 2016-03-23 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
WO2016049828A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 肥胖人群特异性生物标志组合物及其用途
CN105486773A (zh) * 2015-12-25 2016-04-13 齐炼文 用于诊断冠心病的代谢标志物
CN105628809A (zh) * 2015-12-25 2016-06-01 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
CN106680473A (zh) * 2017-01-23 2017-05-17 首都医科大学附属北京朝阳医院 生物标志物在筛选治疗或缓解代谢综合征的药物中的用途
CN106979982A (zh) * 2016-01-19 2017-07-25 上海市第六人民医院 一种用于糖尿病风险预测、治疗评价的方法及试剂盒
CN107121540A (zh) * 2016-02-24 2017-09-01 中国科学院上海生命科学研究院 酰基肉碱谱或其检测试剂在2型糖尿病发病风险预测中的应用
CN109709228A (zh) * 2019-01-14 2019-05-03 上海市内分泌代谢病研究所 脂质联合标志物在制备诊断糖尿病的检测试剂或检测物的用途
CN112180013A (zh) * 2020-09-29 2021-01-05 上海透景生命科技股份有限公司 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用
CN112230003A (zh) * 2020-11-05 2021-01-15 江苏省中医院 三种血清脂质联合用于糖尿病肾病诊断的用途
CN112268962A (zh) * 2020-09-08 2021-01-26 南京医科大学 长链酰基肉碱作为缺血性脑卒中生物标志物的应用
CN112630330A (zh) * 2020-12-08 2021-04-09 河北医科大学第二医院 小分子物质在脑梗死诊断中的应用
CN112697889A (zh) * 2019-10-22 2021-04-23 中国科学院大连化学物理研究所 一种血清代谢标志物的用途及检测试剂盒
CN112986425A (zh) * 2021-02-09 2021-06-18 首都医科大学 Pm2.5对脂质代谢影响的检测标志物及应用
CN113008972A (zh) * 2021-02-26 2021-06-22 南芯芯仪(广州)制造有限公司 用于妊娠期糖尿病诊断的血清代谢标志物及其应用
CN113484511A (zh) * 2021-06-30 2021-10-08 华中科技大学 妊娠期糖尿病的孕早期血液脂质生物标志物的筛选及应用
WO2022133738A1 (zh) * 2020-12-22 2022-06-30 中山大学附属第一医院 一种术前鉴别甲状腺良恶性结节的生物标志物、试剂盒及其应用
CN115112776A (zh) * 2021-03-18 2022-09-27 中国科学院大连化学物理研究所 联合标志物及在诊断心房颤动中应用及诊断试剂或试剂盒
WO2025039607A1 (zh) * 2023-08-18 2025-02-27 上海市内分泌代谢病研究所 多不饱和脂肪酸联合标志物在制备诊断糖尿病的检测产品中的应用

