JP2010515721A5 - - Google Patents

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Publication number
JP2010515721A5
JP2010515721A5 JP2009545295A JP2009545295A JP2010515721A5 JP 2010515721 A5 JP2010515721 A5 JP 2010515721A5 JP 2009545295 A JP2009545295 A JP 2009545295A JP 2009545295 A JP2009545295 A JP 2009545295A JP 2010515721 A5 JP2010515721 A5 JP 2010515721A5
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JP
Japan
Prior art keywords
compound
group
glycerol backbone
moiety
phosphorus
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JP2009545295A
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English (en)
Japanese (ja)
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JP2010515721A (ja
JP5453109B2 (ja
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Priority claimed from US11/650,973 external-priority patent/US7807847B2/en
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Publication of JP2010515721A5 publication Critical patent/JP2010515721A5/ja
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Publication of JP5453109B2 publication Critical patent/JP5453109B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009545295A 2007-01-09 2008-01-02 酸化リン脂質の改良された調製方法 Expired - Fee Related JP5453109B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/650,973 US7807847B2 (en) 2004-07-09 2007-01-09 Process for the preparation of oxidized phospholipids
US11/650,973 2007-01-09
PCT/IL2008/000013 WO2008084472A2 (en) 2007-01-09 2008-01-02 Improved process for the preparation of oxidized phospholipids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014000036A Division JP2014088415A (ja) 2007-01-09 2014-01-06 酸化リン脂質の改良された調製方法

Publications (3)

Publication Number Publication Date
JP2010515721A JP2010515721A (ja) 2010-05-13
JP2010515721A5 true JP2010515721A5 (https=) 2010-11-25
JP5453109B2 JP5453109B2 (ja) 2014-03-26

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ID=39609128

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JP2009545295A Expired - Fee Related JP5453109B2 (ja) 2007-01-09 2008-01-02 酸化リン脂質の改良された調製方法
JP2014000036A Pending JP2014088415A (ja) 2007-01-09 2014-01-06 酸化リン脂質の改良された調製方法

Family Applications After (1)

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JP2014000036A Pending JP2014088415A (ja) 2007-01-09 2014-01-06 酸化リン脂質の改良された調製方法

Country Status (13)

