MX2009008864A - Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina. - Google Patents

Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina.

Info

Publication number
MX2009008864A
MX2009008864A MX2009008864A MX2009008864A MX2009008864A MX 2009008864 A MX2009008864 A MX 2009008864A MX 2009008864 A MX2009008864 A MX 2009008864A MX 2009008864 A MX2009008864 A MX 2009008864A MX 2009008864 A MX2009008864 A MX 2009008864A
Authority
MX
Mexico
Prior art keywords
pyrrolopyridinyl
pyrimidin
ylamine derivatives
ylamine
derivatives
Prior art date
Application number
MX2009008864A
Other languages
English (en)
Inventor
Dieter Dorsch
Christian Sirrenberg
Thomas J J Mueller
Eugen Merkul
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2009008864A publication Critical patent/MX2009008864A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos de la fórmula I (ver fórmula I) en donde R1, R2, R3, R4 y R5 son cada uno como se definen en la reivindicación 1, son inhibidores de la proliferación celular / vitalidad celular y se pueden emplear para el tratamiento de tumores.
MX2009008864A 2007-02-21 2008-01-28 Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina. MX2009008864A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007008419A DE102007008419A1 (de) 2007-02-21 2007-02-21 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
PCT/EP2008/000634 WO2008101587A1 (de) 2007-02-21 2008-01-28 4-(pyrrolopyridinyl)-pyrimidin-2-yl-amin-derivate

Publications (1)

Publication Number Publication Date
MX2009008864A true MX2009008864A (es) 2009-08-28

Family

ID=39410261

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008864A MX2009008864A (es) 2007-02-21 2008-01-28 Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina.

Country Status (18)

Country Link
US (2) US8293891B2 (es)
EP (1) EP2121682B1 (es)
JP (1) JP5508026B2 (es)
KR (1) KR20090110948A (es)
CN (1) CN101616918A (es)
AR (1) AR065390A1 (es)
AU (1) AU2008217297B2 (es)
BR (1) BRPI0808167A2 (es)
CA (1) CA2678691C (es)
DE (1) DE102007008419A1 (es)
DK (1) DK2121682T3 (es)
EA (1) EA200901100A1 (es)
ES (1) ES2427594T3 (es)
IL (1) IL200470A (es)
MX (1) MX2009008864A (es)
PT (1) PT2121682E (es)
WO (1) WO2008101587A1 (es)
ZA (1) ZA200906539B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140263A2 (en) * 2006-05-26 2007-12-06 University Of Louisville Research Foundation, Inc. Macrophage migration inhibitory factor antagonists and methods of using same
EP2480235A4 (en) 2009-09-24 2013-05-08 Univ Louisville Res Found NEW IODO-PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ILLNESSES AND SUFFERING IN CONNECTION WITH THE MACROPHAGE MIGRATION-INHIBITING FACTOR
WO2011146824A1 (en) 2010-05-20 2011-11-24 University Of Louisville Research Foundation, Inc. Methods and compositions for modulating ocular damage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
KR100983997B1 (ko) * 2001-01-09 2010-09-28 메르크 파텐트 게엠베하 수용체 타이로신 키나아제 저해제 및 혈관형성 저해제를 사용하는 병용 요법
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
WO2006038001A1 (en) * 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors

Also Published As

Publication number Publication date
ZA200906539B (en) 2010-06-30
PT2121682E (pt) 2013-10-17
US20110092527A1 (en) 2011-04-21
JP5508026B2 (ja) 2014-05-28
EP2121682A1 (de) 2009-11-25
WO2008101587A1 (de) 2008-08-28
EP2121682B1 (de) 2013-07-10
AU2008217297B2 (en) 2013-01-17
AR065390A1 (es) 2009-06-03
US8557977B2 (en) 2013-10-15
CN101616918A (zh) 2009-12-30
US8293891B2 (en) 2012-10-23
IL200470A (en) 2014-02-27
DK2121682T3 (da) 2013-09-08
JP2010519230A (ja) 2010-06-03
KR20090110948A (ko) 2009-10-23
IL200470A0 (en) 2010-04-29
CA2678691C (en) 2015-09-08
AU2008217297A1 (en) 2008-08-28
EA200901100A1 (ru) 2010-02-26
US20120264999A1 (en) 2012-10-18
DE102007008419A1 (de) 2008-08-28
ES2427594T3 (es) 2013-10-31
BRPI0808167A2 (pt) 2014-07-08
CA2678691A1 (en) 2008-08-28

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Legal Events

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