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EP2407562A1 (en) * 2006-05-08 2012-01-18 Tethys Bioscience, Inc. Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
JP2011528117A (ja) * 2008-07-15 2011-11-10 メタノミクス ヘルス ゲーエムベーハー 胃バイパス及びそれに関連する状態を診断する手段及び方法
WO2010114897A1 (en) * 2009-03-31 2010-10-07 Metabolon, Inc. Biomarkers related to insulin resistance and methods using the same
US11835503B2 (en) * 2009-05-28 2023-12-05 The Cleveland Clinic Foundation TMA-formation inhibitor treatment for elevated TMA-containing compound diseases
CA2790371C (en) * 2009-05-28 2020-09-01 The Cleveland Clinic Foundation Trimethylamine-containing compounds for diagnosis and prediction of disease
JP2013509588A (ja) * 2009-10-29 2013-03-14 テシス バイオサイエンス， インコーポレイテッド ２型糖尿病の予防に対して一貫した改善をもたらすタンパク質バイオマーカーおよび脂質代謝物バイオマーカー
EP3273247A1 (en) 2010-06-10 2018-01-24 Metanomics Health GmbH Methods for the diagnosis of liver diseases
US10226209B2 (en) 2010-10-15 2019-03-12 Brain Sentinel, Inc. Method and apparatus for classification of seizure type and severity using electromyography
KR101303825B1 (ko) * 2011-06-02 2013-09-05 연세대학교 산학협력단 혈장 대사체를 이용한 제2형 당뇨병 진단 키트
CA2840101A1 (en) * 2011-07-05 2013-01-10 Lgch, Inc. Method and apparatus for detecting seizures
JP6158186B2 (ja) * 2011-09-14 2017-07-05 メタボロン，インコーポレイテッド インスリン抵抗性に関連するバイオマーカーおよびそれを使用する方法
AU2014377039A1 (en) 2014-01-08 2016-05-26 Société des Produits Nestlé S.A. Biomarkers for epicardial adipose tissue
WO2015109116A1 (en) * 2014-01-15 2015-07-23 The Regents Of The University Of California Metabolic screening for gestational diabetes
US11255866B2 (en) * 2015-02-26 2022-02-22 Wisconsin Alumni Research Foundation Methods for predicting glucoregulatory dysfunction via diacylglycerol fatty acid species concentrations
CN105486778B (zh) * 2016-01-25 2017-11-03 齐炼文 诊断区分稳定型心绞痛和急性冠脉综合征的代谢标志物
CN105445408B (zh) * 2016-01-25 2018-06-12 齐炼文 诊断区分冠状动脉粥样硬化和稳定型心绞痛的代谢标志物
CN106483212B (zh) * 2016-09-22 2019-03-01 南京医科大学 与特发性男性不育相关的尿液雌激素代谢物标志物及其检测方法和应用
CN108152502A (zh) * 2017-11-23 2018-06-12 上海阿趣生物科技有限公司 可用于检测糖尿病早期的组合标志物及其用途
KR102377089B1 (ko) 2018-11-27 2022-03-21 대한민국 전당뇨 진단 키트 및 진단 방법
JP6725928B1 (ja) * 2020-02-13 2020-07-22 東洋インキＳｃホールディングス株式会社 回帰モデル作成方法、回帰モデル作成装置、及び、回帰モデル作成プログラム
JP7517036B2 (ja) * 2020-09-30 2024-07-17 東ソー株式会社 統計的手法によるクロマトグラムの分類方法
CN114317671B (zh) * 2021-12-27 2024-04-16 复旦大学附属儿科医院 可作为1型糖尿病生物标志物的肠道细菌和粪便代谢物及其应用

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AU2002230848B2 (en) * 2000-12-14 2008-01-24 The Brigham And Women's Hospital, Inc. Inflammatory markers for detection and prevention of diabetes mellitus
CA2459508A1 (en) * 2001-09-24 2003-04-03 Lipomics Technologies, Inc. Methods of using quantitative lipid metabolome data
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US20070218519A1 (en) * 2005-10-11 2007-09-20 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof

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CN102495217B (zh) * 2011-12-06 2014-06-25 黄传峰 一种临床病例监测管理系统
CN102495217A (zh) * 2011-12-06 2012-06-13 谢文茹 一种临床病例监测管理系统
CN105008931A (zh) * 2013-03-08 2015-10-28 佐拉生物科学公司 非高密度脂蛋白来源的cvd标志物
WO2016049828A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 肥胖人群特异性生物标志组合物及其用途
CN105628809A (zh) * 2015-12-25 2016-06-01 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
CN105486773A (zh) * 2015-12-25 2016-04-13 齐炼文 用于诊断冠心病的代谢标志物
CN105424841A (zh) * 2015-12-25 2016-03-23 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
CN105424841B (zh) * 2015-12-25 2017-11-03 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
CN105628809B (zh) * 2015-12-25 2018-04-03 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
CN106979982A (zh) * 2016-01-19 2017-07-25 上海市第六人民医院 一种用于糖尿病风险预测、治疗评价的方法及试剂盒
CN106979982B (zh) * 2016-01-19 2021-01-05 上海市第六人民医院 一种用于糖尿病风险预测、治疗评价的方法及试剂盒
CN107121540B (zh) * 2016-02-24 2020-06-12 中国科学院上海营养与健康研究所 酰基肉碱谱或其检测试剂在2型糖尿病发病风险预测中的应用
CN107121540A (zh) * 2016-02-24 2017-09-01 中国科学院上海生命科学研究院 酰基肉碱谱或其检测试剂在2型糖尿病发病风险预测中的应用
CN106680473A (zh) * 2017-01-23 2017-05-17 首都医科大学附属北京朝阳医院 生物标志物在筛选治疗或缓解代谢综合征的药物中的用途
CN106680473B (zh) * 2017-01-23 2019-04-09 首都医科大学附属北京朝阳医院 生物标志物在筛选治疗或缓解代谢综合征的药物中的用途
CN109709228A (zh) * 2019-01-14 2019-05-03 上海市内分泌代谢病研究所 脂质联合标志物在制备诊断糖尿病的检测试剂或检测物的用途
CN109709228B (zh) * 2019-01-14 2022-06-14 上海市内分泌代谢病研究所 脂质联合标志物在制备诊断糖尿病的检测试剂或检测物的用途
CN112697889A (zh) * 2019-10-22 2021-04-23 中国科学院大连化学物理研究所 一种血清代谢标志物的用途及检测试剂盒
CN112268962A (zh) * 2020-09-08 2021-01-26 南京医科大学 长链酰基肉碱作为缺血性脑卒中生物标志物的应用
CN112180013A (zh) * 2020-09-29 2021-01-05 上海透景生命科技股份有限公司 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用
CN112180013B (zh) * 2020-09-29 2022-11-15 上海脉示生物技术有限公司 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用
CN112230003A (zh) * 2020-11-05 2021-01-15 江苏省中医院 三种血清脂质联合用于糖尿病肾病诊断的用途
CN112630330B (zh) * 2020-12-08 2021-12-21 河北医科大学第二医院 小分子物质在脑梗死诊断中的应用
CN112630330A (zh) * 2020-12-08 2021-04-09 河北医科大学第二医院 小分子物质在脑梗死诊断中的应用
WO2022133738A1 (zh) * 2020-12-22 2022-06-30 中山大学附属第一医院 一种术前鉴别甲状腺良恶性结节的生物标志物、试剂盒及其应用
CN112986425A (zh) * 2021-02-09 2021-06-18 首都医科大学 Pm2.5对脂质代谢影响的检测标志物及应用
CN113008972A (zh) * 2021-02-26 2021-06-22 南芯芯仪(广州)制造有限公司 用于妊娠期糖尿病诊断的血清代谢标志物及其应用
CN115112776A (zh) * 2021-03-18 2022-09-27 中国科学院大连化学物理研究所 联合标志物及在诊断心房颤动中应用及诊断试剂或试剂盒
CN115112776B (zh) * 2021-03-18 2023-07-04 中国科学院大连化学物理研究所 联合标志物及在诊断心房颤动中应用及诊断试剂或试剂盒
CN113484511A (zh) * 2021-06-30 2021-10-08 华中科技大学 妊娠期糖尿病的孕早期血液脂质生物标志物的筛选及应用
WO2025039607A1 (zh) * 2023-08-18 2025-02-27 上海市内分泌代谢病研究所 多不饱和脂肪酸联合标志物在制备诊断糖尿病的检测产品中的应用

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JP2010519543A (ja) 2010-06-03
AU2008219700B2 (en) 2014-05-29
CA2678670A1 (en) 2009-09-04
US20100197028A1 (en) 2010-08-05
EP2126589A4 (en) 2011-06-08
WO2008106054A3 (en) 2008-12-11
AU2008219700A1 (en) 2008-09-04
WO2008106054A2 (en) 2008-09-04
EP2126589A2 (en) 2009-12-02
BRPI0807612A2 (pt) 2015-06-16

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Application publication date: 20100811