Country Link
US (5) US7807847B2 (https=)
EP (2) EP2522672A1 (https=)
JP (2) JP5453109B2 (https=)
KR (1) KR20090109095A (https=)
CN (2) CN103864842A (https=)
AU (1) AU2008204238B2 (https=)
CA (2) CA2674902C (https=)
ES (1) ES2574586T3 (https=)
IL (1) IL199792A (https=)
MX (1) MX2009007422A (https=)
NZ (3) NZ603980A (https=)
WO (1) WO2008084472A2 (https=)
ZA (1) ZA200905601B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
US7784501B2 (en) 2005-04-08 2010-08-31 Air Products And Chemicals, Inc. Efficient system and method for delivery of product and return of carrier
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
JP2010047550A (ja) * 2008-08-25 2010-03-04 Daicel Chem Ind Ltd アルコキシアルカンカルボン酸エステルの製造方法
US8999960B2 (en) * 2008-10-08 2015-04-07 Vascular Biogenics Ltd. Oxidized thiophospholipid compounds and uses thereof
CN102271517B (zh) 2008-11-06 2015-04-08 脉管生物生长有限公司 氧化的脂质化合物和其用途
EP2748299B1 (en) 2011-08-24 2018-03-14 The Regents of The University of California Targeting microbubbles
SG11201400208PA (en) 2011-09-01 2014-03-28 Vascular Biogenics Ltd Formulations and dosage forms of oxidized phospholipids
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
CN105622665B (zh) * 2016-03-16 2017-11-24 北京美亚斯磷脂技术有限公司 一种改性大豆磷脂的制备方法
WO2018000339A1 (zh) * 2016-06-30 2018-01-04 深圳市亚辉龙生物科技股份有限公司 改性心磷脂包被的纳米磁珠及其制备方法
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
KR20220166785A (ko) * 2020-01-28 2022-12-19 어플러드 메디컬 인코퍼레이티드 인지질 화합물 및 제형
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN114195821B (zh) * 2021-12-17 2024-03-12 郑州安图生物工程股份有限公司 一种心磷脂衍生物及其制备方法和应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5638578B2 (https=) * 1973-05-18 1981-09-08
CH642665A5 (en) 1979-02-08 1984-04-30 Rudolf Berchtold Process for the preparation of 1-(omega-carboxyalkyl)-2-alkyl- glycero-3-phosphatides
US4329302A (en) * 1980-06-27 1982-05-11 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
DE3307925A1 (de) 1983-03-05 1984-09-06 A. Nattermann & Cie GmbH, 5000 Köln Neue 0-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4614796A (en) * 1983-03-25 1986-09-30 Nippon Shinyaku Co., Ltd. Liposome and method of manufacture therefor
JPS6041652A (ja) * 1983-08-13 1985-03-05 Morinaga Milk Ind Co Ltd Ν−カルボベンジルオキシ−L−グルタミン酸−γ−コリンエステル塩の製造法
JPS60100544A (ja) 1983-11-08 1985-06-04 Ono Pharmaceut Co Ltd 新規なグリセリン誘導体,その製造方法及びその誘導体を含有する薬剤
JPS60104066A (ja) 1983-11-10 1985-06-08 Ono Pharmaceut Co Ltd グリセリン誘導体
AT383130B (de) 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
US4710579A (en) 1984-11-09 1987-12-01 Takeda Chemical Industries, Ltd. 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof
JPH0617307B2 (ja) 1984-11-09 1994-03-09 武田薬品工業株式会社 抗腫瘍剤
US4827011A (en) * 1984-12-10 1989-05-02 American Cyanamid Company Antihypertensive phosphate derivatives
JPS61246196A (ja) * 1985-04-22 1986-11-01 Fuji Kagaku Kogyo Kk 5′−0−アシル−5−フルオロウリジン及びその製造方法
DE3663522D1 (en) * 1985-11-29 1989-06-29 Takeda Chemical Industries Ltd Phospholipid derivatives, their production and use
US5061626A (en) 1986-03-24 1991-10-29 University Of Sydney Antigenic anarogues of platelet activating factor
AU7285487A (en) * 1986-04-07 1987-11-09 Upjohn Company, The Anthelmintic quaternaryalkyl acylhydrazones, method of use and compositions
JPS6294A (ja) 1986-05-09 1987-01-06 Toyama Chem Co Ltd 新規なグリセロリン酸誘導体およびその塩並びにそれらの製造法
JPS6354386A (ja) 1986-08-26 1988-03-08 Takeda Chem Ind Ltd リン脂質およびその用途
JPS63190859A (ja) * 1986-09-18 1988-08-08 Takeda Chem Ind Ltd グリセリン誘導体
JPS63135395A (ja) 1986-11-28 1988-06-07 Nippon Oil & Fats Co Ltd リン脂質誘導体及びその製造方法
JPS63188692A (ja) * 1987-01-29 1988-08-04 Nippon Oil & Fats Co Ltd リン脂質誘導体の製造方法
DE3807123A1 (de) 1988-03-04 1989-09-14 Boehringer Mannheim Gmbh Substrate fuer phospholipasen
JPH01258691A (ja) 1988-04-06 1989-10-16 Nippon Oil & Fats Co Ltd リン脂質誘導体及びその製造方法
