JP2010519230A5 - - Google Patents
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- Publication number
- JP2010519230A5 JP2010519230A5 JP2009550227A JP2009550227A JP2010519230A5 JP 2010519230 A5 JP2010519230 A5 JP 2010519230A5 JP 2009550227 A JP2009550227 A JP 2009550227A JP 2009550227 A JP2009550227 A JP 2009550227A JP 2010519230 A5 JP2010519230 A5 JP 2010519230A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitors
- atoms
- receptor modulator
- nha
- naa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 241001274216 Naso Species 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000002834 estrogen receptor modulator Substances 0.000 claims 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 2
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229940075993 receptor modulator Drugs 0.000 claims 2
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 2
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- -1 COOA Chemical group 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007008419.8 | 2007-02-21 | ||
| DE102007008419A DE102007008419A1 (de) | 2007-02-21 | 2007-02-21 | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
| PCT/EP2008/000634 WO2008101587A1 (de) | 2007-02-21 | 2008-01-28 | 4-(pyrrolopyridinyl)-pyrimidin-2-yl-amin-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519230A JP2010519230A (ja) | 2010-06-03 |
| JP2010519230A5 true JP2010519230A5 (enExample) | 2011-03-17 |
| JP5508026B2 JP5508026B2 (ja) | 2014-05-28 |
Family
ID=39410261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550227A Expired - Fee Related JP5508026B2 (ja) | 2007-02-21 | 2008-01-28 | ４−（ピロロピリジニル）ピリミジン−２−イルアミン誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8293891B2 (enExample) |
| EP (1) | EP2121682B1 (enExample) |
| JP (1) | JP5508026B2 (enExample) |
| KR (1) | KR20090110948A (enExample) |
| CN (1) | CN101616918A (enExample) |
| AR (1) | AR065390A1 (enExample) |
| AU (1) | AU2008217297B2 (enExample) |
| BR (1) | BRPI0808167A2 (enExample) |
| CA (1) | CA2678691C (enExample) |
| DE (1) | DE102007008419A1 (enExample) |
| DK (1) | DK2121682T3 (enExample) |
| EA (1) | EA200901100A1 (enExample) |
| ES (1) | ES2427594T3 (enExample) |
| IL (1) | IL200470A (enExample) |
| MX (1) | MX2009008864A (enExample) |
| PT (1) | PT2121682E (enExample) |
| WO (1) | WO2008101587A1 (enExample) |
| ZA (1) | ZA200906539B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2026654A4 (en) * | 2006-05-26 | 2013-07-17 | Univ Louisville Res Found | MACROPHAGE MIGRATION HEMMFAKTOR ANTAGONISTS AND USE METHOD THEREFOR |
| US9162987B2 (en) | 2009-09-24 | 2015-10-20 | University Of Louisville Research Foundation, Inc. | Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions |
| US9155790B2 (en) | 2010-05-20 | 2015-10-13 | University of Lousiville Research Foundation, Inc. | Methods and compositions for modulating ocular damage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| RU2292904C2 (ru) * | 2001-01-09 | 2007-02-10 | Мерк Патент Гмбх | Комбинированная терапия, использующая ингибиторы рецептора тирозинкиназы и ингибиторы ангиогенезиса |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| WO2006038001A1 (en) * | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
-
2007
- 2007-02-21 DE DE102007008419A patent/DE102007008419A1/de not_active Withdrawn
-
2008
- 2008-01-28 CN CN200880005794A patent/CN101616918A/zh active Pending
- 2008-01-28 EP EP08707340.9A patent/EP2121682B1/de not_active Not-in-force
- 2008-01-28 MX MX2009008864A patent/MX2009008864A/es not_active Application Discontinuation
- 2008-01-28 KR KR1020097019557A patent/KR20090110948A/ko not_active Withdrawn
- 2008-01-28 AU AU2008217297A patent/AU2008217297B2/en not_active Ceased
- 2008-01-28 WO PCT/EP2008/000634 patent/WO2008101587A1/de not_active Ceased
- 2008-01-28 BR BRPI0808167-0A patent/BRPI0808167A2/pt not_active IP Right Cessation
- 2008-01-28 ES ES08707340T patent/ES2427594T3/es active Active
- 2008-01-28 DK DK08707340.9T patent/DK2121682T3/da active
- 2008-01-28 PT PT87073409T patent/PT2121682E/pt unknown
- 2008-01-28 US US12/527,671 patent/US8293891B2/en not_active Expired - Fee Related
- 2008-01-28 CA CA2678691A patent/CA2678691C/en not_active Expired - Fee Related
- 2008-01-28 EA EA200901100A patent/EA200901100A1/ru unknown
- 2008-01-28 JP JP2009550227A patent/JP5508026B2/ja not_active Expired - Fee Related
- 2008-02-20 AR ARP080100678A patent/AR065390A1/es unknown
-
2009
- 2009-08-18 IL IL200470A patent/IL200470A/en active IP Right Grant
- 2009-09-18 ZA ZA200906539A patent/ZA200906539B/xx unknown
-
2012
- 2012-06-19 US US13/527,008 patent/US8557977B2/en not_active Expired - Fee Related
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