JP2534894B2 (ja) 1988-06-24 1996-09-18 日本ケミファ株式会社 新規なグリセリン誘導体およびその誘導体を含有する血圧降下剤
JPH0248585A (ja) 1988-08-10 1990-02-19 Nippon Oil & Fats Co Ltd リン脂質誘導体及びその製造方法
JPH03258740A (ja) 1990-03-06 1991-11-19 Kao Corp 液体油、その製造法及びこれを含有する化粧料
ES2019552A6 (es) 1990-04-11 1991-06-16 Menarini Lab Procedimiento para la preparacion de glicerofosfolipidos.
JP2869572B2 (ja) 1990-05-14 1999-03-10 和光純薬工業株式会社 ホスファチジルコリン誘導体の製造方法
US5561052A (en) * 1992-06-18 1996-10-01 Koike; Katsumasa Process for detecting oxidized lipids and process for forming oxidized lipids
FR2714382B1 (fr) * 1993-12-27 1996-02-02 Roussel Uclaf Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques.
AU1751795A (en) 1994-03-04 1995-09-18 University Of British Columbia, The Liposome compositions and methods for the treatment of atherosclerosis
JP3364313B2 (ja) 1994-03-22 2003-01-08 株式会社トクヤマ ポルフィリン/インジウム錯体及び陰イオン感応膜
EP0781138B1 (en) 1994-08-29 2008-05-21 Wake Forest University Lipid analogs for treating viral infections
JPH08208548A (ja) 1995-02-01 1996-08-13 Kao Corp グリセリン誘導体の製造法
US5660855A (en) * 1995-02-10 1997-08-26 California Institute Of Technology Lipid constructs for targeting to vascular smooth muscle tissue
US6261597B1 (en) * 1995-08-31 2001-07-17 Seymour J. Kurtz Method for treating periodontal disease
US6096291A (en) * 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
EP1001971A1 (en) * 1997-07-31 2000-05-24 Elan Pharmaceuticals, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4
JP3781877B2 (ja) 1997-10-03 2006-05-31 株式会社ムック アスコルビン酸誘導体またはその塩、および医薬
US6376450B1 (en) 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
US6414168B1 (en) * 1998-12-28 2002-07-02 Caschem, Inc. Epoxidation of ricinic compounds using a phase-transfer catalyst
US6348583B1 (en) 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
DE60017787T2 (de) 1999-11-30 2006-01-05 ARIZONA BOARD OF REGENTS, on behalf of THE UNIVERSITY OF ARIZONA, Tucson Strahlung-sensitive liposomen
AU4976101A (en) 2000-03-31 2001-10-15 Univ California Control of a gene induced by oxidized lipids in human artery wall cells
JP2002302470A (ja) * 2000-05-15 2002-10-18 Toagosei Co Ltd 新規な第四アンモニウム塩及びその製造方法
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
AU1846102A (en) * 2000-11-24 2002-06-03 Cardimmune Ltd Methods employing and compositions containing defined oxidized phospholipids forprevention and treatment of atherosclerosis
FI20011466A0 (fi) * 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
DE10155095A1 (de) 2001-11-09 2003-05-22 Cognis Deutschland Gmbh Alkyl(en)ylglycerinethercarbonsäuren
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
CN103880876A (zh) * 2004-07-09 2014-06-25 脉管生物生长有限公司 制备氧化磷脂的改进方法
US20060194765A1 (en) 2004-11-16 2006-08-31 Garcia Joe G N Methods and compositions using oxidized phospholipids
WO2007014001A2 (en) 2005-07-21 2007-02-01 The Board Of Trustees Of The Leland Stanford Junior University Multiplex determination of lipid specific binding moieties
US8137977B2 (en) 2006-04-24 2012-03-20 Children's Hospital & Research Center At Oakland Lipidomic approaches to determining drug response phenotypes in cardiovascular disease
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
JP2008037763A (ja) 2006-08-01 2008-02-21 Adeka Corp 抗菌剤及び抗菌剤組成物
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US20090149541A1 (en) 2007-11-28 2009-06-11 Yafit Stark Method of delaying the onset of clinically definite multiple sclerosis
US8999960B2 (en) 2008-10-08 2015-04-07 Vascular Biogenics Ltd. Oxidized thiophospholipid compounds and uses thereof
CN102271517B (zh) 2008-11-06 2015-04-08 脉管生物生长有限公司 氧化的脂质化合物和其用途
JP2013516455A (ja) 2010-01-05 2013-05-13 バスキュラー バイオジェニックス リミテッド Vb−201を用いた治療
SG11201400208PA (en) 2011-09-01 2014-03-28 Vascular Biogenics Ltd Formulations and dosage forms of oxidized phospholipids

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